岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 Kartagener症候群の1例 585 589 EN Yoshio Ogura Takashi Takiguchi Kiyoshi Arakawa Wataru Tani Hideo Kasai Naoyuki Terashima Minoru Morita Kartagener's syndrome has been noticed since Max Kartagener had reported eleven cases with chronic sinusitis, bronchiectasis, and situs inversus viscerum. The following case report demonstrated Kartageners syndrome at the Okayama University Hospital. A 20 year old woman visited the clinic with the chief complaint of coughing and sputum. On examination she was proved to have bronchiectasis and situs inversus viscerum. She also had nasal sinusitis for which she was operated at her fifteen years of age. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 肺癌のBleomycin療法について1―その評価と副作用防止対策― 575 584 EN Ikuro Kimura Masayoshi Kibata Atsumasa Hanzawa Yoshiaki Moritani Taisuke Onoshi Hiromi Takata Yoshitomo Nishizaki Ikuya Kunimasa Akira Nishishita Yoshiro Tanizaki Junko Takano Bleomycin was administered to 35 patients with lung cancer (primary lung cancer in 28 cases, metastatic lung cancer in 7 cases), and produced following results. Fibroblast-inhibiting agents were simultaneously administered as multiple combination therapy, "CPBP", with chloroquine, phytonadione, Bleomycin and prednisolone. In consequence, beneficial effect was seen in a fairly large number of cases including small sized lung cancer and terminal cancer cases. In comparison with other antineoplastic agents, Bleomycin had the advantage of not causing hematopoietic disturbances in host. It is considered, however, that the therapeutic efficacy of Bleomycin above mentioned can not be evaluated without prevention of its side effects. Of 67 cases given Bleomycin treatment 10 cases showed fever and 8 cases lung disturbances. Among these side effects lung distur bances rather than hematopoietic disturbances should be kept in mind. In 44 cases of cancer patients who were treated with combination of Blcomycin and a fibroblast-inhibiting agent, chloroquine, lung disturbances were seen in only 4 of them. On the other hand, in 12 cases of malignant lymphoma which were treated without the combined therapy, 4 of them showed lung disturbances-a high rate pulmonary complications than in cancer. In an experimental study of combination of Bleomycin and dextran sulfate inhibition of lung disturbances was observed histologically. And an increase of α and β globulin, triglyceride, seromucoid and fibrinogen was depressed by this combination therapy. This combination therapy also inhibited metastasis by intravenous inoculation of Ehrlich ascites tumor cell in lungs impaired by administration of Bleomycin. It is important that an effective method of preventing side effects of Bleomycin is established so that enough dose of the drug can be admistered. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 筋肉コルニンの細胞分裂調節作用と，そのin vivo応用への基礎的研究 549 560 EN Yoshinobu Fujii The sterilizing effect and hemolytic effect of cornin, extracted from skeletal muscle of rabbit were studied in vivo and in vitro. The results are summarized as follows: 1. Muscle cornin has no effect whatever on sterility when administrated into new born mice and adult mice. 2. There is no difference on the period of pregnancy and on the new born numbers as compared with no treated control. 3. When the erythrocytes are incubated with muscle cornin and then transfered into the hypotonic salt solution, the hemolytic effect occurs below 0.7 per cent salt solution. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第3編 クロロキンとマイトマイシンC併用による各種癌患者の治療に関する研究 539 547 EN Toshio Mori On the basis of our unique idea that damage of the stromal tissue might result secondarily in damage of the cancer cells, an attempt was made to administer a fibroblast-inhibiting agent, chloroquine, in combination with mitomycin C in 20 patients with malignant tumors. 1) Of the 20 cases treated, the combined chemotherapy was effective in 6, induced no significant change in 6, caused aggravation in 3, and its evaluation was impossible in 5. 2) Of various malignant tumors treated, excellent therapeutic effects were obtained in patients with pleuritis carcinomatosa.. Among subjective complaints this regimen was most efficacious in alleviating pain. 3) Side effects of chloroquine were slight and its prolonged administration was possibl. Leucopenia often associated with administration of antitumor agents was relatively rare. 4) Accordingly, the combined chemotherapy with chloroquine and mitomycin C appears to be recommendable in the treatment of human tumors from the unique chemotherapeutic point of view. