start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1345 end-page=1353 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Intestinal Absorption of Heterogeneous Proteins 2. Experimental Studies on Intestinal Absorption of heterogeneous protein in the Rabbit kn-title=異種蛋白の消化管吸収に関する免疫血清学的研究 第2編 実験的肝障害時の異種蛋白の消化管吸収について en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study presented an immunoserological estimate of the intestinal absorption by oral administration of egg-white in experimental rabbits. The results were as follows; 1. By repeated oral administration of egg-white in rabbits, a decreased intestinal absorption of egg-white was presented, On the contraly, the rabbits being injected with CCl(4) intracutaneously an showed slightly an increased intestinal absorption of egg-white. Increased egg-white antigens in peripheral blood was considered to result from the disorder of intestinal absorption activity. 2. There was no close relationship between the circulating antibody to egg-white and a decreased mobility of red cell electrophoresis. This finding suggested that there was few possibility of egg-white antigen-red cell binding in vivo. 3. In the phase contrast-microscopic findings of the liver cell from the rabbits with or without liver damage with CCl after several ingestion of egg-white, changes of liver cell (swelling of cytoplasma and mitochondria etc.) were observed remarkably in the Tyrode solution to which the correspondent antibody added beforehand. These findingd was considered to result from the sensitization with egg-white after oral administration of egg-white. en-copyright= kn-copyright= en-aut-name=TakayamaAriyasu en-aut-sei=Takayama en-aut-mei=Ariyasu kn-aut-name=高山有泰 kn-aut-sei=高山 kn-aut-mei=有泰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1337 end-page=1344 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Intestinal Adsorption of Heterogeneous Proteins T. Clinical Observations on Intestinal Absorption of Food Peoteins in Liver Diseases kn-title=異種蛋白の消化管吸収に関する免疫血清学的研究 第1編 肝疾患における異種蛋白の消化管吸収について en-subtitle= kn-subtitle= en-abstract= kn-abstract=This work dealed with the intestinal absorption after oral administration of food proteins (Cow's milk, egg-white, beef and chicken) in cases with liver diaeaaes. The results were as follows: 1. Sere from cases with the liver function disorder were largely positive in circulating antibodies to food proteins, since in the majority of cases with the compensated liver function circulating antibodies to food proteins were almost negative. These cases with positive food protein antibodies showed no allergic gastroenteropathia. 2. Cases with circulating antibodies to food proteins represented predominatly with drug hypersensitivities, urticaria, contact dermatitis and bronchial asthma. 3. There was no close relationship between circulating antibodies and skin test reactions to food proteins. 4. In cases with positive circulating antibodies to food proteins the possibility of red cell-food protein allergen compound formation was not recoginized by using red cell electrophoresis. en-copyright= kn-copyright= en-aut-name=TakayamaAriyasu en-aut-sei=Takayama en-aut-mei=Ariyasu kn-aut-name=高山有泰 kn-aut-sei=高山 kn-aut-mei=有泰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1317 end-page=1336 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental stndies on Open Heart Surgery by Profound Hypothermia. With a Special Reference to Physiologic Observations and Histologic Changes of Internal Organs kn-title=超低体温法による開心術の研究 特に生理的観察ならびに主要臓器の病理組織学的変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Experimental studies of profound hypothermia were performed on dogs. Rapid cooling and rewarming were obtained by means of extracorporeal circulation combined with heat exchanger. Some physiologic and pathohistologic changes of several organs were followed at the various stages through the experiment. Following results were obtained. 1) There were found no marked differences in results between Kay-Anderson machine and bubble type oxygenator. 2) Changes of temperature of internal organs on cooling and rewarming were observed proportionately to vascularity of the given organ, most rapid in liver and most lagging in muscles. Changes of rectal temperature were not constant. 3) Pupils of dogs became dilated on cooling, maximum during circulatory cessation, and retuned to previous size on rewarming. 4) On histologic study of liver, appearance of vecuoles was observed at both stages of cooling and rewarming, which were proved to be neither fat nor glycogen by histochemical examination. They were considered merely watery vacuoles and reversible changes. Marked decreaae of liver glycogen was observed on both cooling and rewarming and its disappearanse was first observed at the vicinity of central vein. 5) Renal congestion and claudy swelling of epithelial cell of renal tubules, especially in proximal part, were prominent, although these changes were considered reversible. 