start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=101
end-page=111
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the Free and Cojugated Steroids in Normal Placenta
kn-title=正常胎盤組織中遊離型並に結合型ステロイドホルモンの含有量に関する研究
en-subtitle=
kn-subtitle=
en-abstract=In this study, the approach was tried with the determination of steroids in placenta. Twenty one steroids in placenta were determined by new method, which was consisted of following procedure. 1) 2 steps hydrolysis (hydrolysis with β-glucuronidase in acetate buffer and solvolysis) 2) Florisil column chromatography 3) Thin layer chromatography The results of this determination were as followings. I. Free steroid in placenta A) Estrogen (μg/one placenta) Estrone: 33.0±:6.9, Estradiol: 37.6±11.7, 16-epi-Estriol: 17.9±2.6, Estriol: 57.6±10.3, Estriol content in placenta was not high as was considered. B) Gestagens (μg/one placenta) P. nolone: 43.8±10.3, 17-OH-P. nolone: 50.2±13.3, Prog.: 36.1±10.6, 17-OH-Prog.: 16.9±5.9 C) Androgens (μg/placenta) ⊿4-A-dione: 23.0±4.0, DHA+Andr.: 8.6±3.8, Etio.: 7.9±2.5, 11-keto-Etio.: 14.6±3.2, 11-OH-Etio.; 14.6±4.6 D) Corticoids (μg/placenta) Less polar subst.: 10.2±1.6, DOC: 6.8±3.5, Comp. A: 3.7±2.3, Comp. B: 1.1±1.1, Comp. E: 17.9±2.8, Comp. F: 13.2±4.2, Comp. S: (一), THS: 3.1±2.8, THE: 13.9±4.6, THF: 35.0±5.8, More polar subst.: 13.0±5.8 II. Cojugated steroids in placenta A) Estrogen (μg/placenta) Estrogen as sulfate were present one tenth of free type in placenta. There were a little content of 16-epi-Estriol and Estriol glucuronide. B) Gestagens (μg/placenta) P. nolone and 17-OH-P. nolone that were ⊿5-3β-ol type steroids were estimated as sulfate. C) Androgens DHA+Andr. fraction as sulfate was estimated higher content than free
type. All androgens glucuronide were not meassurable in placentar tissue. D) Corticoids Tetrahydro. comp. that were THF, THE, THS etc, as glucuronide were estimated considerably high. Above all, THE glucuronide was estimated higher content than free type of THE.
kn-abstract=従来,内分泌臓器としての胎盤からステロイドホルモンを抽出分離定量している報告は数多くあるが,そのいずれもが単一のステロイドのみを定量したものか,あるいは大量複数の胎盤を使つてのステロイドの抽出分離定量したかのいずれかにすぎなかつた.しかし胎盤組織内でのステロイドの代謝過程が次第に解明されつつある現在単一のステロイドのみ測定や大量複数の胎盤を使つてのステロイド測定の意義は徐々に失なわれつつある.そこで著者は正常満期産1個の胎盤におけるmetabolitesを測定することは胎盤における個体差及びその特徴を知る上に重要と考え,従来の定量法の難点を解決し満期産1胎盤組織中から測定しうる各種ステロイド(21種)を同時に抽出分離精製定量する新定量法を確立した.この方法により正常満期産胎盤16個について遊離型ステロイド21種を測定することができた.更に結合型ステロイドであるGlucuronide, Sulfateについても独自の方法により3胎盤を1つの測定単位として抽出分離定量し遊離型ステロイドと対比した.その結果中性遊離型ステロイドでは活性型以外に5位の飽和された不活性型が相当みとめられ△4-typeと5位の飽和型の比は1:1.7であつた.結合型ステロイドについてはエストロゲンは少量ながらGlucuronide, Sulfate共にみとめられたがP. nolone, 17-OH-P. nolone, DHA+Andr.にはSulfateが認められ,中でもDHA+Andr.では遊離型より多く認められた.Tetrahydro. Comp.のCorticoidにはGlucuronideが認められTHEは遊離型より多量に胎盤中に存在していた.
en-copyright=
kn-copyright=

