| ID | 16521 |
| Eprint ID | 16521
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| フルテキストURL | |
| タイトル（別表記） | Studies on immunological aberration and its pathogenetic roles in patients with systemic lupus erythematosus. Part 2. Studies on suppressor T cell function
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| 著者 |
中村 善一
岡山大学医学部第三内科学教室
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| 抄録 | Peripheral mononuclear cells from patients with systemic lupus erythematosus(SLE), when incubated for 48hr with or without concanavalinA(ConA), were found to be capable of inhibiting the pokeweed mitogen(PWM)-induced polyclonal immunoglobulin(Ig) secretion of cells from normal individuals. Furthermore, anti-T cell antibody in sera from patients with SLE could not preferentially kill the precursor cells of ConA-induced suppressor cells. However, in SLE these suppressor cells did not significantly affect the Ig secretion of autologous B cells. These results suggest that defective suppressive activity in patients with SLE does not occur at the T cell level, but that it is most likely due too the defect of B cells in recognizing suppressive information from suppressor T cells, which is caused by in vivo polyclonal B cell activation.
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| キーワード | suppressor T cell function
PWM-induced Ig secretion
polyclonal B cell activation
systemic lupus erythematosus
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| 発行日 | 1981-04-30
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 93巻
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| 号 | 3-4号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 203
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| 終了ページ | 217
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/93/3-4/93_3-4_203/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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