6) Stagnation of blood was a main change found in the histologic study of heart, lung and adrenal gland. It was most prominent in liver, kidney and spleen, however, degeneration or necrosis of the tissue were not found at all. 7) Based on these experimental data, profound hypothermia is considered applicable to the clinical case and better results will be expected with the use of low molecular weight dextran. en-copyright= kn-copyright= en-aut-name=KimuraHiroshi en-aut-sei=Kimura en-aut-mei=Hiroshi kn-aut-name=木村博 kn-aut-sei=木村 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1291 end-page=1316 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Reparation of the Lymph Drainage of the Stomach after Removal of Lymph Nodes and Lymphatics Part 2. Macroscopic Findings of the Reparation of the Lymph Drainage of the Stomach after Removal of Lymph Nodes and Lymphatics kn-title=胃リンパ路廓清術後の修復に関する実験的研究 第2編 胃リンパ路廓清術後の修復に関する形態学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) The lymphatics and lymph nodes which concerned the drainage of the certain parts of the stomach were visualized with dye solution and removed in nineteen adult mongrel dogs. About two months after the operation, the reparation of the lymph drainage of the stomach was precisely studied. 2) Oedema was never seen in the stomach or in the other viscera which had been drained by the removed lymph paths. In the operated sites, the tissue loss had been replaced with scar, and neither lymph cyst nor lymphrrhoe was seen. 3) The removed lymph routs were, in general, reconstructed in those normal courses which had been visualized preoperatively, such as the left gastric, the right gastric, the right gastroepiploic, the left gastroepiploic and the fundic rout. However, the lymph drainage through the right gastric rout was seldom reconstructed. 4) Usually the lymph drainage was repaired postoperatively through the normal routs. Sometimes, abnormal routs appeared besides the normal routs. 5) Most of the postoperative routs were reconstructed in the preoperative course, but a few were visualized only postoperatively, which had not been visualized preoperatively. 6) The reconstruction of the preoperatively visualized routs was established by opening of traversing paths through the operated site or of circumventing paths in the pre-existing net of lymphatics. After removal of the lymph paths adjacent to the stomach the reconstruction depended mainly upon circumvention, while after removal of the distant lymph paths mainly upon opening of traversing paths. Commonly to both types of removal, the lymph drainage was reconstructed usually in the original courses as to the regions distal and proximal to the removed site. 7) Postoperative opening of the normal routs which had not been visualized preopeoatively was established through circumvention of the removed site via the pre-existing net of anastomosing lymphatics in the stomach wall. 8) In the postoperative lymph paths through the normal routs, visualization showed often such morphologic changes of lymphatics as increase in number and dilatation and retrograde migration of dye. These changes appeared to respond to increased resistance in lymph flow. 9) Abnormal lymph rout through anastomosing lymphatics, usually not visualized but pre-existing, appeared infrequently. Some of the lymphatics which drained the greater curvature side of the body via the left gastroepiploic rout passed onto the spleno-mesenteric ligament, a part of the greater omentum, and reached to the middle colic lymph nodes. 10) When adjacent organs adhered to the removed sites, new formation of connection between the gastric lymphatics and the lymphatics of the adherent organs appeared in an higher percentage only in firm adhesions, and never in loose adhesions. New connection of lymphatics between the gastric remnant and the anastomosed jejunum through gastrojejunostomy stoma was infrequently visualized. Several abnormal lymph routs were established through such new formation of connection between the lymphatics of adherent organs. Of these new routs, the ones through the pancreas, the anastomosed jejunum or the posterior leaf of the greater omentum terminated in the truncus intestinalis or in the rete intestinale, and the one via the right costal part of the diaphragm passed through the sternal lymph node. en-copyright= kn-copyright= en-aut-name=HiroseShuhei en-aut-sei=Hirose en-aut-mei=Shuhei kn-aut-name=広瀬周平 