フルテキストURL fulltext.pdf
著者 Saito, Yukihiro| Nose, Naoko| Iida, Toshihiro| Akazawa, Kaoru| Kanno, Takayuki| Fujimoto, Yuki| Sasaki, Takanori| Akehi, Masaru| Higuchi, Takahiro| Akagi, Satoshi| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi| Nakamura, Kazufumi|
キーワード sodium/iodide symporter human induced pluripotent stem cell-derived cardiomyocytes single photon emission computed tomography cell-based therapy in vivo imaging
発行日 2023-09-07
出版物タイトル Frontiers in Cardiovascular Medicine
10巻
出版者 Frontiers Media
開始ページ 1261330
ISSN 2297-055X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 Saito, Nose, Iida, Akazawa, Kanno, Fujimoto, Sasaki, Akehi, Higuchi, Akagi, Yoshida, Miyoshi, Ito and Nakamura.
論文のバージョン publisher
PubMed ID 37745108
DOI 10.3389/fcvm.2023.1261330
Web of Science KeyUT 001069842100001
関連URL isVersionOf https://doi.org/10.3389/fcvm.2023.1261330
フルテキストURL fulltext.pdf
著者 Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji|
キーワード boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect
発行日 2022-10-21
出版物タイトル CELLS
11巻
20号
出版者 MDPI
開始ページ 3307
ISSN 2073-4409
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 36291173
DOI 10.3390/cells11203307
Web of Science KeyUT 000872497500001
関連URL isVersionOf https://doi.org/10.3390/cells11203307
フルテキストURL fulltext.pdf
著者 Lim, Melissa Siaw Han| Ohtsuki, Takashi| Takenaka, Fumiaki| Kobayashi, Kazuko| Akehi, Masaru| Uji, Hirotaka| Kobuchi, Hirotsugu| Sasaki, Takanori| Ozeki, Eiichi| Matsuura, Eiji|
キーワード theranostics single chain variable fragment of IgG (scFv) drug delivery system (DDS) photodynamic therapy (PDT) PET imaging accelerated blood clearance (ABC) cell penetrating peptide (CPP) siRNA ATP-binding cassette subfamily G member 2 (ABCG2)
発行日 2021-02-18
出版物タイトル Life
11巻
2号
出版者 MDPI
開始ページ 158
ISSN 2075-1729
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 33670777
DOI 10.3390/life11020158
Web of Science KeyUT 000622756700001
関連URL isVersionOf https://doi.org/10.3390/life11020158
JaLCDOI 10.18926/AMO/53999
フルテキストURL 70_1_13.pdf
著者 Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji|
抄録 Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis.
キーワード β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-02
70巻
1号
出版者 Okayama University Medical School
開始ページ 13
終了ページ 24
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26899605
Web of Science KeyUT 000371288700002