start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=3
article-no=
start-page=e70003
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240822
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Forgetfulness in adult attention-deficit/hyperactivity disorder masks transient epileptic amnesia: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Inattention due to attention-deficit/hyperactivity disorder (ADHD) can lead to forgetfulness. Transient epileptic amnesia (TEA) can cause forgetfulness, similar to ADHD. We report a patient with ADHD who developed TEA.
Case Presentation: The patient was a 40-year-old woman with ADHD. She has been prone to forgetfulness since childhood. Two years before visiting our outpatient clinic, she had begun to occasionally forget events that had occurred several days earlier. However, she was largely unaware of the emergence of new amnestic symptoms. She had also begun to experience various other amnestic symptoms 2 months before she visited our clinic, which prompted her to visit our outpatient clinic. The combination of a detailed interview, electroencephalography (EEG) examination, and consideration of TEA enabled us to diagnose her with TEA and provide treatment accordingly. In our patient, daily forgetfulness due to ADHD delayed the recognition of new additional forgetfulness attributed to TEA.
Conclusion: Psychiatrists need to consider TEA when patients with ADHD present with changes in or exacerbation of forgetfulness. We report a patient with ADHD who developed TEA. In our patient, daily forgetfulness due to ADHD delayed the recognition of new additional forgetfulness attributed to TEA. Psychiatrists need to consider TEA when patients with ADHD present with changes or exacerbation of forgetfulness.
en-copyright=
kn-copyright=
en-aut-name=FukaoTakashi
en-aut-sei=Fukao
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=FujiwaraMasaki
en-aut-sei=Fujiwara
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YamadaYuto
en-aut-sei=Yamada
en-aut-mei=Yuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=SakamotoShinji
en-aut-sei=Sakamoto
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TakakiManabu
en-aut-sei=Takaki
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Department of Neuropsychiatry, OkayamaUniversity Hospital
kn-affil=
affil-num=2
en-affil=Department of Neuropsychiatry, OkayamaUniversity Hospital
kn-affil=
affil-num=3
en-affil=Department of Neuropsychiatry, OkayamaUniversity Hospital
kn-affil=
affil-num=4
en-affil=Department of Neuropsychiatry, OkayamaUniversity Hospital
kn-affil=
affil-num=5
en-affil=Okayama University Hospital Gender Center
kn-affil=
affil-num=6
en-affil=Department of Neuropsychiatry, OkayamaUniversity Faculty of Medicine, Dentistry andPharmaceutical Sciences
kn-affil=
en-keyword=anti-seizure medications
kn-keyword=anti-seizure medications
en-keyword=attention-deficit/hyperactivity disorder
kn-keyword=attention-deficit/hyperactivity disorder
en-keyword=electroencephalography
kn-keyword=electroencephalography
en-keyword=transient epileptic amnesia
kn-keyword=transient epileptic amnesia
END
start-ver=1.4
cd-journal=joma
no-vol=134
cd-vols=
no-issue=1
article-no=
start-page=22
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Developing a scale to measure nurses' difficulty related to the treatment of gender dysphoric patients
kn-title=看護師の性別違和への関わりにくさについての尺度作成
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study aimed to develop a scale to measure the perceived difficulty experienced by nurses in treating and caring for patients diagnosed with gender dysphoria and examine its reliability and validity. We developed a 26-item preliminary scale through discussions with experts in gender dysphoria treatment. We administered a questionnaire including this scale to 1,010 nurses working at Okayama University Hospital and analyzed the data of 346 nurses who had been involved in the treatment of gender dysphoria and had no missing responses.
A total of 20 items consisting of two factors, “relationship building” and “negative emotion for gender dysphoria,” were extracted by exploratory factor analysis, and we used them in the final version of the scale. Cronbach's alpha coefficient for the entire scale was 0.879, indicating a high degree of internal consistency.