kn-aut-sei=広瀬 kn-aut-mei=周平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1267 end-page=1289 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Reparation of the Lymph Drainage of the Stomach after Removal of Lymph Nodes and Lymphatics Part 1. Anatomical Findings of the Lymph System of the Stomach in the Dog kn-title=胃リンパ路廓清術後の修復に関する実験的研究 第1編 解剖学的犬胃リンパ路に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) For clarifying the accurate information about the normal anatomy of the gastric lymph nodes and lymphatics of the dog, twenty adult mongrel dogs were utilized, and the gastric lymph nodes and lymphatics were visualized with direct sky blue or india ink under as physiological condition as possible. 2) The lymph nodes found in the upper abdomen of the dog were classified into these fifteen groups: lymphonodi gastrici superiores, ln. suprapyloricus, lnn. subpylorici, hilus-lienis lymph node, lnn. pancreaticolienales, lnn. coeliaci sinistri, ln. coeliacus superioris, ln. coeliacus dexter, ln. retropyloricus, lnn. pancreaticoduodenales, porta-hepatis lymph node, lnn. colici dextri, lnn. colici medii, lnn. mesenterici and lnn. lumbales superiores. Of these, the superior gastric nodes, the suprapyloric node, the subpyloric nodes, the hilus-lienis node, the pancreaticolienal nodes, the left coeliac nodes, the superior coeliac node, the right coeliac node, the retropyloric node, the pancreaticoduodenal nodes, the right colic nodes and the superior lumbar nodes received lymph from the stomach. The suprapyloric node and the hilus-lienis node were rarely present, and the right colic nodes, though constantly present, received a little of the gastric lymph only infrequently. 3) The left coeliac nodes, the superior coeliac node, the right coeliac node, the retropyloric node and the pancreaticoduodenal nodes were considered as the terminal lymph nodes of the stomach. 4) The lymphatics of the stomach were classified into these five routs: the left gastric, the right gastric, the right gastroepiploic, the left gastroepiploic and the fundic rout. 5) The lymphatics of the cardiac portion followed the left gastric rout, and those of the fundus followed the left gastric and the fundic rout. The lymphatics of the lesser curvature side of the body and those of the same side of the pyloric portion followed the left gastric and the right gastric rout. The lymphatics of the greater curvature side of the body took the left gastroepiploic and the fundic rout, and those of the same side of the pyloric portion took the right gastroepiploic rout. 6) The terminal lymph nodes were common to the lymphatics of the right gastric rout and to those of the right gastroepiploic rout. These two groups of lymphatics terminated in the retropyloric node or in the right coeliac node, and, partially, often in the pancreaticoduodenal nodes and rarely in the right colic nodes. They showed resemblance in the course near the terminal lymph nodes. 7) It was emphasized that the retropyloric node was the main terminal lymphatic station of the right gastric and the right gastroepiploic rout, and, in relation to the fact above, the descriptions formerly reported about the right coeliac node were criticized. 8) The efferent lymphatics from the terminal lymph nodes of the stomach and from the lymph nodes which drained the viscera supplied by the superior mesenteric artery (the right colic, the middle colic and the mesenteric nodes) joined together complicatedly. These efferent lymphatics formed a single trunk, the truncus intestinalis, beside the root of the superior mesenteric artery in thirty three per cent, and in sixty seven per cent formed a network, the rete intestinale, around the root of the artery. en-copyright= kn-copyright= en-aut-name=HiroseShuhei en-aut-sei=Hirose en-aut-mei=Shuhei kn-aut-name=広瀬周平 kn-aut-sei=広瀬 kn-aut-mei=周平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1257 end-page=1265 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Treatment of Bronchial Asthma with Chloroquine and it's Pharmacological Actions Part. 3. Studies on Fibroblast-inhibiting Action of Chloroquine kn-title=クロロキンによる気管支喘息の臨床的並びに薬理学的研究 第3編 クロロキンの線維芽細胞抑制作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of chloroquine on the growth and oxygen consumption of cultured fibroblasts were investigated. 1) Chloroquine diphosphate inhibited the growth of chick embryo heart fibroblasts in tissue culture medium containing 5γ/dl and also other chloroquine derivatives such as chloroquine diorotate, chloroquine chondroitine sulfate, chloroquine polygalacturonate showed same result in medium containing 2γ/dl of chloroquine too. 2) Furthermore, chloroquine diphosphate inhibited the growth of L strain cell in tissue culture medium containing 2γ/dl of chloroquine. 