杉山斉

Pembrolizumab-induced hypothyroidism caused reversible increased serum creatinine levels: a case report

フルテキストURL	fulltext.pdf
著者	Matsuoka, Natsumi\| Tsuji, Kenji\| Ichihara, Eiki\| Hara, Takayuki\| Fukushima, Kazuhiko\| Toma, Kishio\| Kitamura, Shinji\| Inagaki, Kenichi\| Sugiyama, Hitoshi\| Wada, Jun\|
キーワード	Pembrolizumab Hypothyroidism Creatinine Cystatin C
発行日	2020-03-31
出版物タイトル	BMC Nephrology
巻	21巻
出版者	BMC
開始ページ	113
ISSN	1471-2369
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32234009
DOI	10.1186/s12882-020-01775-z
Web of Science KeyUT	000522961400004
関連URL	isVersionOf https://doi.org/10.1186/s12882-020-01775-z

Robotic Renal Autotransplantation: A Feasibility Study in a Porcine Model

JaLCDOI	10.18926/AMO/57953
フルテキストURL	74_1_53.pdf
著者	Kubota, Risa\| Araki, Motoo\| Wada, Koichiro\| Kawamura, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Ariyoshi, Yuichi\| Iwata, Takehiro\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Kano, Yuzuki\| Kitagawa, Masashi\| Tanabe, Katsuyuki\| Sugiyama, Hitoshi\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
抄録	We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery.
キーワード	renal autotransplantation robotic porcine model transplantation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	53
終了ページ	58
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099249
Web of Science KeyUT	000516606200008
NAID	120006795620

Immunohistochemistry of Vasohibin-2 in Human Kidney Disease : Implications in Impaired Glucose Tolerance and Reduced Renal Function

JaLCDOI	10.18926/AMO/55434
フルテキストURL	71_5_369.pdf
著者	Arata, Yuka\| Tanabe, Katsuyuki\| Hinamoto, Norikazu\| Yamasaki, Hiroko\| Sugiyama, Hitoshi\| Maeshima, Yohei\| Kanomata, Naoki\| Sato, Yasufumi\| Wada, Jun\|
抄録	Several angiogenesis-related factors are known to play important roles in the pathogenesis of kidney disease. Vasohibin-2 (VASH-2) was recently reported as a novel proangiogenic factor. Although VASH-2 was demonstrated to accelerate tumor angiogenesis, its roles in non-tumor processes including renal disease have not been well elucidated yet. Here, we performed a retrospective study including an immunohistochemical analysis of human kidney biopsy specimens from 82 Japanese patients with a variety of kidney diseases, and we evaluated the correlations between the immunoreactivity of VASH-2 and the patients’ clinicopathological parameters. VASH-2 immunoreactivity was detected in varying degrees in renal tubules as well as in peritubular capillaries and vasa recta. The cortical and medullary tubule VASH-2+ scores were correlated with the presence of hypertension, and the medullary tubule VASH-2+ score was significantly correlated with the blood glucose (p=0.029, r=0.35) and hemoglobin A1c levels (p=0.0066, r=0.39). Moreover, decreased VASH-2+ scores in the vasa recta were associated with reduced renal function (p=0.0003). These results suggest that VASH-2 could play an important role in the pathogenesis of renal diseases, and that VASH-2 is closely associated with hypertension and impaired glucose tolerance.
キーワード	vasohibin-2 kidney disease vasa recta medullary tubules
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2017-10
巻	71巻
号	5号
出版者	Okayama University Medical School
開始ページ	369
終了ページ	380
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29042694

Comparison of severity classification in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study

フルテキストURL	Mod_Rheumatol_26_5_730.pdf
著者	Sada, Ken-ei\| Harigai, Masayoshi\| Amano, Koichi\| Atsumi, Tatsuya\| Fujimoto, Shouichi\| Yuzawa, Yukio\| Takasaki, Yoshinari\| Banno, Shogo\| Sugihara, Takahiko\| Kobayashi, Masaki\| Usui, Joichi\| Yamagata, Kunihiro\| Homma, Sakae\| Dobashi, Hiroaki\| Tsuboi, Naotake\| Ishizu, Akihiro\| Sugiyama, Hitoshi\| Okada, Yasunori\| Arimura, Yoshihiro\| Matsuo, Seiichi\| Makino, Hirofumi\|
キーワード	Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis
備考	This is an Accepted Manuscript of an article published by Taylor & Francis Group\|
発行日	2016-03-11
出版物タイトル	Modern Rheumatology
巻	26巻
号	5号
出版者	Taylor & Francis
開始ページ	730
終了ページ	737
ISSN	1439-7595
NCID	AA1157187X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	26873424
DOI	10.3109/14397595.2016.1140274
Web of Science KeyUT	000393120600018
関連URL	https://doi.org/10.3109/14397595.2016.1140274

