start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=963
end-page=967
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The course of the outbreak of Japanese Encephalitis-patients and factors from 1965 to 1980 (Epidemiological study on Japanese Encephalitis, 69)
kn-title=昭和40年以後の日本脳炎患者発生の変遷とそのその要因について (日本脳炎の疫学的研究69)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Variations in the amount of Japanese Encephalitis (JE) virus in the field and outbreaks of JE were examined. The causes of changes in outbreaks were examined. The following results were obtained. 1. The level of JE virus estimated by positive rates of HI reaction and the 2-ME reaction of JE of swine tended to decrease from 1972 to 1977, and tended to increase from 1978 to 1980. On the other hand, positive rates of 2-ME reaction in 1978-1980 were higher than those in 1965-1971. 2. The number of JE-patients was more than 50 from 1965 to 1967, thereafter it decreased and no JE-patient was detected from 1971 to 1977. Thereafter an outbreak occurred again. Two definite cases and one suspected case were recognized in 1978, one suspeted case in 1979, and one definite case in 1980. 3. One cause of the decrease in JE-patients is that the size of a pigsty has been increased and sanitary conditions have been improved. 4. Discussion was made that the course of the outbreak of JE-patients from 1965 to 1980 was attributed to the amount of JE virus in the field estimated by antibody reaction in swine, the number of Ct, the arrangement of pigsties, the spread of window setting nets, improvement of nutrition, decrease of overwork and ruralization.
en-copyright=
kn-copyright=

en-aut-name=JitsunariFumihiko
en-aut-sei=Jitsunari
en-aut-mei=Fumihiko
kn-aut-name=実成文彦
kn-aut-sei=実成
kn-aut-mei=文彦
aut-affil-num=1
ORCID=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部養護・保健教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=日本脳炎
kn-keyword=日本脳炎
en-keyword=疫学
kn-keyword=疫学
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=951
end-page=961
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Blood vascular architecture of the rhesus monkey kidney Glomerulus. A scanning electron microscope study of corrosion casts
kn-title=アカゲザルの腎糸球体血管構築鋳型走査電子顕微鏡法による観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Blood vascular beds of the rhesus monkey kidney glomerulus were replicated with low viscosity methacrylate resin and observed in a scanning electron microscope. The glomerular blood vascular beds consisted of freely and multiply anastomosing capillary networks, which showed lobulations. The lobules intercommunicated with each other by a few bridging capillaries. The lobules, however, could be recognized as fairly independent units in the glomerular microcirculation as the bridging vessels were small in size. Very faint capillaries were sometimes observed in and near the vascular pole of the glomerulus. These faint vessels represented new formations of the glomerular capillaries. Neither short-cut communication nor main pathways were noted between the glomerular afferent and efferent vessels nor within the glomerular capillary networks.
en-copyright=
kn-copyright=

en-aut-name=UnehiraMagosaburo
en-aut-sei=Unehira
en-aut-mei=Magosaburo
kn-aut-name=畦平孫三郎
kn-aut-sei=畦平
kn-aut-mei=孫三郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学第二講座
en-keyword=アカゲザル (rhesus monkey)
kn-keyword=アカゲザル (rhesus monkey)
en-keyword=腎糸球体 (kidney glomerulus)
kn-keyword=腎糸球体 (kidney glomerulus)
en-keyword=血管構築 (vascular architecture)
kn-keyword=血管構築 (vascular architecture)
en-keyword=鋳型 (corrosion cast)
kn-keyword=鋳型 (corrosion cast)
en-keyword=走査電顕観察 (scanning electron microscopy)
kn-keyword=走査電顕観察 (scanning electron microscopy)
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=941
end-page=949
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Application of microwave radiation as a handy method of sterilization
kn-title=簡易滅菌法としてのマイクロ波照射応用の試み
en-subtitle=
kn-subtitle=
en-abstract=The effect of microwave radiation (2450MHz) on fungi, bacteria and viruses was examined to determine its applicability as a handy method of sterilization. Fungi (C. albicans) and bacteria (E. coli, P. aeruginosa, S. aureus and B. subtilis) stuck on the inside of a glass or plastic milk bottle were sterilized within 5 minutes of radiation regardless of whether the bacteria were dry or wet. Spores of B. subtilis and virus (ECHO virus and Herpes virus) were inactivated within 10 min without affecting the plastic or glass bottle. Wet condition rendered the micro-organisms more susceptible than dry conditions. The results indicate that the microwave oven may be suitable for sterilization of things such as feeding bottles or trays in infant rooms of hospitals.
kn-abstract=マイクロ波は周波数300MHz〜30GHzの電波であるが,このマイクロ波の電界に誘電物質をおくと,電波エネルギーは物質に吸収され熱エネルギ-に変る.この高周波誘電加熱に立脚して開発された電子レンジが日常の簡易滅菌に如何なる有効性を示すかを検討した.供試微生物はS. aureus, E. coli, Ps. aeruginosa, B. subtilisの芽胞, C. albicans, Echo virus及びHerpes simplexである.これらをガラス及びプラスティク哺乳瓶に定量的に附着させ電子レンジ(2450MHz 500W)で照射した.微生物の大低のものは5〜6分,芽胞でも7分で完全死滅した.付着後乾燥状態にした場合はやや長時間を要したが,芽胞やウイルスでも12分では完全死滅した.以上のことから,マイクロ波による滅菌はその局部内部加熱作用が微生物の滅菌に有効に働き,包装状態のままで短時間で行える上に,プラスティク,ゴムなどの容器は損傷されず極めて有用性の高いことが判明した.
en-copyright=
kn-copyright=

en-aut-name=AbeMasufumi
en-aut-sei=Abe
en-aut-mei=Masufumi
kn-aut-name=安部益文
kn-aut-sei=安部
kn-aut-mei=益文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
en-keyword=マイクロ波
kn-keyword=マイクロ波
en-keyword=殺菌効果
kn-keyword=殺菌効果
en-keyword=ウィルス不活化効果
kn-keyword=ウィルス不活化効果
en-keyword=滅菌法
kn-keyword=滅菌法
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=931
end-page=939
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunochemotherapy with tumor antibody-Neocarzinostatin(NCS) conjugates Part 1. Preparation of antibody-NCS conjugates
kn-title=抗腫瘍抗体結合Neocarzinostatin(NCS)による免疫化学療法の研究 第1編 抗体結合Neocarzinostatin(NCS-immune IgG)の作製
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rabbit xenoantiserum was produced against a human null cell type leukemia cell line (NALL-1), and immune IgG was purified. NCS, a unique antitumor antibiotic that works on the tumor cell surface, was reacted with anti-NALL-1 rabbit IgG, in the presence of water soluble carbodiimide (WSCD). The resulting mixture was chromatographed on a Sephadex G-200 column. The first and second fractions were shown to contain NCS-immune IgG and no free NCS by the Ouchterlony double diffusion method and by immunoelectrophoresis. The conjugates inhibited the growth of Sarcina lutea and were more stable at conditions of 37℃ or 56℃ than free NCS. The conjugates did not loose inhibitory activities against the growth of S.lutea after frequent freezings and thawings. NCS-immune IgG might be useful in treating patients with cancer.
en-copyright=
kn-copyright=

en-aut-name=KobayashiTakashi
en-aut-sei=Kobayashi
en-aut-mei=Takashi
kn-aut-name=古林太加志
kn-aut-sei=古林
kn-aut-mei=太加志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=免疫化学療法
kn-keyword=免疫化学療法
en-keyword=抗腫瘍抗体
kn-keyword=抗腫瘍抗体
en-keyword=Neocarzinostatin
kn-keyword=Neocarzinostatin
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=925
end-page=929
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The present status of parasitic infections in Manabe island, Okayama prefecture
kn-title=笠岡市真鍋島における最近の寄生虫感染の実相
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A fecal examination for each of 471 residents of Manabe island was performed to clarify the status of parasitic infection by direct smear in August, 1977. The results were as follows: 1. Helminths found included Ascaris lumbricoides (2 cases, 0.4%), Trichuris trichiura (18 cases, 3.8%), Ancylostoma duodenale (5 cases, 1.1%) and Heterophyes heterophyes (4 cases, 0.9%). 2. The average infection rate was 6.2% for the whole area.
en-copyright=
kn-copyright=

