荒木元朗

Clinical Outcomes of Neoadjuvant Paclitaxel/Cisplatin/Gemcitabine Compared with Gemcitabine/Cisplatin for Muscle-Invasive Bladder Cancer

JaLCDOI	10.18926/AMO/68646
フルテキストURL	79_2_081.pdf
著者	Kawada, Tatsushi\| Kobayashi, Yasuyuki\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Kobayashi, Tomoko\| Edamura, Kohei\| Ebara, Shin\| Araki, Motoo\|
抄録	We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia.
キーワード	urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-04
巻	79巻
号	2号
出版者	Okayama University Medical School
開始ページ	81
終了ページ	92
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り

Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors

フルテキストURL	fulltext.pdf
著者	Kano, Yuzuki\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Sugiyama, Hitoshi\| Yamanoi, Tomoaki\| Yoshinaga, Kasumi\| Bekku, Kensuke\| Nishimura, Shingo\| Araki, Motoo\| Wada, Jun\|
発行日	2025-03-25
出版物タイトル	PLoS ONE
巻	20巻
号	3号
出版者	Public Library of Science
開始ページ	e0320482
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Kano et al.
論文のバージョン	publisher
PubMed ID	40131973
DOI	10.1371/journal.pone.0320482
Web of Science KeyUT	001456889900024
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0320482

Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk

JaLCDOI	10.18926/AMO/67868
フルテキストURL	78_6_429.pdf
著者	Kubota, Risa\| Bekku, Kensuke\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Edamura, Kohei\| Kobayashi, Tomoko\| Kobayashi, Yasuyuki\| Araki, Motoo\|
抄録	Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers.
キーワード	chronic kidney disease hypertension nephrectomy proteinuria
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-12
巻	78巻
号	6号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	437
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	39719315
Web of Science KeyUT	001397799300001

Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models

フルテキストURL	fulltext.pdf
著者	Watanabe, Tomofumi\| Sadahira, Takuya\| Tominaga, Yusuke\| Maruyama, Yuki\| Nagasaki, Naoya\| Sekito, Takanori\| Edamura, Kohei\| Watanabe, Toyohiko\| Araki, Motoo\| Watanabe, Masami\|
発行日	2024-05-28
出版物タイトル	Veterinary Medicine International
巻	2024巻
出版者	Hindawi
開始ページ	6505595
ISSN	2090-8113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2024 Tomofumi Watanabe et al.
論文のバージョン	publisher
PubMed ID	38836165
DOI	10.1155/2024/6505595
Web of Science KeyUT	001242506200002
関連URL	isVersionOf https://doi.org/10.1155/2024/6505595

The Diagnosis and Treatment Approach for Oligo-Recurrent and Oligo-Progressive Renal Cell Carcinoma

フルテキストURL	fulltext.pdf
著者	Bekku, Kensuke\| Kawada, Tatsushi\| Sekito, Takanori\| Yoshinaga, Kasumi\| Maruyama, Yuki\| Yamanoi, Tomoaki\| Tominaga, Yusuke\| Sadahira, Takuya\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Edamura, Kohei\| Kobayashi, Tomoko\| Kobayashi, Yasuyuki\| Araki, Motoo\| Niibe, Yuzuru\|
キーワード	renal cell carcinoma oligo-metastasis oligo-recurrence oligo-progression metastasectomy stereotactic body radiation therapy
発行日	2023-12-17
出版物タイトル	Cancers
巻	15巻
号	24号
出版者	MDPI
開始ページ	5873
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	38136417
DOI	10.3390/cancers15245873
Web of Science KeyUT	001131355800001
関連URL	isVersionOf https://doi.org/10.3390/cancers15245873

腎虚血再灌流障害における好中球動態

タイトル（別表記）	Neutrophil dynamics in renal ischemia-reperfusion injury
著者	荒木元朗\|
キーワード	腎虚血再灌流障害リアルタイムイメージング好中球腎移植
出版物タイトル	岡山医学会雑誌
発行日	2023-12-01
巻	135巻
号	3号
開始ページ	136
終了ページ	141
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.135.136
言語	日本語
著作権者	Copyright (c) 2023 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.135.136

Geriatric nutritional risk index as a prognostic marker of first-line immune checkpoint inhibitor combination therapy in patients with renal cell carcinoma: a retrospective multi-center study

