start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=913
end-page=925
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Neuropeptides and neuropeptide receptors in stroked gerbil brain
kn-title=実験的脳梗塞gerbilにおける神経ペプチドと受容体結合に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Unilateral occlusion of the right common carotid artery in adult gerbils produced right homolateral cerebral ischemia and neurologic deficits (stroke) in 41.4% (Group S). The other 58.6% of the gerbils did not develop signs of stroke (Group N). Brains from gerbils of both groups were analyzed for levels of 8 immunoreactive neuropeptides and 4 CNS-receptor bindings. The level of β-endorphin was 90% higher in the ischemic right hemisphere than in the control left hemisphere, although the levels of the other 7 neuropeptides, i.e., Met-enkephalin (ENK), dynorphin, thyrotropin releasing hormons (TRH), cholecystokinin-oktapeptide, substance P, somatostatin and vasoactive intestinal polypeptide (VIP), were not different between the two hemispheres. However, the dynorphin level in the right hemisphere of Group S was significantly lower than that in the right hemisphere of Group N. Opioid receptor bindings were significantly lower in the ischemic hemispheres than in the control hemispheres. On the other hand, ischemia did not produce any change in TRH receptor binding and VIP receptor binding in the brain. An intraperitoneal (i.p.) injection of the opiate antagonist naloxone (1mg/kg) reversed signs of stroke within 3-5 min in 20 of 20 Group S gerbils; the effect lasted for up to 20-30 min, after which stroke returned. Remarkably, 16 of 22 Group N gerbils injected i.p. with pentazocine (15mg/kg) 5 hr after ligation developed stroke within 10min. The pentazocine-induced stroke could be reversed by an i.p. injection of naloxone (10mg/kg). Injection of an enkephalin analogue (FK33824; 15mg/kg, i.p.) 5 hr after ligation also produced stroke in 14 other Group N gerbils. Without medication, all of the stroke gerbils died with in 12 to 28 hours, but with a subcutaneous implantation of a 10-mg pellet of naloxone, 20% of the gerbils lived for 4 weeks. These findings suggest that β-endorphin and opioid receptors may be involved in the pathophysiology of stroke.
en-copyright=
kn-copyright=

en-aut-name=KishimotoTakeshi
en-aut-sei=Kishimoto
en-aut-mei=Takeshi
kn-aut-name=岸本武
kn-aut-sei=岸本
kn-aut-mei=武
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門
en-keyword=stroke
kn-keyword=stroke
en-keyword=mongolian gerbil
kn-keyword=mongolian gerbil
en-keyword=neuropeptides
kn-keyword=neuropeptides
en-keyword=CNS receptors
kn-keyword=CNS receptors
en-keyword=opiate antagonist
kn-keyword=opiate antagonist
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=889
end-page=912
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A scanning electron microscopic study of microcirculation of rabbit and human lymph nodes
kn-title=家兎およびヒトリンパ節の微細血管構築の走査電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Corrosion casts of rabbit and human lymph nodes were observed by SEM. Casts showed a broad bean appearance. On the outer surface of casts, the afferent and efferent vessels and the vessels of the capsule were seen. Cross-sectioned surfaces of the casts showed a marked difference between the architecture of the cortex and the medulla. The casts of primary nodules appeared as small roundish capillary networks. The casts of secondary nodules formed spheres, inside of which there were poor capillaries. Secondary nodules showed many transitions. Pseudo-nodules appeared as egg-like, large capillary networks and included secondary nodules. The capillaries in diffuse lymphoid tissue anastomosed with the PCV. The PCV, which ran deeply into the cortex, anastomosed with the veins of the medulla in the cortico-medullary junction. The capillaries of medulla anastomosed directly with the veins of the medulla. Basically, the elements and arrangements of the vascular casts of the rabbit lymph node were similar to those of the human lymph node.
en-copyright=
kn-copyright=

