start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=251
end-page=259
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bacterial contamination in the operation theater of Okayama University Hospital ―May through October, 1978―
kn-title=中央手術部の汚染調査とその対策
en-subtitle=
kn-subtitle=
en-abstract=S. epidermidis and Acinetobacter caused contamination in the central operation theater of Okayama University Hospital in May '78. The Acinetobacter contamination was caused by the detergent 'Nikkol' which was added to 1% Hibitane (Chlorhexidine) solution to make bubbles during hand washing. Hibitane had no effect on Acinetobacter and 'Nikkol', at a concentration of 1%, helped bacterial growth. An investigation of various disinfectants revealed that an iodine preparation (Poridone-iodine) and Vista 300 were effective in preventing bacterial growth. Hibitane was replaced with Poridone-iodine and contamination was no longer a problem. S. epidermidis and other air-born bacteria were brought in by carriers who included doctors and nurses from outside of the operation theater. Installation of UV lamps in the sanitary hall of the operation room reduced the number of air-born bacteria. To avoid contamination, routine microbial examination of the facilities, rearrangement of the sanitary zone and the installation of air-showers is planned.
kn-abstract=昭和53年5月から10月にかけて,岡大附属病院中央手術部における細菌を指標とした汚染状態を調査したところ, Staphylococcus epidermidisとAci netobacter calcoaceticus (Acin, calc)を主体とした汚染が明らかになった.Acin. calc.は一般消毒剤,抗生剤に耐性を示し,特に病院内で頻用されているクロルヘキシジン(ヒビテン)は全く無効であった.しかも手術時手洗い用に使用していたヒビテン液から多量のAcin. calc.が検出されたが,これは洗浄者の泡立ちによる使用時の満足感の為に添加されている「ニッコール」がむしろ菌の増殖を助長していることに起因することが判明した.このため,手術時手洗いに用いる消毒剤について検討した結果,ヨード剤が現時点ではより有効であると判定された.手術室内では床・棚の上,無影灯上蓋,落下細菌などを調べた結果,主としてS. epidermidisが検出されたが,これらは実験的に手術室廊下に終夜殺菌灯をつけること,床を消毒剤で清拭することで改善された.更に手術室内への立入り人員の制限,作業通路の変更等について汚染源混入を防ぐ方法について検討を加えた.
en-copyright=
kn-copyright=

en-aut-name=HayashiHideo
en-aut-sei=Hayashi
en-aut-mei=Hideo
kn-aut-name=林英生
kn-aut-sei=林
kn-aut-mei=英生
aut-affil-num=1
ORCID=

en-aut-name=HiraiYoshikazu
en-aut-sei=Hirai
en-aut-mei=Yoshikazu
kn-aut-name=平井義一
kn-aut-sei=平井
kn-aut-mei=義一
aut-affil-num=2
ORCID=

en-aut-name=WadaMomoko
en-aut-sei=Wada
en-aut-mei=Momoko
kn-aut-name=和田百子
kn-aut-sei=和田
kn-aut-mei=百子
aut-affil-num=3
ORCID=

en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=4
ORCID=

en-aut-name=KawakamiYasuto
en-aut-sei=Kawakami
en-aut-mei=Yasuto
kn-aut-name=河上靖登
kn-aut-sei=河上
kn-aut-mei=靖登
aut-affil-num=5
ORCID=

en-aut-name=MitsuokaToshito
en-aut-sei=Mitsuoka
en-aut-mei=Toshito
kn-aut-name=光岡利人
kn-aut-sei=光岡
kn-aut-mei=利人
aut-affil-num=6
ORCID=

en-aut-name=TomitaKouro
en-aut-sei=Tomita
en-aut-mei=Kouro
kn-aut-name=富田校郎
kn-aut-sei=富田
kn-aut-mei=校郎
aut-affil-num=7
ORCID=

en-aut-name=ArataTakiji
en-aut-sei=Arata
en-aut-mei=Takiji
kn-aut-name=新太喜治
kn-aut-sei=新
kn-aut-mei=太喜治
aut-affil-num=8
ORCID=

en-aut-name=YoshizawaKeiko
en-aut-sei=Yoshizawa
en-aut-mei=Keiko
kn-aut-name=吉沢圭子
kn-aut-sei=吉沢
kn-aut-mei=圭子
aut-affil-num=9
ORCID=

en-aut-name=YasuiAkie
en-aut-sei=Yasui
en-aut-mei=Akie
kn-aut-name=安井晃栄
kn-aut-sei=安井
kn-aut-mei=晃栄
aut-affil-num=10
ORCID=

en-aut-name=FujiwaraKiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Kiyoshi
kn-aut-name=藤原清
kn-aut-sei=藤原
kn-aut-mei=清
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部中央手術部

affil-num=6
en-affil=
kn-affil=岡山大学医学部中央手術部

affil-num=7
en-affil=
kn-affil=岡山大学医学部中央手術部

affil-num=8
en-affil=
kn-affil=岡山大学医学部中央手術部

affil-num=9
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=10
en-affil=
kn-affil=岡山大学医学部中央検査部

