和田淳

The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study

フルテキストURL	fulltext.pdf
著者	Katayama, Akihiro\| Tone, Atsuhito\| Watanabe, Mayu\| Teshigawara, Sanae\| Miyamoto, Satoshi\| Eguchi, Jun\| Nakatsuka, Atsuko\| Shikata, Kenichi\| Wada, Jun\|
キーワード	Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP)
備考	This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.\|
発行日	2019-09-16
出版物タイトル	Diabetology International
巻	11巻
号	2号
出版者	Springer
開始ページ	97
終了ページ	104
ISSN	2190-1678
NCID	AA12503387
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32206479
DOI	10.1007/s13340-019-00408-7
NAID	40022198977
Web of Science KeyUT	000520711100004
関連URL	isVersionOf https://doi.org/10.1007/s13340-019-00408-7

Robotic Renal Autotransplantation: A Feasibility Study in a Porcine Model

JaLCDOI	10.18926/AMO/57953
フルテキストURL	74_1_53.pdf
著者	Kubota, Risa\| Araki, Motoo\| Wada, Koichiro\| Kawamura, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Ariyoshi, Yuichi\| Iwata, Takehiro\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Kano, Yuzuki\| Kitagawa, Masashi\| Tanabe, Katsuyuki\| Sugiyama, Hitoshi\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
抄録	We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery.
キーワード	renal autotransplantation robotic porcine model transplantation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	53
終了ページ	58
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099249
Web of Science KeyUT	000516606200008
NAID	120006795620

Cavernous Transformation and Granulomatous Epididymis in Behçet Disease

フルテキストURL	JCR25_4_45.pdf Fig.pdf
著者	Motokura, Yumi\| Watanabe, Haruki\| Yamamura, Yuriko\| Kano, Yuzuki\| Matsumoto, Yoshinori\| Kawabata, Tomoko\| Sada, Ken-ei\| Wada, Jun\|
発行日	2019-06
出版物タイトル	Journal of Clinical Rheumatology
巻	25巻
号	4号
出版者	Lippincott, Williams & Wilkins
開始ページ	45
終了ページ	47
ISSN	1076-1608
NCID	AA11016642
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	29470260
DOI	10.1097/RHU.0000000000000723
Web of Science KeyUT	000470908400007
関連URL	isVersionOf https://doi.org/10.1097/RHU.0000000000000723

Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+T cells

フルテキストURL	SR9_1_3054.pdf
著者	Hiramatsu, Sumie\| Watanabe, Katsue S.\| Zeggar, Sonia\| Asano, Yosuke\| Miyawaki, Yoshia\| Yamamura, Yuriko\| Katsuyama, Eri\| Katsuyama, Takayuki\| Watanabe, Haruki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Kawabata, Tomoko\| Sada, Ken-Ei\| Wada, Jun\|
発行日	2019-2-28
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	3054
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	30816218
DOI	10.1038/s41598-019-38809-y
Web of Science KeyUT	000459891700064
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-38809-y

Contrast-enhanced Computed Tomography-Guided Percutaneous Cryoablation of Renal Cell Carcinoma in a Renal Allograft: First Case in Asia

JaLCDOI	10.18926/AMO/56871
フルテキストURL	73_3_269.pdf
著者	Tsuboi, Ichiro\| Araki, Motoo\| Fujiwara, Hiroyasu\| Iguchi, Toshihiro\| Hiraki, Takao\| Arichi, Naoko\| Kawamura, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Sako, Tomoko\| Takamoto, Atsushi\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Watanabe, Toyohiko\| Yanai, Hiroyuki\| Kitagawa, Masashi\| Tanabe, Katsuyuki\| Sugiyama, Hitoshi\| Wada, Jun\| Shiina, Hiroaki\| Kanazawa, Susumu\| Nasu, Yasutomo\|
抄録	Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new treatment option for treating small-sized renal cell cancer (RCCs). We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up.
キーワード	cryoablation partial nephrectomy renal cell carcinoma renal allograft renal transplantation
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-06
巻	73巻
号	3号
出版者	Okayama University Medical School
開始ページ	269
終了ページ	272
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31235976