en-aut-name=UsuiTakashi
en-aut-sei=Usui
en-aut-mei=Takashi
kn-aut-name=臼井隆
kn-aut-sei=臼井
kn-aut-mei=隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=高知医科大学第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=871
end-page=887
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Increase in hepatic metallothionein in tumor bearing mice
kn-title=担癌マウスにおける肝メタロチオネインの増加について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The amount of metallothinoein was examined in mice after Ehrlich-tumor-cell implantation. The amount of hepatic metallothionein in tumor-bearing mice increased 10-fold 7 days after tumor implantation as compared with control mice. Actinomycin D administration inhibited zinc uptake into liver and hepatic metallothionein synthesis induced in tumor-bearing mice. The increase in hepatic metallothionein content did not appear earlier than 6 days. In other tissues and tumor, an increase in metallothionein content was not observed for 7 days after tumor implantation. However, in tumors from zinc- or cadmium-loaded, tumor-bearing mice, an increase in metallothionein content was observed. The zinc level in the serum of tumor-bearing mice gradually decreased, and the zinc content was one half of the control content 7 days after implantation. Actionmycin D administration inhibited the decrease in serum zinc content. The zinc content of liver was increased as compared with control mice 7 days after implantation, but in other tissues changes in zinc content were not observed. The corticosterone level in the serum of tumor-bearing mice increased 2.5 fold 7 days after implantation as compared with control mice.
en-copyright=
kn-copyright=

en-aut-name=KimotoShin
en-aut-sei=Kimoto
en-aut-mei=Shin
kn-aut-name=木本真
kn-aut-sei=木本
kn-aut-mei=真
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=Metallothionein
kn-keyword=Metallothionein
en-keyword=zinc
kn-keyword=zinc
en-keyword=tumor-bearing mouse
kn-keyword=tumor-bearing mouse
en-keyword=EATC
kn-keyword=EATC
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=855
end-page=870
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of bilateral ventral hippocampal lesions on amygdaloid kindling in cats
kn-title=両側腹側海馬破壊による扁桃核キンドリングへの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinical relevance of Ammon's horn sclerosis in epilepsy has not been fully ellucidated. This study was designed to examine the effects of bilateral ventral hippocampal lesions (Ammon's horn + dentate gyrus) on the minimal electroconvulsive threshold (ECT) intensity, kindling rates and transference phenomenon in cats kindled from the amygdala (AM). Ten adult cats were used. In the first experiment, lesions were made electrolytically in the bilateral hippocampi after completion of the primary site (PS) kindling from the left AM. Subsequently, the right AM (secondary site: SS) was kindled. In the second experiment, the hippocampal lesion was made prior to the PS-kindling which was followed by the SS-kindling. In the first experiment, the ECT intensity was unchanged by the hippocampal lesions after PS-kindling. The seizure pattern and EEG pattern in the generalized convultion were changed to show an asymmetrical, asynchronous pattern by the lesions. Facilitation of SS-kindling following the PS-kindling (positive transfer) was diminished by the lesions. In the second experiment, the formation of hippocampal lesions prior to the kindling retarded the PS kindling rates slightly. The seizure pattern and EEG pattern of the generalized convulsion was asymmetrical and asynchronous. In addition, positive transfer from PS to SS was blocked by the lesions. These results indicate that the ventral hippocampal formation and hippocampal commissure may be critical brain sites for the establishment of the transference phenomenon that reflects secondary epileptogenic changes in the brain.
en-copyright=
kn-copyright=

