Okayama University Medical SchoolActa Medica Okayama0386-300X4511991A case of non-Hodgkin's lymphoma associated with hypercalcemia.5559ENShusoSuemaruJingoKageyamaZenskeOtaTaisukeOhnoshiKenjiSakamotoJuntaKamuraArticle10.18926/AMO/32221<p>A patient with a diffuse, small cleaved cell, non-Hodgkin's lymphoma associated with marked hypecalcemia was described. Antibody to the adult T-cell leukemia-lymphoma virus was absent. Although bone marrow was infiltrated by lymphoma cells, destructive or lytic bone lesions could not be detected. The serum level of immunoreactive parathyroid hormone C-terminal (PTH-C) was normal. The serum level of 1, 25-dihydroxyvitamin D was lower than normal. This case suggests that other humoral substances produced by lymphoma cells may be responsible for hypercalcemia.</P></p>
No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X3511981A different distribution of corticotropin releasing factor and arginine vasopressin contents in the hypothalamic nuclei after estrogen administration.3743ENKozoHashimotoNorihitoOhnoYoshiyukiAokiJingoKageyamaJiroTakaharaTadashiOfujiArticle10.18926/AMO/31293<p>The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.</p>
No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X3511981A different distribution of corticotropin releasing factor and arginine vasopressin contents in the hypothalamic nuclei after estrogen administration.3743ENKozoHashimotoNorihitoOhnoYoshiyukiAokiJingoKageyamaJiroTakaharaTadashiOfujiArticle10.18926/AMO/31290<p>The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.</p>
No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X4431990Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors.141147ENKozoHashimotoShinyaMakinoRyutoHirasawaToshihiroTakaoJingoKageyamaTakashiOgasaZensukeOtaArticle10.18926/AMO/30454<p>We examined 8 normal subjects and 16 patients with non-functioning pituitary tumors with a combined anterior pituitary test to evaluate the clinical usefulness of the test. Diagnoses included 9 of chromophobe adenoma, 3 of craniopharyngioma, 2 of Rathke's cleft cyst, and 1 each of intrasellar cyst and tuberculum sella meningioma. All subjects received hypothalamic releasing hormones: 1 micrograms/kg corticotropin releasing hormone (CRH), 1 micrograms/kg growth hormone releasing hormone (GRH), 500 micrograms thyrotropin-releasing hormone (TRH), 100 micrograms luteinizing hormone releasing hormone (LH-RH), and a relatively small dose (5 mU/kg) of lysine vasopressin (LVP). In the normal subjects, the addition of LVP potentiated the secretion of adenocorticotropic hormone (ACTH) induced by CRH, but had no significant effect on the secretion of other anterior pituitary hormones. In the combined test with 5 releasing hormones, the plasma ACTH and cortisol responses were not impaired in the majority of the patients before pituitary surgery. Serum thyroid-stimulating hormone (TSH), prolactin (PRL) and follicle-stimulating hormone (FSH) responses were not