start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=399
end-page=404
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Electrocardiogram in the Aged. Part 3 A Study on Ventricular Gradient
kn-title=老壮年者の心電図に関する研究 第3編 Ventricular Gradientについて
en-subtitle=
kn-subtitle=
en-abstract=In this paper, a ventricular gradient was studied in the frontal and horizontal planes, respectively, in the Einthoven's trigangle and the chest leads. An angle of the frontal plane, in 30 healthy young persons, varied from 97℃ to -7° and was 36℃ 48' in its mean. A magnitude of the plane varied from 74 μvsec to 17 μvsec and was 38.2 μvsec in its mean. An angle of the horizontal plane varied from 63° to-53° and was 16° 10' in its mean. A magnitude of the plane varied from 280 μvsec to 22 μvsec and was 86.3 μvsec in its mean. The ventricular gradient was observed in 66 normal elder persons with less than 150mmHg in the systolic pressure. It showed a shift to the left and posterior and a slight decrease. As the blood pressure augmented, the ventricular gradient also showed an increase, in the 26 patients. It seems that, though an augmentation of the ventricular gradient derives from an enlargement of AT at the initial elevation of the blood pressure, it may gradually be resulted from an enlargment of AQRS. The ventricular gradient was also studied in 25 patients with left ventricular hypertrophy and strain. An alteration of the ST and T was noted. It is conceivable that the change primarilly occurred from a marked deviation of the angle and the abnormal direction shifted.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HaraokaSyoichi
en-aut-sei=Haraoka
en-aut-mei=Syoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=393
end-page=398
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Electrocardiogram in the Aged. Part 2 A Study on the Electrocardiogram of Left Ventricular Hypertrophy
kn-title=老壮年者の心電図に関する研究 第2編 左室肥大心電図について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, chest X-ray and electrocardiogram by means of the conventional 12 lead and Nehb's lead, were taken in 96 persons aged more than 50 years. Fifty-two of them showed left ventricular hypertrophy upon the roentgenographic diagnosis. A comparative study was undertaken between the X-ray and E. C. G. It would seen that the following values may be available for criteria of the left ventricular hypertrophy.(1mv=10mm) 1)S(v1)+R(v5)≧35mm 2) S(v1)+R(v6)≧28mm 3) R(I)≧5mm 4) R(I)+S(III)≧8mm 5) Q(avR) or S(avR)≧8mm 6) R(avL)≧5mm 7) S(v1)≧10mm
8) R(v5)≧25mm 9) R(v6)≧20mm 10) R(A)≧10mm 11) R(D)≧8mm 12) R(J)≧7mm 13) S(J)≧9mm
en-copyright=
kn-copyright=

en-aut-name=HaraokaSyoichi
en-aut-sei=Haraoka
en-aut-mei=Syoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=381
end-page=392
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Electrocardiogram in the Aged Part 1 A Study on the Scalar Electrocardiogram
kn-title=老壮年者の心電図に関する研究 第1編 スカラー心電図
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of the lead X, Y, Z, the scalar recording of its component, a difference of the electrocardiogram was compared between the young and the old persons. They include the normal healthy and diseased ones. The former consisted of 88 elder and 32 younger persons. In this study, criteria of ventricular hypertrophy ere sought.P-wave showed a positive or diphasic one in the lead X, Y, but a negative in the lead Z. QRS-wave also showed a positive one in the lead X, Y, and a diphasic or positive, in the lead Z. T. wave showed a positive one in the lead X, Y, and a negative in the lead Z. The frontal QRS axis calculated from the lead X, Y, exhibited a correlation with the Eintoven's triangle, although the normal range of the former was narrower than that of the latter. It was found that the mean spatial T-magnitude was smaller in the younger aged groups than in the elder groups, in hypertensive patients an increase of the elevational QRS-V° was considered to be due a shift of the QRS vecthr to the left and posterior. It was also noted that the mean spatial QRS-T angle and QRS, T. magnitude were angmented. The mean spatial T-magnitude showed a decrease upon an elevation of the diastolic presure. Thus, it would seem that Rx+R=≧20mm is more quantitative method for criteria of the diagnosis of left ventricular hypertrophy. This leading method is found to be more quantitative method than ever before and to have fewer leading sited of the electrodes. Therefore, it may clinically be useful.
en-copyright=
kn-copyright=