Study about the Efficacy of Metformin to Immune Function in Cancer Patients

JaLCDOI	10.18926/AMO/54514
フルテキストURL	70_4_327.pdf
著者	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Eikawa, Shingo\| Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Hotta, Katsuyuki\| Wada, Jun\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\| Kiura, Katsuyuki\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\| Udono, Heiichiro\| Toyooka, Shinichi\|
抄録	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
キーワード	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	327
終了ページ	330
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549683
Web of Science KeyUT	000384748600018

The Efficacy of Rituximab in High-risk Renal Transplant Recipients

JaLCDOI	10.18926/AMO/54507
フルテキストURL	70_4_295.pdf
著者	Araki, Motoo\| Wada, Koichiro\| Mitsui, Yosuke\| Kubota, Risa\| Yoshioka, Takashi\| Ariyoshi, Yuichi\| Kobayashi, Yasuyuki\| Kitagawa, Masashi\| Tanabe, Katsuyuki\| Sugiyama, Hiroshi\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Hotta, Katsuyuki\| Nasu, Yasutomo\|
抄録	Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients.
キーワード	end-stage renal disease immunosuppression kidney transplantation
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	295
終了ページ	297
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549676
Web of Science KeyUT	000384748600011

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes

JaLCDOI	10.18926/AMO/54413
フルテキストURL	70_3_151.pdf
著者	Wada, Jun\| Nakatsuka, Atsuko\|
抄録	The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy.
キーワード	fusion fission oxidative stress mitochondria diabetes
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2016-06
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	151
終了ページ	158
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339203
Web of Science KeyUT	000379406100001

Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy

著者	Watanabe, Mayu\| Nakatsuka, Atsuko\| Murakami, Kazutoshi\| Inoue, Kentaro\| Terami, Takahiro\| Higuchi, Chigusa\| Katayama, Akihiro\| Teshigawara, Sanae\| Eguchi, Jun\| Ogawa, Daisuke\| Watanabe, Eijiro\| Wada, Jun\| Makino, Hirofumi\|
発行日	2014-05-25
出版物タイトル	PLOS ONE
巻	9巻
号	3号
資料タイプ	学術雑誌論文

Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines

著者	Ogawa, Daisuke\| Eguchi, Jun\| Wada, Jun\| Terami, Naoto\| Hatanaka, Takashi\| Tachibana, Hiromi\| Nakatsuka, Atsuko\| Sato Horiguchi, Chikage\| Nishii, Naoko\| Makino, Hirofumi\|
発行日	2014-01-22
出版物タイトル	PLOS ONE
巻	9巻
号	1号
資料タイプ	学術雑誌論文

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

著者	Nakatsuka, Atsuko\| Matsuyama, Makoto\| Yamaguchi, Satoshi\| Katayama, Akihiro\| Eguchi, Jun\| Murakami, Kazutoshi\| Teshigawara, Sanae\| Ogawa, Daisuke\| Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Takaki, Akinobu\| Watanabe, Eijiro\| Wada, Jun\|
発行日	2016-02-17
出版物タイトル	Scientific Reports
巻	6巻
資料タイプ	学術雑誌論文

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis

著者	Katayama, Akihiro\| Nakatsuka, Atsuko\| Eguchi, Jun\| Murakami, Kazutoshi\| Teshigawara, Sanae\| Kanzaki, Motoko\| Nunoue, Tomokazu\| Hida, Kazuyuki\| Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Takaki, Akinobu\| Yamamoto, Kazuhide\| Kiyonari, Hiroshi\| Makino, Hirofumi\| Wada, Jun\|
発行日	2015
出版物タイトル	Scientific reports
巻	5巻
資料タイプ	学術雑誌論文

Therapeutic protein targets liver disease

著者	和田淳\|
発行日	2016-01
出版物タイトル	Okayama University Medical Research Updates
巻	18巻
資料タイプ	その他

Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes

著者	Terami, Takahiro\| Wada, Jun\| Inoue, Kentaro\| Nakatsuka, Atsuko\| Ogawa, Daisuke\| Teshigawara, Sanae\| Murakami, Kazutoshi\| Katayama, Akihiro\| Eguchi, Jun\| Makino, Hirofumi\|
発行日	2013-10-22
出版物タイトル	International Journal of Nephrology and Renovascular Disease
巻	6巻
資料タイプ	学術雑誌論文

Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray

著者	Inoue, Kentaro\| Wada, Jun\| Eguchi, Jun\| Nakatsuka, Atsuko\| Teshigawara, Sanae\| Murakami, Kazutoshi\| Ogawa, Daisuke\| Terami, Takahiro\| Katayama, Akihiro\| Tone, Atsuhito\| Iseda, Izumi\| Hida, Kazuyuki\| Yamada, Masao\| Ogawa, Tomohisa\| Makino, Hirofumi\|
発行日	2013-10-15
出版物タイトル	PLoS ONE
巻	8巻
号	10号
資料タイプ	学術雑誌論文

Long-term effect of cinacalcet hydrochloride on abdominal aortic calcification in patients on hemodialysis with secondary hyperparathyroidism

著者	Nakayama, Kazunori\| Nakao, Kazushi\| Takatori, Yuji\| Inoue, Junko\| Kojo, Shoichirou\| Akagi, Shigeru\| Fukushima, Masaki\| Wada, Jun\| Makino, Hirofumi\|
発行日	2013-12-18
出版物タイトル	International Journal of Nephrology and Renovascular Disease
巻	7巻
資料タイプ	学術雑誌論文

Factors Associated with Remission and/or Regression of Microalbuminuria in Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/52789
フルテキストURL	68_4_235.pdf
著者	Ono, Tetsuichiro\| Shikata, Kenichi\| Obika, Mikako\| Miyatake, Nobuyuki\| Kodera, Ryo\| Hirota, Daisyo\| Wada, Jun\| Kataoka, Hitomi\| Ogawa, Daisuke\| Makino, Hirofumi\|
抄録	The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
キーワード	microalbuminuria type 2 diabetes mellitus remission regression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	235
終了ページ	241
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145409
Web of Science KeyUT	000340687500005
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52828

Current status of the treatment of microscopic polyangiitis and granulomatosis with polyangiitis in Japan

著者	Sugiyama, Koichi\| Sada, Ken-ei\| Kurosawa, Michiko\| Wada, Jun\| Makino, Hirofumi\|
発行日	2013-02
出版物タイトル	Clinical and Experimental Nephrology
巻	17巻
号	1号
資料タイプ	学術雑誌論文

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease

著者	Kurose, Yuko\| Wada, Jun\| Kanzaki, Motoko\| Teshigawara, Sanae\| Nakatsuka, Atsuko\| Murakami, Kazutoshi\| Inoue, Kentaro\| Terami, Takahiro\| Katayama, Akihiro\| Watanabe, Mayu\| Higuchi, Chigusa\| Eguchi, Jun\| Miyatake, Nobuyuki\| Makino, Hirofumi\|
発行日	2013-01-22
出版物タイトル	BMC Nephrology
巻	14巻
資料タイプ	学術雑誌論文

The serum vaspin levels are reduced in Japanese chronic hemodialysis patients

著者	Inoue, Junko\| Wada, Jun\| Teshigawara, Sanae\| Hida, Kazuyuki\| Nakatsuka, Atsuko\| Takatori, Yuji\| Kojo, Shoichirou\| Akagi, Shigeru\| Nakao, Kazushi\| Miyatake, Nobuyuki\| McDonald, John F.\| Makino, Hirofumi\|
発行日	2012-12-03
出版物タイトル	BMC Nephrology
巻	13巻
資料タイプ	学術雑誌論文

和田 淳