affil-num=11
en-affil=
kn-affil=岡山大学医学部中央検査部
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=241
end-page=250
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Changes in cholesterol content and fatty acid composition of serum lipid in irradiated rat
kn-title=放射線全身照射にともなうラット血清脂質分画の変動-コレステロール値と分画脂酸構成について-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of single dose whole body irradiation on the serum cholesterol content and fatty acid composition of serum lipids of rats was investigated. A change in fatty acid composition of liver lipid was also observed. 1) The serum cholesterol content increased in parallel with the increase in body weight. The change in cholesterol ester was more marked than that of free cholesterol. 2) After 600 rad irradiation, cholesterol content increased, reached maximum 3 days after irradiation, and then decreased. This temporary increase was due to cholesterol ester. 3) Cholesterol and triglyceride both accounted for about 40 % , as measured by color determination on thin-layer chromatography. After irradiation, an increase in cholesterol content and the marked decrease in triglyceride content were observed bringing about a change in the amount of total serum lipid. 4) The fatty acid composition of normal and irradiated rat sera were compared. The relative percentages of total lipid of palmitic and oleic acids decreased while those of stearic and arachidonic acid increased. Serum phospholipid had little arachidonic acid and the fatty acid composition did not change after irradiation. Serum triglyceride had trace amounts of arachidonic acid and the unsaturated fatty acid component decreased after irradiation. On the other hand, unsaturated fatty acid in cholesterol ester increased after irradiation while linoleic and arachidonic acids made up 29 % and 22 % in control and 17 % and 61 % after irradiation, respectively. These results indicate that after irradiation the amount of oleic acid decreased in all lipid fractions, and that the decrease in linoleic acid and the increase in arachidonic acid after irradiation were due mainly to changes in the amounts of the cholesterol ester of these fatty acids. 5) Fatty acid composition of total liver lipid after irradiation showed a decrease in palmitic and oleic acids and an increase in stearic and arachidonic acids, the same trend as observed in serum lipid fatty acid. Liver cholesterol ester showed trace amounts of linoleic and arachidonic acids and an increase in short chain fatty acid after irradiation. 6) The major component of serum phospholipid was phosphatidylcholine, while palmitostearyl lecithine and unsatulated fatty acid were small components. Moreover, phosphatidylcholine and -ethanolamine were the major components of liver phospholipid, having highly unsatulated fatty acids. The changes in fatty acid composition were similar to the changes in total phospholipids.
en-copyright=
kn-copyright=

en-aut-name=OhashiShigeru
en-aut-sei=Ohashi
en-aut-mei=Shigeru
kn-aut-name=大橋茂
kn-aut-sei=大橋
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部口腔外科学教室
en-keyword=ラット血清
kn-keyword=ラット血清
en-keyword=脂質分画
kn-keyword=脂質分画
en-keyword=脂肪酸分析
kn-keyword=脂肪酸分析
en-keyword=コレステロール
kn-keyword=コレステロール
en-keyword=放射線照射
kn-keyword=放射線照射
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=229
end-page=240
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fatty acid composition of lipids and cholesterol content of normal and irradiated rat incisor pulps
kn-title=ラット切歯歯髄における脂質分画の脂肪酸組成とコレステロールにおよぼす放射線照射の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fatty acid composition of various lipids isolated and fractionated from rat incisor pulps were analyzed by means of thin layer and gas chromatography. The changes of the compositions after whole body X-irradiation were also investigated. The results are as follows. 1) The fatty acid composition of total lipid from rat incisor pulps was similar to that of total lipids from rat incisor (hard tissue). 2) Palmitic, oleic, stearic and arachidonic acids, in that order, accounted for most of the fatty acids (>88 % ) in total lipid. In the irradiated group (at 3 days after whole body irradiation), oleic acid had decreased and arachidonic acid had increased. 3) The fatty acids of phospholipid were found in the order, palmitic, stearic, oleic and arachidonic acids. After irradiation, the percentage of oleic acid decreased and that of arachidonic acid increased. 4) Similarly, the fatty acids of triglyceride and cholesterol ester were in the order, palmitic, stearic, myristic, oleic and palmitoleic acid, and palmitic acid accounted for 60 % . Saturated fatty acids accounted for over 80 % of both lipid fractions and arachidonic acid was a trace component. After irradiation, the changes of fatty acid composition of both lipid fractions were different. A decrease in palmitoleic acid and an increase in myristic acid in the compositions of triglyceride were observed. On the other hand, a decrease in stearic and palmitoleic acids and an increase in myristic acid were observed in cholesterol ester. 5) The fatty acids of phosphatidyl-choline (a), ethanolamine (b) and serine (c) were in the orders; (a) palmitic, oleic, stearic and arachidonic acid; (b) stearic, oleic, palmitic and arachidonic acid; and (c) palmitic, oleic and stearic acid. Arachidonic acid in phosphatidyl choline and ethanolamine accounted for a high percentage of the composition, but was low in phosphatidyl serine. After irradiation, a decrease in oleic acid and an increase in palmitic and arachidonic acid in the compositions of phosphatidyl-choline and -ethanolamine were observed, whereas an increase in stearic and oleic acids and a decrease in palmitic acid was observed in the composition of phosphatidyl serine. 6) The contents of free and ester type cholesterol in the incisor pulps were determined. Total cholesterol content increased in parallel with increase in body weight, this increase could be accounted for by an increase in ester type. 7) After whole body X-irradiation, the content of total cholesterol increased temporarily and reached maximum 3 days after irradiation. This change of the content was due mainly to the change in the amount of ester type.
en-copyright=
kn-copyright=

en-aut-name=OhashiShigeru
en-aut-sei=Ohashi
en-aut-mei=Shigeru
kn-aut-name=大橋茂
kn-aut-sei=大橋
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部口腔外科学教室
en-keyword=ラット切歯歯髄
kn-keyword=ラット切歯歯髄
en-keyword=脂質分画
kn-keyword=脂質分画
en-keyword=脂肪酸分析
kn-keyword=脂肪酸分析
en-keyword=コレステロール
kn-keyword=コレステロール
en-keyword=放射線照射
kn-keyword=放射線照射
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=217
end-page=228
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental research on chronological changes in glomerular epithelial and endothelial cells after ischaemia
kn-title=虚血に伴う糸球体上皮および内皮細胞の経時的変化に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The kidney is an organ with an extremely large blood flow. During deep anesthesia or under conditions such as occur with haemorrhagic shock, however, renal blood flow falls, the blood flow being directed to other essential organs so that any fall in blood pressure throughout the whole organism is obviated. The kidney itself, however, is plunged into ischaemic conditions. The object of the present work was to study both the changes with time which occur in renal cytology after the establishment of ischaemic conditions, and to define the point in time at which renal cytology undergoes the change from a reversible to an irreversible state. In an experiment using domesticated rabbits, continuous renal artery ligation was performed (0, 1, 2.5, 5 hours) and the time course investigated histologically (mainly by observation of glomerular epithelial and endothelial cytology) with both light and electron (transmission and scanning) microscopes. The following results were obtained: 1) After one hour of ischaemia, the surface of the glomerular epithelial cells showed mild swelling and some change in its smooth appearance. One part had taken on a sponge-like appearance. 2) After 2.5 hours of ischaemia, the epithelial cells had atrophied and the entire cell surface was clearly sponge-like. It was no longer possible to distinguish the small pore-like structures that had been observed on the cell surface of normal kidney. 3) After 5 hours of ischaemia, cells were markedly atrophied and the appearance of the surface had become even more sponge-like. 4) Moreover, 2.5 hours of ischaemia was the time when, biochemically, cell metabolism had completely ceased and the permeability of the cell membrane had altered. The cell was considered to have undergone irreversible change by this stage.
en-copyright=
kn-copyright=