en-aut-name=HaraokaSyoichi
en-aut-sei=Haraoka
en-aut-mei=Syoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=375
end-page=379
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of Prosthesis Test as a Preoperative Examination Method for the Sound Conductive System
kn-title=術前伝音機能検査法としての人工補聴法（Prothese法）の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the prupose to foreknow the condition of ossicles and, if possible, the hearing level attainable by tympanoplasty, prosthesis test was carried out preoperatively on 110 cases of chronic otitis media, and these results were compared statistically with the findings of the surgery and the postoperative hearing acuity. As to the prosthesis, thin patch paper or small rubber bag was employed to cover the drum perforation closely. And puretone audiometry was conducted with and without the prosthesis. The results obtained were as follows; 1) The data were investigated in each of two groups, one with disconnected ossicles, the other intact. Thereby, following two criteria were introduced, i.e. the improved hearing level better than 20 db loss or the gain of hearing more than 15 db with prosthesis. Using these criteria, the author considered, the condition of ossicles could be surmised. That is, in cases within the criteria it might be possible to diagnose that the ossicles are intact. And in the other cases without he criteria, the continuity of ossicles would be indefinite. 2) In addition, findings of the prosthesis test and hearing test after tympanoplasty were compared, an it was suggested that the prosthesis test could offer a clue to estimate possible gain of tympanoplasty.
en-copyright=
kn-copyright=

en-aut-name=YokoyaSosuke
en-aut-sei=Yokoya
en-aut-mei=Sosuke
kn-aut-name=横矢聰佑
kn-aut-sei=横矢
kn-aut-mei=聰佑
aut-affil-num=1
ORCID=

en-aut-name=MasudaYuzuru
en-aut-sei=Masuda
en-aut-mei=Yuzuru
kn-aut-name=益田弦
kn-aut-sei=益田
kn-aut-mei=弦
aut-affil-num=2
ORCID=

en-aut-name=TamuraMinoru
en-aut-sei=Tamura
en-aut-mei=Minoru
kn-aut-name=田村実
kn-aut-sei=田村
kn-aut-mei=実
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=361
end-page=374
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Kidney Auto-Antibody Part Ⅱ Experimental Studies on Auto-Kidney or Homologeous-Kidney Antibody
kn-title=腎自己抗体に関する研究 第2編 腎自己又は同種抗体に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The vicissitude of the anti-kidney antibody was mainly observed on the cases of experimental nephritis in tabbit by the methode of Masugi's nephritis and kidney homosensitization, and the significance of its antibody and the movement of its antibody into urine were also studied. And the following results were obtained. 1. The slight elevation of the kidney auto-antibody was observed in all cases of Masugi's nephritis and the elevation of its antibody was observed since the 5th or 7th day after the injection of nephrotoxin and the persistence of the elevated antibody titer (1:4~1:8) was observed until one month later. 2. The correlation between the appeance of the kidney auto-antibody in peripheral blood in Masugi's nephritis and the various clinical findings or histological changes in kidney was relatively observed. 3. The elevation of the kidney homo-antibody was observed in all cases with the homo-sensitization by the kidney emulsion adding adjuvant, after 17 or 24 days and the occurrence of nephritis was even slightly observed in half of them, comparing with Masugi's nephritis. 4. In the above cases of experimental nephritis, the decrease of complement value was observed in accordance with the appearance of the anti-kidney antibody (kidney auto-or homo-antibody). 5. The movement of the kidney auto-antibody into urine was observed, and the correlation between the above phenomenon and the fall of the Albumin-Globulin ratio in urinary protein or the increase of the γ-globulin fraction was also observed. 6. Since the above results, the participation of the anti-kidney antibody (kidney auto-or homo-antibody) was clear for the development of the above experimental nephritis. And it was thought that the participation of its antibody could not be disregarded for the appearance of the pathological change in the kidney since there was the close correlation between the appearance of the anti-kidney antibody and the fall of the complement titer or the appearance of renal symptom.
en-copyright=
kn-copyright=