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第2編 クロロキンと所謂制癌剤併用の担腫瘍動物鉄代謝に及ぼす影響について 529 538 EN Toshio Mori Studies on iron metabolism, especially on organ iron were performed in mice with Bashford cancer treated by combined administration of chloroquine and several anti-tumor agents. 1) Chloroquine alone tended to inhibit the storage of non-hemin iron in the tumor tissues or organs. 2) No definite tendency was shown in the storage of non-hemin iron following administration of anti-tumor agents alone. 3) Generally, it was difficult to find a definite tendency in organs such as the liver and spleen after combined administration, but in the tumors the storage of non-hemin iron (γ/g) tended to be more inhibited by combineda dministration than in controls and in mice treated by anti-tumor drugs alone. 4) These data suggest that the combined chemotherapy with choroquine and several antitumor drugs exhibits more effective anti-tumor activity with respect to iron metabolism of animals bearing Bashford cancer than single administration of anti tumor drugs. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第1編 クロロキンと所謂制癌剤の併用療法に関する基礎的研究 517 528 EN Toshio Mori A fibroblast-inhibiting agent, chloroquine, was administered against Basford cancer in combination with several anti-tumor drugs. 1) In combination with mitomycin C, cyclosphamide and hematoporphyllin-Hg, chloroquine showed more inhibitory effect on the growth of the tumor in comparison with single administration of these drugs. 2) The combination of chloroquine and prednisolone showed almost the same inhibitory effect on the growth of the tumor as single administration of either drug. 3) The combination of chloroquine and chromomycin A(3) was less effective than administration of chromomycin A(3) alone. 4) Histologically, the combination of chloroquine and mitomycin C induced an increase of necrotic areas, degeneration of cancer cells and inhibition of stromal connective tissue fromation in comparison with single administration of either drug. 5) From these results it is considered that a fibroblast-inhibiting agent, chloroquine, when used in combination with anti-tumor agents which inhibit DNA synthesis is more effective against malignant tumors. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 腹部症状を伴う非特異性脳脊髄炎症（SMON）の疫学 511 515 EN Shigeo Sunami Masana Ogata Concerning cause of the SMON, there are many opinions from epidemiological, clinical and pathological points of view, and yet no distinct cause has been found. In order to clarify the cause by epidemiological procedure, we tried to investigate the relation between chinoform administration and the SMON from the data of the clinical cards in a hospital. 1) The average amount of chinoform administered during the whole course of treatment to the SMON patients in Y district was about 281g. and that in all Jaqan was about 147g, while the average amount calculated from the data of Berggren and others was 863g. 2) The average amount of chinoform administered to SMON patients until nervous symptom appeared was 69g in Y district, and that was 52g in all Japan. 3) The SMON patients of multiple occurrences in a family were all administered chinoform. The eight of nine SMON patients of multiple occurrences in a hospital were administered chinoform. 4) The tendency was recognized that SMON patients who received appendectomy had stayed for rather longer duration in a hospital and the SMON patients who did not receive appendectomy had relatively benign progress. The tendency was also recognized that the amount of chinoform administered to the SMON patients who received appendectomy was a little larger than that administered to the SMON patients who did not receive appendectomy. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 甲状腺腫瘍のシンチグラムについて 503 509 EN Masatada Tanabe Katsuhiko Sugita Yasuo Morino Setsuo Watanabe Yoshio Haisa Yasumasa Kumada Possiblity of differential diagnosis by means of the scintigram of thyroid gland was investigated with 15 cases with chronic inflammation, 54 with benign tumor, 22 with malignant tumor as the subjects of the study. The results are briefly summarized as follows. 