3) Effects of chloroquine on respiratory functions were observed in L strain cells with using Warburg's apparate, showing a decrease of oxygen consumption of the cells in the concertration of 2γ/dl of chloroquine. 4) Also fibroblast-inhibiting action was observed by administrating several drugs in the cultured chick embryo heart fibroblasts. The growth of the cells was not influenced by ACTH administration but several drugs such as tetrahydroxyquinone, phytonadione or oxophenarsine hydrochloride, arsphenamine sodium as well as prednisolone showed considerably potent fibroblast-inhibiting action. As mentioned above marked inhibition of the growth of fibroblasts was definitely demonstrated by chloroquine administration and this fibroblast-inhibiting action of chloroquine is thought to be important mechanisum of action to the treatment of bronchial asthma with lung fibrosis. en-copyright= kn-copyright= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室/大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1245 end-page=1256 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Treatment of Bronchial Asthma with Chloroquine and it's Pharmacological Actions Part. 2. Studies on Mechanism of Action of Chloroquine in Treatment of Bronchial Asthma kn-title=クロロキンによる気管支喘息の臨床的並びに薬理学的研究 第2編 気管支喘息に対するクロロキンの作用機序に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to clarify the mechanism of action of chloroquine, pharmacological actions of the drug were studied in the resected intestine of guinea pig, inflammatory edema caused on the paw of rat and passive cutaneous anaphylaxis in guinea pig. 1) In the study of the resected intestine of guinea pig, anti-histamine action of chloroquine was noted by showing that the drug had complete antagonistic action against the intestinal contraction caused by histamine administration. While chloroquine did not show anti-serotonine action; contraction of the intestine by serotonine was not influenced at all by the drug administration. 2) In the study of making inflammatory edema on the paw of rat, chloroquine showed inhibitory effect to the edema caused by histamine administration. However, the drug showed scarcely inhibitory effect to the serotonine and dextran edema. Other signs of antinflammatory effct of chloroqine was demonstrated by such finding that remarkable anti-inflammatory inhibition was revealed by the drug administration to the edema caused by anti-serum allergic inflammation. 3) Furthermore, chloroquine showed marked anti-allergic action on passive cutaneous anaphylaxis of guinea pig. Above mentioned pharmacological actions of chloroquine such as anti-histamine, anti-inflammatory and anti-allergic action as well as other actions of chloroquine such as relaxation of the smooth muscle, fibroblast-inhibiting action, inactivity of the antibody or improvement of general constitution are thought to be very important mechanism of actions to the treatment of bronchial asthma. en-copyright= kn-copyright= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室/大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1233 end-page=1244 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Treatment of Bronchial Asthma with Chloroquine and it's Pharmacological Actions Part. 1. Studies on Treatment of Bronchial Asthma with Chloroquine kn-title=クロロキンによる気管支喘息の臨床的並びに薬理学的研究 第1編 クロロキンによる気管支喘息の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chloroquine was employed in treatment of bronchial asthma and clinical follow up performed in 634 cases, some of which had been observed for 4 years. 1) Clinical effctiveness was obtained in 91.3% of the patients with this treatment regimen and disappearance of asthmatic attack was observed in 42.7% of the all cases. 2) Equally effective results were obtained by this treatment regimen in all cases with asthmatic attacks in spite of many different factors of the disease such as sex, age, duration of the disease, type of the disease or symptoms. 3) Clinical therapeutic effectiveness was obtained within one month in most of cases and a positive correlation was noted between effectiveness and treatment duration. 4) To severely attacked patient, an excellent therapeutic results was obtained from the beginning of treatment by combined therapy with prednisolone, which was attempted to supplement the late effctiveness of chloroquine. 5) The patients resulting satisfactory course by long term administration of the drug were followed up by decreasing dosage or discontinuing of the drug, showing good result in most cases of them. 6) Side effects of the drug was minimal and transient. There were no discontinued cases by side effects. Main side effects were gastrointestinal, ocular and neurological symptoms. But this treatment regimen brought no detestable side effects on the hematopoetic organ, liver or retina. 