Springer-Verlag Acta Medica Okayama 0941-4355 21 2 2013 Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation 367 368 EN Yoshihiko Soga Yoshinobu Maeda Mitsune Tanimoto Takayuki Ebinuma Hiroshi Maeda Shogo Takashiba No potential conflict of interest relevant to this article was reported.

Springer Berlin Heidelberg Acta Medica Okayama 0941-4355 22 6 2014 Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation 1679 1683 EN Takayuki Ebinuma Yoshihiko Soga Takamaro Sato Kazuyuki Matsunaga Chieko Kudo Hiroshi Maeda Yoshinobu Maeda Mitsune Tanimoto Shogo Takashiba [Purpose] We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. [Methods] Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 ± 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day −7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 ± 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. [Results] Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days −7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days −7 to −1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA). [Conclusions] mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported. No potential conflict of interest relevant to this article was reported.