impaired in 82%, 70% and 67% of the patients, respectively, while the serum LH and GH responses were impaired in 67% and 73% of the patients, respectively. Following pituitary surgery, responses of these hormones to combined testing were similarly impaired in more than 75% of the patients. These results indicate that plasma ACTH, cortisol and serum TSH responses are fairly good before pituitary surgery but are impaired significantly after surgery. No subjects experienced any serious adverse effects related to the testing. These results suggest that combined testing with hypothalamic hormones is a convenient and useful method for evaluating pituitary function.</p>
No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X4911995Enhanced pressor response in spontaneously hypertensive rats induced by stimulation of vasopressin-V1 receptors.5359ENTakayoshiYamauchiToshioOguraTetsuyaOishiKazushiHaradaMasamiHashimotoYukariMimuraNaokoAsanoZensukeOtaJingoKageyamaArticle10.18926/AMO/30419<p>To elucidate the effect of the arginine vasopressin (AVP) system in vivo, especially V1 and V2 activity, on blood pressure, we measured the acute changes in blood pressure and heart rate after AVP, OPC-21,268 (a V1 receptor antagonist), and OPC-31,260 (a V2 receptor antagonist) were injected intravenously in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at the age of 15 weeks. Compared with the control period, single injection of AVP 5 ng/kg significantly increased systolic blood pressure in WKY rats without a concomitant increase in heart rate, but there was no significant increase in blood pressure in SHR. In contrast, single injection of either OPC-21,268 3 mg/kg or OPC-31,260 3 mg/kg did not affect blood pressure or heart rate in either SHR or WKY rats. Injection of AVP after the administration of OPC-31,260 induced a greater increase in blood pressure in SHR than in WKY rats, whereas injection of AVP after the administration of OPC-21,268 did not induce any clear increase in blood pressure in SHR or WKY rats. These results suggest that SHR have enhanced pressor activity mediated by V1 receptors and that this increase may be due to an increase in their number. In conclusion, enhancement of V1 activity may contribute to the development of high blood pressure in SHR.</p>
No potential conflict of interest relevant to this article was reported.岡山大学医療技術短期大学部Acta Medica Okayama0917-4494721997医療技術教育に対する高校生の認識と関心に関する研究113120ENTakeoOhtaYasuakiShimoishiJingoKageyamaKoichiShibuyaHirokoTohgeHiroshiEndo10.18926/152911996年7〜9月にかけて,岡山県周辺の10県下高校普通科3年在学中の学生に志望進路,志望分野とともに大学,短期大学における医療技術教育への認識と関心についてアンケート調査を行った｡サンプリングによって依頼した127校のうち回答が得られたのは52校(回収率40.9%)で,得られた回答数は合計1,998人(男子891人,女子1,077人,不明30人)であった｡これらの分析から,これらの地域では進学志望者の率は高く,特に男子に著名で,男女ともに理系への志望が多いことを認めた｡医療技術系大学の認識は看護学科を除いて低く,関心も特に男子で低かった｡4年制大学の進学を志望する学生にとっては, 3年制の多い医療技術系短期大学には関心が寄せがたく, 4年制へ移行した場合には関心も志望も高まる事が認められた｡将来この分野を担う人材の確保には現在の医療短大の4年制化や医療技術職の待遇改善が重要である