7) The therapeutic effectiveness of this treatment was supported by improved pulmonary function tests of the patients. 8) Fate and organ distribution of chloroquine were observed in vivo. A constant plasma level was kept after one week administration of the drug, which was distributed in the liver, spleen and lungs in high concentration. The drug was disappeared considerably fast from plasma by discontinuation of administration. It is clear from above data that this is an excellent treatment of the bronchial asthma and long term oral administration of chloroquine with small dosage induces cure or improvement of the bronchial asthma, without any detestable side effects. en-copyright= kn-copyright= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室/大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1223 end-page=1231 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Humoral Resistant Factors and Cancer 3. Action mechanism of the drugs that possess ability to raise the serum properdin level and their anticancer effects kn-title=液性抵抗因子と癌に関する実験的研究 第3編 血清properdin上昇作用および制癌性を有する薬剤の作用機序に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose to elucidate action mechanism of pantothenic acid (PaA) and γ-aminobutyric acid (GABA) that possess the ability to raise the serum properdin level and show anticancer effect when administered to cancer-bearing animals, a series of in vivo and in vitro experiments was carried out and the following results were obtained. 1. PaA, when give to normal mice, accelerates the liver catalase activity, and when it is administered alone or concurrently with anticancer agent to cancer-bearing mice, the catalase activity is enhanced to a still greater extent. 2. PaA, GABA, Orotic acid, Thio-TEPA, and mitomycin C have been found to accelerate the anaerobic glycolysis of Ehrlich carcinoma cells but carzinophilin rather suppresses it. 3. The effect of PaA and GABA on the serum properdin level resembles closely to that of ACTH, but differs from the effect of cortisone in that the high level of the serum properdin is sustained even after the completion of drug administration. 4. GABA, ACTH, and PaA have the ability to prolong the survival time of cancer-bearing mice, but cortisone rather aggravates cancer. 5. From these findings it is concluded that PaA and GABA do not act directly on tumor cells but act on the pituitary body by way of the higher nervous center while on the other hand, these drugs act on the cells of host, especially those of the reticuloendothelial system and liver, thus potentiating anticancer factors including the serum properdin level. en-copyright= kn-copyright= en-aut-name=MiyakeKazutada en-aut-sei=Miyake en-aut-mei=Kazutada kn-aut-name=三宅一忠 kn-aut-sei=三宅 kn-aut-mei=一忠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1213 end-page=1222 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Humoral Resistant Factors and Cancer 2. Effects of the agents, that elevate the serum properdin level, on cancer-bearing animals kn-title=液性抵抗因子と癌に関する実験的研究 第2編 血清properdin上昇作用を有する薬剤の担癌生体におよぼす影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to see the effects cf the drugs that elevate the serum properdin level on cancerbearing animals, pantothenic acid (PaA), GABA, orotic acid (OrA), and vitamin K were given singly to mice bearing Ehrlich ascites carcinoma or these were concurrently administered with such anticancer drugs as Thio-TEPA and mitomycin C. The results of this study are given in the following. 1. The administration of PaA or GABA alone not only prevents the fall in the serum properdin level but also prolongs the survival time of cancer bearing animals as compared with the control group not given such treatment. When these drugs are used concurrently with the anticancer agents mentioned above, the anticancer effect and the preventive effect on the diminution in the properdin level are further enhanced. 2. Orotic acid and vitamin K have been found to have not much effect as to prolong the survival time nor to prevent the fall in the serum properdin level, whether given alone or concurrently with the anticancer agents. 