フルテキストURL	fulltext.pdf
著者	Watari, Shogo\| Katayama, Satoshi\| Shiraishi, Hiromasa\| Tokunaga, Moto\| Kubota, Risa\| Kusumi, Norihiro\| Ichikawa, Takaharu\| Tsushima, Tomoyasu\| Kobayashi, Yasuyuki\| Bekku, Kensuke\| Araki, Motoo\|
キーワード	Geriatric Nutritional Risk Index Immune checkpoint inhibitor Renal cell carcinoma Prognosis
備考	The version of record of this article, first published in Discover Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12672-023-00816-x\|
発行日	2023-11-16
出版物タイトル	Discover Oncology
巻	14巻
号	1号
出版者	Springer
開始ページ	204
ISSN	2730-6011
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37968545
DOI	10.1007/s12672-023-00816-x
Web of Science KeyUT	001103962100001
関連URL	isVersionOf https://doi.org/10.1007/s12672-023-00816-x

Percutaneous cryoablation for clinical T3a renal cell carcinoma (< 7 cm) with segmental vein involvement or perinephric fat invasion based on preoperative evaluation of high-resolution multidetector computed tomography scan

フルテキストURL	fulltext.pdf
著者	Uka, Mayu\| Iguchi, Toshihiro\| Okawa, Nanako\| Matsui, Yusuke\| Tomita, Koji\| Umakoshi, Noriyuki\| Munetomo, Kazuaki\| Gobara, Hideo\| Araki, Motoo\| Hiraki, Takao\|
キーワード	Kidney neoplasms Cryosurgery Image-guided
備考	The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-022-01297-8\|
発行日	2022-06-21
出版物タイトル	Japanese Journal of Radiology
巻	40巻
号	11号
出版者	Springer Science and Business Media LLC
開始ページ	1201
終了ページ	1209
ISSN	1867-1071
NCID	AA12375935
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35727459
DOI	10.1007/s11604-022-01297-8
Web of Science KeyUT	000814035800002
関連URL	isVersionOf https://doi.org/10.1007/s11604-022-01297-8

Etiology of recurrent cystitis in postmenopausal women based on vaginal microbiota and the role of Lactobacillus vaginal suppository

フルテキストURL	fulltext.pdf
著者	Sekito, Takanori\| Wada, Koichiro\| Ishii, Ayano\| Iwata, Takehiro\| Matsubara, Takehiro\| Tomida, Shuta\| Watanabe, Masami\| Araki, Motoo\| Sadahira, Takuya\|
キーワード	cystitis vagina microbiota Lactobacillus urinary tract infection
発行日	2023-05-18
出版物タイトル	Frontiers in Microbiology
巻	14巻
出版者	Frontiers Media
開始ページ	1187479
ISSN	1664-302X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Sekito, Wada, Ishii, Iwata, Matsubara, Tomida, Watanabe, Araki and Sadahira.
論文のバージョン	publisher
PubMed ID	37275169
DOI	10.3389/fmicb.2023.1187479
Web of Science KeyUT	000998008400001
関連URL	isVersionOf https://doi.org/10.3389/fmicb.2023.1187479

Renal cryoablation combined with prior transcatheter arterial embolization in non-dialysis patients with stage 4 or 5 chronic kidney disease: a retrospective study

フルテキストURL	fulltext20230418-06.pdf
著者	Umakoshi, Noriyuki\| Iguchi, Toshihiro\| Matsui, Yusuke\| Tomita, Koji\| Uka, Mayu\| Kawabata, Takahiro\| Munetomo, Kazuaki\| Nagata, Shoma\| Gobara, Hideo\| Araki, Motoo\| Hiraki, Takao\|
キーワード	Renal cryoablation Transcatheter arterial embolization Chronic kidney disease
備考	The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-023-01416-z\|
発行日	2023-04-01
出版物タイトル	Japanese Journal of Radiology
出版者	Springer Science and Business Media LLC
ISSN	1867-1071
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37002430
DOI	10.1007/s11604-023-01416-z
Web of Science KeyUT	000961195900001
関連URL	isVersionOf https://doi.org/10.1007/s11604-023-01416-z

Complications of Percutaneous Cryoablation for Renal Tumors and Methods for Avoiding Them

