start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1111
end-page=1114
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ultrastructure of the rat glomerular basement membrane after enzymatic digestion
kn-title=酵素処理によるラット腎糸球体基底膜の微細構造の観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although various hypotheses have been proposed about the ultrastructure of the glomerular basement membrane (GBM) of the kidney, it has not clearly revealed. At present, it is thought to be composed of a meshwork of fibrils as reported by Ota et al. We successfully observed the meshwork structure of the GBM under an electron microscope after enzymatic treatment with α-amylase and elastase. The fibrils were about 30nm in width and were thought to be composed of type �W collagen.
en-copyright=
kn-copyright=

en-aut-name=IchiyasuAkira
en-aut-sei=Ichiyasu
en-aut-mei=Akira
kn-aut-name=一安朗
kn-aut-sei=一安
kn-aut-mei=朗
aut-affil-num=1
ORCID=

en-aut-name=TakaokaMichio
en-aut-sei=Takaoka
en-aut-mei=Michio
kn-aut-name=高岡道夫
kn-aut-sei=高岡
kn-aut-mei=道夫
aut-affil-num=2
ORCID=

en-aut-name=TakahashiKayo
en-aut-sei=Takahashi
en-aut-mei=Kayo
kn-aut-name=高橋香代
kn-aut-sei=高橋
kn-aut-mei=香代
aut-affil-num=3
ORCID=

en-aut-name=OtaZenske
en-aut-sei=Ota
en-aut-mei=Zenske
kn-aut-name=太田善介
kn-aut-sei=太田
kn-aut-mei=善介
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第三内科

affil-num=2
en-affil=
kn-affil=岡山大学第三内科

affil-num=3
en-affil=
kn-affil=岡山大学第三内科

affil-num=4
en-affil=
kn-affil=岡山大学第三内科
en-keyword=glomerular basement membrane
kn-keyword=glomerular basement membrane
en-keyword=enzymatic digestion
kn-keyword=enzymatic digestion
en-keyword=ultrastructure
kn-keyword=ultrastructure
en-keyword=type �W collagen
kn-keyword=type �W collagen
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1099
end-page=1109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on toxicity of trichlotoethane Part 3. Changes in liver function of mice after exposure to 1, 1, 1-and 1, 1, 2-trichloroethane
kn-title=Trichloroethane中毒に関する実験的研究 第3編 1,1,1-或は1,1,2-trichloroethane,carbon tetrachlorideなどの塩素系有機溶剤投与後の肝ATP,肝triglycerideなどの変動
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Variations in the levels of ATP and triglyceride (TG) in the liver and TG concentration and GPT activity in the plasma of mice exposed to 1, 1, 1-and 1, 1, 2-trichloroethane (TCE) were studied. The decrease in liver ATP, increase in liver TG, decrease in plasma TG and increase in plasma GPT were greater in mice exposed to 1, 1, 2-TCE than in mice exposed to 1, 1, 1-TCE. It was inferred that the biosynthesis of serum lipoprotein in the liver was inhibited, thus causing fatty liver. The increased level in plasma GPT is considered to be a sensitive and early indication of liver disturbance caused by TCE. The decrease in liver ATP, and the increase in liver TG in the mice were in the desending order of carbon tetrachloride, 1, 1, 2, 2-tetrachloroethane, 1, 1, 2-TCE, tetrachloroethylene, trichloroethylene, 1, 1, 1, 2-tetrachloroethane, and 1, 1, 1-TCE. The inhibitory effect of 1, 1, 2-TCE on the liver was stroner than that of 1, 1, 1-TCE, suggesting that the effect of 1, 1, 2-TCE is due to production of free radicals.
en-copyright=
kn-copyright=

en-aut-name=TakaharaKazuo
en-aut-sei=Takahara
en-aut-mei=Kazuo
kn-aut-name=高原和夫
kn-aut-sei=高原
kn-aut-mei=和夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=1,1,1-トリクロロエタン
kn-keyword=1,1,1-トリクロロエタン
en-keyword=1,1,2-トリクロロエタン
kn-keyword=1,1,2-トリクロロエタン
en-keyword=四塩化炭素
kn-keyword=四塩化炭素
en-keyword=肝ATP
kn-keyword=肝ATP
en-keyword=トリグリセライド
kn-keyword=トリグリセライド
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1091
end-page=1097
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on toxicity of trichloroethane Part 2. 1, 1, 1-and 1, 1, 2-trichloroethane in expired air and in urine of injucted mice
kn-title=Trichloroethane中毒に関する実験的研究 第2編 1,1,1-或は1 1 2-trichloroethane 投与後の呼気および尿への排泄
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mice were injected intraperitoneally with 1, 1, 1-and 1, 1, 2-trichloroethane (TCE), and the amounts of their metabolites exhaled from the lungs and excreted in the urine were measured. Exhalation from the lungs ended 7 hours after the injection. The ratio of the accumulated amount of 1, 1, 1-TCE to the amount of 1, 1, 1-TCE injected was 84.7% , and the ratio for 1, 1, 2-TCE was 9.8% . The accumulated amount of total trichloro-compounds in the urine of mice to the amount of 1, 1, 1-TCE injected was 1.07% , and that for 1, 1, 2-TCE was 0.15% . The total amount exhaled from the lungs and that excreted in the urine of mice injected with 1, 1, 1-TCE was greater than that of mice injected with 1, 1, 2-TCE.
en-copyright=
kn-copyright=

en-aut-name=TakaharaKazuo
en-aut-sei=Takahara
en-aut-mei=Kazuo
kn-aut-name=高原和夫
kn-aut-sei=高原
kn-aut-mei=和夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=1,1,1-トリクロロエタン
kn-keyword=1,1,1-トリクロロエタン
en-keyword=1,1,2-トリクロロエタン
kn-keyword=1,1,2-トリクロロエタン
en-keyword=呼気排泄
kn-keyword=呼気排泄
en-keyword=尿排泄
kn-keyword=尿排泄
en-keyword=尿中代謝産物
kn-keyword=尿中代謝産物
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1079
end-page=1089
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on toxicity of trichoroethane Part 1. Organ distribution of 1, 1, 1-and 1, 1, 2-trichloroethanes in exposed mice
kn-title=Trichloroethane中毒に関する実験的研究 第1編 1,1,1-或は1,1,2-trichloroethane投与後の臓器組織内分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mice were exposed to 1,000ppm of 1, 1, 1-and 1, 1, 2-trichloroethane (TCE) for one hour, and the organ distribution was examined. The levels of both TCEs in the organs were in the descending order of adipose tissue, the liver and the kidneys. The levels of 1, 1, 2-TCE in adipose tissue and the kidneys were higher than those of 1, 1, 1-TCE, but the level of the former was lower than that of the latter in the liver. The biological half-life of 1, 1, 2-TCE in the organs was longer than that of 1, 1, 1-TCE.
en-copyright=
kn-copyright=

