| ID | 70081 |
| フルテキストURL | |
| 著者 |
Matsuoka, Daiki
Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Suehara, Kana
Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Naka, Shuhei
Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Misaki, Taro
Division of Nephrology, Seirei Hamamatsu General Hospital
Nagasawa, Yasuyuki
Department of General Internal Medicine, Hyogo Medical University
Ito, Seigo
Department of Internal Medicine, Japan Self-Defense Force Iruma Hospital
Suehiro, Yuto
Department of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka
Nomura, Ryota
Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University
Nakano, Kazuhiko
Department of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka
Matsumoto-Nakano, Michiyo
Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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| 抄録 | Background: The present study was conducted to examine the interaction between collagen-binding protein (Cnm) of Streptococcus mutans and immunoglobulin (IgA) to clarify the possible involvement in IgA nephropathy (IgAN) development.
Methods: The binding of Cnm to human immunoglobulins was examined using an enzyme-linked immunosorbent assay. A nephritis-induced rat model was employed to confirm the localization of Cnm. Results: IgA1 showed significantly greater binding ability to Cnm than to other bacterial surface proteins, and Cnm showed significantly greater binding ability to IgA1 than to other immunoglobulins. In rats administered Cnm, IgA deposition was observed in the glomerular mesangial region. Furthermore, biotin-labeled Cnm was observed in the same region as IgA deposition in the Cnm group. Conclusions: Taken together, it is considered that following invasion into the bloodstream, Cnm binds to and forms a complex with IgA1, leading to deposition of IgA1 in renal glomeruli. |
| キーワード | bacterial surface proteins
collagen-binding protein
human immunoglobulins
IgA nephropathy
Streptococcus mutans
|
| 発行日 | 2026-01-07
|
| 出版物タイトル |
Frontiers in Cellular and Infection Microbiology
|
| 巻 | 15巻
|
| 出版者 | Frontiers Media SA
|
| 開始ページ | 1673581
|
| ISSN | 2235-2988
|
| 資料タイプ |
学術雑誌論文
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| 言語 |
英語
|
| OAI-PMH Set |
岡山大学
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| 著作権者 | © 2026 Matsuoka, Suehara, Naka, Misaki, Nagasawa, Ito, Suehiro, Nomura, Nakano and Matsumoto-Nakano.
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| 論文のバージョン | publisher
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.3389/fcimb.2025.1673581
|
| ライセンス | https://creativecommons.org/licenses/by/4.0/
|
| Citation | Matsuoka D, Suehara K, Naka S, Misaki T, Nagasawa Y, Ito S, Suehiro Y, Nomura R, Nakano K and Matsumoto-Nakano M (2026) Binding of IgA1 and surface-expressed collagen-binding protein of Streptococcus mutans contributes to IgA nephropathy pathogenesis. Front. Cell. Infect. Microbiol. 15:1673581. doi: 10.3389/fcimb.2025.1673581
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| 助成情報 |
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