Ivyspring International PublisherActa Medica Okayama1449-19071882021Artificial intelligence supported anemia control system (AISACS) to prevent anemia in maintenance hemodialysis patients 18311839ENToshiakiOharaDepartment of Pathology & Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesHiroshiIkedaDepartment of Internal Medicine, Shigei Medical Research HospitalYoshikiSugitaniAdvanced Institute for Materials Research, Tohoku UniversityHiroshiSuitoAdvanced Institute for Materials Research, Tohoku UniversityViet Quang HuyHuynhAdvanced Institute for Materials Research, Tohoku UniversityMasaruKinomuraDivision of Hemodialysis and Apheresis, Okayama University HospitalSoichiroHaraguchiKobayashi Medicine ClinicKazufumiSakuramaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesAnemia, for which erythropoiesis-stimulating agents (ESAs) and iron supplements (ISs) are used as preventive measures, presents important difficulties for hemodialysis patients. Nevertheless, the number of physicians able to manage such medications appropriately is not keeping pace with the rapid increase of hemodialysis patients. Moreover, the high cost of ESAs imposes heavy burdens on medical insurance systems. An artificial-intelligence-supported anemia control system (AISACS) trained using administration direction data from experienced physicians has been developed by the authors. For the system, appropriate data selection and rectification techniques play important roles. Decision making related to ESAs poses a multi-class classification problem for which a two-step classification technique is introduced. Several validations have demonstrated that AISACS exhibits high performance with correct classification rates of 72%-87% and clinically appropriate classification rates of 92%-98%.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Back matter145145ENHiroshiSUITOTimoHUTTULANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Water quality affects diatom diversity in Finnish rivers121131ENMakikoODAMattiLEPPÄNENAnnaKARJALAINENSatu-MaariaKARJALAINENHiroshiSUITOTimoHUTTULANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Juvenile salmon patch identification and comparison using Echelon analysis110120ENMakikoODASaijaKOLJONENFumioISHIOKAPetteriALHOHiroshiSUITOTimoHUTTULAKojiKURIHARANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Seto Inland Sea tidal flow simulation93100ENShinyaMORIFUJIHiroshiSUITOJanneROPPONENKenjiOKUBONo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014The sink of sediments suspended by waves in Lake Pyhäjärvi4856ENKenjiOKUBOTimoHUTTULAHiroshiSUITOJanneROPPONENAkikoMANOTakashiNAKAZAWANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Coupled simulation for atmospheric and water current models for Lake Pyykösjärvi1722ENHiroshiSUITOMikaKOBAYASHINinniLIUKKOTimoHUTTULANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Front matter18ENTimoHUTTULAHiroshiSUITONo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2014Assessment Tools for Solving Aquatic Problems (all chapters)ENHiroshiSUITOTimoHUTTULANo potential conflict of interest relevant to this article was reported.Acta Medica Okayama3432008Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in ratsENYujiKurosakiMasahiroTagawaAkihoOmotoHiroshiSuitoYukikoKomoriHiromuKawasakiTetsuyaAiba<p>To clarify to what extent topically administered drug molecules horizontally permeate into tissues surrounding the administration site, the intramuscular lateral concentration profile of acetaminophen was investigated in vivo using the microdialysis method in rats. When acetaminophen was intramuscularly administered for 6 hr in a pinpoint manner at a constant rate of 3 μg/min, it was clearly detected in the muscle surrounding the administration site, being 17.5 μg/ml when measured at a 2 mm distance from the administration site. The concentration in the muscle was decreased as the distance increased, and those measured at 5 mm and 40 mm were 0.35 μg/ml and 0.09 μg/ml, respectively. In addition, it was shown that the concentration in the muscle at 40 mm reflected the compound’s concentration in plasma, but not the compound’s horizontal
permeation from the administration site. With these observations, the intramuscular distribution profile of acetaminophen was numerically characterized according to Fick’s law. As a result, it was revealed that horizontal permeation is the primary process accountable for the increased intramuscular concentration only in the area adjacent to the administration
site, and the radius of the adjacent area was calculated to be 5.80 mm for acetaminophen. </p>
No potential conflict of interest relevant to this article was reported.岡山大学環境理工学部Acta Medica Okayama1341-9099912004湧昇循環装置によって誘起される湖沼内流れの数値シミュレーション6568ENHiroshiSuitoMasakatsuNouka10.18926/fest/11458The purpose of this research is solving the flow in a lake which caused by a fan who rotates at the low speed set on the water surface for the purpose of water quality purification of a lake. Although it is shown clearly by various experiments that the water quality in a lake improved by operation of this kind of equipment, the mechanism of the flow was not fully understood. In this research simulation of the flow which was caused by this equipment was carried out numerically, and the aspect of the flow corresponding to various conditions or the form of a lake was investigated.No potential conflict of interest relevant to this article was reported.