と結論づけた｡No potential conflict of interest relevant to this article was reported.岡山大学医療技術短期大学部Acta Medica Okayama0917-4494811997進路指導を行う高校教師の看護職についての認識4348ENTakeoOhtaYasuakiShimoishiJingoKageyamaKoichiShibuyaHirokoTohgeHiroshiEndo10.18926/152831993年に岡山県で行った先の研究で,高校生の看護課程の選択にあたって,進路指導を行っている教師の役割が大きい事を報告した｡今回は3年経った1996年に,同じ郵送調査を岡山県および周辺10県の普通科高校617校より無作為に選んだ127校において実施した｡64校より得られた回答を要約すると以下の通りであった｡1.教師が挙げた看護婦不足の理由はまず｢勤務時間が厳しい(85.9%)｣,｢仕事の内容が厳しい(53.1%)｣といった仕事のきつさで,次いで｢仕事の割には社会的評価が低い(32.8%)｣であった｡2.教師が学生に肯定的イメージとして看護課程を勧める理由は,｢まず専門職であること(73.4%)｣,次いで｢人に貢献できる喜び(53.1%)｣であった｡これらの結果は前回の結果と比較して統計的な有意差は認めなかった｡3.近年進められている3年制看護課程(準学士課程)から4年制課程(学士課程)への移行に関して,教師はこれらは学生の関心を呼ぶとし(79.8%),看護課程へ進学する者は増加するであろうとしている(57.8%)｡またこれまでよりこの課程への進学を教師は勧め易くなるとしている(56.3%)。これらの率は前回の結果と比較すると統計的に有意に高かった。No potential conflict of interest relevant to this article was reported.岡山大学医療技術短期大学部Acta Medica Okayama0917-4494821998学生の自己評価による成人看護実習の達成度 ―3週後･5週後の自己評価結果の分析―147155ENNiwaOhtaToshikoIkedaNobukoOhiJingoKageyamaNaomiKanaoYuKobayashiYukoHayashi10.18926/15264この研究目的は,実習目標の達成度に対する学生の自己評価を明らかにすることである｡調査対象は短大の看護学科3年生74名である｡調査は自記式の調査票により成人看護実習の3週後と終了時の5週後に行った｡この自己評価は実習目標11項目について5件法で行った｡その結果,患者理解,患者指導,自己の内面の気づきなど目標は,3週後より5週間の実習によってより評価が高くなった｡最も自己評価が低いのは社会資源の活用の理解であった｡悪性の患者を受け持った学生の方は良性の患者の受け持ち学生より,人間としての態度や死生観などに関して5週後有意に高値であった｡今後の課題は,限られた実習期間内で,学生個々の経験をどのように共有させるかや患者の福祉について理解を深めることである｡No potential conflict of interest relevant to this article was reported.岡山大学医療技術短期大学部Acta Medica Okayama0917-4494921999推薦入試制度の検討5964ENJingoKageyamaTakeoOhtaIchiroYamada10.18926/15249岡山大学医療技術短期大学部看護学科では,平成5年度より定員の約20%を募集人員とした推薦入試制度を導入し,以来本年で3回卒業生を送りだしてきた｡本学は来年度から保健学科として新入生を募集することになっており,推薦入学もとられる予定である｡そこで,これを機会に推薦入学学生と一般入試による入学生との在学成績,学習態度等を比較検討し,推薦入試制度の有用性を検討した｡推薦入学生の在学成績は一般入試による入学者の成績とほとんど差はないか,むしろよい傾向にある結果を得た｡今回の検討結果は在学成績のみでしかも期間が3回しか卒業生を送りだしていない時点であることから推薦入学制度の有用性を結論づけるためには更に今後検討が必要である｡No potential conflict of interest relevant to this article was reported.岡山大学医学部保健学科Acta Medica Okayama1345-09481322003成人看護実習(慢性期)における実習目標の到達度8390ENYukoHayashiJingoKageyamaYoshikoNakanishiHiroyukiIshizakiMichikoMorimotoKeikoMoriKeikoTsuboi10.18926/15216実習目標の到達度及び実習目標間の関係を明らかにするために,74名の学生による実習目標の自己評価を分析した｡その結果,実習目標の到達度は,｢自己の看護観や自己成長を培う｣が最も高かった｡そして｢疾患の病態生理や検査･治療についての理解と看護援助｣｢セルフケアに向けた看護援助｣｢危機に直面している患者の看護援助｣などの看護実践面に関する目標が高値を示していた｡学生は目標に沿った看護を実践する中で,経験したひとつひとつのケアを意味づけたり,看護とは何かを探求していったと思われ,それが看護観の形成や自己成長につながっていったものと考えられた｡実習目標間の関係では,各実習目標との間に相関が見られ,それらは信頼性のある妥当な慢性期看護実習の目標であることが確認された｡No potential conflict of interest relevant to this article was reported.岡山大学医療技術短期大学部Acta Medica Okayama0917-449461996腎 vasopressin 受容体と血圧調節2934ENJingoKageyama10.18926/11738Arginine vasopressin (AVP) は血管平滑筋細胞のV1受容体を介して、強い収縮作用を発揮し、血管昇圧反応を示すことはよく知られている。しかし、AVPが最も顕著な作用を発揮するのは腎集合管のV2受容体を介する抗利尿作用である。従って、AVPが高血圧の発症・維持には果たす役割については、いまだに十分に解明されていない。我々は、実験的高血圧モデルを用いて、腎のV2受容体の変化について検討してきた。ここでは、我々の成績を紹介して、実験的高血圧の分野での概要を示すとともに、本態性高血圧におけるAVPの役割についての最近の知見をまとめた。No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1984プロラクチン放出機構に関する研究 ラット下垂体前葉細胞灌流系を用いた検討ENNo potential conflict of interest relevant to this article was reported.