| タイトル（別表記） | Two cases of acute pulmonary embolism after esophageal cancer operation |
|---|---|
| フルテキストURL | 118_41.pdf |
| 著者 | 金澤 卓| 渡辺 信之| 猶本 良夫| 小林 正彦| 白川 靖博| 山辻 知樹| 小林 直哉| 藤原 俊義| 松原 長秀| 岩垣 博巳| 松岡 順治| 田中 紀章| |
| 抄録 | We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy. |
| キーワード | 食道癌 (esophageal cancer) 肺塞栓症 (pulmonary embolism) 深部静脈血栓症 (deep venous thrombs) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2006-05-01 |
| 巻 | 118巻 |
| 号 | 1号 |
| 開始ページ | 41 |
| 終了ページ | 45 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.118.1_41 |
| NAID | 10017417131 |
| フルテキストURL | 118_9.pdf |
|---|---|
| 著者 | 梅岡 達生| 川嶋 健| 香川 俊輔| 寺石 文則| 滝 正樹| 京 哲| 永井 勝幸| 浦田 泰生| 田中 紀章| 藤原 俊義| |
| キーワード | GFP アデノウイルス テロメラーゼ 増幅 遺伝子治療 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2006-05-01 |
| 巻 | 118巻 |
| 号 | 1号 |
| 開始ページ | 9 |
| 終了ページ | 15 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright© 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma1947.118.1_9 |
| NAID | 10017417061 |
| タイトル（別表記） | Adenoviral p53 gene therapy for lung cancer |
|---|---|
| フルテキストURL | 119_229.pdf |
| 著者 | 藤原 俊義| 田中 紀章| |
| 抄録 | To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. |
| キーワード | p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2008-01-04 |
| 巻 | 119巻 |
| 号 | 3号 |
| 開始ページ | 229 |
| 終了ページ | 234 |
| ISSN | 00301558 |
| 言語 | 日本語 |
| 著作権者 | 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.119.229 |
| NAID | 10020282723 |
| タイトル（別表記） | In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus |
|---|---|
| フルテキストURL | 120_01_013_021.pdf |
| 著者 | 岸本 浩行| 児島 亨| 渡邉 雄一| 香川 俊輔| 藤原 俊哉| 宇野 太| 寺石 文則| 京 哲| 水口 裕之| 橋本 悠里| 浦田 泰生| 田中 紀章| 藤原 俊義| |
| キーワード | GFP アデノウイルス ヒトテロメラーゼ逆転写酵素 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2008-05-01 |
| 巻 | 120巻 |
| 号 | 1号 |
| 開始ページ | 13 |
| 終了ページ | 21 |
| ISSN | 00301558 |
| 言語 | 日本語 |
| 著作権者 | 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.120.13 |
| NAID | 10024170197 |
| フルテキストURL | K000876.pdf |
|---|---|
| 著者 | 藤原 俊義| |
| 発行日 | 1990-09-30 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第876号 |
| 学位授与年月日 | 1990-09-30 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 |