en-aut-name=TomitaSeiichiro
en-aut-sei=Tomita
en-aut-mei=Seiichiro
kn-aut-name=富田精一郎
kn-aut-sei=富田
kn-aut-mei=精一郎
aut-affil-num=1
ORCID=

en-aut-name=TanakaIsao
en-aut-sei=Tanaka
en-aut-mei=Isao
kn-aut-name=田中勇夫
kn-aut-sei=田中
kn-aut-mei=勇夫
aut-affil-num=2
ORCID=

en-aut-name=TonguYasumasa
en-aut-sei=Tongu
en-aut-mei=Yasumasa
kn-aut-name=頓宮廉正
kn-aut-sei=頓宮
kn-aut-mei=廉正
aut-affil-num=3
ORCID=

en-aut-name=SuguriSetsuo
en-aut-sei=Suguri
en-aut-mei=Setsuo
kn-aut-name=村主節雄
kn-aut-sei=村主
kn-aut-mei=節雄
aut-affil-num=4
ORCID=

en-aut-name=SakumotoDaigoro
en-aut-sei=Sakumoto
en-aut-mei=Daigoro
kn-aut-name=作本台五郎
kn-aut-sei=作本
kn-aut-mei=台五郎
aut-affil-num=5
ORCID=

en-aut-name=AjiToshiki
en-aut-sei=Aji
en-aut-mei=Toshiki
kn-aut-name=安治敏樹
kn-aut-sei=安治
kn-aut-mei=敏樹
aut-affil-num=6
ORCID=

en-aut-name=ItanoKazuo
en-aut-sei=Itano
en-aut-mei=Kazuo
kn-aut-name=板野一男
kn-aut-sei=板野
kn-aut-mei=一男
aut-affil-num=7
ORCID=

en-aut-name=InatomiSeiiti
en-aut-sei=Inatomi
en-aut-mei=Seiiti
kn-aut-name=稲臣成一
kn-aut-sei=稲臣
kn-aut-mei=成一
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=2
en-affil=
kn-affil=笠岡市真鍋島診療所