en-aut-name=MoritaniYui
en-aut-sei=Moritani
en-aut-mei=Yui
kn-aut-name=森谷有為
kn-aut-sei=森谷
kn-aut-mei=有為
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=349
end-page=360
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Kidney Auto-Antibody Part 1 Clinical Significance of Auto-Kidney Antibody
kn-title=腎自己抗体に関する研究 第1編 腎自己抗体の臨床的意義について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Kidney auto-antibody was measured by the complement fixation test on the 92 cases in kidney diseases, mainly diffuse glomerulonephritis and 305 cases in other various diseases and the clinical significance was studied, And the following results were obtained. 1. The positive rate of the kidney auto-antibody in diffuse glomerulonephritis was 48.4% at the acute stage and 80.0% at the chronic stage, but it was 20.0% in nephrosis, 25.0% in kidney tuberculosis, 20.0% in kidney tumor and 33.3% of the kidney in pregnancy. 2. It was 18.3% in various diseases other than kidney diseases, and 16.6% in acute tonsillitis, 20.0% in chronic tonsilitis, 20.8% in essential hypertension with albuminuria, 8.7% in that without albuminuria, and it was shown a little high rate in liver diseases, such as 18.6% in acute hepatitis, 28.3% in chronic hepatitis and 59.0% in livercirrhosis, but the peculiarity to the each antigen was relatively strong by the crossing test with the liver and kidney antigen. The diseases, other than the above diseases, showing the rather high positive rate of kidney auto-antibody were 22.2% in diabetes mellitus and 66.6% in collagen disease. 3. In diffuse glomerulonephritis, it was low at the acute early stage and it gradually elevated since about one month later and it showed the tendency of decrease since two month later at which time it was the highest, but it was generally high at the chronic stage. 4. The serum complement titer showed relatively high decrease at the acute stage of diffuse glomerulonephritis and it showed a little decrease in most of the chronic cases, and the correlation between the kidney auto-antibody and the complement titer was observed. 5. The correlation between the kidney auto-antibody and the findings of various clinical tests, for example urinary change, glomerular filtrating value, nonprotein nitrogen and the increase of serum γ-globulin fraction was observed. 6. The vicissitude of the kidney auto-antibody became the characteristic of the clinical cause and prognosis in diffuse glomerulonephritis, and it also agreed with the histological change of kidney. 7. The kidney auto-antibody moved into urine in the form not loosing the activity and its antibody contained in the γ-globulin of urinary ablumin.
en-copyright=
kn-copyright=

en-aut-name=MoritaniYui
en-aut-sei=Moritani
en-aut-mei=Yui
kn-aut-name=森谷有為
kn-aut-sei=森谷
kn-aut-mei=有為
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=335
end-page=347
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Liver Function in Skin Diseases Liver Function in Patients with Skin Diseases
kn-title=皮膚疾患と肝機能に関する研究 皮膚疾患患者における肝機能
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There is the closs relationship between skin diseases and the other organs, especially liver. However in spite of many reports the mechanism of their relationship and its details have not been made clear yet. For the purpose of studying this relation, the vearious kinds of liver funtion tests were performed to obtain the following data. 1. The disturbance of the liver function was observed in almost all the group. 2. The disturbed liver function was observed in 53 (32.5%) out of 163 cases. 3. Among liver function tests performed, Cobalt Reaction in serum was positive in 59.5% of all cases, Thymol Turbidity Test 24.5%, Takata Reaction 22.7%, Cephalin Cholesterol Flocculation Test 18.6% , Gros Test 17.9%, Meulengracht 4.4%. 4. The degree of disturbance of the liver function is seen in the following order; Lupus erythematodes, Bullous diseases, Sclerosis cutis, Erythrodermia, Pyodermia, Dermal tumors, Diseases due to fungi, Eczema chronicum, Eczema acutum, Atrophia cutis, Erythematous diseases except Lupus erythematodes, Pigmentanomalies, Diseases of the cutaneous blood vessels, Keratosis cutis, Contact dermatitis Tuberculosis cutis, Urticaria and Cutaneous neurosis.
en-copyright=
kn-copyright=