en-aut-name=TakaharaKazuo
en-aut-sei=Takahara
en-aut-mei=Kazuo
kn-aut-name=高原和夫
kn-aut-sei=高原
kn-aut-mei=和夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=1,1,1-トリクロロエタン
kn-keyword=1,1,1-トリクロロエタン
en-keyword=1,1,2-トリクロロエタン
kn-keyword=1,1,2-トリクロロエタン
en-keyword=臓器組織内分布
kn-keyword=臓器組織内分布
en-keyword=半減期
kn-keyword=半減期
en-keyword=マウス
kn-keyword=マウス
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1065
end-page=1077
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The embryogenic and developmental changes of guanidino compounds in various chick tissues
kn-title=ニワトリの発生, 発育に伴うグアニジノ化合物の変動に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Guanidino compounds in various chick tissues were systematically analyzed by high performance liquid chromatography, and the changes in guanidino compound levels were studied during chick embryogenesis and development. In the whole chick embryo, arginine (Arg), creatinine (CRN), guanidinoacetic acid (GAA), β-guanidinopropionic acid (GPA), homoarginine (HArg), guanidine (G) and methylguanidine (MG) were detected. Arg, CRN and GAA appeared after the sixth day of incubation, and the other compounds appeared after the eighth day of incubation. All of the compounds, except for Arg which temporarily decreased on the eighth day of incubation, increased as embryogenesis progressed. In the yolk, Arg, CRN, GAA, GPA, HArg, G and MG were detected. Most of them dramatically increased at the late stage of embryogenesis. A slight increase in Arg, CRN and G in unfertile eggs was also observed after incubation. In the albumen, Arg, CRN, GAA, G and MG were detected. Arg, CRN, GAA, G and MG increased during embryogenesis. A slight increase in Arg, CRN and G in unfertile eggs was also observed after incubation. In the chick brain, liver, kidney and heart, Arg, CRN, GAA, GPA, HArg and MG were detected. Guanidinosuccinic acid and γ-guanidinobutyric acid, which are commonly detectable in the mammalian liver and brain, were not detectable in the chick organs. All guanidino compounds in the chick organs fluctuated greatly during development. GPA decreased as the chicks developed and was not detected in the adult organs. These observations suggest that birds have a different metabolic system of guanidino compounds from that of mammals, and that this system is activated during embryogenesis and affected by various physiological factors after hatching. It was also suggested that guanidino compounds, even at very low levels, might have some important roles in animal tissues during development.
en-copyright=
kn-copyright=

en-aut-name=KadoyaTakashi
en-aut-sei=Kadoya
en-aut-mei=Takashi
kn-aut-name=角谷隆司
kn-aut-sei=角谷
kn-aut-mei=隆司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門
en-keyword=グアニジノ化合物
kn-keyword=グアニジノ化合物
en-keyword=鶏胚
kn-keyword=鶏胚
en-keyword=ニワトリ脳
kn-keyword=ニワトリ脳
en-keyword=肝臓
kn-keyword=肝臓
en-keyword=腎臓
kn-keyword=腎臓
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1049
end-page=1064
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Histochemical and electron microscopic study of the false tendons in the heart of several mammals
kn-title=心臓の仮腱索に関する組織学的・電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=False tendons in the heart of several mammals were investigated by light and electron microscopies. False tendons were recognized macroscopically as chordal structures in the inner surface of the ventricles in the cow, pig, monkey, dog and rabbit. The outer surface of false tendons were covered with the same endothelial cell layer as the endocardium. Under the cell layer, there was thick connective tissue whose center was occupied by several bundles of Purkinje fibers. Among Purkinje fibers, thin connective tissue was present, in which small vessels and non-myelinated nerve fibers were observed. False tendons were identified in rats by light microscopy, but they were not found in mice. Purkinje fibers in false tendons varied among species. In artiodactyla, Purkinje fibers were larger and had fewer cell organella than those of other animals. Three types of intercellular junctions, desmosomes, intermediate junctions and gap junctions (nexus), were observed. Nexuses were often observed. Nerve fibers in the false tendons were all nonmyelinated. These nerve fibers only passed through the false tendons, and nerve endings were not found. Nerve cell bodies were not found either. From these results, the roles of false tendons in heart conduction were discussed.
kn-abstract=仮腱索はBrowicz1)により,心室内にみられる異常な索状構造物として詳しく報告された.その後,仮腱索は異常な状態におかれたときに生じるものと考えられた13,17).一方, Tawara15)は仮腱索は決して異常なものではなく,ウシやヒツジやイヌでは心室腔内に必ずみられる構造で,その大部分のものに刺激伝導系の,Purkinje線維が関係していることを観察した.さらにHoll4)は,ヒトやウシではその肉眼的解剖においても刺激伝導系の房室系と仮腱索とは深い関連があることをみとめている.現在では,仮腱索は心内膜下のPurkinje細胞の研究材料として検索されていることが多い.そこで,本研究においては,仮腱索がどの動物にも必ず存在するものかどうか,また,どの動物でも必ずPurkinje線維を含んでいるか,さらに仮腱索の中に神経がみられるかどうかということなどを考えて,この仮腱索が機能的にいかなる働きをしているかということを検索した.
en-copyright=
kn-copyright=