en-aut-name=KobayashiNaohide
en-aut-sei=Kobayashi
en-aut-mei=Naohide
kn-aut-name=小林尚日出
kn-aut-sei=小林
kn-aut-mei=尚日出
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔学教室
en-keyword=糸球体上皮細胞 (Glomerular epithelial cell)
kn-keyword=糸球体上皮細胞 (Glomerular epithelial cell)
en-keyword=糸球体内皮細胞 (Glomerular endothelial cell)
kn-keyword=糸球体内皮細胞 (Glomerular endothelial cell)
en-keyword=虚血 (Ischaemia)
kn-keyword=虚血 (Ischaemia)
en-keyword=不可逆性 (Irreversible)
kn-keyword=不可逆性 (Irreversible)
en-keyword=海綿状 (sponge-like)
kn-keyword=海綿状 (sponge-like)
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=197
end-page=215
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Search for viral particles in human papillomas
kn-title=人の乳頭腫におけるウイルスの検索
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By electron microscopy, viral particles were searched for in specimens taken from 3 cases of verruca vulgaris, 2 cases of verruca plana, 2 cases of epidermodysplasia verruciformis, 8 cases of oral papilloma, 2 cases of nasal papilloma, 4 cases of laryngeal papilloma, 2 cases of condyloma acuminatum, 3 cases of bladder papilloma and 1 case of familial intestinal polyposis. Viral particles were detected in all 3 cases of verruca vulgaris, 2 cases of verruca plana, 2 cases of epidermodysplasia verruciformis and in one of 2 cases of condyloma acuminatum. All the viral particles detected in these papillomas were similar morphologically and antigenically and appeared to belong to the papilloma virus group. Vacuolation of cells in the upper epidermal layers was observed histologically in both virus-positive and virus-negative papillomas, and the histologically recognizable characteristics of virus-positive papillomas appeared to be the swelling of the nucleus, peripheral accumulation of the chromatin and clearly distinguished nucleoli in vacuolated cells. These nuclear changes were also observed electron microscopically. Malignant histological features were observed in 1 case of epidermodysplasia verruciformis, 1 case of oral papilloma, 1 case of laryngeal papilloma, and 1 case of familial intestinal polyposis. The significances of these findings are discussed.
en-copyright=
kn-copyright=

en-aut-name=YasuiMasazumi
en-aut-sei=Yasui
en-aut-mei=Masazumi
kn-aut-name=安井正純
kn-aut-sei=安井
kn-aut-mei=正純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設ウイルス部門
en-keyword=human papilloma
kn-keyword=human papilloma
en-keyword=electron microscopy
kn-keyword=electron microscopy
en-keyword=virus particles
kn-keyword=virus particles
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=183
end-page=196
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bioassay by sea urchin eggs for heavy metal pollution
kn-title=ウニ卵を用いての重金属汚染の測定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of HgCl(2), CuCl(2),CdCl(2) and ZnCl(2) on the fertilization, cell division and pluteus formation of eggs from the sea urchins, Hemicentrotus purcherrimus and Temnopleurus toreumatics, were studied. Inhibition of the development of sea urchin eggs by these heavy metals was ameliorized by slag from both paper manufacturing effluent and the ended at the river mouth. The development of sea urchin eggs was completely inhibited by HgCl(2) at 10(-6)M. A concentration of 10(-4)M was needed for this inhibitory effect after HgCl(2) had been mixed with slag. Abnormalities of larvae were not observed with a concentration of 10(-4)M. The critical concentration of CuCl(2) was 10(-5)M. This dose to 10(-4)M after treatment with slag. CdCl(2) caused complete inhibition of spicule formation at 10(-5)M, resulting in the formation of permanent blastulae. A concentration of 10(-4)M was needed to obtain the same effects after slag treatment. The critical concentration of ZnCl(2) was 10(-5)M. The same effect was obtained with this concentration even after the addition of slag from river mouth slag, whereas after the addition of paper mill effluent, a concentration of 10(-4)M was needed.
en-copyright=
kn-copyright=

en-aut-name=KisidaAkira
en-aut-sei=Kisida
en-aut-mei=Akira
kn-aut-name=岸田昭
kn-aut-sei=岸田
kn-aut-mei=昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=165
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies to establish a procedure for successful selective endoscopic retrograde cholangiography (ERC)
kn-title=内視鏡的胆管造影成功率に関係する因子の検討(胆管造影成功率改善を目的として) 第二編
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The following studies were made to establish a procedure for successful selective endoscopic retrograde cholangiography (ERC): 1) 787 cases of ERC performed in the past five years were divided into three groups. The first period was devoted to establishing the position of the patient most suitable to successful cholangiography. The second period was used to evaluate the validity of antispasmodics for successful cholangiography. The third period was devoted to making use of the knowledge obtained by anatomical studies reported in the previous paper. The success rate of selective cholangiography was 70.8 percent in the first period, 82.4 percent in the second period and 90.8 percent in the third period. This remarkable improvement in success rate indicates the importance of the use of anti-COMT drug and the improved cannulation resulting from anatomical evaluation. 2) 194 cases in the third period were analysed to establish the factors concerned with a success rate. Important factors included the type of the major papilla and orifice, swelling of the major papilla, site, direction, depth, and number of cannulation, positioning of the patient, the use of antispasmodics, and the skill of the endoscopist. As a result, several ways of cannulation for a successful selective ERC were established according to the type of major papilla and orifice and the presence or absence of swelling of the major papilla.
en-copyright=
kn-copyright=