en-aut-name=OmoriHiroyuki
en-aut-sei=Omori
en-aut-mei=Hiroyuki
kn-aut-name=大森弘之
kn-aut-sei=大森
kn-aut-mei=弘之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=329
end-page=334
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electromyographical Studies on Regulation of Voluntary Contraction of the Skeletal Muscle. Part 3. Studies on the Fluctuation of the Amplitude of the H-Reflex in the Pathological Condition
kn-title=骨骼筋随意收縮の調節に関する誘発筋電図的研究 第3編 病的状態におけるH波振巾の動搖性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The H-reflex was studied on 27 cases of Parkinsonism, including 8 cases of hemiparkinsonism. 1. The fluctuation of H-reflex amplitude was more unstable on the parkinsonism, comparing with normal subject. 2. On the hemiparkinsonism, the fluctuation of H-reflex amplitude in nonaffected side showed interest character. The fluctuation was in the normal level at tremor-rest stadium in the affected side, abnormally increased level at tremor stadium in the affected side. 3. The fluctuation of H-reflex amplitude was considered to be influenced by the descending impulses from the higher level of the central nervous system at the time of tremor.
en-copyright=
kn-copyright=

en-aut-name=NumotoIkuo
en-aut-sei=Numoto
en-aut-mei=Ikuo
kn-aut-name=沼本育夫
kn-aut-sei=沼本
kn-aut-mei=育夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部陣内外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=323
end-page=328
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electromyographical Studies on Regulation of Voluntary Contraction of the Skeletal Muscle. Part 2. Studies on the Fluctuation of H-Reflex by the Voluntary Contraction
kn-title=骨骼筋随意収縮の調節に関する誘発筋電図的研究 第2編 意収縮によるH波の変化に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The H-refrex was studied on 22 cases of the normal subject. 1. According to the grade of the voluntary contraction of the gastrocnemius muscle, the silent period of the H-reflex was decreased, i.e. the recovery curve of the H-reflex was shifted to the left, and supanormality was appeard. 2. The shortning of the silent period of H-reflex was also clearly observed on the single motoneuron by voluntary contraction. 3. The increasing of H-reflex amplitude by the surface electrodes was consideced to be caused by the increasing of excitability of the cells, and the increasing of number of excitable cells in the anterior horn of the spinal cord.
en-copyright=
kn-copyright=

en-aut-name=NumotoIkuo
en-aut-sei=Numoto
en-aut-mei=Ikuo
kn-aut-name=沼本育夫
kn-aut-sei=沼本
kn-aut-mei=育夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部陣内外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=313
end-page=321
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electromyographical Studies on Regulation of Voluntary Contraction of the Skeletal Muscle. Part 1. Studies on the Amplitude of the H-Reflex in the Normal Subject
kn-title=骨骼筋随意収縮の調節に関する誘発筋電図的研究 第1編 正常人の誘発筋電図におけるH波の振巾に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An lectromyographical examination was studied on the normal subject. The actionpotential _??_ the gastrocnemius muscle was recorded combining with the electrical stimulation on the tibial nerve. The record was consisted with two kinds of actionpotentials, the faster was called M-wave and considerd as the actionpotential by the direct stimulation on the efferent fibers, and the later was called H-wave (Hcffman's wave) and considerd as monosinaptic reflex actionpotential. 1. The H-wave and M-wave appeard to have rather unstable amplitude even by the same parameter of stimulation in the lower voltage, but showed more stable amplitude in the higher voltage on the same subject. At maximum stimulation for H-reflex, the fluctuation index of H-reflex amplitude was 5.4% , and the same of M-reflex amplitude was 7.9% . 2. No influense on the amplitude of H-reflex was observed by selective procaine bolck of γ fiber in the tibial nerve. 3. The fluctuation of H-reflex amplitude was increased by a voluntary contraction of the gastrocnemius muscle. 4. No relationship was observed between the fluctuation of H-reflex amplitude and respiratory movement.
en-copyright=
kn-copyright=

en-aut-name=NumotoIkuo
en-aut-sei=Numoto
en-aut-mei=Ikuo
kn-aut-name=沼本育夫
kn-aut-sei=沼本
kn-aut-mei=育夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部陣内外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=307
end-page=312
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of unsaturated high fatty acid fraction extracted from X-ray irradiated rabbit liver (OX) on the mitochondrial swelling of normal rat liver
kn-title=X-線照射家兎肝より抽出した高級不飽和脂肪酸分画により惹起されたmitochondriaのswellingに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of OX, a high unsaturated fatty acid fraction extracted from x-ray irradiated rabbit liver, on rat liver mitochondrial swelling was studied and following results were obtained. 1) Strong swelling action is demonstrated at OX concentration above 0.001% in 0.15KCl solution. 2) Swelling action on mitochondria is reduced by sucrose but not changed by sodium succinate. On the other hand, serum albumin and ATP inhibit completely mitochondrial swelling. 3) Mitochondrial swelling caused by OX is reversed by serum albumin and ATP. The intensity of contraction is found in the following order containing ATP, ATP+Mg and ATP +Mg+serum in the media. 4) M itochondrial swelling is induced by 0.005% OX in the substrate of succinate but respiration is not largely prevented. 5) The incorporation of P(32) into Δ10P of swollen mitochondria is almost completely inhibited by OX.
en-copyright=
kn-copyright=