腹膜透析Update

タイトル（別表記）	Peritoneal dialysis update
フルテキストURL	127_111.pdf
著者	杉山斉\|
キーワード	持続携行式腹膜透析（CAPD）自動腹膜透析（APD） SMAP法尿素Kt/V 腹膜平衡試験（peritoneal equilibration test:PET）
出版物タイトル	岡山医学会雑誌
発行日	2015-08-03
巻	127巻
号	2号
開始ページ	111
終了ページ	115
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.127.111
言語	日本語
著作権者	Copyright (c) 2015 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.127.111
NAID	130005096252

A Paraganglioma in a Hypertensive Patient with Unilateral Renal Hypoplasia

JaLCDOI	10.18926/AMO/53341
フルテキストURL	69_2_119.pdf
著者	Terasaka, Tomohiro\| Hagiya, Hideharu\| Kimura, Kosuke\| Nada, Takahiro\| Nakamura, Eri\| Hanayama, Yoshihisa\| Sugiyama, Hitoshi\| Kobayashi, Yasuyuki\| Yanai, Hiroyuki\| Otsuka, Fumio\|
抄録	We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.
キーワード	catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2015-04
巻	69巻
号	2号
出版者	Okayama University Medical School
開始ページ	119
終了ページ	122
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25899634
Web of Science KeyUT	000353181700007

ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells

JaLCDOI	10.18926/AMO/53117
フルテキストURL	69_1_1.pdf
著者	Watatani, Hiroyuki\| Yamasaki, Hiroko\| Maeshima, Yohei\| Nasu, Tatsuyo\| Hinamoto, Norikazu\| Ujike, Haruyo\| Sugiyama, Hitoshi\| Sakai, Yoshiki\| Tanabe, Katsuyuki\| Makino, Hirofumi\|
抄録	Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells.
キーワード	prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-02
巻	69巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	15
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25703166
Web of Science KeyUT	000349740300001
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/53128

Renal Distribution of Vasohibin-1 in Patients with Chronic Kidney Disease

JaLCDOI	10.18926/AMO/52788
フルテキストURL	68_4_219.pdf
著者	Hinamoto, Norikazu\| Maeshima, Yohei\| Saito, Daisuke\| Yamasaki, Hiroko\| Tanabe, Katsuyuki\| Nasu, Tatsuyo\| Watatani, Hiroyuki\| Ujike, Haruyo\| Kinomura, Masaru\| Sugiyama, Hitoshi\| Sonoda, Hikaru\| Kanomata, Naoki\| Sato, Yasufumi\| Makino, Hirofumi\|
抄録	Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
キーワード	chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	233
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145408
Web of Science KeyUT	000340687500004
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52824

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

著者	Kitagawa, Masashi\| Sugiyama, Hitoshi\| Morinaga, Hiroshi\| Inoue, Tatsuyuki\| Takiue, Keiichi\| Ogawa, Ayu\| Yamanari, Toshio\| Kikumoto, Yoko\| Uchida, Haruhito Adam\| Kitamura, Shinji\| Maeshima, Yohei\| Nakamura, Kazufumi\| Ito, Hiroshi\| Makino, Hirofumi\|
発行日	2013-02-19
出版物タイトル	PLoS ONE
巻	8巻
号	2号
資料タイプ	学術雑誌論文

Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi’s Syndrome

JaLCDOI	10.18926/AMO/52145
フルテキストURL	68_1_53.pdf
著者	Terasaka, Tomohiro\| Ueta, Eijiro\| Ebara, Hirotaka\| Waseda, Koichi\| Hanayama, Yoshihisa\| Takaki, Akinobu\| Kawabata, Tomoko\| Sugiyama, Hitoshi\| Hidan, Ko\| Otsuka, Fumio\|
抄録	A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.
キーワード	adefovir dipivoxil (ADV) eldecalcitol Fanconi's syndrome hypophosphatemia osteomalacia
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	53
終了ページ	56
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553490

Acatalasemic mice are mildly susceptible to Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis

著者	Takiue, Keiichi\| Sugiyama, Hitoshi\| Inoue, Tatsuyuki\| Morinaga, Hiroshi\| Kikumoto, Yoko\| Kitagawa, Masashi\| Kitamura, Shinji\| Maeshima, Yohei\| Wang, Dahong\| Masuoka, Noriyoshi\| Ogino, Keiki\| Makino, Hirofumi\|
発行日	2012-05-25
出版物タイトル	BMC Nephrology
巻	13巻
号	14号
資料タイプ	学術雑誌論文

血管新生negative feedback制御因子Vasohibin-1によるマウス糖尿病性腎症進展制御効果の検討

著者	那須達世\| 前島洋平\| 木野村賢\| 川原（広越）久美子\| 田邊克幸\| 杉山斉\| 園田光\| 佐藤靖史\| 槇野博史\|
発行日	2011-04-01
出版物タイトル	岡山医学会雑誌
巻	123巻
号	1号
資料タイプ	学術雑誌論文

杉山 斉