en-aut-name=TsurumiTetsuya
en-aut-sei=Tsurumi
en-aut-mei=Tetsuya
kn-aut-name=鶴見哲也
kn-aut-sei=鶴見
kn-aut-mei=哲也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=153
end-page=163
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Anatomical studies on the Vaterian bile duct and the pancreatic duct for successful endoscopic retrograde cholangio-pancreatography
kn-title=内視鏡的膵胆管造影を目的とした十二指腸乳頭および,膵胆管末端部の解剖学的検討 第一編
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Comparative studies between the shape of the Vaterian papilla, appearance of the orifice, and the course of the intraduodenal bile duct and the pancreatic duct were made on fifty-eight autopsy materials in order to improve the success rate of selective cholangiography by the endoscopic retrograde method. The following results were obtained: 1) The Vaterian papilla was classified into five types according to its appearance. In each type, an attempt was made to measure the angle between the bile/pancreatic duct and a longitudinal axis on the surface paralell to the inner duodenal surface at the orifice of the major papilla. 2) The orifice of the papilla was classified into one of three types according to the macroscopic appearance. The appearance of the orifice was classified into further ten subtypes using a magnifying lens. The interrelationship of the three major types and the ten subtypes was evaluated. 3) It was demonstrated that both the site and the direction of cannulation at the orifice of the major papilla had to be carefully fitted to both the shape of the papilla and the appearance of the orifice to obtain a successful cholangiography and/or pancreatography. Some important points to be observed for successful cannulation are described in relation to the type of the major papilla and of the orifice. 4) A common channel was observed in 61 percent of cases. 5) A widely separated type of orifice (Mehnen I type) was observed in three, 5.3 percent, of cases.
en-copyright=
kn-copyright=

en-aut-name=TsurumiTetsuya
en-aut-sei=Tsurumi
en-aut-mei=Tetsuya
kn-aut-name=鶴見哲也
kn-aut-sei=鶴見
kn-aut-mei=哲也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科
en-keyword=内視鏡的膵胆管造影成功率
kn-keyword=内視鏡的膵胆管造影成功率
en-keyword=十二指腸主乳頭
kn-keyword=十二指腸主乳頭
en-keyword=膵胆管末端部走行
kn-keyword=膵胆管末端部走行
en-keyword=成功率関係因子
kn-keyword=成功率関係因子
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=141
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ruthenium red-binding glycoprotein of the AH-130 ascites hepatoma cell surface and its biological activity
kn-title=腹水肝癌AH-130細胞表層のルテニューム赤結合糖蛋白質とその生物作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to examine the surface structure of cancer cells, ascites hepatoma cells (AH-130) were treated with ruthenium red known to interact readily with certain acidic carbohydrates. This treatment induces specific cell agglutination, which has been shown to depend upon the cell surface acidic mucopolysaccharide and glycoprotein. In the present study, an attempt was made to isolate the ruthenium red-binding glycoprotein and to examine its biochemical properties and biological characteristics.
Ruthenium red-binding glycoprotein was solubilised by treating AH-130 ascites hepatoma cells with a low concentration of papain, then fractionated by Sephadex G-200. This glycoprotein eluted as the fastest band on gel electrophoresis (glycine buffer pH 7.8) and showed a positive reaction for metachromatic toluidine blue. This fraction was isolated. The purified glycoprotein had a molecular weight a little higher than that of bovine serum albumin. There was a high content of acidic amino acid similar to that of Ca(++)-binding proteins described by other investigators. A considerable amount of galactose, hexosamine and sialic acid was also present. The glycoprotein bound strongly to ruthenium red. Ruthenium red inhibited PHA-induced blastoid transformation of lymphocytes and increased the endogenous respiratory activity of AH-130 ascites hepatoma cells. It was concluded that the ruthenium redbinding glycoprotein on the cell surface was related to the metabolic regulation of cells and to the metabolic disorder of cancer cells.
en-copyright=
kn-copyright=

en-aut-name=MatsunagaKazuyoshi
en-aut-sei=Matsunaga
en-aut-mei=Kazuyoshi
kn-aut-name=松永和義
kn-aut-sei=松永
kn-aut-mei=和義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌研生化学部
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=135
end-page=140
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=(103)Ru for Tumor Scanning Part II. The mechanism of ruthenium binding to tumor cells
kn-title=(103)Ruの腫瘍親和性 第2編 ルテニウムのがん細胞結合機構の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mechanism of (103)Ru-uptake in tumors was investigated through the incubation of rat ascites hepatoma cells (AH-130) in vitro with various concentrations of Ru-chloride containing (103)Ru-chloride as a tracer. Quantitative analysis of Ru binding to the cells indicated that ascites hepatoma cells contained high and low-affinity binding sites for Ru. When ascites hepatoma cells were incubated with Ru after incubation with a low concentration of papain, most of the Ru was not bound to the cells but was found in the medium containing solubilized glycoproteins. However Ru bound mainly to washed cells after the incubation with papain. About 65 % of the Ru bound to ascites hepatoma cells was liberated by the papain treatment, and about 45 % of the liberated Ru was precipitated by cetyltrimethylammonium bromide, indicating that Ru bound tightly to glycopeptides. These results suggest that the tumor affinity of (103)Ru is related to specific binding to glycopeptides on the tumor cell surface.
en-copyright=
kn-copyright=

en-aut-name=MizukawaKiichiro
en-aut-sei=Mizukawa
en-aut-mei=Kiichiro
kn-aut-name=水川帰一郎
kn-aut-sei=水川
kn-aut-mei=帰一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=127
end-page=134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=(103)Ru for Tumor Scanning Part I. Subcellular distribution of (103)Ru-chloride in tumor and liver
kn-title=(103)Ruの腫瘍親和性 第1編 (103)Ru-chlorideの腫瘍および肝臓内分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Subcellular distributions of (103)Ru in tumors and livers from Ehrlich's solid tumor-bearing mice (given (103)Ru-chloride intravenously) and in AH-130 ascites hepatoma cells (incubatedin vitro with (103)Ru-chloride) were investigated by differential centrifugation. Fractionations showed that most of the total radioactivity was recovered in the mitochondrial, and cell dibrisplus nuclear, fractions. The highest relative radioactivity per protein was found in the mitochondria1 fraction. These results indicate that (103)Ru accumulates especially in the mitochondria. (97)Ru and (67)Ga in livers showed similar subcellular distributions.
en-copyright=
kn-copyright=

