Pergamon-Elsevier Science Ltd. Acta Medica Okayama 0960-894X 21 19 2011 In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A 5901 5904 EN Hidekazu Ishimoto Mari Shibata Yuki Myojin Hideyuki Ito Yukio Sugimoto Akihiro Tai Tsutomu Hatano Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 74 2008 New dimeric flavans from gambir, an extract of Uncaria gambir 595 605 EN Shoko Taniguchi Kayo Kuroda Naomi Yoshikado Kou-ichi Doi Masahiro Tanabe Takashi Shibata Takashi Yoshida Tsutomu Hatano <p>Three new dimeric flavans, catechin-(4 alpha -&#62; 8)-ent-epicatechin (7), gambirflavan D1 (8), and gambirflavan D2 (9), were isolated from gambir (an extract from the leaves and young twigs of Uncaria gambir), and their structures were determined based on spectroscopic and chemical data.</p> No potential conflict of interest relevant to this article was reported.