en-aut-name=TakagiTetsuhiro
en-aut-sei=Takagi
en-aut-mei=Tetsuhiro
kn-aut-name=高木哲弘
kn-aut-sei=高木
kn-aut-mei=哲弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
en-keyword=仮腱索
kn-keyword=仮腱索
en-keyword=肉眼的
kn-keyword=肉眼的
en-keyword=光学顕微鏡的
kn-keyword=光学顕微鏡的
en-keyword=電子顕微鏡的観察
kn-keyword=電子顕微鏡的観察
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1037
end-page=1047
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Acute Gastric Mucosal Lesion Due to Brain Damage �U: Analysis of Gastric Mucosal Prostaglandin E(1) in Rats with Acute Upper Gastrointestinal Mucosal Lesions
kn-title=中枢神経障害における胃粘膜障害の研究 第2編 ラット胃粘膜Prostaglandin E(1)を中心として
en-subtitle=
kn-subtitle=
en-abstract=Changes in gastric mucosal prostaglandin (PG) E(1) in rats with acute gastric mucosal lesions caused by water immersion stress or by brain damage were studied. Rats with brain damage were prepared by injecting cyanoacrylate into the brain. PGs were extracted from gastric mucosae, and PGE(1) was separated by silicic acid column chromatography and converted into PGB by alkaline treatment. PGE(1) was measured by radioimmunoassay using a double antibody method with anti-PGB(1) antibody. In normal rats, values of PGE(1) in the gastric mucosa were 249.3+64.3 pg/mg protein (mean+standard deviation). In the rats which underwent water immersion stress, PGE(1) values were significantly elevated (p<0.01) above the normal values 2, 3, and 6 hours after the treatment. In the rats with brain damage, PGE(1) values did not change significantly for 3 hours after the brain damage. However, 6 hours after the treatment, PGE(1) values were significantly elevated (p<0.01) above the normal values. In the rat which underwent water immersion stress, the elevation of PGE(1) was inhibited by intraperitoneal administration of atropine sulfate, diazepam, hexamethonium bromide or 6-hydroxy dopamine (6-OHDA). In contrast, in the rats with brain damage, the elevation of PGE(1) was significantly suppressed only by hexamethonium bromide and 6-OHDA which suppress the sympathetic nerve.
kn-abstract=脳障害に伴う急性上部消化管病変は1952年Cushingによって詳細に検討,報告され1),以後Cushing ulcerと呼ばれており,多くの検討がなされている.著者も第1編においてヒト脳血管障害における急性上部消化管病変を内視鏡的に検討した.さらに本編にて胃粘膜障害を中枢神経障害モデルと水浸拘束モデルで検討し,胃粘膜Prostaglandin(以下PG)E(1)の分泌調節機序と,防御因子としてのPGE(1)の胃粘膜障害への関与の程度を明らかにするため研究を行った.PGは消化管においては,胃分泌抑制作用2),抗潰瘍作用3),下痢誘発作用4)などを有しており,抗潰瘍作用は胃分泌抑制作用とは独立した作用であるとされている5,6).このためPGは最近では胃粘膜防御因子の一つとして論じられている.しかし胃内のPG分泌量は小量であり,その防御因子としての働きが生体にとってどの程度の意義があるかは確認されていない.また, PG分泌と自律神経との関係についても定説はない.著者の用いた2種類の実験モデルの1つは水浸拘束ストレスモデル7)であり,もう1つは脳内に合成樹脂を注入した圧迫破壊法による脳障害モデル8)である.後者のモデルに関しては教室の永原が基礎的研究を行ない,胃病変が高率に発生し,酸・ペプシン分泌の有意の低下,胃粘膜糖蛋白転移酵素活性の有意の低下,硫酸アトロピン投与による活性低下の抑制を報告している.
en-copyright=
kn-copyright=

en-aut-name=HaradaHitoshi
en-aut-sei=Harada
en-aut-mei=Hitoshi
kn-aut-name=原田仁史
kn-aut-sei=原田
kn-aut-mei=仁史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科
en-keyword=Prostaglandin E(1)
kn-keyword=Prostaglandin E(1)
en-keyword=ストレス潰瘍
kn-keyword=ストレス潰瘍
en-keyword=防御因子
kn-keyword=防御因子
en-keyword=中枢神経障害
kn-keyword=中枢神経障害
en-keyword=交換神経系
kn-keyword=交換神経系
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1027
end-page=1035
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Acute Gastric Mucosal Lesion Due to Brain Damage I: Endoscopic Study of Upper Gastrointestinal Lesions following Cerebrovascular Accidents
kn-title=中枢神経障害による胃粘膜障害の研究 第1編 ヒト脳血管障害における内視鏡的検討
en-subtitle=
kn-subtitle=
en-abstract=Endoscopic examinations were performed in 59 patients under general anesthesia just before or after surgery for cerebrovascular accidents. Acute gastric mucosal lesions were observed in 32 cases (54.2%). By the second day after the cerebrovascular accident, gastric petechiae and/or erosions in the corpus of the stomach were mainly observed. Acute duodenal ulcer became obvious from the third day after the accident. These upper gastrointestinal lesions were observed frequently in cases with low consciousness levels and cases with large hematomas. Gastrointestinal bleedings was observed in 19 cases. Bleeding in 6 cases observed by the second day after the cerebrovascular accidents was relatively mild. In contrast, bleedings in 7 cases observed 3days after the third day from the accident was serious. Three patients died, and 2 cases underwent surgery stop to the bleeding. These data suggest that it is important to perform endoscopic examination in patients with cerebrovascular accidents as soon as possible to check for acute upper gastrointestinal lesions and bleedings. Mild bleeding observed by the second day after the accident can be treated conservatively. In contrast, since the bleeding observed after the third day can potentially be severe, immediate endoscopic treatment or an emergency operation may be necessary to stop the bleeding.
kn-abstract=脳障害に伴う急性上部消化管病変についてCushing1)は1952年,脳腫瘍術後患者に発生した食道,胃,十二指腸潰瘍の自験例について詳細に報告している.その後,中枢神経障害に合併する胃・十二指腸病変はCushing ulcerと呼ばれ多くの報告がなされているが,臨床例に対して内視鏡的検討を行なった報告は少ない.著者は脳血管障害による急性上部消化管病変をごく早期より内視鏡的に観察し,両者の関係について検討したので報告する.
en-copyright=
kn-copyright=