However, the correlations with a communication skills scale (ENDCOREs) and the Scale of Gender Conception were limited, and the external validity could not be proven. This scale may be useful for evaluating nursing practice and educational support for nurses; however, there is room for further study on the scale validation.
en-copyright=
kn-copyright=
en-aut-name=MiyakeMaki
en-aut-sei=Miyake
en-aut-mei=Maki
kn-aut-name=三宅麻希
kn-aut-sei=三宅
kn-aut-mei=麻希
aut-affil-num=1
ORCID=
en-aut-name=OshimaYoshitaka
en-aut-sei=Oshima
en-aut-mei=Yoshitaka
kn-aut-name=大島義孝
kn-aut-sei=大島
kn-aut-mei=義孝
aut-affil-num=2
ORCID=
en-aut-name=NambaShihoko
en-aut-sei=Namba
en-aut-mei=Shihoko
kn-aut-name=難波志穂子
kn-aut-sei=難波
kn-aut-mei=志穂子
aut-affil-num=3
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=松本洋輔
kn-aut-sei=松本
kn-aut-mei=洋輔
aut-affil-num=4
ORCID=
en-aut-name=HoriuchiMakiko
en-aut-sei=Horiuchi
en-aut-mei=Makiko
kn-aut-name=堀内真希子
kn-aut-sei=堀内
kn-aut-mei=真希子
aut-affil-num=5
ORCID=
en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=山田了士
kn-aut-sei=山田
kn-aut-mei=了士
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Department of Nursing, Okayama University Hospital
kn-affil=岡山大学病院 看護部
affil-num=2
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=岡山大学病院 精神科神経科
affil-num=3
en-affil=Department of Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=岡山大学病院 新医療研究開発センター
affil-num=4
en-affil=Department of Gender Center, Okayama University Hospital
kn-affil=岡山大学病院 ジェンダーセンター
affil-num=5
en-affil=Department of Medical Support, Clinical Psychology section, Okayama University Hospital
kn-affil=岡山大学病院 医療技術部 臨床心理部門
affil-num=6
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学学術研究院医歯薬学域 精神神経病態学
en-keyword=性別違和 (gender dysphoria)
kn-keyword=性別違和 (gender dysphoria)
en-keyword=関わりにくさ (difficulty in relating)
kn-keyword=関わりにくさ (difficulty in relating)
en-keyword=コミュニケーション (communication)
kn-keyword=コミュニケーション (communication)
en-keyword=性差観 (gender conception)
kn-keyword=性差観 (gender conception)
END
start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=102
end-page=114
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear.
Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules.
Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production.
en-copyright=
kn-copyright=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TakahashiYu
en-aut-sei=Takahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=
affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=
affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=7
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=8
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=10
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Epilepsy
kn-keyword=Epilepsy
en-keyword=Kindling
kn-keyword=Kindling
en-keyword=Pentylenetetrazol
kn-keyword=Pentylenetetrazol
en-keyword=Perineuronal nets
kn-keyword=Perineuronal nets
en-keyword=Wisteria floribunda
kn-keyword=Wisteria floribunda
END
start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=5817
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201949
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated whether helping-like behaviour could be observed in mice similar to that in rats. Because mice are social animals widely used in neuroscience, the discovery of helping-like behaviour in mice would be valuable in clarifying the psychological and biological mechanisms underlying pro-sociability. We constrained mice inside tubes. Subject mice were allowed to move freely in cages with tubes containing constrained conspecifics. The subject mice released both cagemates and stranger mice but did not engage in opening empty tubes. Furthermore, the same behaviour was observed under aversive conditions and with anesthetised conspecifics. Interestingly, hungry mice opened the tubes containing food before engaging in tube-opening behaviour to free constrained conspecifics. Mice showed equal preferences for constrained and freely moving conspecifics. We demonstrated for the first time that mice show tube-opening behaviour. Furthermore, we partly clarified the purpose and motivation of this behaviour. An effective mouse model for helping-like behaviour would facilitate research on the mechanisms underlying prosocial behaviour.
