Acta Medica Okayama 126 8 2005 Intermolecular-medium and intramolecular-weak hydrogen bonding chains in the crystals of chiral trifluoromethylated amino alcohols 1134 1139 EN Toshimasa Katagiri Yasuyuki Fujiwara Satoshi Takahashi Kenji Uneyama <p>A structural feature of hydrogen bonding chains found in the crystals of trifluoromethylated amino alcohols is reported. Hydrogen bondings of 3-(N,N-dialkylamino)-1,1,1-trifluoro-2-propanols construct chiral spiral hydrogen bonding chains. Lone pairs on the nitrogen atoms of the amino alcohols participate in two hydrogen bondings. Detailed structural analysis of the hydrogen bonds of the 3-(N,N-dimethylamino)-1,1,1-trifluoro-2-propanol suggested that the chain built up with alternating intermolecular medium and intramolecular weak hydrogen bonds. The medium intermolecular hydrogen bond, which transfers a proton from the hydroxy group to the amino nitrogen, would make a tentative zwitterionic form of the molecule. Then, electrostatic attraction between the charges in the zwitterion centers induced a weak intramolecular hydrogen bond.</p> No potential conflict of interest relevant to this article was reported.

岡山大学保健環境センター環境安全部門 Acta Medica Okayama 0917-1533 28 2006 ヒヤリハットの書き方・書かせ方 9 16 EN Toshimasa Katagiri No potential conflict of interest relevant to this article was reported.