| JaLCDOI |
10.18926/AMO/61433
|
| フルテキストURL |
75_1_45.pdf
|
| 著者 |
Otsuka, Hiroaki|
Miyoshi, Toru|
Ejiri, Kentaro|
Kohno, Kunihisa|
Nakahama, Makoto|
Doi, Masayuki|
Munemasa, Mitsuru|
Murakami, Masaaki|
Nakamura, Kazufumi|
Ito, Hiroshi|
|
| 抄録 |
Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI.
|
| キーワード |
remote ischemic preconditioning
stable angina
serum creatinine
acute kidney injury
|
| Amo Type |
Original Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 |
2021-02
|
| 巻 |
75巻
|
| 号 |
1号
|
| 出版者 |
Okayama University Medical School
|
| 開始ページ |
45
|
| 終了ページ |
53
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 著作権者 |
CopyrightⒸ 2021 by Okayama University Medical School
|
| 論文のバージョン |
publisher
|
| 査読 |
有り
|
| PubMed ID |
33649613
|
