ID | 46851 |
JaLCDOI | |
フルテキストURL | |
著者 |
Ogata, Yoshiko
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutical Sciences
Aoe, Keisuke
Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center
Hiraki, Akio
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutical Sciences
Murakami, Kazuo
Department of Respiratory Medicine, NHO Yamaguchi-Ube Medical Center
Kishino, Daizo
Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center
Chikamori, Kenichi
Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center
Maeda, Tadashi
Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center
Ueoka, Hiroshi
Department of Medical Oncology, NHO Yamaguchi-Ube Medical Center
Kiura, Katsuyuki
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Tanimoto, Mitsune
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
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抄録 | The objective of this study was to evaluate the utility of the determination of adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) in Japan, a country with intermediate incidence of tuberculosis (TB). We retrospectively reviewed the clinical records of 435 patients with pleural effusion and investigated their pleural ADA levels as determined by an auto analyzer. ROC analysis was also performed. The study included patients with MPE (n=188), TPE (n=124), benign nontuberculous pleural effusion (n=94), and pleural effusion of unknown etiology (n=29). The median ADA level in the TPE group was 70.8U/L, which was significantly higher than that in any other groups (p<0.05). The area under the curve (AUC) in ROC analysis was 0.895. With a cut-off level for ADA of 36U/L, the sensitivity, specificity, positive predictive value, and negative predictive value were 85.5%, 86.5%, 69.7%, and 93.6%, respectively. As many as 9% of patients with lung cancer and 15% of those with mesothelioma were false-positive with this ADA cutoff setting. Although the ADA activity in pleural fluid can help in the diagnosis of TPE, it should be noted that some cases of lung cancer or mesothelioma show high ADA activity in geographical regions with intermediate incidence of TB, in contrast to high prevalence areas.
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キーワード | pleural effusion
adenosine deaminase
tuberculosis
lung cancer
mesothelioma
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2011-08
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巻 | 65巻
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号 | 4号
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出版者 | Okayama University Medical School
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開始ページ | 259
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終了ページ | 263
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2011 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |