start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=965
end-page=979
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Relations between Reticulo-endothelial System, Tumor and X-Rays
kn-title=網内系機能と悪性腫瘍並びに放射線との関係に就いて 第2編 実験腫瘍（吉田肉腫），網内系，放射線との相関に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vol. Ⅰ The effect given to the blood picture and the function of the reticulo-endothelial system using reticulo-endothelial system blocked by the Indian ink method and also the tumor growth, survival rates and metastasis after transplanting Yoshida sarcoma cells intramusclarlly in the albino-rat thigh were examined. Experiment was done to find out the relations between the reticulo-endothelial system and the latter, which the results were as follows: 1) As formerly reported, the reticulo-endothelial system blocked by the Indian ink method showed anaemia by a certain quantity of ink but it passed by and restored gradually. It showed parallel relation with the function of the reticulo-endothelial system. 2) If the ink was small in quantity, it did not give much effects to tumor growth though the function of the reticulo-endothelial system was low. 3) The reticulo-endothelial system blocked by the Indian ink method had a connection with the growth of tumor to some extent and gave pictures which accelerated its growth. And stromal reaction near the tumor was weak. 4) Using the reticulo-endothelial system blocked by the Indian ink method, the appearance of the reticulo-endothelial cells in the tumor tissue was less compared with the control. Vol. Ⅱ Chapter 1 To prove the reaction on the X-rays of the reticulo-endothelial system and tumor growths, the author made an experiment based on the idea of tumor-host relationship. X-rays, 600r a day continuing 5 days totalling 3000r, were irradiated into the tumor bed, albino-rat thigh, and then Yoshida sarcoma cells were transplanted on the irradiated part. The influence against tumor growth, survival rates and metastasis were examined and the effects were found as follows: 1) Compared with the control, the tumor growths were restrained in the order of transplanted groups of the next day after irradiation, transplanted groups of 10 days after irradiation, and transplanted groups of 30 days after irradiation. With the survival rates, life extension could be recognized in the same order. 2) Stromal reaction could be strongly found in pre-irradiated groups, especially in these being transplanted the next day. Reticulo-endothelial cells could be found many compared with the control. Above all, it could be presumed that in case of preoperative irradiation, the part of reticulo-endothelial cells which has not been infiltrated by tumor cells shows protection system by stromal reaction. Chapter 2 When the tumor which was transplanted by Yoshida sarcoma cells became a regular induration; the size, the rise and fall, and the survival rates were examined by irradiating 300r a day for 10 days totalling 3000r. The effect showed that when the function of the reticulo-endothelial system which is one of the living body reaction was irradiated after it was restrained, the irradiation effect was less than the non-treated group. Consequently if the function of the reticulo-endothelial system would be irradiated after it was accelerated, it would obtain satisfactory result to medical treatments.
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邊正忠
kn-aut-sei=田邊
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=959
end-page=964
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=網内系機能と悪性腫瘍並びに放射線との関係に就いて 第1編 墨汁塡塞に依るラッテの血液像，網内系機能並びに吉田肉腫接種後の腫瘍発育，生存率，転移形成に及ぼす影響に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田邊正忠
kn-aut-sei=田邊
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=951
end-page=958
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 3, Electrophoretic Behaviors of Easily Split Off Blood Iron
kn-title=放射性鉄による易分離鉄の研究 第3編 Starch Block Electrophoresisによる血色素易分離鉄の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the purpose of clarifying the significance of E S Fe, starch block electrophoresis of rabbit hemoglobin was been carried out and the following results were obtained. 1. The hemoglobin was separated in three fractions, Ⅰ, Ⅱ and Ⅲ. In the migration distances, these fractions corresponded to Hemoglobin A(1), A(2) and A(3) of adult hemoglobin respectively. 2. E S Fe was detected most in the fraction Ⅲ (largest at mobility), while free iron in that fraction was less than the other fractions. 3. In estimating the ratio of Fe(59)-radioactivity to hemoglobin volume (mg) of the Fe(59) labeled hemoglobin solution in the each fraction eluate, it was noticed that the specific activity of the fraction Ⅲ was less than those of others during 3 weeks after the administration of Fe(59), followed by a significant increase after 6 weeks. It was thought from the above that the hemoglobin in fraction Ⅲ different from that in the other fractions, and that in the early stage was different from that in the later one. 4. The ratio of radioactivities in easily split off iron to that in hemoglobin iron of the same samples as the above increased markedly in the fraction Ⅲ in the early stage, followed by a gradual decrease during 2 weeks and again a tendency of increase at 4 weeks later in the same fraction. 5. It was indicated from these results that the characters of the globin in new formed hemoglobin and aged one were different from that in mature one, and that this difference in the characters was resulted in an increase of E S Fe due to hemoglobin degradation.
en-copyright=
kn-copyright=

en-aut-name=TabuchiHiroshi
en-aut-sei=Tabuchi
en-aut-mei=Hiroshi
kn-aut-name=田渕博司
kn-aut-sei=田渕
kn-aut-mei=博司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=943
end-page=950
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 2. The Significances of Easily Split Off Blood Iron in the Immature Erythrocyte
kn-title=放射性鉄による易分離鉄の研究 第2編 幼若赤血球内易分離鉄の本態について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fe(59)-radioactivities in the both hemin iron fraction(Hemin-Fe(59)) and easily split off iron fraction (E S Fe(59)) of the rabbit erythrocyes obtained in reticulocytosis were determined respectively after incubating them with Fe(59) in vitro. On the other hand, immature rabbit erythrocytes labeled with Fe(59) in vivo were incubated in nonradioactive medium, and the same determinations as the above were carried out. The following results were obtained. 1. Reticulocytes of rabbit uptook considerably Fe(59) during incubation in vitro. 2. Fe(59) uptaken in reticulocyte were quickly utilized to the synthesis of hemin. However, Fe(59) at preceding stage of the synthesis were found to be extracted as false ealily split off iron. 3. With the incubation of reticulocytes for 5 hours in vitro, the E S Fe(59) increased after the synthesis of hemin-Fe(59). 4. In vivo, the E S Fe(59) increased in new formed labeled erythrocytes at 6 to 9 hours after intravenous administration of Fe(59), originating from hemoglobin break-down at that stage.
en-copyright=
kn-copyright=

en-aut-name=TabuchiHiroshi
en-aut-sei=Tabuchi
en-aut-mei=Hiroshi
kn-aut-name=田渕博司
kn-aut-sei=田渕
kn-aut-mei=博司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=935
end-page=942
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 1. The Influences of CO and Reducing Agents on the Yield of Easily Split off Blood Iron in vitro
kn-title=放射性鉄による易分離鉄の研究 第1編 赤血球内易分離鉄に対するCO並びに還元剤の鉄遊離抑制作用について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fe(59)-radioactivities in easily split off iron fraction (E S Fe(59)) of the rabbit erythrocytes labeled with Fe(59) were determined respectively under the each condition saturated with N(2) or CO gas and added with reducing agents such as Na(2)S(2)O(4) or l-ascorbic acid. The following results were obtained. 1. There was no significant difference in the yields of E S Fe(59) between the saturation with N(2) or CO gas and the exporsure to the air. 2. E S Fe(59) under the addition with l-ascorbic acid as reducing agents (E S Fe(59)(asc)) was decreased to 35.8% of the E S Fe(59) in the case exporsed to the air (E S Fe(59)(O(2)), while E S Fe(59) under the addition with Na(2) S(2) O(4) was rather increased. 3. The yield of E S Fe(59) under the addition of l-ascorbic acid in the presence of CO gas (E S Fe(59CO+asc)) was decreased to 23.1% of E S Fe(59)(O(2)). It was thought that the difference between these two yields indicate the artificial products as a result of hemoglobin oxidation. The inhibitory capacity in isolation of iron from hemoglobin was the largest in the presence of l-ascorbic acid and N(2) gas. 4. In the hourly determinations of E S Fe(59) in rabbit erythrocytes in vivo after intravenous administration of Fe(59), E S Fe(59)(CO+asc) was found to be the maximum in the immature cells, the minimum in the mature ones and tended to increase in older ones. These results were found to be same as that of E S Fe(59)(O(2)).
en-copyright=
kn-copyright=

en-aut-name=TabuchiHiroshi
en-aut-sei=Tabuchi
en-aut-mei=Hiroshi
kn-aut-name=田渕博司
kn-aut-sei=田渕
kn-aut-mei=博司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=923
end-page=934
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Viral Tumors cultivated in the embryonated Egg Part Ⅱ. Cultivation of Viral materials isolated from mouse leukemia and mammary cancer
kn-title=ウイルス性腫瘍の発育鶏卵内培養に関する研究 第2編 マウス白血病並びに乳癌より得られたウイルス材料の発育鶏卵内培養
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The viral materials isolated from the spleen of C58 strain mice with myelogenous and lymphocytic leukemia were inoculated on the chorio-allantoic membrane, in the allantoic cavity and in the yolk sac of embryonated eggs. Purification of the viral materials was done by filtration through Berkefeld N filters or emulsification with fluorocarbon. From the observations on the changes of the chorio-allantoic membrane and on the influence of the inoculation to chick embryos, the following results are obtained. 1) Inoculation on the chorio-allantoic membrane. Inoculation of the filtered viral materials caused slight thickning, hyperemia, opacities and edema of the inoculated areas of the chorio-allantoic membrane. but no changes were observed in other embryonic organs. Histologically, the chorio-allantoic mambrane showed proliferation of fibroblasts and epithelial cells and infiltration of monocytoid cells and eosinophils in the interstitial tissue. In the inoculation of the fluorocarbon-purified viral materials from myelogenous and lymphocytic leukemia, the changes of the chorioallantoic membrane were almost the same as findings described above. But in the case of mammary cancer, changes such as thickning, opacities, hyperemia and edema of the inoculated areas of the chorioallantoic membrane were more remarkable and sometimes hemorrhages and tumor-like nodular swellings were also observed. Histologically, proliferation of epithelial cells, fibroblasts and infiltration of eosinophils, lymphoid and monocytoid cells were much more prominent. No pathologic changes of other embryonic organs were observed following inocuration of the viral materials isolated by either method. 2) Inoculation in the allantoic cavity. In all cases, no significant organ changes were observed and no death of the embryos occurred. 3) Inoculation in the yolk sac. Inoculation of the filtered viral materials caused 100 % desth of the embryos by the ninth day after inoculation in the case of myelogenous leukemia, by the twelfth day in lymphocytic lukemia and by the fifth day in mammary cancer.
On the other hand, in the inoculation of the fluorocarbon-purified viral materials, 100 % mortality occurred by the fifth day in myelogenous leukemia and mammary cancer and by the ninth day in lymphocytic leukemia. These varied experimental results are considered to be related to the differences in strains and virulencies of the viruses.
en-copyright=
kn-copyright=

en-aut-name=IshihamaShinzi
en-aut-sei=Ishihama
en-aut-mei=Shinzi
kn-aut-name=石濱真治
kn-aut-sei=石濱
kn-aut-mei=真治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=913
end-page=921
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Viral Tumors cultivated in the embryonated Egg Part 1. Cultivation of mouse leukemia and mammary cancer in the embryonated egg
kn-title=ウイルス性腫瘍の発育鶏卵内培養に関する研究 第1編 マウス白血病並びに乳癌組織の発育鶏卵内培養
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The splenic tissue of C58 strain mice with myelogenous or lymphocytic leukemia, and mammary cancer tissue of C3H strain mice were transplanted on the chorio allantoic membrane, in the allantoic cavity and in the yolk sac of embryonated eggs. Observations on the growth of the transplanted tumors and their influences on the embryos have provided the following results. I) Transplantation on the chorio-allantoic membrane. In the case of myelogenous leukemia and mammary cancer, growth of the transplanted tissue and a reactive response of various kinds of host cells in the surrounding chorio-allantoic membrane were observed. While these changes were slight in the ease of lymphocytic leukemia. The transplanted splenic tissue of myelogenous leukemia was successfully back-transplantable after five days' cultivation in the heterologous host. As controls, normal splenic tissue of C58 strain mice were similarly transplanted, but soon regressed in the course of the cultivation, 2) Transplantation in the allantoic cavity. Grossly and histologically, no signficant changes were observed in all cases. 3) Transplantation in the volk sac. The chick embryos died in 100% of cases in the transplantation of myelogenous leukemia and mammary cancer. On the other hand, the death rate was reduced to 50% in the case of lymphocytic leukemia. In the case of mammary cancer some localized necrosis was observed in the liver of the embryos.
en-copyright=
kn-copyright=

en-aut-name=IshihamaShinzi
en-aut-sei=Ishihama
en-aut-mei=Shinzi
kn-aut-name=石濱真治
kn-aut-sei=石濱
kn-aut-mei=真治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=903
end-page=912
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 3. Megakaryocytes in the Human Spleen
kn-title=脾組織培養法による脾内巨核球に関する研究 第3編 ヒト脾内巨核球について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Followings are the results of studies by our clinical tissue culture method mainly on motility and ability of platelet formation of megakaryocytes in the spleen of human embryo and a patient with osteomyelofibrosis. 1) Megakaryocytes are always found in the spleen of human embryo, and no significant morphological differences are noted from those in the bone marrow. 2) Deformated movement, pseudopodial movement, and tentacle formation for the platelet formation are noted on megakaryocytes in the spleen of human embryos. As for functions of megakaryocytes, motility and ability of the platelet formation are significantly found at 4 month of age, but are remarkably decreased after 5 month of age. 3) A correlation is noted in human embryo between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other. 4) In a patient with osteomyelofibrosis, megakaryocytes found in the spleen show a remarkable decrease in the functions.
en-copyright=
kn-copyright=

en-aut-name=HanzawaAtsumasa
en-aut-sei=Hanzawa
en-aut-mei=Atsumasa
kn-aut-name=半澤敦正
kn-aut-sei=半澤
kn-aut-mei=敦正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=893
end-page=902
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 2. Megakaryocytes in the Spleen of the Carnivora (Dogs and Cats)
kn-title=脾組織培養法による脾内巨核球に関する研究 第2編 食肉類（イヌ及びネコ）脾内巨核球について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Among the mammalia, the carnivora (dogs and cats) was chosen to make studies mainly by our clinical tissue culture method on megakaryocytes in the spleen of the successive stage from newborn up to adult. Followings are the results. 1) In dogs and cats, megakaryocytes are found in the spleen from newborn up to adult. During newborn, dogs have more megakaryocytes in the spleen than cats, but the reverse comes to be true during the following stages. 2) In dogs and cats, no significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have motility as those in the bone marrow. Ability of platelet separation from megakaryocytes in the spleen are found during newborn and infancy (1 month of age) in dogs, and during newborn in cats. During the successive stages of growth, the functions of megakaryocytes are noted to be decreased. 4) A correlation is noted in dogs and cats between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other.
en-copyright=
kn-copyright=

en-aut-name=HanzawaAtsumasa
en-aut-sei=Hanzawa
en-aut-mei=Atsumasa
kn-aut-name=半澤敦正
kn-aut-sei=半澤
kn-aut-mei=敦正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=877
end-page=891
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 1. Megakaryocytes in the Spleen of the Rodent (Mice, Rats, Guinea Pigs, and Rabbits)
kn-title=脾組織培養法による脾内巨核球に関する研究 第1編 齧歯類（マウス，ラツテ，モルモツト，及び家兎）脾内巨核球について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Followings are the results of studies on megakaryocytes in the spleen of the rodent of the successive stages from the embryonic stage up to the adult. 1) In the rodent, megakaryocytes are always found in the spleen from the embryonic stage up to the adult, especially in large numbers in the infant. Among the rodent, the largest numbers of megakaryocytes are found in the spleen of mice, less in rats, and only very small numbers in guinea pigs and rabbits. 2) No significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have deformated movement, pseudopodial movement, and tentacle formation for the platelet separation as those in the bone marrow. 4) Megakaryocytes in the spleen of mice and rats have motility and ability of platelet formation from the embryonic up to the infant stage, but these functions are found to be decreased during the adolescent and adult life. In guinea pigs and rabbits, the functions of megakaryocytes in the spleen are decreased after the mid-embryonic stage. 5) A correlation is noted between the functions of the megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanide by the other.
en-copyright=
kn-copyright=