en-aut-name=MizukawaKiichiro
en-aut-sei=Mizukawa
en-aut-mei=Kiichiro
kn-aut-name=水川帰一郎
kn-aut-sei=水川
kn-aut-mei=帰一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=115
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of multiple hemangioma developing in the oral cavity and somatically
kn-title=口腔領域および全身に多発した血管腫の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hemangioma is a benign tumor composed of vascular tissue which occurs in various parts of the body. In the oral area, it occurs preferentially in soft tissues such as the tongue, lips and buccal mucosa, and in rare cases it is said to develop even in the mandible. However, most cases are solitary and the development of multiple hemangioma all over the body is rare. We report a case of a girl aged 3 years and 5 months with multiple hemangioma in the oral cavity and all over the body. Treatment consisted of injection of sclerosing agents (Sodium Morrhuate), packing, and cryosurgery. The postoperative course was favorable with some reduction in the size of the tumors.
en-copyright=
kn-copyright=

en-aut-name=NagahataShunichiro
en-aut-sei=Nagahata
en-aut-mei=Shunichiro
kn-aut-name=長畠駿一郎
kn-aut-sei=長畠
kn-aut-mei=駿一郎
aut-affil-num=1
ORCID=

en-aut-name=OkamotoYoshimitsu
en-aut-sei=Okamoto
en-aut-mei=Yoshimitsu
kn-aut-name=岡本全允
kn-aut-sei=岡本
kn-aut-mei=全允
aut-affil-num=2
ORCID=

en-aut-name=KobayashiSeishi
en-aut-sei=Kobayashi
en-aut-mei=Seishi
kn-aut-name=小林清司
kn-aut-sei=小林
kn-aut-mei=清司
aut-affil-num=3
ORCID=

en-aut-name=MatsumuraKazuyoshi
en-aut-sei=Matsumura
en-aut-mei=Kazuyoshi
kn-aut-name=松村和良
kn-aut-sei=松村
kn-aut-mei=和良
aut-affil-num=4
ORCID=

en-aut-name=KochiHiroyoshi
en-aut-sei=Kochi
en-aut-mei=Hiroyoshi
kn-aut-name=高知宏喜
kn-aut-sei=高知
kn-aut-mei=宏喜
aut-affil-num=5
ORCID=

en-aut-name=MonzenMoshiho
en-aut-sei=Monzen
en-aut-mei=Moshiho
kn-aut-name=門前モシホ
kn-aut-sei=門前
kn-aut-mei=モシホ
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部口腔外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部口腔外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部口腔外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部口腔外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部口腔外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部口腔外科学教室
en-keyword=口腔内軟組織
kn-keyword=口腔内軟組織
en-keyword=多発性血管腫
kn-keyword=多発性血管腫
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=101
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of colcemid and lidocaine on the avoidance training in mice
kn-title=マウスの回避学習に及ぼすcolcemid及びlidocaineの影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mice of the ddN strain with high training scores were selected for the study of genetic improvement through avoidance training. Mice used were from 7th to 9th generations. Colcemid and lidocaine, which are known to temporarily disrupt microtubules and impede axonal flow. In the present study the effect of these two drugs on learning behavior in mice were studied. Animals were injected with colcemid and lidocaine either intraperitoneally (50 μg in 0.5 ml) or intracerebrally (10 μg in 10 μl) on both sides of the frontal lobe to a depth of 3 mm. Injections were performed either before or after training sessions. Autoradiographic analysis confirmed that (3)H-colcemid injected intraperitoneally had been incorporated into the peripheral regions of the cerebral ventricles and had not extended into adjacent regions in less than one hour. Similally, (3)H-colcemid injected intracerebrally was shown to be incorporated into ventricle regions and to have extended into adjacent regions. Colcemid and lidocaine did not produce any remarkable change in open field activity of the mice.
Intraperitoneal administration of colcemid and lidocaine did not affect either acquisition or retention of avoidance behavior. Intracerebral administraion of colcemid interfered only slightly with the acquisition and retention of avoidance behavior, but produced a profound loss of memory acquired previously. Intracerebral injection of lidocaine before or after training sessions did not affect either acquisition or retention of avoidance behaviour.
en-copyright=
kn-copyright=