3. In the concurrent use of anticancer agents, it has been demonstrated that a greater effect of prolongation of survival time as well as prevention of the fall in the serum properdin level is attained when the properdin level-raising agent is administered prior to the administration of anticancer drug. 4. Although properdin seems to be one of the anticancer factors, the anticancer effect of these drugs cannot be directly connected to the action to elevate properdin level. en-copyright= kn-copyright= en-aut-name=MiyakeKazutada en-aut-sei=Miyake en-aut-mei=Kazutada kn-aut-name=三宅一忠 kn-aut-sei=三宅 kn-aut-mei=一忠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1195 end-page=1199 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Evaluation of Lipoathledin Ointment On the Superficial Fungal Infections kn-title=リポアスレヂン軟膏の治験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lipoathledin is the fatty acid fractions extracted from x-ray irradiated rabit organs. We applicated 2% Lipoathledin absorption ointment to the superficial fungal infections clinically and following results were obtained. 1) Lipoathledin has obvious antifungal effect. 2) 56 in 67 patients of superficial fungal infections (83.6%) were improved clinically. 3) No significant side effects were observed. en-copyright= kn-copyright= en-aut-name=OomoriSumio en-aut-sei=Oomori en-aut-mei=Sumio kn-aut-name=大森純郎 kn-aut-sei=大森 kn-aut-mei=純郎 aut-affil-num=1 ORCID= en-aut-name=MiyoshiMakoto en-aut-sei=Miyoshi en-aut-mei=Makoto kn-aut-name=三好信 kn-aut-sei=三好 kn-aut-mei=信 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部皮膚科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部皮膚科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1187 end-page=1194 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two Cases of Lupus Erythematosus Disseminatus presenting Psychic and Neurotic Symptoms kn-title=精神・神経症状を呈したLupus Erythematosus disseminatusの2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This communication deals with two cases of lupus erythemetosus disseminatus who presented psychic and neurotic symptoms. We treated them with adrenocorticosteroid hormone and found that the neuro-psychic symptoms were alleviated in parallel with the improvement of somatic conditions. Case 1, 22-year old female: On the basis of the findings of cerebro-spinal fluid and those of fundus of the eye we judged the case to be of a primary injury on the central nervous system with circulatory disturbances brought about by inflammatory mechanism. Her principal psychic symptoms were anxiety, excitation and amnesia accompanied with clouding of consciousness and change in her personality. Case 2, 28-year old female: This was a typically acute, extrinsic inflammatory type, whose main psychic symptoms were consisted of clouding of consciousness, illusion and hallucination. The report was made about the course taken by these cases, and some considerations were given on available literature. en-copyright= kn-copyright= en-aut-name=YokoyamaShigeo en-aut-sei=Yokoyama en-aut-mei=Shigeo kn-aut-name=横山茂生 kn-aut-sei=横山 kn-aut-mei=茂生 aut-affil-num=1 ORCID= en-aut-name=HosokawaKiyoshi en-aut-sei=Hosokawa en-aut-mei=Kiyoshi kn-aut-name=細川清 kn-aut-sei=細川 kn-aut-mei=清 aut-affil-num=2 ORCID= en-aut-name=MatsudaKiyoshi en-aut-sei=Matsuda en-aut-mei=Kiyoshi kn-aut-name=松田清 kn-aut-sei=松田 kn-aut-mei=清 aut-affil-num=3 ORCID= en-aut-name=MiiTakashi en-aut-sei=Mii en-aut-mei=Takashi kn-aut-name=三井尚 kn-aut-sei=三井 kn-aut-mei=尚 aut-affil-num=4 ORCID= en-aut-name=EdamatsuKazuyasu en-aut-sei=Edamatsu en-aut-mei=Kazuyasu kn-aut-name=枝松一安 kn-aut-sei=枝松 kn-aut-mei=一安 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=4 en-affil= kn-affil=財団法人慈圭会慈圭病院 affil-num=5 en-affil= kn-affil=財団法人慈圭会慈圭病院 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=8-9 article-no= start-page=1169 end-page=1173 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental studies on the leukemogenesis in mice. Part 2. Effects of thymectomy and splenectomy on the incidence of leukemia by X-ray-irradiation in RF mice kn-title=マウス白血病の発生機構に関する実験的研究 第2編 X線照射によるRF系マウス白血病の発生に及ぼす胸腺及び脾摘出の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the object to elucidate the role played by thymus and spleen in radiation leukemogenesis, effects of thymectomy and splenectomy on the induction of leukemia in RF mice by X-ray-irradiation were studied, dividing lymphocytic leukemia into thymic type and non-thymic type. As the result it has been clarified that thymectomy mainly inhibits the occurrence of the thymic type lymphocytic leukemia while splenectomy on the occurrence of the non-thymic type lymphocytic leukemia. As for the mechanism of this inhibition, a discussion was made on the significance of thymus and spleen as the organs that are constituted of the cells most susceptible to neoplastic transformation. After both thymectomy and splenectomy not a single mouse developed leukemia when exposed to X-ray-irradiation. en-copyright= kn-copyright= en-aut-name=KunisadaMineo en-aut-sei=Kunisada en-aut-mei=Mineo kn-aut-name=国定岑生 kn-aut-sei=国定 kn-aut-mei=岑生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END