en-copyright=
kn-copyright=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=115
cd-vols=
no-issue=
article-no=
start-page=108879
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comprehensive behavioral study of the effects of vanillin inhalation in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20 min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects.
en-copyright=
kn-copyright=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TakahashiYu
en-aut-sei=Takahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=FujiwaraYuko
en-aut-sei=Fujiwara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=
affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=
affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=7
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=8
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=10
en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare
kn-affil=
affil-num=11
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Anti-nociceptive
kn-keyword=Anti-nociceptive
en-keyword=Vanillin
kn-keyword=Vanillin
en-keyword=Essential oil
kn-keyword=Essential oil
en-keyword=Inhalation
kn-keyword=Inhalation
en-keyword=Analgesia
kn-keyword=Analgesia
END
start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=
article-no=
start-page=1
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding the perineuronal net (PNN) area, the distribution, constituent elements, and expression level of granular ECM molecules (diffuse ECM) present in the mature CNS remain unclear. Diffuse ECM molecules in the CNS share the components of PNNs and are likely functional. As cortical functions are greatly region-dependent, we hypothesized that ECM molecules would differ in distribution, expression level, and components in a region- and layer-dependent manner. We examined the layer-specific expression of several chondroitin sulfate proteoglycans (aggrecan, neurocan, and brevican), tenascin-R, Wisteria floribunda agglutinin (WFA)-positive molecules, hyaluronic acid, and link protein in the somatosensory and piriform cortices of mature mice. Furthermore, we investigated expression changes in WFA-positive molecules due to aging. In the somatosensory cortex, PNN density was particularly high at layer 4 (L4), but not all diffuse ECM molecules were highly expressed at L4 compared to the other layers. There was almost no change in tenascin-R and hyaluronic acid in any somatosensory-cortex layer. Neurocan showed high expression in L1 of the somatosensory cortex. In the piriform cortex, many ECM molecules showed higher expression in L1 than in the other layers. However, hyaluronic acid showed high expression in deep layers. Here, we clarified that ECM molecules differ in constituent elements and expression in a region- and layer-dependent manner. Region-specific expression of ECM molecules is possibly related to functions such as region-specific plasticity and vulnerability.
en-copyright=
kn-copyright=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=
affil-num=2
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Extracellular matrix
kn-keyword=Extracellular matrix
en-keyword=Perineuronal nets
kn-keyword=Perineuronal nets
en-keyword=Piriform cortex
kn-keyword=Piriform cortex
en-keyword=Proteoglycans
kn-keyword=Proteoglycans
en-keyword=Somatosensory cortex
kn-keyword=Somatosensory cortex
en-keyword=Wisteria floribunda
kn-keyword=Wisteria floribunda
END
start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=6
article-no=
start-page=e01945
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
en-copyright=
kn-copyright=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=FujiwaraYuko
en-aut-sei=Fujiwara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=
affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=
affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
affil-num=7
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare
kn-affil=
affil-num=10
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Neuroscience
kn-keyword=Neuroscience
en-keyword=Physiology
kn-keyword=Physiology
END
start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=2
article-no=
start-page=143
end-page=154
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of FcγRllB-deficient Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recent studies have demonstrated the important role of immune molecules in the development of neuronal
circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin-
containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance
of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons
in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
en-copyright=
kn-copyright=
en-aut-name=WatanabeMakiko
en-aut-sei=Watanabe
en-aut-mei=Makiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YokobayashiEriko
en-aut-sei=Yokobayashi
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=UsuiShinichi
en-aut-sei=Usui
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=SujiuraHiroko