JaLCDOI	10.18926/AMO/65141
フルテキストURL	77_2_121.pdf
著者	Iguchi, Toshihiro\| Matsui, Yusuke\| Tomita, Koji\| Uka, Mayu\| Umakoshi, Noriyuki\| Kawabata, Takahiro\| Munetomo, Kazuaki\| Nagata, Shoma\| Araki, Motoo\| Hiraki, Takao\|
抄録	Percutaneous cryoablation of renal tumors is widely used because of its high efficacy and safety. This high safety can be attributed, at least in part, to the visibility of the ablated area as an “ice ball”. This therapy has fewer complications (incidence, 0-7.2%) and is less invasive than surgery. Minor bleeding is inevitable in most kidney-related procedures, and indeed the most common complication of this therapy is bleeding (hematoma and hematuria). However, patients require treatment such as transfusion or transarterial embolization in only 0-4% of bleeding cases. Various other complications such as ureteral or collecting system injury, bowel injury, nerve injury, skin injury, infection, pneumothorax, and tract seeding also occur, but they are usually minor and asymptomatic. However, operators should know and avoid the various complications associated with this therapy. This study aimed to summarize the complications of percutaneous cryoablation for renal tumors and provide some techniques for achieving safe procedures.
キーワード	cryosurgery kidney neoplasms carcinoma renal cell complication
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2023-04
巻	77巻
号	2号
出版者	Okayama University Medical School
開始ページ	121
終了ページ	129
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37094949
Web of Science KeyUT	000982503800001

The Genotypic and Phenotypic Characteristics Contributing to Flomoxef Sensitivity in Clinical Isolates of ESBL-Producing E. coli Strains from Urinary Tract Infections

フルテキストURL	fulltext.pdf
著者	Sakaeda, Kazuma\| Sadahira, Takuya\| Maruyama, Yuki\| Iwata, Takehiro\| Watanabe, Masami\| Wada, Koichiro\| Araki, Motoo\|
キーワード	antimicrobial resistance Escherichia coli urinary tract infections flomoxef ST131
発行日	2023-03-06
出版物タイトル	Antibiotics
巻	12巻
号	3号
出版者	MDPI
開始ページ	522
ISSN	2079-6382
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	36978389
DOI	10.3390/antibiotics12030522
Web of Science KeyUT	000952995400001
関連URL	isVersionOf https://doi.org/10.3390/antibiotics12030522

Activated CTLA-4-independent immunosuppression of Treg cells disturbs CTLA-4 blockade-mediated antitumor immunity

フルテキストURL	fulltext.pdf
著者	Watanabe, Tomofumi\| Ishino, Takamasa\| Ueda, Youki\| Nagasaki, Joji\| Sadahira, Takuya\| Dansako, Hiromichi\| Araki, Motoo\| Togashi, Yosuke\|
キーワード	antibody-dependent cell cytotoxicity cytotoxic T-lymphocyte-associated antigen 4 immune checkpoint inhibitors regulatory T cell renal cell carcinoma
発行日	2023-02-10
出版物タイトル	Cancer Science
出版者	Wiley
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	36762794
DOI	10.1111/cas.15756
Web of Science KeyUT	000940385500001
関連URL	isVersionOf https://doi.org/10.1111/cas.15756

Bladder tuberculosis with ureteral strictures after bacillus Calmette‑Guérin therapy for urinary bladder cancer: A case report

フルテキストURL	fulltext20230317-1.pdf
著者	Tominaga, Yusuke\| Fujii, Masanori\| Sadahira, Takuya\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Bekku, Kensuke\| Edamura, Kohei\| Kobayashi, Tomoko\| Kobayashi, Yasuyuki\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Wada, Koichiro\| Araki, Motoo\|
キーワード	bladder tuberculosis bacillus Calmette-Guerin bladder cancer ureteral stricture voiding dysfunction
発行日	2022-12-20
出版物タイトル	Molecular and Clinical Oncology
巻	18巻
号	2号
出版者	Spandidos Publications
開始ページ	7
ISSN	2049-9450
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Tominaga et al.
論文のバージョン	publisher
PubMed ID	36761388
DOI	10.3892/mco.2022.2603
Web of Science KeyUT	000928771000001
関連URL	isVersionOf https://doi.org/10.3892/mco.2022.2603

Simplified PADUA REnal (SPARE) Nephrometry System can Describe the Surgical Difficulty of Renal Masses With High Accuracy Even Without 3D Renal Models

フルテキストURL	fulltext20230509-02.pdf fig1_20230509-02.pdf fig2_20230509-02.pdf fig3_20230509-02.pdf table20230509-02.pdf suppl table1_20230509-02.pdf suppl table2_20230509-02.pdf
著者	Watanabe, Tomofumi\| Sadahira, Takuya\| Sekito, Takanori\| Maruyama, Yuki\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\|
キーワード	renal cell carcinoma robot-assisted surgery three-dimensional imaging
備考	© 2022 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.urology.2022.09.015. \| This fulltext file will be available in Dec. 2023.\|
発行日	2022-12
出版物タイトル	Urology
巻	170巻
出版者	Elsevier
開始ページ	132
終了ページ	138
ISSN	00904295
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Elsevier Inc.
論文のバージョン	author
PubMed ID	36206826
DOI	10.1016/j.urology.2022.09.015
関連URL	isVersionOf https://doi.org/10.1016/j.urology.2022.09.015

Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma

フルテキストURL	fulltext20230207-1.pdf
著者	Matsumoto, Jun\| Nishimoto, Anzu\| Watari, Shogo\| Ueki, Hideo\| Shiromizu, Shoya\| Iwata, Naohiro\| Takeda, Tatsuaki\| Ushio, Soichiro\| Kajizono, Makoto\| Fujiyoshi, Masachika\| Koyama, Toshihiro\| Araki, Motoo\| Wada, Koichiro\| Zamami, Yoshito\| Nasu, Yasutomo\| Ariyoshi, Noritaka\|
キーワード	Genetic variant Polymorphism Renal cell carcinoma Survival UDP-glucuronosyltransferase
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11010-022-04637-4\|
発行日	2022-12-26
出版物タイトル	Molecular and Cellular Biochemistry
巻	478巻
号	8号
出版者	Springer Science and Business Media LLC
開始ページ	1779
終了ページ	1790
ISSN	0300-8177
NCID	AA00745800
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
論文のバージョン	author
PubMed ID	36571650
DOI	10.1007/s11010-022-04637-4
Web of Science KeyUT	000904010400001
関連URL	isVersionOf https://doi.org/10.1007/s11010-022-04637-4

Identification of MICALL2 as a Novel Prognostic Biomarker Correlating with Inflammation and T Cell Exhaustion of Kidney Renal Clear Cell Carcinoma

フルテキストURL	fulltext.pdf
著者	Lin, Wenfeng\| Chen, Wenwei\| Zhong, Jisheng\| Ueki, Hideo\| Xu, Abai\| Watanabe, Masami\| Araki, Motoo\| Liu, Chunxiao\| Nasu, Yasutomo\| Huang, Peng\|
キーワード	MICALL2 biomarker inflammation T cell exhaustion kidney renal clear cell carcinoma
発行日	2022-01-16
出版物タイトル	Journal Of Cancer
巻	13巻
号	3号
出版者	Ivyspring International Publisher
開始ページ	1214
終了ページ	1228
ISSN	1837-9664
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The author(s).
論文のバージョン	publisher
DOI	10.7150/jca.66922
Web of Science KeyUT	000746177200025
関連URL	isVersionOf https://doi.org/10.7150/jca.66922

Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy

フルテキストURL	fulltext.pdf
著者	Sun, Jingkai\| Lin, Wenfeng\| Li, Chaoming\| Ueki, Hideo\| Xue, Ruizhi\| Sadahira, Takuya\| Hu, Hao\| Wada, Koichiro\| Li, Na\| Liu, Chunxiao\| Araki, Motoo\| Xu, Abai\| Huang, Peng\|
キーワード	Posaconazole cell cycle autophagy rhabdomyosarcoma hedgehog proteins
発行日	2021-09-30
出版物タイトル	American Journal of Cancer Research
巻	11巻
号	9号
出版者	e-Century Publishing Corporation
開始ページ	4528
終了ページ	4540
ISSN	2156-6976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	AJCR (c)2021 e-Century Publishing Corp.
論文のバージョン	publisher
PubMed ID	34659903
Web of Science KeyUT	000707716300029

Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections

JaLCDOI	10.18926/AMO/62820
フルテキストURL	75_6_763.pdf
著者	Iwata, Takehiro\| Sadahira, Takuya\| Maruyama, Yuki\| Sekito, Takanori\| Yoshinaga, Kasumi\| Watari, Shogo\| Nagao, Kentaro\| Kawada, Tatsushi\| Tominaga, Yusuke\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Ishii, Ayano\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\| Wada, Koichiro\|
抄録	The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants.
キーワード	genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	763
終了ページ	766
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955548
Web of Science KeyUT	000735319800006
NAID	120007180272

Testosterone Recovery after Neoadjuvant Gonadotropin-Releasing Hormone Antagonist versus Agonist on Permanent Iodine-125 Seed Brachytherapy in Prostate Cancer Patients: A Propensity Score Analysis

JaLCDOI	10.18926/AMO/62810
フルテキストURL	75_6_705.pdf
著者	Iwata, Takehiro\| Maruyama, Yuki\| Kawada, Tatsushi\| Sadahira, Takuya\| Katayama, Satoshi\| Takamoto, Atsushi\| Sako, Tomoko\| Wada, Koichiro\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
抄録	Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients.
キーワード	testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	705
終了ページ	711
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955538
Web of Science KeyUT	000735297900006
NAID	120007180282

荒木 元朗