en-aut-name=OtukaKenichi
en-aut-sei=Otuka
en-aut-mei=Kenichi
kn-aut-name=大塚憲一
kn-aut-sei=大塚
kn-aut-mei=憲一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=91
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of ACTH and Glycyrrhizin on Neonatal Joundice
kn-title=新生児黄疸の薬物療法に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It has been well established that an exchange transfusion is a radical therapeutic measure for prevention of "Kern Ikterus". However, side effects of massive transfusion have been reported in large number of cases and several attempts of medicamental treatment to reduce an opportunity of the exchange transfusion have also been evaluated. In this connection, effects of ACTH and Glycyrrhizin on neonatal jaundice were determined in mature infants during first 7 days of life. 1) Serum bilirubin was significantly decreased by ACTH administration, while suppression of serum bilirubin increment, characteristic changes in neonatal period, was observed following Glycyrrhizin administration. 2) ACTH administration resulted in hyperglycemia, increased urinary electrolytes, 17 KGS and bilirubin excretion. However, amounts of increased urinary bilirubin excretion was found to be one tenth of amounts of decreased serum bilirubin. On the contrast, no remarkable changes in blood sugar, electrolytes, urinary electrolytes, 17 KGS, and bilirubin excretion was noted following Glycyrrhizin administration. 3) On the treatment of hyperbilirubinemia, serum bilirubin were significantly decreased in cases of induced hyperglycemia. 4) Characteristic decrease on red blood cell counts, osmotic fragidity, Hb. and Ht. during neonatal period were improved by Glycyrrhizin, while no effect was found on reticulocyte counts. It may be summarized that ACTH has wide effects on bilirubin metabolism including a interaction of glucose metabolism and Glycyrrhizin relate a prevention of hemolysis increasing osmotic fragidity of red blood cell. Therefor, it may be emphasized that ACTH may be used for the treatment of neonatal hyperbilirubinemia, while Glycyrrhizin may be expected for the prevention of neonatal hyperbilirubinemia.
en-copyright=
kn-copyright=

en-aut-name=NishikawaNoboru
en-aut-sei=Nishikawa
en-aut-mei=Noboru
kn-aut-name=西川昇
kn-aut-sei=西川
kn-aut-mei=昇
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=85
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two Cases of Laurence-Moon-Biedl Syndrome -Special Reference to Mental Symptoms-
kn-title=Laurence-Moon―Biedl症候群の2例-精神症状を中心に
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two cases of Laurence-Moon-Biedl syndrome were reported with marked mental symptoms. Case 1 had mental defficiency, obesity, polydactylia and Retinitis pigmentosa, and was recognized periodic mental symptoms (repeated alternatively increased psychomotor activity and decreased psychomotor activity). Case 2 had mental defficiency, obesity, polydactylia and Retinitis pigmentosa, and was recognized constant mental symptoms (lacking in spontaneity, mutism, negativism and so on). The mental symptoms of Laurence-Moon-Biedl syndrome seems to be classified as two groups. That is, the first group has constant mental symptoms and the second group has periodic mental symptoms. Our Case 1 belongs to the second group and Case 2 belongs to the first group.
en-copyright=
kn-copyright=

en-aut-name=IkedaHisao
en-aut-sei=Ikeda
en-aut-mei=Hisao
kn-aut-name=池田久男
kn-aut-sei=池田
kn-aut-mei=久男
aut-affil-num=1
ORCID=

en-aut-name=HiramatsuIzumi
en-aut-sei=Hiramatsu
en-aut-mei=Izumi
kn-aut-name=平松泉
kn-aut-sei=平松
kn-aut-mei=泉
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=71
end-page=83
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of atypical psychosis characterized by periodic stupor, with marked epileptic factors
kn-title=著明なてんかん性要因を示し，挿間性昏迷状態をくりかえした非定型精神病の1例
en-subtitle=
kn-subtitle=
en-abstract=A 16-year old girl. It is said that there was a psychotic case in the relatives on the paternal side of the patient. Her hereditary history remains obscure, but her own history is uneventful. A review was made of this case who had episodes of stuporous state six times, and episodes of delutional-hallucinatory state twice since the age of 13. Clinical and EEG observations were carried out from Nov. 1965 to Aug. 1966, and from March 1967 to July 1967 when she was admitted to our clinic. The results are breifly summarized as follows. The stuporous state which presented mutism and akinesia as the principal symptom was difficult to differentiate from the stupor observable in schizophrenia, and it developed in a day or two at the onset, which lasted for about two weeks and then was alleviated. During this period of episodes she showed no noteworthy symptom of disturbed consciousness and she could recall what had happened to her precisely. Her EEG revealed that paroxysmal abnormal waves characterized by spike wave were inhibited during the stuporous state, but in the stage of remission paroxysmal abnormal waves appeared spontaneously and were activated easily by hyperventilation. This stuporous state could be alleviated transiently by the administration of amytal sodium, and also with a large dose of valium it was improved. On the contrary, anti-epileptic agents had no effect at all on the stuporous state. From the characteristic features of the psychotic state, this case could be construed as a type of atypical psychosis, but paroxysmal abnomality on EEG was similar to that of epilepsy, and so this was the case that had clearly shown to stand on the boundary line between atypical psychosis and epilepsy. Therefore, it seemed that epileptic factors of atypical psychosis should be dicided only after long, continuous observations of the case. Some discussion was made on physiological mechanism inducing a stuporous state. Namely, the mechanism that induced a stuporous state seemed to have a close relation to the excitation of system which tried to inhibit the abnormal EEG, and this system was provably the reticular formation system of the midbrain.
kn-abstract=症例は13才女子.患者の7親等にあたる父系に精神病者があつたというが遺伝歴の詳細は不明.既往歴に特記すべきものはない.本症例に招来した前後7回の昏迷状態と,その他幻覚妄想の表面化した,昏迷状態と異なる状態像をあわせ観察し,発病より入院に至る経過,及び前後2回の入院の経過を詳述した.昏迷状態はつよい無動無言を主兆とする分裂病性昏迷と区別のつかないもので,始まりは急で1日を境にして訪れ,2週間前後続き寛解をみる.この間認むべき意識障害はなく,患者は些細な出来事迄すべてを想起できる.前後18回の脳波による継時的観察を行なつた結果,昏迷状態下では,棘波を中心とする発作性異常波は抑制され,寛解期にはこれが出現しやすい傾向を認めた.昏迷状態はAmytal sodiumで,一時的ではあるが劇的に改善され, Valiumの大量内服でも臨床像を改善できた.しかし抗てんかん剤は,むしろ昏迷状態には奏効しなかつた.本症は精神病像からは非定型精神病群の1型としてみられるが,発作波の消長からは,てんかんにみられる所見と同一の傾向を有し,両者を結ぶ1点を鮮やかに示した1例であつた.非定型精神病のてんかん性要因はかかる症例の継時的観察から決定されるべきものであると考えた.その他昏迷状態の出現と,発作波の消長に関し,若干の生理学的推論を試み,考察を加えた.
en-copyright=
kn-copyright=