en-aut-name=ItamiYoshiaki
en-aut-sei=Itami
en-aut-mei=Yoshiaki
kn-aut-name=伊丹義明
kn-aut-sei=伊丹
kn-aut-mei=義明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=89
end-page=99
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on blood vessels in experimental tumors Part II. Influence of anti-cancer agent on tumor vessels
kn-title=腫瘍血管に関する実験的研究 第2編 腫瘍血管と癌化学療法との関連性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The following results were obtained by serial investigation of tumor vessels in a transparent chamber in rat skin: 1) Normal vessels and tumor vessels tended to be disturbed by the administration of bleomycin. Cyclophosphamide therapy begun at an early stage of tumor when the vascular supply was copious resulted in improvement of the irregular pattern and size variation of vessels. Moreover, the central tumor mass regressed. Chemotherapy applied at an advanced stage of tumor when the circulation was sluggish and scatterd tumor necrosis was present did not cause any tumor regression. Moreover, tumor necrosis increased. 3) Prolongation of survival in tumor-bearing rats and tumor regression due to cyclophosphamide were significantly enhanced by the additional use of high pressure oxygen with the drug. Microscopic observation of tumor vessels in vivo indicated that this combination therapy produced favorable conditions in the tumor microcirculatory system. These results clarify the relationship between tumor microcirculation and tumor growth, as well as the therapeutic effects of anti-cancer agents.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTatsuo
en-aut-sei=Watanabe
en-aut-mei=Tatsuo
kn-aut-name=渡部達夫
kn-aut-sei=渡部
kn-aut-mei=達夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部木村内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=77
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on blood vessels in experimental tumors Part I. Formation of tumor vessels in transparent chambers
kn-title=腫瘍血管に関する実験的研究 第1編 腫瘍血管の形成について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Neovascularization and tumor vessels in various cancers transplanted into a transparent chamber in rat skin were investigated. The following results were obtained: 1) Development of neovascularization toward an avascular area was apparent one week after the installation of the chamber. 2) Differentiation into arterioles and venules was a common occurrence. Arteriolar neovascularization were more vigorous toward an implanted tumor than toward an avascular area. 3) The change of pre-existing normal vessels into tumorous one was characteristic. Vessels within tumors became abnormal in size, dilatated, tortous, and showed cross-anastomosing and distortion at the capillary level. Slowing of blood flow was marked in tumor vessels. This abundant vascular bed seemed inefficient mechanically as well as functionally, as tumor tissues became hypoxic. The tumor developed necrotic centers so that, finally, tumor cells survived only within narrow space around large vessels.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTatsuo
en-aut-sei=Watanabe
en-aut-mei=Tatsuo
kn-aut-name=渡部達夫
kn-aut-sei=渡部
kn-aut-mei=達夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部木村内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=47
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on vascularization of oral mucosal graft after transplantation
kn-title=口腔粘膜への粘膜移植後の血管新生に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Damage inflicted on the oral mucosa may result in the development of an unfavorable appearance, functional disturbances, or growth retardation in the buccal-oral cavity region. In an attempt to minimize such disturbances, transplantation of the free oral mucosa was investigated. Changes in the vascular picture were studied by the intravascular injection of chloropercha. Three-dimensional and morphological observations of blood vessels were supported by macroscopical and pathohistological studies. The animals used were 60 adult dogs weighing about 4-8 kg raised in similar conditions. The left and right buccal mucosal flaps and the left and right maxillary third incisors served as the material. Intravenous anesthesia was used. In Exp. 1: a 1.0 x 1.0 cm piece was taken from the left buccal mucosa. A mucosal graft of the same size was obtained from the right buccal mucosa (used for the free buccal mucosa transplantation). In Exp. 2: the right buccal mucosa from which the mucosal flap had been taken was left as an open wound. In Exp. 3: a gingival section (1.0 x 1.0 cm) was taken from both sides of the maxillary gingiva at the level of the third maxillary incisors. A free buccal gingival graft was prepared from the left side and transplanted to the open wound on the right. The free buccal gingival graft from the right side was transplanted to the open wound on the left. 1) In the free buccal mucosal transplantation to the buccal mucosa, slight intrusion of blood vessels into the transplant was obvious 2 days after transplantation. By the fifth day many blood vessels had developed, by the sixth day these blood vessels formed a loop in the epithelial region, by the fourteenth day the arrangement of blood vessels had become well arrayed, and by the twentieth day blood vessels gave the same appearance as vessels in the transplantation bed. 2) Transplantation of the free mucosa on to the buccal mucosa of the opposite side gives better healing than leaving the damaged buccal mucosa as an open wound. 3) With transplantation of free gingiva to the gingiva of tooth neck, blood vessels had partially advanced into the transplant by the fifth post-operative day. By the tenth day, loop formation of vessels on the gingival epithelium together with gingival adhesion were well arranged. By the fortyfifth day, blood vessels in the transplant presented a similar picture to the normal. 4) Gingival transplantation to gingiva of the tooth neck gave better healing than buccal mucosal transplantation. Moreover, the appearance after operation was more satisfying. 5) The pathohistological findings for this vascular picture agreed in general with the macroscopic appearance.
en-copyright=
kn-copyright=

en-aut-name=OkamotoYoshimitsu
en-aut-sei=Okamoto
en-aut-mei=Yoshimitsu
kn-aut-name=岡本全允
kn-aut-sei=岡本
kn-aut-mei=全允
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部口腔外科学教室
en-keyword=頬粘膜移植
kn-keyword=頬粘膜移植
en-keyword=歯肉移植
kn-keyword=歯肉移植
en-keyword=粘膜移植
kn-keyword=粘膜移植
en-keyword=口腔粘膜
kn-keyword=口腔粘膜
en-keyword=血管新生
kn-keyword=血管新生
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=37
end-page=46
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of insulin on the metabolism of catecholamines, tyrosine hydroxylase and tyrosine decarboxylation in rat brain
kn-title=ラット脳内アミン代謝,チロシン水酸化酵素活性およびチロシン脱炭酸反応に及ぼすインスリンの効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Wistar strain albino male rats (100g-150g) were injected intramuscularly with insulin (0.1 IU per 100g body weight). Quantitative analysis of phenylalanine and tyrosine in plasma and the brain cortex, and of catecholamines and tyramine in plasma and whole brain was performed. The activity of tyrosine hydroxylase in brain striata and the adrenal glands, and the activities of tyrosine decarboxylase and aromatic amino acid decarboxylase in both the whole brain (except cerebellum) and the liver were also studied. The quantitative analysis of plasma phenylalanine wass performed using the method of McCaman and Robins. Tyrosine was analysed by the method of Waalkes and Udenfriend. Tyrosine hydroxylase activity was measured by the method of Coyle, and aromatic amino acid decarboxylase activity by the method of Christenson. Catecholamines were quantitated by the method of Kawai. All activities (Results 1-4) were determined 60 minutes after the insulin injection, the time by which hypoglycemia had definitely developed. The results were as follows; 1. Blood glucose decreased to 47.3% sixty minutes after the insulin injection. Phenylalanine in plasma and in the brain decreased significantly but tyrosine levels did not show any change. 2. In the blood, dopamine and norepinephrine decreased significantly whereas epinephrine and tyramine increased significantly. In whole brain (except cerebellum), dopamine and norepinephrine decreased significantly, tyramine increased significantly, but epinephrine increased only slightly. 3. Tyrosine hydroxylase activities in striata and in the adrenal glands increased significantly. 4. Tyrosine decarboxylation in diencephalon combined with striata and in the liver was also high. 5. Tyrosine hydroxylase activity in whole brain (except cerebellum) was high 60 minutes to 90 minutes after the insulin injection. Tyrosine hydroxylase activity in the adrenal glands was high 30 minutes to 90 minutes after the insulin injection. 6. Tyrosine decarboxylation in the whole brain (except cerebellum) and in the liver was significantly high 30 minutes to 60 minutes after the insulin injection. When L-DOPA was used as the substrate, the activity of aromatic amino acid decarboxylase in the brain increased 90 minutes after the insulin injection. The activity of this enzyme in the liver, however, was not different from that of in the liver of the control rats. These results suggest that insulin causes an increase in the activity of tyrosine hydroxylase and an increase in the production of catecholamines. It also accelerates the metabolic pathway from tyrosine to tyramine by increasing the activity of tyrosine decarboxylase.
en-copyright=
kn-copyright=