en-aut-name=HaradaHitoshi
en-aut-sei=Harada
en-aut-mei=Hitoshi
kn-aut-name=原田仁史
kn-aut-sei=原田
kn-aut-mei=仁史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科
en-keyword=脳血管障害
kn-keyword=脳血管障害
en-keyword=急性胃病変
kn-keyword=急性胃病変
en-keyword=消化管出血
kn-keyword=消化管出血
en-keyword=内視鏡検査
kn-keyword=内視鏡検査
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1017
end-page=1026
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on vitamin E and lipoperoxide in stroke Part �U. Effects of vitamin E administration on serum α-tocopherol, lipoperoxide, total cholesterol and free fatty acid in the acute stage of stroke
kn-title=脳卒中におけるビタミンEと過酸化脂質 第2編 脳卒中発作後の血清ビタミンE,過酸化脂質,総コレステロール,遊離脂肪酸に対するビタミンE投与の影響
en-subtitle=
kn-subtitle=
en-abstract=Serum levels of α-tocopherol (α-Toc), lipoperoxide (TBARS), total cholesterol (TC) and free fatty acid (FFA) were studied before and after the administration of vitamin E (dl-α-tocopheryl acetate) for 4 weeks (400mg/day im for the first week, thereafter 600mg/day po) in the acute stage of stroke. Serum α-Toc was significantly lowel, but TBARS was higher than that of the control in the first day of outbreak. Vitamin E administration elevated the serum α-Toc level in a few days, but did not affect the TC level. On the otherhand, the serum TBARS level remained at a plateau for 4 weeks. These results led us to conclude that vitamin E must inhibit the elevation of TBARS, which otherwise was observed in most cases of stroke in the first week. There were three stroke patients whose serum α-Toc happened to have been measured 2 or 4 months prior to attack, and two of them had low levels of α-Toc (1ess than 0.5mg/dl) at that time. Soon after stroke developed, serum α-Toc was lower in the three patients. These findings suggest that a low level of serum α-Toc could be one of the risk factors of stroke.
kn-abstract=各種動脈硬化疾患で血清過酸化脂質が増加することが明らかにされ,動脈硬化の成因および進展に過酸化脂質が重要な役割を果たしているのではないかと注目されている.第1編で脳卒中発作後に血清過酸化脂質が増加し血清ビタミンEが減少すること,血清ビタミンE減少の一機序として脳血管障害部位での過酸化脂質生成に対してビタミンEが抗酸化剤として動員され消費される可能性を論じたが,第2編ではこの結果にもとづき,脳卒中発症直後よりビタミンEを投与し,血清ビタミンE,過酸化脂質,総コレステロール,遊離脂肪酸に対する影響を検討した.
en-copyright=
kn-copyright=

en-aut-name=ShojiKojiro
en-aut-sei=Shoji
en-aut-mei=Kojiro
kn-aut-name=正路浩二郎
kn-aut-sei=正路
kn-aut-mei=浩二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第2内科
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=ビタミンE
kn-keyword=ビタミンE
en-keyword=TBARS
kn-keyword=TBARS
en-keyword=脳卒中
kn-keyword=脳卒中
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=1007
end-page=1016
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on vitamin E and lipoperoxide in stroke Part I. Changes in serum α-tocopherol and lipoperoxide levels in the acute stage of stroke
kn-title=脳卒中におけるビタミンEと過酸化脂質 第1編 脳卒中における血清ビタミンE,過酸化脂質の経時的変動
en-subtitle=
kn-subtitle=
en-abstract=Serum levels of α-tocopherol (α-Toc), lipoperoxide (TBARS) and lipids were studied in the acute stage of stroke. Serum α-Toc was 0.74±0.32mg/dl (n=67) within 48 hours of the onset of stroke, which was significantly lower than the level of the control group (0.99±0.22mg/dl). Concurrently, serum TBARS was 6.04±2.17 nmol/ml (n=57) which was markedly higher than the level of the control group (3.22±0.89 nmol/ml). No correlation was seen in serum α-Toc and TBARS. However, serum total cholesterol (TC) correlated with α-Toc in stroke. Serum α-Toc of most cases of stroke dropped to the lowest level in the first 5 to 6 days and thereafter recovered gradually. The ratio of a-Toc to TC in serum reached a minimum in the early phase and then rose gradually over two weeks. Serum TBARS increased during the first week, and thereafter decreased slowly. These results imply that α-Toc may be consumed as an antioxidant against lipoperoxide which presumably increases depending on tissue damage induced by stroke.
kn-abstract=脳卒中や心筋梗塞をはじめとする動脈硬化性病変の発生や進展に過酸化脂質が関与していることが最近注目されてきたが,これは1952年にGlavindら1)が大動脈粥状硬化巣に過酸化脂質の存在を証明し,粥状硬化の程度と過酸化脂質の量との間に相関があるとした報告に端を発している.過酸化脂質は高度不飽和脂肪酸が,酸素と直接結合したもので,強い反応性を持つため酵素やビタミンを失活させ,蛋白や生体膜を変性させ,その結果として,細胞機能に障害を及ぼし,老化や動脈硬化と関連しているとされている2〜4).一方,生体には過酸化脂質生成を制御している種々の機構も存在し,superoxide dismutaseあるいはビタミンE,還元グルタチオンなどのようないわゆるfree radical scavengerや抗酸化剤がその役割をはたしている.著者はその中で抗酸化剤であるビタミンEに注目し,代表的血管障害である脳卒中において,発症後より経時的に血清ビタミンE,過酸化脂質,血清脂質を測定し,ビタミンEの動態を過酸化脂質との関連において検討した.
en-copyright=
kn-copyright=