en-aut-name=HosokawaK.
en-aut-sei=Hosokawa
en-aut-mei=K.
kn-aut-name=細川清
kn-aut-sei=細川
kn-aut-mei=清
aut-affil-num=1
ORCID=

en-aut-name=NishimuraS.
en-aut-sei=Nishimura
en-aut-mei=S.
kn-aut-name=西村幸子
kn-aut-sei=西村
kn-aut-mei=幸子
aut-affil-num=2
ORCID=

en-aut-name=IkedaH.
en-aut-sei=Ikeda
en-aut-mei=H.
kn-aut-name=池田久男
kn-aut-sei=池田
kn-aut-mei=久男
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学神経精神医学教室

affil-num=2
en-affil=
kn-affil=岡山大学神経精神医学教室

affil-num=3
en-affil=
kn-affil=岡山大学神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=39
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on Profound Hypothermia with Special Reference to Large Volume Hemodilution Perfusion
kn-title=超低体温法の研究―とくに大量稀釈灌流冷却法について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Study on profound hypothermia with aid of extracoporeal circulation with large volume hemodilution using 20cc/Kg of LMWD in 5% dextrose as diluents, was performed. Expermitents were devided into four groups; whole blood group, 20% hemodilution group and 70% hemodilution group. In 50% and 70% group, the perfusion cooling was initiated with 20% diluted blood and at 25℃ of esophagno temparature (E. T.) the perfused blood was partially replaced with diluents, resulting in 50% hemodilution or 70% hemodilution. On rewarming the large volume hemodilution was adjusted to 20% by replacing with fresh heparinized blood at 25℃ of E. T. The results obtained were as follows. 1) Four of 14 cases of 70% hemodilution group were died of pulmonary edema at the end of perfusion. Two of 14 cases survived inlong term. One of 5 cases of 50% hemodilution group survived long term and others of all group were died within 24 hours post perfusion. 2) High grade metabolic acidosis occured in 50% and 70% hemodilution group at 10℃ of E. T. but by replacing with fresh heparinized blood at 25℃ of E. T. was improved. In several cases of 50% and 70% hemodilution group it still continued at the end of perfusion. 3) In all cases arterial PO(2) was kept higer than normal value during the whole perfusion. 4) Serum Na and K concentration were not changed during perfusion with whole blood below 25 C of E. T. 5) Blood pooling volume was increased higher in whole blood group than in hemodilution groups. No significant difference was found among all hemodilution groups. 6) There was no significant change of arterial blood viscosity between 50% and 70 group during perfusion. In whole blood group, viscosity was increased higher on cooling and decreased on rewarming. In 20% hemodilution group, viscosity was increased relatively higher on cooling and decreased to preoperative value on rewarming. 7) In whole blood group blood flow in carotid artery maintained 32% of the preoperative value at 10℃ of E. T. when blood pressure was 39% of the preoperative level. In 70% hemodilution group; the flow and pressure were 42% and 26% of the preoperative values respectively. 8) From the results of the studies optimal hemodilution ratio below 26℃ of E. T. was thought to be between 20% and 50% 9) Clinical study on profound hypothermia were performed in 12 cases by closed or open chest method with 35-40% hemodilution below 25℃ of E, T. Three of 12 cases were not awake after perfusion but in no cases was profound hypothermia ineriminated as being responsible for the death of the patients.
en-copyright=
kn-copyright=