en-aut-sei=Sujiura
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Koyodai Hospital
affil-num=4
en-affil=
kn-affil=Department of Psychiatry, Kawasaki Medical University
affil-num=5
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=6
en-affil=
kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
affil-num=7
en-affil=
kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
en-keyword=parvalbumin
kn-keyword=parvalbumin
en-keyword=fast-spiking interneurons
kn-keyword=fast-spiking interneurons
en-keyword=FcγRllB
kn-keyword=FcγRllB
en-keyword=barrel cortex
kn-keyword=barrel cortex
en-keyword=sensory deprivation
kn-keyword=sensory deprivation
END
start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=1
article-no=
start-page=119
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hepatocyte growth factor (HGF) is useful as a potential therapeutic agent for hepatic and renal fibrosis and cardiovascular diseases through inducing proliferation of epithelial and endothelial cells. HGF inducers may also be useful as therapeutic agents for these diseases. However, there have been no reports on induction of HGF production by plant extracts or juices. An extract of bitter melon (Momordica charantia L.) pulp markedly induced HGF production. There was a time lag of 72 h before induction of HGF production after the extract addition. Its stimulatory effect was accompanied by upregulation of HGF gene expression. Increases in mitogen-activated protein kinases (MAPKs) were observed from 72 h after the extract addition. Inhibitors of MAPKs suppressed the extract-induced HGF production. The extract also stimulated cell proliferation. Both activities for induction of HGF production and cell proliferation were eluted together in a single peak with 14,000 Da on gel filtration. The results indicate that bitter melon pulp extract induced HGF production and cell proliferation of human dermal fibroblasts and suggest that activation of MAPKs is involved in the HGF induction. Our findings suggest potential usefulness of the extract for tissue regeneration and provide an insight into the molecular mechanism underlying the wound-healing property of bitter melon.
en-copyright=
kn-copyright=
en-aut-name=OnoTakehiro
en-aut-sei=Ono
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TsujiTomoe
en-aut-sei=Tsuji
en-aut-mei=Tomoe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SakaiMiho
en-aut-sei=Sakai
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YukizakiChizuko
en-aut-sei=Yukizaki
en-aut-mei=Chizuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=InoHisatoshi
en-aut-sei=Ino
en-aut-mei=Hisatoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=AkagiIsao
en-aut-sei=Akagi
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HiramatsuKaori
en-aut-sei=Hiramatsu
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MatsumotoYohsuke
en-aut-sei=Matsumoto
en-aut-mei=Yohsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=SugiuraYoshihiro
en-aut-sei=Sugiura
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=UtoHirofumi
en-aut-sei=Uto
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TsubouchiHirohito
en-aut-sei=Tsubouchi
en-aut-mei=Hirohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=GohdaEiichi
en-aut-sei=Gohda
en-aut-mei=Eiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=2
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=3
en-affil=
kn-affil=Miyazaki Prefectural Food R&D Center
affil-num=4
en-affil=
kn-affil=Miyazaki Prefectural Food R&D Center
affil-num=5
en-affil=
kn-affil=Miyazaki Agricultural Research Institute
affil-num=6
en-affil=
kn-affil=Miyazaki Prefectural Industrial Support Foundation
affil-num=7
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=8
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=9
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
affil-num=10
en-affil=
kn-affil=Department of Digestive Disease and Life-style Related Diseases, Health Research Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences
affil-num=11
en-affil=
kn-affil=Department of Digestive Disease and Life-style Related Diseases, Health Research Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences
affil-num=12
en-affil=
kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=Hepatocyte growth factor
kn-keyword=Hepatocyte growth factor
en-keyword=Bitter melon
kn-keyword=Bitter melon
en-keyword=Extracellular signal-regulated kinase
kn-keyword=Extracellular signal-regulated kinase
en-keyword=Cell proliferation
kn-keyword=Cell proliferation
en-keyword=Dermal fibroblast
kn-keyword=Dermal fibroblast
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=扁桃核キンドリングされたてんかん源性の周嗅領皮質においてin vitroで記録されるてんかん様の場の電位の特性
kn-title=Characterization of epileptiform field potentials recorded in the in vitro perirhinal cortex of amygdala-kindled epileptogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松本洋輔
kn-aut-sei=松本
kn-aut-mei=洋輔
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
END