affil-num=3
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部寄生虫学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部寄生虫学教室
en-keyword=parasitic infection
kn-keyword=parasitic infection
en-keyword=Ascaris lumbricoides
kn-keyword=Ascaris lumbricoides
en-keyword=Trichuris trichiura
kn-keyword=Trichuris trichiura
en-keyword=Ancylostoma duodenale
kn-keyword=Ancylostoma duodenale
en-keyword=Heterophyes heterophyes
kn-keyword=Heterophyes heterophyes
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=909
end-page=923
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The antitumor effects and effect on cell-mediated immunity of Corynebacterium parvum
kn-title=コリネバクテリウム・パルバムの抗腫瘍効果並びにその細胞性免疫能に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The antitumor effects and influence on cell-mediated immunity of Corynebacterium parvum (C. parvum) were studied using C3H/He mice and syngenic mouse ascites hepatoma MH 134 tumor. With the administration of C. parvum alone, a significant antitumor effect was obtained in the group given 0.4mg per day intraperitoneally for 5 consecutive days from the fifth day after transplanting 5x10(5)cells/0.1ml of MH 134 tumor subcutaneously on the back. A significant antitumor effect was also obtained when C. parvum was combined with MF chemotherapy (Mitomycin C 1mg/kg, 5-Fluorouracil 25mg/kg), in the group given MF i.p. on the fifth day and 0.4mg/day of C. parvum i.p. for 5 consecutive days from the seventh day after tumor transplantation. The cell-mediated immunity in these two groups was investigated by using the delayed type hypersensitivity (DTH) and macrophage migration inhibition factor (MIF activity). The results were: no decrease in DTH was shown compared with the tumor-bearing untreated group. MIF activity was marked compared with the tumor-bearing untreated group and tended to persist for a long period. From these findings, it was concluded that C. parvum was an effective immunopotentiator which yeilded an antitumor effect by restoring the cell-mediated immunity of the tumor bearing host. The effect seemed to be enhanced when used in combination with chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=NakamuraKenji
en-aut-sei=Nakamura
en-aut-mei=Kenji
kn-aut-name=中村憲治
kn-aut-sei=中村
kn-aut-mei=憲治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第一外科教室
en-keyword=Corynebacterium parvum
kn-keyword=Corynebacterium parvum
en-keyword=抗腫瘍効果
kn-keyword=抗腫瘍効果
en-keyword=遅延型過敏反応
kn-keyword=遅延型過敏反応
en-keyword=マクロファージ遊走阻止(MIF)活性
kn-keyword=マクロファージ遊走阻止(MIF)活性
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=897
end-page=907
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on superoxide production of human neutrophils Part 3. In vitro and in vivo studies on the effects of antileukemic agents on the superoxide production of neutrophils
kn-title=好中球スーパーオキサイド産生能に関する基礎的並びに臨床的研究 第3編 好中球スーパーオキサイド産生能に及ぼす各種抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Previous work, described in part 2 of this study, showed that the superoxide production of neutrophils was suppressed by induction chemotherapy. These findings suggest direct effects of antileukemic agents on intracellular bactericidal activity; however, there is little information available concerning this aspect. The superoxide of neutrophils is one of the active oxygens and it is thought to be one of the major substances related to the intracellular bactericidal activities of neutrophils. This experiment was conducted in order to evaluate the direct effects of antileukemic agents on superoxide production of human neutrophils. The following results were obtained; 1. The effects of antileukemic agents on superoxide production were examined before and after intensification chemotherapy in 14 patients with complete remission. Significant suppression of superoxide production was found 60 minutes after initiation chemotherapy; however, it recovered 24 hours after chemotherapy. 2. In the in vitro system, neutrophils were incubated with antileukemic agents for 3 minutes prior to stimulation by Concanavalin A and Cytochasin D. Among the antileukemic agents examined, Methotrexate, Vincristine and Prednisolone inhibited superoxide production with a concentration dependency. The 50 % inhibition concentrations of these agents were 3.6x10(-4)mol for Methotrexate, 3.2x10(-4)mol for Vincristine and 4.2x10(-4)mol for Prednisolone. Cytosine arabinoside, Neocartinostatine and Cyclophosphamide showed no inhibitory effects on superoxide production. 3. The inhibition of superoxide production by Methotrexate could not be reversed by Folinic acid in the medium. 4. In the cell free superoxide production system consisting of Xanthine plus Xanthine oxidase, Methotrexate and Prednisolone inhibited superoxide production with a concentration dependency. The 50% inhibition concentrations were 1.3x10(-3)mol for Methotrexate and 2.4x10(-3)mol for Prednisolone. 5. In the in vitro system, Methotrexate and Prednisolone were not only inhibitors of superoxide production but also scavengers of superoxide. These results suggest that some antileukemic agents directly inhibit intracellular bactericidal activities, resulting in the susceptibility to infection of patients with acute leukemia.
en-copyright=
kn-copyright=