en-aut-name=HujitaYukio
en-aut-sei=Hujita
en-aut-mei=Yukio
kn-aut-name=藤田幸男
kn-aut-sei=藤田
kn-aut-mei=幸男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=17
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and Clinical Study on Prolonged Extracorporeal Circulation
kn-title=長時間体外循環の実験的,臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Effects of prolonged extracorporeal circulation lasting four hours on acid-base balance were studied on dogs. Following results were obtained. 1) High flow perfusion is superior to low flow in all aspects. 2) Low molecular weight dextran is effective to prevent peripheral intravascular pooling of blood resulting in steady venous return, to maintain high flow rate and normal blood pressure, and also to inhibit increase in excess lactate. Dilution rate ranging from 15 to 25 per cent is pertinent. 3) Correction of pH with either sodium bicarbonate or Tris-buffer is preferable to compensation by respiratory alkalosis. 4) Survival time of the experimental animals can be prologed by blood replacement with fresh blood at the termination of the perfusion. However, no experimental animals survived the experiment. The same was studied on patients who underwent open heart surgery. All survived the operation and the results were as follows. 1) The metabolic changes are most prominent immediately after the perfusion and a tendency to recover appears 3 hours after the procedure. The return to normal condition is accomplished later than 5 hours after the perfusion. 2) Recovery of the various factors concerning with the acid-base balance (pH, pCO(2), baseexcess, lactids, excess lactate) is delayed proportionately to the prolongation of the perfusion time.
en-copyright=
kn-copyright=

en-aut-name=IwasaShigeo
en-aut-sei=Iwasa
en-aut-mei=Shigeo
kn-aut-name=岩浅茂夫
kn-aut-sei=岩浅
kn-aut-mei=茂夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Hygienic Study on Water Pollution by Industrial Progress at Port Mizushima Part Ⅱ A Device of Triangle Co-ordinates as a Method for Evaluation of the Water Pollution
kn-title=臨海工業地帯開発に伴う水島港海水の衛生学的調査研究 第Ⅱ報 三角座標による海水汚染の評価に関する考案
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Port Mizushima has been artificially modified during the development of industries. The shape is long and narrow like a canal where no stream ispouring into. The pollution of sea water of the port was investigated for six years and the results were reported in Peport (1). In this report, the auther has devised a method to evaluate the degree of the sea pollution using a system of triangle co-ordinates. The first axis (X) shows places, the second (Y) years and the third (Z) degrees of pollution expressed by disorbed oxygen (DO), chemical oxygen demand (COD). biochemical oxygen demand (BOD) and iodine consumptions. This device has been proved possible to evaluate the degree of pollution simultaneously concerning places, laps of years. He has shown the changing patterns of the sea pollution at Port Mizushima as a whole using this triangle co-ordinates.
en-copyright=
kn-copyright=

en-aut-name=MaruyaHiroshi
en-aut-sei=Maruya
en-aut-mei=Hiroshi
kn-aut-name=丸屋博
kn-aut-sei=丸屋
kn-aut-mei=博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Hygienic Study on Water Pollution by Industrial Progress at Port Mizushima Part Ⅰ The Actual Status of the Pollution
kn-title=臨海工業地帯開発に伴う水島港海水の衛生学的調査研究（第1報）水島港に於ける海水汚染の実態
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=At Port Mizushima in Okayama Prefecture as a center of an heavy industrial area in the Seto Inland Sea, many factories have been built and more are in construction for the future progress. This industrial progress has brought water pollution which is one of the public nuisances, a serious problem from the stand point of public health. The anther has investigated the actual feature of the pollution of sea water in this port for six years. The results ware as follows: (1) Water at this port area has been polluted year by year during last six years. (2) The degree of the pollution changes by places: at the innermost the most serious and the entrance the least. (3) At the low-tide water was more polluted than high-water.(4) Industrial wastes were investigated and some of them were out of hygienic criteria.
en-copyright=
kn-copyright=

en-aut-name=MaruyaHiroshi
en-aut-sei=Maruya
en-aut-mei=Hiroshi
kn-aut-name=丸屋博
kn-aut-sei=丸屋
kn-aut-mei=博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学衛生学教室
END