Cancer of Unknown Primary Site:A Review of 28 Cases and the Efficacy of Cisplatin/Docetaxel Therapy at a Single Institute in Japan

Nishimori, Hisakazu; Takahashi, Shunji; Kiura, Katsuyuki; Ennishi, Daisuke; Kobayashi, Takayuki; Sano, Koji; Shinozaki, Eiji; Yokoyama, Masahiro; Mishima, Yuko; Terui, Yasuhito; Chin, Keisho; Mizunuma, Nobuyuki; Ito, Yoshinori; Nishimura, Seiichiro; Takeuchi, Kengo; Ishikawa, Yuichi; Oguchi, Masahiko; Tanimoto, Mitsune; Hatake, Kiyohiko

ID	40503
JaLCDOI	10.18926/AMO/40503
フルテキストURL	64_5_285.pdf 320 KB
著者	Nishimori, Hisakazu Department of Hematology, Oncology, Allergy, and Respiratory Medicine, Okayama University Hospital Takahashi, Shunji Division of Medical Oncology and Hematology, Cancer Institute Hospital Kiura, Katsuyuki Department of Hematology, Oncology, Allergy, and Respiratory Medicine, Okayama University Hospital ORCID Kaken ID publons researchmap Ennishi, Daisuke Department of Hematology, Oncology, Allergy, and Respiratory Medicine, Okayama University Hospital Kobayashi, Takayuki Division of Medical Oncology and Hematology, Cancer Institute Hospital Sano, Koji Division of Medical Oncology and Hematology, Cancer Institute Hospital Shinozaki, Eiji Division of Medical Oncology and Hematology, Cancer Institute Hospital Yokoyama, Masahiro Division of Medical Oncology and Hematology, Cancer Institute Hospital Mishima, Yuko Division of Medical Oncology and Hematology, Cancer Institute Hospital Terui, Yasuhito Division of Medical Oncology and Hematology, Cancer Institute Hospital Chin, Keisho Division of Medical Oncology and Hematology, Cancer Institute Hospital Mizunuma, Nobuyuki Division of Medical Oncology and Hematology, Cancer Institute Hospital Ito, Yoshinori Division of Medical Oncology and Hematology, Cancer Institute Hospital Nishimura, Seiichiro Division of Breast Surgery, Cancer Institute Hospital Takeuchi, Kengo Division of Pathology, Cancer Institute of the Japanese Foundation for Cancer Research Ishikawa, Yuichi Division of Pathology, Cancer Institute of the Japanese Foundation for Cancer Research Oguchi, Masahiko Division of Radiology, Cancer Institute Hospital Tanimoto, Mitsune Department of Hematology, Oncology, Allergy, and Respiratory Medicine, Okayama University Hospital Kaken ID publons researchmap Hatake, Kiyohiko Division of Medical Oncology and Hematology, Cancer Institute Hospital
抄録	We evaluated the efficacy and toxicity of cisplatin/docetaxel (CDDP/TXT) chemotherapy and identified prognostic factors in Japanese patients with cancer of unknown primary site (CUP). Twenty-eight consecutive patients seen at a single institute were reviewed retrospectively. Sixteen patients were treated with TXT 80mg/m2, followed by CDDP 75mg/m2. The overall response rate to CDDP/TXT treatment was 62.5%, with a median survival time (MST) of 22.7 months. Common adverse reactions were myelosuppression and hyponatremia. The MST of all 28 patients with CUP was 8.3 months, and the 1-year overall survival rate was 45.6%. Univariate analysis identified 5 prognostic factors:performance status, liver involvement, bone involvement, pleural involvement, and lymph node involvement. In conclusion, CDDP/TXT chemotherapy is effective with tolerable toxicity in patients with CUP. Japanese patients with CUP might be chemosensitive and may survive longer.
キーワード	cancer of unknown primary site (CUP) cisplatin docetaxel prognosis
Amo Type	Original Article
発行日	2010-10
出版物タイトル	Acta Medica Okayama
巻	64巻
号	5号
出版者	Okayama University Medical School
開始ページ	285
終了ページ	291
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2010 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	20975761
Web of Science KeyUT	000283563300003