en-aut-name=MiyoshiKimiaki
en-aut-sei=Miyoshi
en-aut-mei=Kimiaki
kn-aut-name=三好公明
kn-aut-sei=三好
kn-aut-mei=公明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=25
end-page=35
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A cardiovascular epidemiologic survey in three different areas of Okayama Prefecture (Sakuto-cho, Sanyo-cho and Osafune-cho) during the period from 1966 to 1976 III. Cerebro-cardiovascular risk factors
kn-title=岡山県の三地区(作東町,山陽町,長船町)の循環器疫学調査(1966〜1976) 第3報 脳・心事故と危険因子との関係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A cardiovascular epidemiologic survey has been carried out in three different areas (Sakuto-cho, Sanyo-cho and Osafune-cho) of Okayama Prefecture since 1966. Cerebro-cardiovascular risk factors were investigated using data obtained in the first examination. The following results were obtained: 1. Sixty-six cerebro-cardiovascular accidents (CCA) occurred in 1906 subjects over a ten year period (1966 to 1976); of these, 33 were cerebrovascular accidents (CVA) and 33 were cardiac accidents. The prevalence rate was the highest in Sakuto-cho and the lowest in Sanyo-cho. This reflected the degree of control of blood pressure. 2. Cardiovascular accidents had a slightly higher prevalence rate in females than in males. 3. CCA in males showed a positive correlation to increase in relative body weight. In females, there was no significant relationship between CCA and relative body weight. 4. Compared to subjects with normal urinalysis, the prevalence rate of CCA was 1.7 in subjects with proteinuria and 3.2 in those with glucosuria. 5. CCA occurred more frequently in both the systolic hypertension group and the group with combined systolic and diastolic hypertension.
en-copyright=
kn-copyright=

en-aut-name=HaraokaShoichi
en-aut-sei=Haraoka
en-aut-mei=Shoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

en-aut-name=SaitoDaiji
en-aut-sei=Saito
en-aut-mei=Daiji
kn-aut-name=斎藤大治
kn-aut-sei=斎藤
kn-aut-mei=大治
aut-affil-num=2
ORCID=

en-aut-name=UedaMinoru
en-aut-sei=Ueda
en-aut-mei=Minoru
kn-aut-name=上田稔
kn-aut-sei=上田
kn-aut-mei=稔
aut-affil-num=3
ORCID=

en-aut-name=OginoYasuhiro
en-aut-sei=Ogino
en-aut-mei=Yasuhiro
kn-aut-name=荻野泰洋
kn-aut-sei=荻野
kn-aut-mei=泰洋
aut-affil-num=4
ORCID=

en-aut-name=KusuharaShunichi
en-aut-sei=Kusuhara
en-aut-mei=Shunichi
kn-aut-name=楠原俊一
kn-aut-sei=楠原
kn-aut-mei=俊一
aut-affil-num=5
ORCID=

en-aut-name=YoshidaHidenori
en-aut-sei=Yoshida
en-aut-mei=Hidenori
kn-aut-name=吉田英紀
kn-aut-sei=吉田
kn-aut-mei=英紀
aut-affil-num=6
ORCID=

en-aut-name=KawasakiTomoko
en-aut-sei=Kawasaki
en-aut-mei=Tomoko
kn-aut-name=川崎智子
kn-aut-sei=川崎
kn-aut-mei=智子
aut-affil-num=7
ORCID=

en-aut-name=MisayakaMinoru
en-aut-sei=Misayaka
en-aut-mei=Minoru
kn-aut-name=宮阪実
kn-aut-sei=宮阪
kn-aut-mei=実
aut-affil-num=8
ORCID=

en-aut-name=YoshiokaNobuhiko
en-aut-sei=Yoshioka
en-aut-mei=Nobuhiko
kn-aut-name=吉岡信彦
kn-aut-sei=吉岡
kn-aut-mei=信彦
aut-affil-num=9
ORCID=

en-aut-name=IkenagaToyotake
en-aut-sei=Ikenaga
en-aut-mei=Toyotake
kn-aut-name=生長豊健
kn-aut-sei=生長
kn-aut-mei=豊健
aut-affil-num=10
ORCID=

en-aut-name=KusachiShowzo
en-aut-sei=Kusachi
en-aut-mei=Showzo
kn-aut-name=草地省藏
kn-aut-sei=草地
kn-aut-mei=省藏
aut-affil-num=11
ORCID=

en-aut-name=SogoTaiji
en-aut-sei=Sogo
en-aut-mei=Taiji
kn-aut-name=十河泰司
kn-aut-sei=十河
kn-aut-mei=泰司
aut-affil-num=12
ORCID=

en-aut-name=YamadaNobuyuki
en-aut-sei=Yamada
en-aut-mei=Nobuyuki
kn-aut-name=山田信行
kn-aut-sei=山田
kn-aut-mei=信行
aut-affil-num=13
ORCID=

en-aut-name=NishiyamaOsamu
en-aut-sei=Nishiyama
en-aut-mei=Osamu
kn-aut-name=西山修
kn-aut-sei=西山
kn-aut-mei=修
aut-affil-num=14
ORCID=

en-aut-name=YasuharaKoichiro
en-aut-sei=Yasuhara
en-aut-mei=Koichiro
kn-aut-name=安原耕一郎
kn-aut-sei=安原
kn-aut-mei=耕一郎
aut-affil-num=15
ORCID=

en-aut-name=HisamatsuMitsuo
en-aut-sei=Hisamatsu
en-aut-mei=Mitsuo
kn-aut-name=久松三生
kn-aut-sei=久松
kn-aut-mei=三生
aut-affil-num=16
ORCID=