en-aut-name=NakatsuTakeshi
en-aut-sei=Nakatsu
en-aut-mei=Takeshi
kn-aut-name=中津武志
kn-aut-sei=中津
kn-aut-mei=武志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=扁桃核キンドリング
kn-keyword=扁桃核キンドリング
en-keyword=腹側海馬破壊
kn-keyword=腹側海馬破壊
en-keyword=転移現象
kn-keyword=転移現象
en-keyword=二次てんかん原性
kn-keyword=二次てんかん原性
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=849
end-page=854
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical classification of asthma in relation to swimming training in a hot spring pool
kn-title=気管支喘息の臨床病型と温泉プール水泳訓練の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Swimming training in a hot spring pool was carried out with 30 patients with bronchial asthma including 22 cases with steroid-dependent intractable asthma. Improvement in ventilatory function after 3 months of swimming training was compared among three asthma types, 1-a, 1-b and 2, classified accoridng to clinical symptoms. The ventilatory function test before the training showed that the mean value of FEV(1.0%) was less than 70% in all asthma types, indicating obstruction of the airways, and that the values of % FVC, % MMF, % V(50) and % V(25) of type 2 (bronchiolar obstruction type) asthma cases were significantly lower compared to those of type 1-a (bronchospasm type) and type 1-b (bronchospasm　+　hypersecretion type) asthma cases. After the 3-month training, type 1-a asthma cases showed an increase in FEV(1.0%) accompanied by an increase in % MMF, % V(50) and % V(25). An increase in % MMF, % V(50) and % V(25) with less increase in FEV(1.0%) was observed in type 2 asthma cases. In type 1-b, the mean increase in all parameters indicating obstruction of the airways was very low even in the cases whose symptoms were improved by the training.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院内科
en-keyword=換気機能―気管支喘息―
kn-keyword=換気機能―気管支喘息―
en-keyword=臨床病型―温泉療法―
kn-keyword=臨床病型―温泉療法―
en-keyword=水泳訓練
kn-keyword=水泳訓練
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=833
end-page=848
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical relevance of the dexamethasone suppression test (DST)in mental disorders
kn-title=精神疾患におけるDSTの臨床的意義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The dexamethasone suppression test (DST) is considered to be a useful diagnostic test for hypothalamic-pituitary-adrenal (HPA) dysfunction in depression, but substantial doubt remains about its specificity. In this study, 21 healthy controls and 238 patients underwent the DST. The clinical diagnosis was made according to the Diagnostic and Statistical Manual for Mental Disorders, 3rd Edition (DSM-III). The specificity of the DST to endogenous depression was not as high as Carroll et al. reported, and the DST did not distinguish significantly between diagnostic categories of depression and schizophrenic disorders. The DST was a state dependent biological marker of the severity of symptoms including psychotic features in endogenous depression and schizophrenic disorders. The DST results indicated remarkable abnormality (post-dexamethasone cortisol level and DST positivity) in major depression with psychotic features, suggesting marked HPA dysfunction. Differential diagnosis is sometimes difficult between paranoid disorders in the aged and major depressive episodes with psychotic features. Nevertheless the DST should be useful in their differentiation, since the former disorder usually shows normal DST results. Accordingly, it was concluded that the DST could be used as a supplementary test in the study of various mental disorders and could be a valuable guide to the psychiatrist in combination with other biological markers.
en-copyright=
kn-copyright=

en-aut-name=NishimonKoichi
en-aut-sei=Nishimon
en-aut-mei=Koichi
kn-aut-name=西紋孝一
kn-aut-sei=西紋
kn-aut-mei=孝一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=デキサメサゾン抑制試験(DST)
kn-keyword=デキサメサゾン抑制試験(DST)
en-keyword=内因性うつ病(メランコリー)
kn-keyword=内因性うつ病(メランコリー)
en-keyword=精神分裂性障害
kn-keyword=精神分裂性障害
en-keyword=精神病像
kn-keyword=精神病像
en-keyword=状態依存性
kn-keyword=状態依存性
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=823
end-page=831
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical evaluation of serum ferritin levels in primary lung cancer patients with radiation therapy Comparing with serum CEA levels
kn-title=放射線治療を施行した原発性肺癌患者における血清フェリチン値の臨床的評価 ―血清CEA値と比較して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Serum ferritin and serum carcinogenic embryonic antigen (CEA) levels in 153 patients (male: 112, female: 41) with primary lung cancer were simultaneously measured and compared with the histological type, clinical stage and clinical course. No correlation between serum ferritin and CEA levels was found. A higher percentage of positive test results for both serum ferritin and CEA was associated with advanced stages and metastasis in other organs. From the point of view of histological classification, high ferritin levels were mainly found in the patients with small-cell types of cancer. In contrast, high CEA levels were found in patients with adenocarcinoma. Therefore, the measurement of serum ferritin was not efficient as a screening test for lung cancer. Serum ferritin levels were, however, correlated with the efficacy of therapy and the clinical course.
en-copyright=
kn-copyright=

en-aut-name=TogamiIzumi
en-aut-sei=Togami
en-aut-mei=Izumi
kn-aut-name=戸上泉
kn-aut-sei=戸上
kn-aut-mei=泉
aut-affil-num=1
ORCID=

en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
kn-aut-mei=祥夫
aut-affil-num=2
ORCID=

en-aut-name=KimotoShin
en-aut-sei=Kimoto
en-aut-mei=Shin
kn-aut-name=木本真
kn-aut-sei=木本
kn-aut-mei=真
aut-affil-num=3
ORCID=

en-aut-name=ShirakamiToshiaki
en-aut-sei=Shirakami
en-aut-mei=Toshiaki
kn-aut-name=白神敏明
kn-aut-sei=白神
kn-aut-mei=敏明
aut-affil-num=4
ORCID=

