| フルテキストURL | OTSR105_1_113.pdf Fig.pdf |
|---|---|
| 著者 | Okazaki, Yuki| Furumatsu, Takayuki| Kodama, Yuya| Hino, Tomohito| Kamatsuki, Yusuke| Okazaki, Yoshiki| Masuda, Shin| Miyazawa, Shinichi| Endo, Hirosuke| Tetsunaga, Tomonori| Yamada, Kazuki| Ozaki, Toshifumi| |
| キーワード | Magnetic resonance imaging Medial meniscus Posterior root tear Tibial rotation Transtibial pullout repair |
| 発行日 | 2019-02-28 |
| 出版物タイトル | Orthopaedics & Traumatology: Surgery & Research |
| 巻 | 105巻 |
| 号 | 1号 |
| 出版者 | Elsevier |
| 開始ページ | 113 |
| 終了ページ | 117 |
| ISSN | 18770568 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30482466 |
| DOI | 10.1016/j.otsr.2018.10.005 |
| Web of Science KeyUT | 000456541300019 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.otsr.2018.10.005 |
| フルテキストURL | OTSR105_1_107.pdf Fig.pdf |
|---|---|
| 著者 | Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| キーワード | Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting |
| 発行日 | 2019-02-28 |
| 出版物タイトル | Orthopaedics & Traumatology: Surgery & Research |
| 巻 | 105巻 |
| 号 | 1号 |
| 出版者 | Elsevier |
| 開始ページ | 107 |
| 終了ページ | 111 |
| ISSN | 18770568 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30442555 |
| DOI | 10.1016/j.otsr.2018.10.001 |
| Web of Science KeyUT | 000456541300018 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001 |
| フルテキストURL | J_Orthop_Sci_22_4_731.pdf fig.pdf tbl.pdf |
|---|---|
| 著者 | Furumatsu, Takayuki| Fujii, Masataka| Kodama, Yuya| Ozaki, Toshifumi| |
| 備考 | This is an Accepted Manuscript of an article published by Elsevier| |
| 発行日 | 2017-07 |
| 出版物タイトル | Journal of Orthopaedic Science |
| 巻 | 22巻 |
| 号 | 4号 |
| 出版者 | Elsevier |
| 開始ページ | 731 |
| 終了ページ | 736 |
| ISSN | 0949-2658 |
| NCID | AA11052566 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 28416188 |
| DOI | 10.1016/j.jos.2017.03.013 |
| Web of Science KeyUT | 000407394700025 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jos.2017.03.013 |
| フルテキストURL | J_Orthop_Sci_22_4_715.pdf fig.pdf |
|---|---|
| 著者 | Lu, Zhichao| Furumatsu, Takayuki| Fujii, Masataka| Maehara, Ami| Ozaki, Toshifumi| |
| キーワード | vascular endothelial growth factor (VEGF) meniscus meniscal injury hypoxia-inducible factor-1α (HIF-1α) |
| 備考 | This is an Accepted Manuscript of an article published by Elsevier| |
| 発行日 | 2017-07 |
| 出版物タイトル | Journal of Orthopaedic Science |
| 巻 | 22巻 |
| 号 | 4号 |
| 出版者 | Elsevier |
| 開始ページ | 715 |
| 終了ページ | 721 |
| ISSN | 0949-2658 |
| NCID | AA11052566 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 28318650 |
| DOI | 10.1016/j.jos.2017.02.006 |
| Web of Science KeyUT | 000407394700022 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jos.2017.02.006 |
| フルテキストURL | J_Orthop_Sci_21_4_524.pdf fig.pdf |
|---|---|
| 著者 | Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi| |
| 備考 | This is an Accepted Manuscript of an article published by Elsevier| |
| 発行日 | 2016-07 |
| 出版物タイトル | Journal of Orthopaedic Science |
| 巻 | 21巻 |
| 号 | 4号 |
| 出版者 | Elsevier |
| 開始ページ | 524 |
| 終了ページ | 529 |
| ISSN | 0949-2658 |
| NCID | AA11052566 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 27113646 |
| DOI | 10.1016/j.jos.2016.02.013 |
| Web of Science KeyUT | 000381142800020 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jos.2016.02.013 |
| JaLCDOI | 10.18926/AMO/54818 |
|---|---|
| フルテキストURL | 70_6_515.pdf |
| 著者 | Fujii, Masataka| Furumatsu, Takayuki| Kadota, Yasutaka| Shimamura, Yoshinobu| Tsuchimochi, Shigeyuki| Ozaki, Toshifumi| |
| 抄録 | The present report describes the first known, case of a pseudoaneurysm of the perforating branch of the deep femoral artery following anterior cruciate ligament (ACL) reconstruction. A 19-year-old man underwent ACL reconstruction using the outside-in femoral tunnel-creation method. Seven days after the surgery, he complained of abnormal thigh pain and had swelling with local heat on the distal lateral thigh. Magnetic resonance imaging, computed tomography, and color Doppler ultrasonography showed the pseudoaneurysm in the thigh. Resection surgery was successfully performed by a vascular surgeon 12 days after ACL reconstruction. Careful examination and awareness of postoperative symptoms such as thigh pain and swelling after ACL reconstruction were critical for the early diagnosis of pseudoaneurysm. |