en-aut-name=ShojiKojiro
en-aut-sei=Shoji
en-aut-mei=Kojiro
kn-aut-name=正路浩二郎
kn-aut-sei=正路
kn-aut-mei=浩二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第2内科
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=lipoperoxide
kn-keyword=lipoperoxide
en-keyword=TBARS
kn-keyword=TBARS
en-keyword=脳卒中
kn-keyword=脳卒中
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=981
end-page=1005
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study of body surface isopotential mapping in the normal aged Japanese
kn-title=健常高齢者の体表面電位図の検討 ―QRS・T波について―
en-subtitle=
kn-subtitle=
en-abstract=To examine the changes in the body surface isopotential maps (maps) with the increase of age, recorded maps at 87 lead points of 296 normal healthy adults, and I analyzed maps comparatively among six groups. On mean maps at the time of 10msec from the QRS initial, the position of the maximum (the greatest positive potential at a certain time point) shifted lower on the anterior chest, and that of the minimum (the greatest negative potential at a certain time point) shifted higher on the back with increasing age. At 30 msec the potential of the maximum decreased on the left anterior chest surface in males, while it increased in females with increasing age. The maximum potential of QRS on each lead (Rmax V) slightly decreased on the antero-superior chest in males, while it clearly increased from the left anterior chest to the left back in females with increasing age. The value of % VC decreased with age in both sexes. These data suggested that the potential of Rmax V was affected by heart size and lung impedance. However in females, changes in the breast might have a greater influence on the changes in Rmax V. The sex difference in Rmax V became smaller with age. The minimum potentials of QRS (Smax V) decreased on the upper anterior chest and back surface. No sex or age differences were found in the ratio of the breakthrough recognition, although the time of the breakthrough tended to increase in both sexes. On ST and T maps, there were few changes with age, but significant sex differences were observed among every age group. These were significant differences in maps between the aged and younger groups. Careful attention should be paid to age and sex differences, when analyzing maps of aged persons.
kn-abstract=体表面上に多数の誘導点を設け,それらの各瞬時の電位を求めて等電位線を作成したものが体表面電位図(以下,電位図)である.従来から心起電力を記録する方法として,標準十二誘導心電図やベクトル心電図が臨床上広く用いられているが,標準十二誘導心電図は胸壁上の誘導点が6ヵ所と少いことに問題があり,またベクトル心電図は心起電力を固定した単一双極子であると仮定すること自体にその限界がある.電位図は多数の誘導点を有し心臓の電気現象に関してより多くの情報を得ることができ,また単極誘導心電図から構成されるため,心筋の局所電位の把握にも優れているという特徴を有している.そこで電位図は,虚血性心疾患,心室肥大,心室内伝導傷害部位の同定や心性不整脈の発生源の診断などに応用される様になってきている.ところでわが国は高齢化社会への急激な移行に伴い高齢者の循環器疾患の発症率はますます高くなった.そこで電位図の虚血性心疾患などへの臨床応用が盛んになる中で,まず基礎となる健常高齢者について検討がなされなければならないが,多数の健常高齢者を対象に検討した報告は少なく1),高齢者の心疾患患者の電位図を検討する場合には問題がある.そこで60歳以上の健常高齢者の電位図を,当教室の木村ら2)が報告した60歳未満の健常成人例のそれと比較し,性差,年齢差につき検討した.
en-copyright=
kn-copyright=

en-aut-name=NakaoYou
en-aut-sei=Nakao
en-aut-mei=You
kn-aut-name=中尾陽
kn-aut-sei=中尾
kn-aut-mei=陽
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=体表面電位図
kn-keyword=体表面電位図
en-keyword=健常高齢者
kn-keyword=健常高齢者
en-keyword=Breakthrough
kn-keyword=Breakthrough
en-keyword=年齢差
kn-keyword=年齢差
en-keyword=性差
kn-keyword=性差
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=965
end-page=979
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Catecholamine and 5-hydroxytryptamine concentrations in the yolk, brain, heart, liver and kidney of the embryonic and developing chick
kn-title=ニワトリの発生と発育に伴うcatecholamine及び5-hydroxytryptamineの変動に関する研究 ―特に卵黄,脳,心臓,肝臓,腎臓について―
en-subtitle=
kn-subtitle=
en-abstract=Catecholamine (CA) and 5-hydroxytryptamine (5-HT) concentrations in the yolk, albumen, whole embryo, brain, heart, liver and kidney of embryonic and developing White Leghorn chicks were determined by high performance liquid chromatography. The brain, kidney, heart and liver were dissected from embryos after 12, 14, 16, 18 and 20 days of incubation, and 3, 7, 11, 15, 19, 39, 59, 99 and 159 days after hatching. 5-HT was found in the fertilized and unfertilized yolk, but CA was not found in either. The 5-HT concentration in the fertilized yolk increased until hatching, while it decreased in the unfertilized yolk. CA and 5-HT were found in the whole embryo on the 6th day, and their concentration increased with development. The CA and 5-HT concentrations in the brain increased from the embryonal stage to the 15th day after hatching, and then they became stable. The CA and 5-HT concentrations fluctuated in the heart, liver and kidney. It was interesting that the 5-HT concentration in the liver and norepinephrine concentration in the kidney showed a very large peak during hatching.
kn-abstract=鶏卵は,胚の発育過程において形態の解剖学的な情報が多いことから,発生形態学の研究に広く使用されているほか,物質の生化学的発生過程の研究にとっても最適な手段の1つであり,これまでに,胚の発育,孵化及び成鶏に至るまでの成長過程におけるmonoamines量やそれらの合成,代謝系の諸酵素の変化についても幾つかの報告がなされている.Burack and Badger1)は,(3)H-dihydro-xyphenylalanine(DOPA)を早期の胚homogenateとincubateしてまずdopamine(DA)が生成されること,ついでnorepinephrine(NE)さらにepinephrine(E)が生成されるようになることを示している.ついで, Ignarro and Shideman2)は,孵卵3日目以後の胚心臓中にNEとEを,また4日目以後の胚心臓中にDOPAとDAを検出し,発生及び発育に伴う変動を報告するとともに,孵卵早期からの心臓中におけるtyrosine hydroxylase, DOPA decarboxylase, dopamine-β-hydroxidase及びphenyletha-nolamine-N-methyltransferase活性の存在を明らかにしている3). Ignarro and Shideman4)はさらに胚及び胚心臓への(3)H-NE及び(3)H-Eの取り込みや細胞下分布を詳細に調べているが,無精卵及び受精卵の卵黄にはNEとEが存在し,DOPAとDAは存在しないと報告しており,NEとEは孵卵4日目に卵黄より胚に移行することを示唆している.その他,脳についても発育に伴うNE,E及びDAの変動が報告されている5),6),7),8).次に5-hydroxytryptamine(5-HT)については,Bourne9)がニワトリ孵卵の胚脳内の5-HTとMAO活性の発生について報告しており,孵化後の発育に伴う5-HTやMAO活性の変動についても観察している9),10).しかし,中枢以外の諸臓器,肝臓,腎臓などについての観察は報告されていない.われわれ11)は,先にニワトリの発生と発育に伴なうグアニジノ化合物の発生と発育について観察を行ったが,α-グアニジノグルタル酸などのグアニジノ化合物のけいれん発現機構には脳内アミンの変動が関与している可能性が示唆されている12).従って本研究においては現在われわれが使用している実験動物としての白色レグホーン種ニワトリの諸臓器中のcatecholamine(CA)及び5-HTの発生と発育に伴なう変動を系統的に測定し,白色レグホーン種ニワトリを使用したmonoaminesに関連する諸実験の基礎データーとするため以下の実験を行った.なお,従来の報告のmonoaminesの測定方法は主として,蛍光定量法あるいはガスクロマトグラフィーによるものであったため,特に高分離能,高感度測定が可能な高速液体クロマトグラフィー(HPLC)による測定値を知ることも本研究の目的に含まれている.
en-copyright=
kn-copyright=