en-aut-name=KohiFumikazu
en-aut-sei=Kohi
en-aut-mei=Fumikazu
kn-aut-name=厚井文一
kn-aut-sei=厚井
kn-aut-mei=文一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=superoxide production
kn-keyword=superoxide production
en-keyword=neutrophilic granulocyte
kn-keyword=neutrophilic granulocyte
en-keyword=antileukemic agent
kn-keyword=antileukemic agent
en-keyword=acute leukemia
kn-keyword=acute leukemia
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=885
end-page=896
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on superoxide production of human neutrophils Part 2. Clinical studies on superoxide production of neutrophils in patients with acute leukemia
kn-title=好中球スーパーオキサイド産生能に関する基礎的並びに臨床的研究 第2編 急性白血病患者における好中球スーパーオキサイド産生能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It is well known that patients with acute leukemia have a predisposition for life threatning infections. Among several factors which disturb host defense mechanisms, quantitative and qualitative disorders of neutrophils are thought to be important. Up to date, there have been some papers concerning the bactericidal activities of neutrophils obtained from patients with acute leukemia; however, little information about the production of active oxygens, especially the superoxide anion, is available. Superoxide of neutrophils is one of the active oxygen related to intracellular bactericidal activities; therefore, in this study, superoxide production of neutrophils in patients with acute leukemia was examined in order to clarify the cause of the high susceptivility to infection. The results were as follows: 1. Before antileukemic chemotherapy, superoxide production was 4.09±1.43 nmol/min/10(6)PMNs in patients with acute leukemia. It was 6.45±1.33 nmol/min/10(6)PMNs in normal subjects. During induction chemotherapy, superoxide production was suppressed to a level of 3.56±1.18 nmol/min/10(6)PMNs; however, it recovered to normal range and somewhat overshot in the complete remission stage. 2. An inverse correlation between superoxide production of neutrophils and the total number of leukemic clls in the bone marrow was recognized. 3. The changes in superoxide production throughout the entire course were not correlated with the type of leukemia. These results clearly indicate disturbance of superoxide production by neutrophils in patients with acute leukemia. They also suggest that alterlations in the intracellular bactericidal activities of neutrophils may be one of the reasons for the high susceptivility to infections of patients with acute leukemia.
en-copyright=
kn-copyright=

en-aut-name=KohiFumikazu
en-aut-sei=Kohi
en-aut-mei=Fumikazu
kn-aut-name=厚井文一
kn-aut-sei=厚井
kn-aut-mei=文一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=superoxide production
kn-keyword=superoxide production
en-keyword=neutrophilic granulocyte
kn-keyword=neutrophilic granulocyte
en-keyword=acute leukemia
kn-keyword=acute leukemia
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=873
end-page=883
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on superoxide production of human neutrophils Part 1. Experimental studies on superoxide production of human neutrophils
kn-title=好中球スーパーオキサイド産生能に関する基礎的並びに臨床的研究 第1編 好中球スーパーオキサイド産生能の測定に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Patients with acute leukemia are prone to get infections. Pathological conditions such as leukocytopenia and disturbances of humoral and cellular immunity are thought to contribute to this high susceptibility to infection. Superoxide, one of the active oxygens, is thought to be related to the intracellular bactericidal activities of neutrophils, particularly in oxygen dependent systems. These findings led the author to speculate that primary and secondary disturbances in the superoxide production of neutrophils are of importance in the high susceptibility of patients with acute leukemia. In this experiment, the superoxide production of normal human neutrophils stimulated by Concanavalin A and Cytocharacin D was assayed by spectrophotometer in order to evaluate its usefulness in clinical applications. The effect of age and sex on supreoxide production was also examined. The following results were obtained: 1. The activity of superoxide production was affected by both time and temperature during cell preservation. It was also dependent on the cell concentration, temperature and pH during stimulation of the neutrophils. The optimal system for assay of the superoxide production of human neutrophils was as follow: Cells should be preserved at 0℃ within 60 minutes. During stimulation, cell concentration, temperature and pH should be ajusted to 0.2-0.5x10(6)/ml, 37℃ and 7.4, respectively. 2. There were no significant changes in superoxide production between males and females. Superoxide production in older subjects(70-89 y/o) was significantly lower than that in younger subjects(20-69 y/o)(p<0.001). The values were 4.72±1.17 nmol/min/10(6)-PMNs in the former and 6.45±1.33 nmol/min/10(6)PMNs in the latter. Assays of superoxide production of human neutrophils can be clinically used because of its simplicity and reproducibility. It was apparent that the assessment of superoxide production of neutrophils by age was necessary in clinical applications.
en-copyright=
kn-copyright=