en-aut-name=HanzawaAtsumasa
en-aut-sei=Hanzawa
en-aut-mei=Atsumasa
kn-aut-name=半澤敦正
kn-aut-sei=半澤
kn-aut-mei=敦正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=869
end-page=875
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of Convulsive Seizure Induced by Decadron Part 3 Studies of the Mechanism of Inducing Convulsive Seizure by Decadron
kn-title=デカドロン痙攣に関する実験的研究 第3編 デカドロン痙攣の作用機序に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mechanism of inducing convulsive seizure by Decadron was investigated as followings: 1) No convulsive seizure was observed after apllying Decadron solution at the motor area of cerebral cortex, but the typical convulsive was observed only by administrating it directly at Nucleus caudatus. 2) The convulsion induced by Decadron could be inhibited by Ca. Mg and homocarnosine. 3) Amongst sodium citratum like substances, citric acid, L-malic acid and oxalic acid were found to elicit the convulsion as Deeadron induced convulsion, but such as malonic acid, fumaric acid, maleic acid, α-ketoglutaric acid, succinic acid, oxalacetic acid and acetic acid were not. 4) Therefore, it was suggested that citric acid conbined in a non ion "complex" with Ca or Mg which inhibited irritability of the mortor neuron. And on the other hand, dexamethasone played the roll of an activator for inducing convulsion. These reactions in the brain are the most impotant factors for inducing the convulsive seizure.
en-copyright=
kn-copyright=

en-aut-name=MiyakeShintaro
en-aut-sei=Miyake
en-aut-mei=Shintaro
kn-aut-name=三宅新太郎
kn-aut-sei=三宅
kn-aut-mei=新太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=863
end-page=867
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of Convulsive Seizure Induced by Decadron Part 2 Studies of the Active Principle in Decadron Solution Effective in Inducing Convulsion
kn-title=デカドロン痙攣に関する実験的研究 第2編 デカドロン注射液中の痙攣惹起成分に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Decadron solution for injection contains Dexamethasone-21-phosphate disodium, phenol, creatine, sodium citrate, sodium bisulfite, and sodium hydroxide. Therefore, the question of which substance of these is really effective for inducing convulsion, was investigated using mice. The results of the present studies were as follows: 1) Sodium citrate is the only substance in the Decadron solution which induces a convulsive seizure, similar to the Decadron Convulsion. 2) Erection the tail and tachypnea were observed in mice after administration of dexamethasone-21-phosphate disodium, but no convulsive seizure was recognized by dexamethasone-21-phosphate disodium itself. 3) In the case of simultaneously administered sodium citrate and Dexamethasone-21-phosphate, a Decadron type of convulsive seizure was observed. Therefore it was suggested that dexamethasone played the roll of an activat or for the convulsive seizure.
en-copyright=
kn-copyright=

en-aut-name=MiyakeShintaro
en-aut-sei=Miyake
en-aut-mei=Shintaro
kn-aut-name=三宅新太郎
kn-aut-sei=三宅
kn-aut-mei=新太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=853
end-page=862
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of Convulsive Seizure Induced by Decadron Part 1 Studies of Convulsive Seizure Induced by Intrathecal of Decadron
kn-title=デカドロン痙攣に関する実験的研究 第1編 デカドロン注射液の膸腔内投与により惹起される痙攣に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Several sexual and adrenal hormones were injected intrathecally to a dog, mouse, and rat. And the effects of these substances on brain activity, especially on convulsive seizure, were investigated. The results of these investigations were as follows: 1) Aspecial type of tonic convulsion was observed after a short period of intra cysternal administration of Decadron. 2) The same type of convulsion was observed also in the case of the mouse or rat after the administration of Decadrin. 3) Spike waves were observed in the EEG findings during the convulsion induced by Decadron. 4) Acetylchorine content increased and ChE activity decreased in the Brain during the convulsion induced by Decadron.
en-copyright=
kn-copyright=

en-aut-name=MiyakeShintaro
en-aut-sei=Miyake
en-aut-mei=Shintaro
kn-aut-name=三宅新太郎
kn-aut-sei=三宅
kn-aut-mei=新太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=849
end-page=852
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 3 The Effect of Several Drugs on the (45)Ca Incorporation in the ep-Mouse Brain
kn-title=ep系マウスのCalcium代謝に関する研究 第3編 ep系マウス脳への(45)Ca移行に及ぼす薬物の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two groups of the ep-mouse and normal mouse were subjected to intraperitoneal injection of (45)Ca, and simultaneous injections of ethylalcohol, histamine, Kallikrein, vitamin E or benzylimidazoline. Then, 6 hours after the administration, (45)Ca concentration incorporated in brain and liver was investigated. The results were as following; 1) (45)Ca concentration incorporated in brain was moderately increased, with administration of these, especially with Kallikrein and benzylimidazoline. 2) (45)Ca concentration incorporated in liver was remarkably increased with administration of ethylacohol, vitamin E, and remarkably with histamine, Kallikrein, benzylimidazoline. 3) With regard to increment in the ratio of (45)Ca incorporation into brain and liver after administration of peripheral vasodilatation on circulatory accelerator, significant difference was hardly recognized between ep-mouse and normal mouse.
en-copyright=
kn-copyright=