en-aut-name=FukuiMasahiro
en-aut-sei=Fukui
en-aut-mei=Masahiro
kn-aut-name=福井正佳
kn-aut-sei=福井
kn-aut-mei=正佳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門
en-keyword=鶏卵
kn-keyword=鶏卵
en-keyword=発生
kn-keyword=発生
en-keyword=catecholamine
kn-keyword=catecholamine
en-keyword=5-hydroxytryptamine
kn-keyword=5-hydroxytryptamine
en-keyword=胚
kn-keyword=胚
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=955
end-page=963
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistological study of humoral and cellular immune events in the small intestinal mucosa of patients with liver cirrhosis
kn-title=肝硬変症の小腸粘膜における液性および細胞性免疫の検討
en-subtitle=
kn-subtitle=
en-abstract=Using an immunoperoxidase method, we analyzed T cell subpopulation, subsets and immunoglobulin-containing cells in the mucosa of small intestines obtained from 19 patients with liver cirrhosis and 8 patients without any liver disease (controls). Percentages of IgA-containing cells in the lamina propria of the small intestines from the liver cirrhosis patients tended to be higher than in the same tissue of the controls. In contrast, percentages of pan T cells and cytotoxic/suppressor T cells in the lamina propria and numbers of intraepithelial pan T and cytotoxic/suppressor T cells in the tissues from liver cirrhosis patients tended to be lower than in the controls. Furthermore, the percentage of IgA-containing cells in the lamina propria was significantly higher and the percentage of pan T and cytotoxic/suppressor T cells in the lamina propria was significantly lower in the small intestines of patients with decompensated liver cirrhosis than in the small intestines of the controls. The lower percentage of pan T and cytotoxic/suppressor T cells observed in the small intestine of patients with liver cirrhosis, especially decompensated liver cirrhosis, may be related to general impairment of cellular immunity in liver cirrhosis and to enhanced humoral immunity in the small intestine as shown by the increase in IgA-containing cells.
kn-abstract=消化管粘膜は,種々の食餌性抗原をはじめとし,細菌・ウィルスなどの外因性抗原や腸内細菌およびそれらが産生する内因性抗原に絶えず曝されている.これらの抗原に対しては,gut associated lymphoid tissue(GALT)が,構成するリンパ球ならびにsecretory IgA(sIgA)を産生することにより防御機構をなしている.そして,sIgAの分泌機構は免疫組織学的に詳細に検討され1,2),腸粘膜の免疫グロブリン(以下Ig)保有細胞やリンパ球についても,モノクローナル抗体の普及とともに検討されてきている3,4).既に,潰瘍性大腸炎5)やceliac disease6)などでは,その本態を検討する目的で腸粘膜内のIg保有細胞やT cell subsetsの変化についての免疫組織学的検討が少数ながら報告されている.しかしながら,肝炎をはじめとする肝疾患,特に細胞性免疫の低下7)や高γグロブリン血症の認められる肝硬変症例における腸管免疫の実態については,ほとんど検討がなされていない.そこで,著者は,酵素抗体法を用い,肝硬変症例の腸管局所における液性および細胞性免疫能の変動を明らかにする目的で,肝硬変症例の十二指腸生検組織を用いて,その腸管粘膜のIg保有細胞,secretory component(SC)およびリンパ球のsubpopulationならびにsubsetsについて免疫組織化学的に詳細に検討したので報告する.
en-copyright=
kn-copyright=

en-aut-name=FujikiShigeatsu
en-aut-sei=Fujiki
en-aut-mei=Shigeatsu
kn-aut-name=藤木茂篤
kn-aut-sei=藤木
kn-aut-mei=茂篤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=腸管免疫
kn-keyword=腸管免疫
en-keyword=肝硬変
kn-keyword=肝硬変
en-keyword=酸素抗体法
kn-keyword=酸素抗体法
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=943
end-page=954
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Myocardial oxygen metabolism of the right ventricle under volume loading and hypoperfusion
kn-title=容量負荷時の右冠動脈血行動態と右室心筋酸素代謝
en-subtitle=
kn-subtitle=
en-abstract=A comparison of blood flow and myocardial O(2) consumption (MVO(2)) in the right and left ventricle was made in 24 open-chest dogs. The effects of volume loading by arteriovenous (AV) and arterio-left atrial shunts, and of ventricular hypoperfusion by rapid removal of blood were examined in the presence and absence of the pericardium. Blood flow per unit myocardium was greater in the left anterior descending coronary artery (LAD) than in the right coronary artery (RCA). Similarly, the myocardial O(2) extraction ratio (EO(2)) was higher in the left than in the right ventricle. The MVO(2) was greater in the left than in the right ventricle. Volume loading to both ventricles by AV shunt increased MVO(2) of the right ventricle by augmenting EO(2) in addition to increasing the coronary arterial blood flow. Decreasing aortic pressure by rapid removal of blood increased EO(2) in both ventricles, though more in the right ventricle than in the left ventricle. When the pericardium was closed by suturing, the right and left end-diastolic pressure rose, but EO(2) and coronary blood flow of neither ventricle changed. We conclude that the reserve capacity of myocardial O(2) extraction was greater in the right ventricle than in the left ventricle.
kn-abstract=近年心機能の測定方法が進歩するにつれて,心臓ポンプ機能におよぼす右心室の影響が指摘されている.臨床的にはRI angiography法, cineangiography法,実験的にはradioactive microsphereを用いて右室機能,右室心筋血流量が測定できるようになり,右室機能の重要性が注目されてきた.また右室梗塞は従来考えられていたよりも頻度が高く,心筋梗塞の14-34% に認められ1)2),Cohnら3)は,右室梗塞の臨床像,治療の特殊性を指摘している.右室は左室に比して内圧が低く,かつ壁厚が薄いにもかかわらず,右冠動脈潅流圧は左冠動脈と等しい.したがって右室では左室と異なった心筋酸素代謝が営まれていることが考えられる.しかし従来左室心筋酸素代謝に関する報告は多いが,右室のそれに関する報告はほとんどない.右室機能さらには右室梗塞の重要性が指摘されるにつれて,右室心筋の酸素代謝の解明が重要となってきた.Murrayら4)は動物実験においてradioactive microsphereを用いて,安静時では右室の心筋血流量は左室のそれの約2/3であると報告し,Kusachiら5)は動物実験で前心静脈血の酸素濃度を測定することにより右室の心筋酸素代謝を検討し,圧負荷時の心筋酸素需要の増加に対して右室は左室と異なり,冠血流量とともに右室の心筋酸素摂取率も増加させると報告している.著者は主として容量負荷を加えた時および心臓のグローバルな虚血時の右冠動脈血行動態と右室の心筋酸素代謝を左室のそれと比較検討した.
en-copyright=
kn-copyright=