en-aut-name=NukadaKaname
en-aut-sei=Nukada
en-aut-mei=Kaname
kn-aut-name=額田要
kn-aut-sei=額田
kn-aut-mei=要
aut-affil-num=17
ORCID=

en-aut-name=ImadaKakuro
en-aut-sei=Imada
en-aut-mei=Kakuro
kn-aut-name=今田格郎
kn-aut-sei=今田
kn-aut-mei=格郎
aut-affil-num=18
ORCID=

en-aut-name=HirataTakako
en-aut-sei=Hirata
en-aut-mei=Takako
kn-aut-name=平田孝子
kn-aut-sei=平田
kn-aut-mei=孝子
aut-affil-num=19
ORCID=

en-aut-name=KasuYoshiko
en-aut-sei=Kasu
en-aut-mei=Yoshiko
kn-aut-name=嘉数佳子
kn-aut-sei=嘉数
kn-aut-mei=佳子
aut-affil-num=20
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=13
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=14
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=15
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=16
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=17
en-affil=
kn-affil=岡山県衛生部

affil-num=18
en-affil=
kn-affil=岡山県衛生部

affil-num=19
en-affil=
kn-affil=岡山県衛生部

affil-num=20
en-affil=
kn-affil=岡山県衛生部
en-keyword=高血圧
kn-keyword=高血圧
en-keyword=性
kn-keyword=性
en-keyword=尿糖
kn-keyword=尿糖
en-keyword=尿蛋白
kn-keyword=尿蛋白
en-keyword=肥満
kn-keyword=肥満
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=17
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of primary pulmonary hypertension treated with yearlong administration of oral phenoxybenzamine
kn-title=Phenoxybenzamineを長期間投与した原発性肺高血圧症の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 26 year old woman with primary pulmonary hypertension received oral phenoxybenzamine, 15-30 mg daily, over a year without serious side effects. The patient was discharged after phenoxybenzamine therapy for 6 months, because her subjective complaints improved gradually with reduction of the Cardiac Thoracic Ration of chest X-ray films from 60% to 54% . However, she was readmitted for right heart failure precipitated by a common cold. It is suggested that oral phenoxybenzamine for primary pulmonary hypertension is effective in alleviating subjective complaints, but the effects may only be temporary.
en-copyright=
kn-copyright=

en-aut-name=HaraokaShoichi
en-aut-sei=Haraoka
en-aut-mei=Shoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

en-aut-name=UedaMinoru
en-aut-sei=Ueda
en-aut-mei=Minoru
kn-aut-name=上田稔
kn-aut-sei=上田
kn-aut-mei=稔
aut-affil-num=2
ORCID=

en-aut-name=YasuharaKoichiro
en-aut-sei=Yasuhara
en-aut-mei=Koichiro
kn-aut-name=安原耕一郎
kn-aut-sei=安原
kn-aut-mei=耕一郎
aut-affil-num=3
ORCID=

en-aut-name=IkenagaToyotake
en-aut-sei=Ikenaga
en-aut-mei=Toyotake
kn-aut-name=生長豊健
kn-aut-sei=生長
kn-aut-mei=豊健
aut-affil-num=4
ORCID=

en-aut-name=MiyasakaMinoru
en-aut-sei=Miyasaka
en-aut-mei=Minoru
kn-aut-name=宮阪実
kn-aut-sei=宮阪
kn-aut-mei=実
aut-affil-num=5
ORCID=

en-aut-name=YoshiokaNobuhiko
en-aut-sei=Yoshioka
en-aut-mei=Nobuhiko
kn-aut-name=吉岡信彦
kn-aut-sei=吉岡
kn-aut-mei=信彦
aut-affil-num=6
ORCID=

en-aut-name=KawasakiTomoko
en-aut-sei=Kawasaki
en-aut-mei=Tomoko
kn-aut-name=川崎智子
kn-aut-sei=川崎
kn-aut-mei=智子
aut-affil-num=7
ORCID=

en-aut-name=MaeRitsuo
en-aut-sei=Mae
en-aut-mei=Ritsuo
kn-aut-name=前律夫
kn-aut-sei=前
kn-aut-mei=律夫
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科教室
en-keyword=primary pulmonary hypertension
kn-keyword=primary pulmonary hypertension
en-keyword=phenoxybenzamine
kn-keyword=phenoxybenzamine
en-keyword=yearlong administration
kn-keyword=yearlong administration
en-keyword=tolazoline
kn-keyword=tolazoline
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=1-2
article-no=
start-page=1
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Guanulocyte cytotoxicity in sera from renal allograft recipients
kn-title=腎移植患者のGranulocyte Cytotoxicityに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A time-lapse study of granulocyte cytotoxicity was performed with sera from 13 renal allograft recipients (living related donor; 10, cadaver donor; 3) using a droplet microgranulocytecytotoxicity test. Of eight patients who had previously received blood transfusions, two gave positive reactions for the granulocyte cross match test and developed acute rejection after renal transplantation. Of seven patients with rejection of a renal graft, four were positive for granulocyte cytotoxicity before and after operation. Five patients showed good results for renal graft and four of these were negative for granulocyte cytotoxicity both before and after operation. Some of the patients with good grafts gave repeated positive reactions for granulocyte cytotoxicity but later showed poor grafting. Results for granulocyte cytotoxicity which were negative early tended to become positive about 10 days before acute rejection. Granulocyte cytotoxicity did not correlate well with HLA-matching or white blood cell counts. Lymphocyte cytotoxicity examined simultaneously was negative in the sera of all 13 patients.
en-copyright=
kn-copyright=

en-aut-name=HorimiTadashi
en-aut-sei=Horimi
en-aut-mei=Tadashi
kn-aut-name=堀見忠司
kn-aut-sei=堀見
kn-aut-mei=忠司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
en-keyword=液性免液
kn-keyword=液性免液
en-keyword=抗顆粒球抗体
kn-keyword=抗顆粒球抗体
en-keyword=抗リンパ球抗体
kn-keyword=抗リンパ球抗体
en-keyword=組織適合性
kn-keyword=組織適合性
en-keyword=既存抗体
kn-keyword=既存抗体
END