en-aut-name=UrakamiHiroyuki
en-aut-sei=Urakami
en-aut-mei=Hiroyuki
kn-aut-name=浦上博之
kn-aut-sei=浦上
kn-aut-mei=博之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属癌源研究代謝部門
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=295
end-page=306
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Salivary Gland Hormone on the Hematopoiesis of Bone Marrow Part 3. Influences of the Salivary Gland Hormone on the Bone-Marrow Tissue Culture of Patients with Hypoplastic Anemia and Banti's Disease
kn-title=唾液腺ホルモンの骨髄造血機能に及ぼす影響-骨髄体外組織培養法による- 第3編 再生不良性貧血及び所謂バンチ氏病患者骨髄培養に及ぼす影響に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to study the direct influences of the salivary gland hormone on the hematopoietic function, of bone marrow, especially on the leucocyte series of patients with hypoplastic anemia and Banti's disease by bone-marrow tissue culture (our simple method), the following results were obtained, 1. In the bone marrow tissue of the cases with hypolastic anemia type 1 (type of blood cell arrest in the bone marrow, according to the classification by Prof. Hiraki) by our simple method, the tissue growth and the wanderiug velocity of mature neutrophils were increased as compared with those of the control. On the other hand, no significant difference could be observed as compared with those of the control in type Ⅱ (type of maturation arrest) and type V (type of panmyelophtisis). 2. In the patients with Banti's disease, the leucocyte series of bone marrow was accelerated by addition of Parotin as compared with those of control, in cases with relatively normal count of nucleated myelogenous cells. On the other hand, in cases with lower count of nucleated myelogenous cells, no significant effect could be observed in the tissue culture by addition of Parotin.
en-copyright=
kn-copyright=

en-aut-name=UgakiMasaaki
en-aut-sei=Ugaki
en-aut-mei=Masaaki
kn-aut-name=宇垣公晟
kn-aut-sei=宇垣
kn-aut-mei=公晟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=289
end-page=294
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Salivary Gland Hormone on the Hematopoiesis of Bone Marrow Part 2. Influences of the Salivary Gland Hormone on the Erythrocyte Series of Normal Rabbits, and the Megakaryocyte Function of Normal Ginea Pigs and Normal Persons
kn-title=唾液腺ホルモンの骨髄造血機能に及ぼす影響―骨髄体外組織培養法による― 第2編 家兎骨髄赤血球系及び海猽,健康入の骨髄巨核球機能に及ぼす唾液腺ホルモンの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. In order to clarify the infinences of the salivary gland hormone on the hematopoietic function of bone marrow, especially on the erythrocyte series, the author studied changes in the erythrocyte count, hemoglobin countent and reticulocyte count in the rabbit fluid medium tissue culture to which Parotin was added directly, and the following results were obtained. As for the influences of Parotin on the erythrocyte count, hemoglobin countent and retieulocyte count in the tissue culture, no significant difference could be observed as compared with the control. 2. When Parotin was added directly to the bone-marrow tissue culture of normal ginea pigs, the megakaryocyte function was accelerated, and likewise in the bone-marrow tissue culture of normal persons, Parotin enhanced the megakaryocyte function.
en-copyright=
kn-copyright=