en-aut-name=UedaHiroyuki
en-aut-sei=Ueda
en-aut-mei=Hiroyuki
kn-aut-name=上田裕之
kn-aut-sei=上田
kn-aut-mei=裕之
aut-affil-num=5
ORCID=

en-aut-name=SatohNobuo
en-aut-sei=Satoh
en-aut-mei=Nobuo
kn-aut-name=佐藤伸夫
kn-aut-sei=佐藤
kn-aut-mei=伸夫
aut-affil-num=6
ORCID=

en-aut-name=NakamuraTetsuya
en-aut-sei=Nakamura
en-aut-mei=Tetsuya
kn-aut-name=中村哲也
kn-aut-sei=中村
kn-aut-mei=哲也
aut-affil-num=7
ORCID=

en-aut-name=YamamotoHiromichi
en-aut-sei=Yamamoto
en-aut-mei=Hiromichi
kn-aut-name=山本博道
kn-aut-sei=山本
kn-aut-mei=博道
aut-affil-num=8
ORCID=

en-aut-name=JojaIkuo
en-aut-sei=Joja
en-aut-mei=Ikuo
kn-aut-name=上者郁夫
kn-aut-sei=上者
kn-aut-mei=郁夫
aut-affil-num=9
ORCID=

en-aut-name=HashimotoKeiji
en-aut-sei=Hashimoto
en-aut-mei=Keiji
kn-aut-name=橋本啓二
kn-aut-sei=橋本
kn-aut-mei=啓二
aut-affil-num=10
ORCID=

en-aut-name=MorimotoSetsuo
en-aut-sei=Morimoto
en-aut-mei=Setsuo
kn-aut-name=森本節夫
kn-aut-sei=森本
kn-aut-mei=節夫
aut-affil-num=11
ORCID=

en-aut-name=AonoKaname
en-aut-sei=Aono
en-aut-mei=Kaname
kn-aut-name=青野要
kn-aut-sei=青野
kn-aut-mei=要
aut-affil-num=12
ORCID=

en-aut-name=TakedaYoshihiro
en-aut-sei=Takeda
en-aut-mei=Yoshihiro
kn-aut-name=竹田芳弘
kn-aut-sei=竹田
kn-aut-mei=芳弘
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=13
en-affil=
kn-affil=国立療養所山陽荘病院放射線科
en-keyword=原発性肺癌
kn-keyword=原発性肺癌
en-keyword=血清フェリチン値
kn-keyword=血清フェリチン値
en-keyword=血清CEA値
kn-keyword=血清CEA値
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=815
end-page=822
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Changes in substances affecting the central nervous systemin stored blood products. I. Ammonia accumulation in platelet concentrates during storage
kn-title=血液保存における中枢神経影響物質の変化に関する研究(第1編) ―血小板濃縮液の保存中におけるアンモニアの蓄積―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To study how to control the ammonia level in platelet concentrates during storage, the effects of storage conditions on ammonia accumulation in the product were examined The ammonia level increased significantly with increasing storage temperature from 4℃ to 37℃ and reached approximately 500μmol/l after 72 hours of storage at 22℃. There was a negative relationship between the ammonia level and pH value of the product. The ammonia accumulation due to a fall in pH was depressed by applying a gentle flat-bed mode of agitation during storage. More vigorous agitation, such as elliptical agitation, resulted in higher ammonia accumulation. Analysis of changes in amino acids of the product showed that ammonia was mainly derived from non-enzymatic hydrolysis of glutamine in plasma. Glutamic acid had a preventing effect on the ammonia accumulation. The effect was dose-dependent and required approximately 50mg/dl final concentration to reduce the ammonia level to about half of the normal value. I consider the addition of glutamic acid to the blood preservative to be useful in reducing transfusion reactions due to ammonia.
en-copyright=
kn-copyright=