en-aut-name=KakudaMasayoshi
en-aut-sei=Kakuda
en-aut-mei=Masayoshi
kn-aut-name=角田正良
kn-aut-sei=角田
kn-aut-mei=正良
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=841
end-page=847
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of the Calcium Metabolisum in the ep-Mouse Part 2 (45)Ca Metabolism in the ep-Mouse
kn-title=ep系マウスのCalcium代謝に関する研究 第2編 ep系マウスにおける(45)Ca代謝に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(45)Ca was injected into the abdominal cavity of normal mouse. Thereafter, (45)Ca incorporated in the blood, bone, brain, cartilago, muscle, spleen, liver and kidney was investigated, and it was observed that the concentration of (45)Ca incorporated in the various tissues was stablest 24 hours following the injection. Thus, investigations were carried out at this time to compare the concentration of (45)Ca in the various tissues of the ep-mouse to that of the normal mouse and its relative efect on the characfer of the convulsion. The results were as follows; 1) Blood (45)Ca content of the ep-mouse was higher than that of normal mouse, and this was not affected by convulsions. 2) There was no significant difference between the ep-mouse and normal mouse in (45)Ca content incorporated in the bone, nor any effect in the convulsive nature. 3) (45)Ca concentration incorporated in the brain of ep-mouse was markedly lower than that of normal mouse, this concentration was slightly increased by convulsion. 4) (45)Ca concentration incorporated in the muscle of ep-mouse was lower than that of normal mouse, and this concentration was slightly increased by convulsion.
en-copyright=
kn-copyright=

en-aut-name=KakudaMasayoshi
en-aut-sei=Kakuda
en-aut-mei=Masayoshi
kn-aut-name=角田正良
kn-aut-sei=角田
kn-aut-mei=正良
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=835
end-page=840
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 1 Calcium Content in Various Tissue and Urine of ep-Mouse
kn-title=ep系マウスのCalcium代謝に関する研究 第1編 ep系マウスの組織Ca量および尿中排泄量に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Calcium content in the serum, bone, muscle, brain tissue and urine of the ep-mouse were measured. The results were as follows; 1) Urinary calcium excretion of the ep-mouse was higher than that of normal mouse. 2) As to the quantitative change of urinary calcium excretion of the ep-mouse in the days following birth, it was observed that the urinary calcium excretion was highest in the early stage of immaturity, thereafter gradually decreased in the late stage, then moderately increased again in the mature stage. 3) As to the quantitative change of urinary calcium excretion during convulsions, it was observed that the urinary calcium excretion decreased in one hour following the convulsion, then gradually increased, attaining the normal range within five hours. 4) No significant difference was found in the calcium content of serum, bone and brain of ep-mouse in comparison to normals, but decreased calcium content was observed in the muscle of ep-mouse. 5) Calcium content in the brain of ep-mouse increased a little during the convulsive stage as compared to that of nonconvulsive stage, but, after convulsion, it gradually reached the normal range.
en-copyright=
kn-copyright=

en-aut-name=KakudaMasayoshi
en-aut-sei=Kakuda
en-aut-mei=Masayoshi
kn-aut-name=角田正良
kn-aut-sei=角田
kn-aut-mei=正良
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（田中）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=827
end-page=833
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part Ⅲ Effects of Parabiosis on Glutamic Acid, γ-Aminobutyric Acid (GABA) and Aspartic Acid Content in the Brain of ep-Mouse
kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第3編 ep系マウス大脳のglutamic acid,γ-aminobutyric acidおよびaspartic acid含有量におよぼすparabiosisの影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Biochemical changes as to amino acid metabolism were investigated in the brain of an ep-mouse, having had convulsive seizures, after parabiosis formation with a CF(1)-mouse, one of the normal other species, and the results of this experimeot were as follows: 1. Glutamic acid content was small in the brain of the ep-mouse compared with the CF(1)-mouse. They were approaching between the two levels 6 days after the procedure. Then, they were decreased below the preparabiosis level, showing insignificant defference between the both contents at the 12 th postparabiosis day. 2. GABA content was large in the brain of the ep-mouse compared with the CF(1)-mouse, but both contents were averaged between the levels 6 days after the procedure. They were recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day. 3. Aspartic acid content was slightly large in the brain of the ep-mouse compared with the CF(1)-mouse. The difference was minimized after the procedure, and recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day as in the case of GABA content.
en-copyright=
kn-copyright=