en-aut-name=KohiFumikazu
en-aut-sei=Kohi
en-aut-mei=Fumikazu
kn-aut-name=厚井文一
kn-aut-sei=厚井
kn-aut-mei=文一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=superoxide production
kn-keyword=superoxide production
en-keyword=neutrophilic granulocyte
kn-keyword=neutrophilic granulocyte
en-keyword=aging neutrophil
kn-keyword=aging neutrophil
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=861
end-page=871
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on determination of urinary protein Part I. The determination of minute amounts of protein in urine
kn-title=尿中の蛋白質の定量の検討 第1報 ゲル濾過を用いる尿中微量蛋白質の定量について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Physical loading can be monitored by measurement of the amounts of urinary protein. The Bio-Rad method in combination with gelfiltration gave the following results. 1. The presence of albumin and γ-globulin in proteinuria was recognized by immuno-diffusion in antigen-containing gel. The presence of α(1)-Acid-Glycoprotein, Transferrin and Zn-α(2)-Glyco-protein was also demonstrated. However, other proteins need to be confirmed. 2. With the direct Bio-Rad method, some low molecular substances other than protein showed coloration. Urinary protein over 4000 molecular weight could be measured by removing lower molecular weight substances by gelfiltration. (Fil-Col method). 3. Small amounts of urinary protein could be determined by the modified turbidimetric method of Meuleman. Good correlation was obtained between the Fil-Col method and the turbidimetric method, and between the Fil-Col method and the TONEIN-TP method. 4. From the above results, it was concluded that the Fil-Col method is useful for the exact quantitative determination of minute amounts of urinary protein, and that the TONEIN-TP method is useful for screening of minute amounts of urinary protein.
en-copyright=
kn-copyright=

en-aut-name=TanakaYukiko
en-aut-sei=Tanaka
en-aut-mei=Yukiko
kn-aut-name=田中由紀子
kn-aut-sei=田中
kn-aut-mei=由紀子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生
en-keyword=アルブミン
kn-keyword=アルブミン
en-keyword=尿蛋白
kn-keyword=尿蛋白
en-keyword=ゲル濾過
kn-keyword=ゲル濾過
en-keyword=トネイン
kn-keyword=トネイン
en-keyword=バイオラッド
kn-keyword=バイオラッド
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=851
end-page=859
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the antitumor activity of interferon II. Effect of interferon on human acute lymphoblastic cell lines grown in hamsters
kn-title=インターフェロンの抗腫瘍性に関する研究 第2編 ハムスターに移植したヒト急性リンパ性白血病細胞株の増殖に及ぼすインターフェロンの効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=B-cell and T-cell human leukemic cell lines, BALL-1 and TALL-1, were transplanted into newborn hamsters immunosuppressed with rabbit anti-hamster lymphocyte serum. The growth inhibitory effect of interferon (IF) was tested by intraperitoneal administration in these tumor-bearing animals. The following results were obtained: (1) TALL-1 transplanted intraperitoneally was inhibited much more than BALL-1 transplanted subcutaneously. The life span of hamsters transplanted with TALL-1 was also prolonged. These findings coincided with the results of in vitro sensitivity of these two cell lines to IF. (2) The antiproliferative effect of a combination of cyclophosphamide and IF to BALL-1 was greatly enhanced compared with when either agent was used alone. (3) The combined use of L-asparaginase and IF was similarly more inhibitory to TALL-1 than either agent alone. It seems that the growth of residual tumor cells after chemotherapy can be effectively inhibited by IF. In using IF for cancer chemotherapy, therefore, it would be advisable to combine chemotherapeutic agents with IF.
en-copyright=
kn-copyright=

en-aut-name=LaiMiinyuh
en-aut-sei=Lai
en-aut-mei=Miinyuh
kn-aut-name=�ｮ敏裕
kn-aut-sei=�ｮ
kn-aut-mei=敏裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科教室
en-keyword=Interferon
kn-keyword=Interferon
en-keyword=Cyclophosphamide
kn-keyword=Cyclophosphamide
en-keyword=L-asparaginase
kn-keyword=L-asparaginase
en-keyword=Human ALL cell lines
kn-keyword=Human ALL cell lines
en-keyword=Heterotrasplantation
kn-keyword=Heterotrasplantation
en-keyword=Hamsters
kn-keyword=Hamsters
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=845
end-page=849
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Excretion of phenylsulfate and phenylglucuronide in the urine of rats given phenol
kn-title=Phenol経口投与ラット尿中におけるPhenylsulfateとPhenylglucuronideの排泄について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The quantity of Phenylsulfate(PhS) and Phenylglucuronide(PhG) excreted by rats after an oral dose of lm mol/Kg phenol was estimated and the following results were obtained. 1. Both PhS and PhG were almost completely excreted within 1 day. 2. The excretory quantity of PhS was greater than that of PhG. 3. High performance liquid chromatography, simplified the determination of PhS and PhG.
en-copyright=
kn-copyright=