1) In chronic inflammatory diseases most cases show an irregularity of the color band, and the lesion site is mostly located in the upper pole followed by the lower pole. 2) In cases of benign tumor warm nodules are decidedly predominant as compared with other diseases, and the margin is mostly either sharp or diffuse, especially sharp one in benign tumor than in malignant one. The peripheral contour is mostly concave. Enlargement of the lesion area is more often observed than in other diseases, and this tendency is especially marked in warm nodule. There can be often observed oppressive deformation. There is no difference of the color level between the right and the left sides. Lesion site does not differ from the right to the left side and it is mostly on the right exterior side and the left lower pole. 3) In malignant tumor, most cases show a large lesion. Ones with irregular margin are more numerous than in other diseases, but here it requires differentiation from inflammation. There is no swelling on the sideof lesion. The oppressive deformity is not so frequent as in benign cases. The affected side in most cases shows a lower color level as compared with healthy side. The lesion site in this case is mostly located in the upper pole. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 成人精薄者に関する2，3の臨床的考察―特にいわゆる家族性精薄を中心として― 493 502 EN Seigo Usui Atsuko Shohmori Kiyoshi Hosokawa 100 cases of institutionalized adult mental retardation are divided into three groups according to the presumed etiology. 1. Familial group (so called familial mental retardation); that is, some pathological or organic change in the brain are excluded from the clinical symptom and past history, and same kind of mental retardation is found in some of their family members. 2. Idiopathic group; clinical symptom, past and family history suggest no precise etiology. 3. Pathological group; 19 cases of so called familial mental retardation are presented and compaired with the other two groups. Social and mental age are very low and abnormal findings on EEG or PEG are found in most of these cases. From these results, complicated relation between intelligence and pathology of brain are suggested. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 胃癌の組織化学的，電子顕微鏡的研究 第1編 単純癌の微細構造 459 468 EN No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 腹水肝癌細胞（AH-130）の脂質過酸化反応欠損とその機構 447 458 EN Nobuyuki Goto Various tissue homogenates can produce lipid peroxide during incubation with Fe(++) or Co(++) in the presence of oxygen. But the homogenate of actively growing cells diminishes or fails to elicit the lipid peroxide formation. In the present report the author studied the mechanism of the failure of lipid peroxidation reaction of ascites hepatoma cells (AH-130) and the following results were obtained. 1. One of the facts of failure of lipid peroxidation reaction was the reduced arachidonic acid content in phospholipid fraction of ascites hepatoma cells. 2. The other facter was the presence of an inhibitor of lipid peroxidation in acetone soluble fraction of the ascites hepatoma cell membrane fractions. Therefore, the phospholipid fraction of the ascites hepatoma cells shows the lipid peroxidation reaction by the treatment with Fe(++). 3. The inhibitor was also found in the acetone soluble fraction of normal rat liver cells but the content was quite low. 4. The chemical nature of the inhibitor was different from the well known, antioxidant such as α-tocopherol, Coenzyme Q and Vitamin K. The chemical structure has not been identified yet, On the basis of these data the author discussed about the mechanism of the regulation of lipid peroxidation reaction in the cells with respect to the regulation of cell growth and cancer cell specificity and to the aging. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 82 11-12 1970 Ehrlich腹水癌移植腫瘍のリボゾームおよびリボゾームタンパクに関する研究 435 445 EN Dairoku Jitsuiki The ribosomal protein of the Ehrlich Ascites tumor was purified. The maximum absorbancy of the ribosome was 260 mμ and the minimum was 237 mμ. The sedimentation coefficient of the ribosome was 75 S(20)W, and the chemical composition of P:N:Ribose was 1:1.46:1.09. The purified ribosomal protein was electrophoretically single, and the maximum absorbancy was 268 mμ and the minimum was 232 mμ. The sedimentation coefficient of the ribosomal protein was 1.59 S(20)w. The molecular weight presumed about 6000. The chemical composition of the ribosomal protein of P:N:Ribose was 1:1.7:0.005. These results indicated that the ribosomal protein was nucleoprotein or phosphoprotein. The components of the ribosomal protein were rich in basic amino acids, especially lysin, and poor tyrosine and phenylalanine. No potential conflict of interest relevant to this article was reported.