en-aut-name=TakedaKou
en-aut-sei=Takeda
en-aut-mei=Kou
kn-aut-name=武田光
kn-aut-sei=武田
kn-aut-mei=光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=931
end-page=942
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Alpha and beta-adrenergic effects on the coronary circulation of the canine right ventricle
kn-title=右室冠循環に及ぼすαおよびβアドレナリン作用の影響（実験的検討）
en-subtitle=
kn-subtitle=
en-abstract=Alpha and beta-adrenergic effect on the coronary circulation of the right ventricle were studied in comparison with those of the left in anesthetized open chest dogs. Norepinephrine was administrated and the cardiac sympathetic nerve was stimulated with beta-blocker pretreatment to determine whether there was any difference in vasoconstriction between the right and left coronary arteries. When the right and left cardiac sympathetic nerves were stimulated, coronary vasoconstriction was considerably greater in the RCA than in the LAD, while coronary vasoconstriction induced by NE injection was greater in the LAD than in the RCA. These data indicated that the pre-synaptic alpha-adrenergic stimulation caused affected the RCA and LAD differently from the post-synaptic alpha-adrenergic stimulation as to the extent of coronary vasocostriction. With phentolamine pretreatment the nerve stimulation caused no difference in the rate of increase of mean coronary blood flow between the RCA and LAD, and the rate of increase of RVSP×HR was greater than that of LVSP×HR. These results indicate that cardiac sympathetic nerve stimulation affected the right ventricle more than the left mainly through beta-adrenoceptors. The response of the right ventricle to increased oxygen demand was possibly, in part, different from that of the left.
kn-abstract=近年虚血性心疾患における冠攣縮の役割が注目され,冠攣縮を認めた患者では交感神経の緊張が亢進しており,α受容体を介する冠血管収縮がその一因をなしていることが報告されている1).Chahineら2)は,人での冠攣縮は右冠動脈では左冠動脈に比し頻度が高いことを報告しており,左右冠動脈ではα受容体を介する冠血管収縮の程度が異なる可能性がある.また左冠動脈におけるα受容体を介する冠血管収縮は,心筋酸素需要増加による代謝性の冠血管拡張時にも重要な役割を果し,両者は互いに競合する状態にあるとされている3).しかし,冠攣縮の頻度がより高い右冠動脈のこのような冠血管収縮の役割については知られていない.一方冠循環へのβ受容体刺激による作用としては,冠動脈へのβ(2)受容体を介する直接作用と,β(1)受容体刺激による心筋への陽性変力作用を介するものが知られている.このうち,β(2)受容体を介する血管拡張については, β(1)およびα-blocker投与後にのみみられることから,生理学的にはさほど重要でないとされている4)ものの,詳細については不明の点が多く特に現在まで交感神経刺激によるβ受容体を介する右冠動脈への影響を検討した報告はみられない.左室とは形態や仕事量の全く異なる右室に分布する右冠動脈では,交感神経刺激に対する反応が左冠動脈とは異なることが推測される.そこで今回の研究では,β-blocker前処置下にて左右心臓交感神経刺激あるいはNE投与をおこない,左右冠動脈で冠血管収縮の程度に差があるか否かを検討した.またα-blocker投与下で,左右心臓交感神経刺激をおこない,β受容体を介する冠循環への影響を左右冠動脈で比較した.
en-copyright=
kn-copyright=