| キーワード | pseudoaneurysm perforating branch of the deep femoral artery anterior cruciate ligament |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-12 |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 515 |
| 終了ページ | 518 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003680 |
| JaLCDOI | 10.18926/AMO/54806 |
|---|---|
| フルテキストURL | 70_6_441.pdf |
| 著者 | Kashihara, Naoko| Furumatsu, Takayuki| Kodama, Yuya| Tanaka, Takaaki| Ozaki, Toshifumi| |
| 抄録 | Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the shortterm clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction. |
| キーワード | lateral meniscus meniscal extrusion meniscal repair anterior cruciate ligament reconstruction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-12 |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 441 |
| 終了ページ | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003668 |
| JaLCDOI | 10.18926/AMO/53910 |
|---|---|
| フルテキストURL | 69_6_355.pdf |
| 著者 | Okada, Yukimasa| Furumatsu, Takayuki| Miyazawa, Shinichi| Tanaka, Takaaki| Fujii, Masataka| Ozaki, Toshifumi| Abe, Nobuhiro| |
| 抄録 | Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8±3.8) and enoxaparin groups (9.4±4.9) than in the control group (15.6±9.8) (p＜0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%;fondaparinux, 49.5%;enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used. |
| キーワード | venous thromboembolism contrast-enhanced computed tomography total knee arthroplasty fondaparinux enoxaparin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-12 |
| 巻 | 69巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 355 |
| 終了ページ | 359 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26690246 |
| Web of Science KeyUT | 000368434500005 |
| 著者 | Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2013-01 |
| 出版物タイトル | International Orthopaedics |
| 巻 | 37巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Matsumoto, Emi| Kanazawa, Tomoko| Fujii, Masataka| Lu, Zhichao| Kajiki, Ryotaro| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2013-05-31 |
| 出版物タイトル | Journal of Biomechanics |
| 巻 | 46巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/49259 |
|---|---|
| フルテキストURL | 67_1_65.pdf |
| 著者 | Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi| |
| 抄録 | Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects. |
| キーワード | bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439511 |
| Web of Science KeyUT | 000316829900009 |
| 著者 | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2009-09-18 |
| 出版物タイトル | Journal of Biomechanics |
| 巻 | 42巻 |
| 号 | 13号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi| |
|---|---|
| 発行日 | 2009-05 |
| 出版物タイトル | The International Journal of Biochemistry & Cell Biology |
| 巻 | 41巻 |
| 号 | 5号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-01 |
| 出版物タイトル | The International Journal of Biochemistry & Cell Biology |
| 巻 | 42巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Hachioji, Motomi| Saiga, Kenta| Takata, Naoki| Yokoyama, Yusuke| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-01-01 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 391巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-11-12 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 402巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| 発行日 | 2011-06-03 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 409巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/41320 |
|---|---|
| フルテキストURL | 64_6_351.pdf |
| 著者 | Furumatsu, Takayuki| Asahara, Hiroshi| |
| 抄録 | Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis. |
| キーワード | Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-12 |
| 巻 | 64巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 351 |
| 終了ページ | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21173804 |
| Web of Science KeyUT | 000285664200001 |
| 著者 | 古松 毅之| 尾﨑 敏文| 浅原 弘嗣| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40007 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Furumatsu, Takayuki| Ozaki, Toshifumi| |
| 抄録 | Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis. |
| キーワード | epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-06 |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 155 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596126 |
| Web of Science KeyUT | 000279094300001 |