en-aut-name=IshiiAkio
en-aut-sei=Ishii
en-aut-mei=Akio
kn-aut-name=石居昭夫
kn-aut-sei=石居
kn-aut-mei=昭夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門
en-keyword=ammonia
kn-keyword=ammonia
en-keyword=glutamine
kn-keyword=glutamine
en-keyword=glutamic acid
kn-keyword=glutamic acid
en-keyword=platelets
kn-keyword=platelets
en-keyword=blood preservation
kn-keyword=blood preservation
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=805
end-page=814
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diagnosis of malignant lymphoma by magnetic resonance imaging
kn-title=磁気共鳴画像による悪性リンパ腫の診断
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Magnetic resonance imaging (MRI) of pathological lymphnodes was reviewed in 12 patients with malignant lymphoma. We examined the characteristics of the images and T(1) values of lesions. Short SE was the most appropriate pulse sequence to delineate the lesions. It was intermediate in signal intensity between that of skeletal muscle and that of fat tissue. On IR image, the signal intensity of skeletal muscle or lung tissue was similar to that of lymphnodes, and on long SE image, that of fat tissue was similar to that of lymphnodes. It was difficult to differentiate Hodgkin's disease (HD) from non Hodgkin's lymphoma (NHL) using only T(1) values. The long SE signal intensity of the latter was higher than that of the former. The distribution of NHL was wider than that of HD. Though MRI has various problems such as long scan time and respiratory motion artifacts, it has various merits which other methods do hot have. We consider MRI to have an important role in the diagnosis and follow up of patients with malignant lymphoma.
en-copyright=
kn-copyright=

en-aut-name=JojaIkuo
en-aut-sei=Joja
en-aut-mei=Ikuo
kn-aut-name=上者郁夫
kn-aut-sei=上者
kn-aut-mei=郁夫
aut-affil-num=1
ORCID=

en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
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affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=13
en-affil=
kn-affil=香川県立中央病院放射線科

affil-num=14
en-affil=
kn-affil=岡山大学医学部第二内科学教室

affil-num=15
en-affil=
kn-affil=岡山大学医学部第二内科学教室

affil-num=16
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
en-keyword=malignant lymphoma
kn-keyword=malignant lymphoma
en-keyword=T(1)-relaxation time
kn-keyword=T(1)-relaxation time
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=9-10
article-no=
start-page=783
end-page=803
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19851030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study of cerebral hemodynamics in extracranial-intracranial arterial anastomosis after middle cerebral artery occlusion
kn-title=頭蓋外―頭蓋内動脈吻合術における脳循環動態に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to evaluate extracranial-intracranial arterial anastomosis in acute ischemic stroke, changes in the local cerebral blood flow (lCBF) in the cortical and subcortical areas were investigated by hydrogen clearance during left middle cerebral artery (MCA) occlusion and maxillary artery (MA)-to-MCA anastomosis in 24 mongrel dogs. Following MCA occlusion, the lCBF was maintained at more than 25ml/100g/min in 17 dogs because of effective leptomeningeal collaterals. In seven dogs, cortical ischemia was shown with progressive lCBF reduction to below 25ml/100g/min. Severe persistent ischemia of less than 10ml/100g/min was not observed. Subcortical ischemia with lCBF reductions to below 25ml/100g/min in the gray matter and below 10ml/100g/min in the white matter occurred more frequently than cortical ischemia. Following MA-MCA anastomosis, the cortical lCBF returned to nearly the preocclusion value, and the subcortical lCBF showed a slight or moderate increase. Reactive hyperemia was noted in two dogs (at three sites), but marked hyperemia was not abserved in any of the animals. The increase in the lCBF after the anastomsis showed a linear relationship to the donor arterial supply. Postmortem and histological examinations revealed no cerebral edema or hemorrhagic infarct. Comparative analyses of these results with the concept of "ischemic penumbra" led to the conclusion that cerebral ischemia with the cortical lCBF ranging from 15 to 25ml/100g/min (30 to 50% of the preocclusion value) after MCA occlusion cannot be reversed even by the leptomeningeal collaterals and may produce progessive neurological dysfunction. In such an ischemic condition, rapid restoration of the lCBF by extracranial-intracranial arterial anastomosis might be effective in the prevention of cerebral infarction as well as in the recovery of neuronal function.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYuji
en-aut-sei=Yamamoto
en-aut-mei=Yuji
kn-aut-name=山本祐司
kn-aut-sei=山本
kn-aut-mei=祐司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科教室
en-keyword=頭蓋外―頭蓋内動脈吻合術
kn-keyword=頭蓋外―頭蓋内動脈吻合術
en-keyword=経眼窩的中大脳動脈閉塞
kn-keyword=経眼窩的中大脳動脈閉塞
en-keyword=水素クリアランス法
kn-keyword=水素クリアランス法
en-keyword=脳循環動態
kn-keyword=脳循環動態
en-keyword=脳虚血
kn-keyword=脳虚血
END