en-aut-name=AbeYukihiro
en-aut-sei=Abe
en-aut-mei=Yukihiro
kn-aut-name=安部行弘
kn-aut-sei=安部
kn-aut-mei=行弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=alpha-adrenergic effect
kn-keyword=alpha-adrenergic effect
en-keyword=beta-adrenergic effect
kn-keyword=beta-adrenergic effect
en-keyword=right ventricle
kn-keyword=right ventricle
en-keyword=right coronary artery
kn-keyword=right coronary artery
en-keyword=sympathetic nerve stimulation
kn-keyword=sympathetic nerve stimulation
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=919
end-page=930
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study of Body Surface Isopotential Mapping Part 2 A Clinacal Study of Varying Types of Right Ventricular Overload
kn-title=体表面心臓電位図に関する研究 第2編 右室負荷疾患の臨床的検討
en-subtitle=
kn-subtitle=
en-abstract=In order to diagnose right ventricular hypertrophy (RVH) more precisely and quantitatively, isopotential body surface mappings (MAPs) and standard 12 lead electrocardiograms (ECGs) were studied in 39 patients with three different hemodynamic types of chronic right ventricular overload. Sokolow and Lyon's criteria were useful in detecting right ventricular overload. However, ECG parameters were not useful in differentiating between hemodynamic states. The increase of R max･V from precordial leads was thought to be characteristic of right ventricular pressure overload. The Increase in S max･V from right precordial leads was thought to be characteristic of right ventricular volume overload, while the increase in S max･V from left lateral chest and left back leads reflected right ventricular volume and pressure overload. T max･V showed no significant findings. The prolongation of R max･T in the right precordial area was thought to be characteristic of right ventricular volume overload, while the prolongation of R max･T in the left high back was regarded as indicating hypertrophy in the right ventricular outflow tract due to pressure overload. The prolongation of S max･T in the right precordial area was thought reflect right ventricular pressure overload, while the prolongation of S max･T in the left high back was regarded as indicating right ventricular volume overload. The prolongation of VAT (V1), BT time and QRS interval suggested chronic right ventricular volume overload. R max･V (F4), S max･V (I3) and QRS interval were selected for analysis of variance, and discriminant analysis was made using these variables. Twenty nine out of 39 patients were classified correctly, and the accuracy of discrimination was 74.4%.
kn-abstract=慢性的右室負荷により右室肥大をきたす疾患は多様である.その原因を血行動態的にみると,右室収縮期圧負荷および右室拡張期容量負荷の2つの負荷様式に大別されるが,両者の合併した負荷様式も臨床的にしばしば見られる.右室肥大の電気生理学的診断法については,Sokolow and Lyon1)の診断基準をはじめとして様々な診断基準2,3)が提唱され未だにそれらの有用性に関する議論が続いている.また,右室肥大の背景としての血行動態差異に基づく心電図波形の差異についても,その有無に関する議論をも含めて多くの報告がみられる.従来の電気生理学的検査法(標準12誘導心電図,ベクトル心電図)による諸家の臨床的検討では,右室肥大の血行動態的負荷様式を識別し得る根拠としてあげられた所見は主に定性的なものである.著者は,第1編に於いて,実験的右室圧負荷犬の電気生理学的所見と病理解剖学的所見を対比検討した結果右室肥大の診断上,右前胸部及び背部にも多くの誘導点をもつ体表面電位図が標準12誘導心電図にない診断情報を含んでいることを示した. Blumenscheinら4)は,小児の心房中隔欠損症,Fallow 4徴症及び肺動脈弁狭窄症について体表面心臓電位図を検討した結果,体表面心臓電位図は圧負荷に基づく右室肥大と容量負荷に基づく右室肥大を鑑別し得る診断情報を含んでいると示唆した.そこで,この体表面電位図を用い,右室負荷疾患39例(原発性肺高血圧症4例,肺動脈狭窄症7例,二次口心房中隔欠損症17例,肺高血圧症合併二次口心房中隔欠損症11例)について臨床的に右室負荷疾患の血行動態的差異を定量的指標により判別しうるか否かについて検討した.また標準12誘導心電図より得た右室肥大診断基準項目の評価も同時に行った.
en-copyright=
kn-copyright=

en-aut-name=ImatakiKensuke
en-aut-sei=Imataki
en-aut-mei=Kensuke
kn-aut-name=今滝健介
kn-aut-sei=今滝
kn-aut-mei=健介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=体表面心臓電位図
kn-keyword=体表面心臓電位図
en-keyword=右室収縮期負荷
kn-keyword=右室収縮期負荷
en-keyword=右室拡張期負荷
kn-keyword=右室拡張期負荷
en-keyword=標準12誘導心電図
kn-keyword=標準12誘導心電図
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=11-12
article-no=
start-page=909
end-page=918
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on Body Surface Isopotential Mapping Part 1 Experimental Right Ventricular Systolic Overload
kn-title=体表面心臓電位図に関する研究 第1編 右室肥大(収縮期負荷)の実験的検討
en-subtitle=
kn-subtitle=
en-abstract=In order to diagnose right ventricular hypertrophy (RVH) more precisely and quantitatively, body surface isopotential mappings (MAPs) and standard 12 lead ECGs (ECGs) were recorded in pulmonary artery banded dogs and sham operated dogs before and after surgery. MAP and pathoanatomical findings (RV/LV weight ratio) were compared, and the relationships among the MAP and ECG parameters were examined. Pathoanatomical RVH (RV/LV weight ratio>0.65) developed 12 months after PA banding. The indices derived from MAPs were analyzed statistically by one way analysis of variance. After PA banding, R max･V gradually increased on the anterior-inferior chest surface, S max･V increased on the left high back, T max･V increased on the lower chest surface and the R max ratio and RV/LV weight ratio were correlated (r=0.55, p<0.1), so R max ratio may reflect anatomical RVH quantitatively. These changes were statistically significant (p<0.05), while the usual parameters for diagnosing RVH such as QRS axis, R/S (V1), RV1, SV5, SV6, RV1+SV5 and VAT (V1) showed no significant changes after the operation. The foregoing findings suggest that MAP is superior to conventional ECG for diagnosis of RVH.
kn-abstract=右室圧負荷の原因疾患として,肺動脈弁狭窄症,原発性肺高血圧症,及び肺高血圧を伴った心室中隔欠損症,動脈管開存症などがあげられる.これらの病理解剖学的特徴は求心性の右室肥大で,その電気生理学的反映として,心電図,ベクトル心電図に,収縮期負荷として特有の右室肥大所見を認める.しかし,心電図,ベクトル心電図の右室肥大所見は,その原因疾患および病態,経過により著しい差を示し,多くの判定基準1〜3)が提唱されている.しかもこれらの基準はいずれも,主として右室肥大の存在を定性的に示し,定量的な判定には十分でない.そこで右前胸部及び背部にも多くの誘導点を有し,体表面電位と時間的変化を同時に表現し得る体表面電位図(電位図)を用い,右室圧負荷に伴う右室の求心性肥大をより詳細に分析し,かつ,その定量的評価の可能性を実験的に検討する目的で犬に肺動脈絞扼術を施行し慢性右室圧負荷を作成した.そして右室肥大の経時的進展に伴う電位図変化を観察し,病理解剖学的所見と対比検討した.更に,標準12誘導心電図の経時的変化についても検討を行った.
en-copyright=
kn-copyright=

en-aut-name=ImatakiKensuke
en-aut-sei=Imataki
en-aut-mei=Kensuke
kn-aut-name=今滝健介
kn-aut-sei=今滝
kn-aut-mei=健介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=体表面心臓電位図
kn-keyword=体表面心臓電位図
en-keyword=右室収縮期負荷
kn-keyword=右室収縮期負荷
en-keyword=肺動脈絞扼術
kn-keyword=肺動脈絞扼術
en-keyword=標準12誘導心電図
kn-keyword=標準12誘導心電図
END