en-aut-name=YamasakiYoshio
en-aut-sei=Yamasaki
en-aut-mei=Yoshio
kn-aut-name=山崎吉郎
kn-aut-sei=山崎
kn-aut-mei=吉郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=phenylsulfate
kn-keyword=phenylsulfate
en-keyword=phenylglucuronide
kn-keyword=phenylglucuronide
en-keyword=phenol
kn-keyword=phenol
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=9-10
article-no=
start-page=835
end-page=843
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallic mercury uptake by catalase In Vitro metallic mercury uptake by rat liver dissociated cells, homogenate, cell components, heme protein and ferric ion, with the effect of ethyl and methyl alcohol on the uptake
kn-title=金属水銀のカタラーゼによる取り込みに関する研究 第2報 ラット肝の遊離細胞,ホモジネート,細胞内顆粒,へム蛋白質及び3価の鉄イオンによる金属水銀の取り込みとエチルアルコール及びメチルアルコールの作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In Vitro metallic mercury uptake by rat liver dissociated cells, homogenate, cell components (microbody-rich fraction, mitochondrial fraction and microsomal fraction), heme protein (catalase, cytochrome c, methemoglobin and hematine) and ferric ion were investigated. The effects of ethyl and methyl alcohol on the uptake were also investigated. The following results were obtained. 1) Mercury uptake by rat liver dissociated celld was similar to the uptake by homogenate. 2) Mercury uptake by rat liver homogenate in the presence of hydrogen peroxide was 1.22 times the uptake in the absence of hydrogen peroxide. The uptake by rat liver dissociated cells in the presence of hydrogen peroxide was similar to the uptake in the absence of hydrogen peroxide. 3) Mercury uptake by crystalline catalase, rat liver dissociated cells and homogenate was inhibited by ethtl alcohol and methyl alcohol, though inhibition of catalase activities was not observed. 4) Mercury uptake by rat liver cell components was observed in the order of microbody-rich fraction > microsomal fraction > mitochondrial fraction, and catalase activities were also observed in the order of microbody-rich fraction > microsomal fraction > mitochondrial fraction. Mercury uptake by rat liver cell components was inhibited by potassium cyanide and azide. 5) Cytochrome c, methemoglobin, catalase and ferric ion oxidized metallic mercury in the presence of hydrogen peroxide. In the absence of hydrogen peroxide, methemoglobin and ferric ion oxidized, but catalase and cytochrome c did not oxidize metallic mercury. 6) Hematine did not oxidize metallic mercury with or without hydrogen peroxide. 7) Uptake by ferric ion was inhibited by equimolar addition of EDTA. 8) In the presence of hydrogen peroxide, mercury uptake by catalase was 27,000 times, cytochrome c was 140 times and methemoglobin was 35 times the uptake by ferric ion. Therefore, of heme protein catalase showed the highest mercury uptake.
en-copyright=
kn-copyright=

en-aut-name=KenmotsuKatashi
en-aut-sei=Kenmotsu
en-aut-mei=Katashi
kn-aut-name=劒持堅志
kn-aut-sei=劒持
kn-aut-mei=堅志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=Catalase
kn-keyword=Catalase
en-keyword=Cytochrom C
kn-keyword=Cytochrom C
en-keyword=Methemoglobin
kn-keyword=Methemoglobin
en-keyword=Cell Components
kn-keyword=Cell Components
en-keyword=Dissociated Cell
kn-keyword=Dissociated Cell
END