en-aut-name=MasukawaSadahiko
en-aut-sei=Masukawa
en-aut-mei=Sadahiko
kn-aut-name=増川禎彦
kn-aut-sei=増川
kn-aut-mei=禎彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=817
end-page=825
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part Ⅱ Effects of Parabiosis on Cholinesterase Activity and Acetylcholine Content in the Brain of ep-Mouse
kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第2編 ep系マウス大脳のcholinesterase活性値およびacetylcholin含有量におよぼすparabiosisの影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of the normal other species, and biochemical changes as to cholinesterase activity and acetylcholine content in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Cholinesterase activity was significantly low in the brain of the ep-mouse compared with the CF(1)-mouse. This difference was averaged by parabiosis formation, and both activities were decreased to the preparabiosis level of the ep-mouse at the 12 th postparabiosis day. 2. Total acetylcholine content was definitely large in the brain of the ep-mouse compared with the CF(1)-mouse, but it was rapidly recovered to the preparabiosis level of the CF(1)-mouse. In contrast to it, the content in the CF(1)-mouse remained unchanged throughout the postparabiosis period.
en-copyright=
kn-copyright=

en-aut-name=MasukawaSadahiko
en-aut-sei=Masukawa
en-aut-mei=Sadahiko
kn-aut-name=増川禎彦
kn-aut-sei=増川
kn-aut-mei=禎彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=805
end-page=815
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part Ⅰ Effects of Parabiosis on Water, Sodium and Potassium Contents in the Brain of ep-Mouse
kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第1編 ep系マウス大脳の含水量およびNa,K含有量におよぼすparabiosisの影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of normal other species, and biochemical changes in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Water content in the brain of the ep-mouse was larger than in the one of the CF(1). It was decreased 6 days after the procedure to the level between the contents in the ep-and the CF(1)-mice of preparabiosis period. At the 12 th postparabiosis day, both contents were decreased to regain the preparabiosis level of the CF(1). The variation in the course was due to the change of the free water content but not due to the bound water content. 2. Total sodium content in the ep-mouse was remarkably large in contrast to the one in the CF(1)-mouse. It was gradually decreased to the level of the CF(1) at the 12 th postparabiosis day. 3. Total potassium content in the ep-mouse was also markedly large in contrast to the one in the CF(1)-mouse, and it followed the tendency of the variation as sodium content.
en-copyright=
kn-copyright=

en-aut-name=MasukawaSadahiko
en-aut-sei=Masukawa
en-aut-mei=Sadahiko
kn-aut-name=増川禎彦
kn-aut-sei=増川
kn-aut-mei=禎彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=799
end-page=804
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=About Two Case of Stomach Cancer Patients Complicating Armoured Pericard
kn-title=胃癌に合併せる装甲心の2例について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently we have been two stomach cancer patients complicating armoured pericard. These two cases are diagnosed by X-ray examination as "armoured pericard" which would be easily differentiated from calcification of mediastinal pleura etc. by means of lateral or oblique projection radiography and tomography, and could be fit for gastrectomy.
en-copyright=
kn-copyright=

en-aut-name=YamamotoMichio
en-aut-sei=Yamamoto
en-aut-mei=Michio
kn-aut-name=山本道夫
kn-aut-sei=山本
kn-aut-mei=道夫
aut-affil-num=1
ORCID=

en-aut-name=NishishitaSoichi
en-aut-sei=Nishishita
en-aut-mei=Soichi
kn-aut-name=西下創一
kn-aut-sei=西下
kn-aut-mei=創一
aut-affil-num=2
ORCID=

en-aut-name=ShiakuTakeru
en-aut-sei=Shiaku
en-aut-mei=Takeru
kn-aut-name=塩飽健
kn-aut-sei=塩飽
kn-aut-mei=健
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END