en-aut-name=UgakiMasaaki
en-aut-sei=Ugaki
en-aut-mei=Masaaki
kn-aut-name=宇垣公晟
kn-aut-sei=宇垣
kn-aut-mei=公晟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=281
end-page=287
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Salivary Gland Hormone on the Hematopoiesis of Bone Marrow (by means of bone-marrow tissue culture) Part 1. On the Bone-Marrow Tissue Culture of Normal Rabbits and Normal Persons
kn-title=唾液腺ホルモンの骨髄造血機能に及ばす影響―骨髄体外組織培養法による― 第1編 健康人及び家兎骨髄組織培養に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to clarify the influences of salivary gland hormone on the hematopoietic function of bone marrow, especially on the leucoyte series, Parotin was added directly in the medium of bone marrow tissue culture of normal rabbits and normal persons, and following results were obtained. 1. In the bone-marrow tissue culture of normal rabbits by hangingdrop method, the tissue growth, the wandering velocity and carbon-particle phagocytosis of pseudoeosinphils were increased as compared those of the control. 2. In the bone-marrow tissue culture of normal persons by our simple method, the tissue growth, the wandering verocity and carbon-particle phagocytosis of mature neutrophils were increased as compared with those of the control. 3. In the tissue culture added Parotin, the growth and function of leucocyte was accelerated most remarkably at the 6-hour culture.
en-copyright=
kn-copyright=

en-aut-name=UgakiMasaaki
en-aut-sei=Ugaki
en-aut-mei=Masaaki
kn-aut-name=宇垣公晟
kn-aut-sei=宇垣
kn-aut-mei=公晟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=275
end-page=280
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Carbon Tetrachloride, Trichioro-ethylene and Tetracloro-ethylene on Serum Protein Fractions of Mice (especially with the effect of A. T. P. and Xanthine)
kn-title=四塩化炭素，三塩化エチレン，及び四塩化エチレン中毒時の血清蛋白分画値の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the purpose of determining the effects of carbon tetrachloride (CCl(4)), trichloroethylene, and tetrachloro-ethylene on the changes in serum protein fractions and the body weight, we injected 1.5ml/kg of these compounds every other day into Cb strain mica, and also 10mg/mouse of A. T. P. and Xanthine was injected every other day 15 times into the animals with CCl(4) poisoning in order to find out the effects of these drugs and obtained the following results. 1. Every group of the mice with experimental CCl(4) poisoning, trichloro-ethlene and tetracbloro-ethylene poisoning, showed a tendency of a decrease in albumin fraction and an increase in β-globulin fraction. Such changes were especially marked in the group with CCl(4) poisoning. 2. As for the change in their body weight, the group with CCl(4) poisoning alone demonstrated clearly a decrease in the body weight, but the other groups did not show any marked change. 3. It was recognized that both A. T. P. and Xanthine had a slight inhibitory effect on the decrease of the albumin, the increase of β-globulin, and the diminution of the body weight, in the CCl(4)- poisoning group.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

en-aut-name=KurodaYasuo
en-aut-sei=Kuroda
en-aut-mei=Yasuo
kn-aut-name=黒田泰生
kn-aut-sei=黒田
kn-aut-mei=泰生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=269
end-page=274
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Relation between Load and Fatigue Reaction by Means of Bicycle Ergometer
kn-title=Ergometer負荷量と疲労反応の関係について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the aid of bicycle ergometer physiological changes, urinary fatigue reactions and flicker values were estimated and their values were compared on group A given the work on a bicycle with a load of 50kg at 90r.p.m. for 10 minutes and group B with the same load but 60r.p.m. for 30 minutes, and the following results were obtained. 1) The number of respiration and the volume of expiration increased very rapidly in group A, reaching their maximum values after the commencement of the work and thereafter these values decreased up to the cessation of the work due to the functional decrease. Group B maintained these values steadily at a fixed point and the recovery from the physical change was more rapid as compared with group A. The increase in blood pressure and number of pulsation in group A was considerably more marked than that in group B. 2) In group A the urinary fatigue reaetions showed a marked increase in all of Donaggio, Shinmei, mercuric iodide, and urinary protein reactions after the start of work, and these values recovered back to the values before the work four hours after stopping the work. The increase in the fatigue reactions after the work is relatively less in group B. Urinary fatigue reactions in both group A and group B are high immediately after the work, reaching their maximum 30 minutes after the cessation of the work. The values of mercuric iodide reaction alone, however, are at the maximum immediately after the work. 3) The rate of decrease in the flicker values reaches its maximum immediately after the work, and the recovery thereafter is rapid. returning the pre-work values 30 minutes after the work. 4) From these results it appears that for the appearance of urinary fatigue reactions the load factor in a given time has a greater influence than the working-time factor and that these reactions appear when there exists a certain imbalance (for an example, acidosis) in vivo brought about by physiological changes and they appear 30 minutes later rather than immediately after the work.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

en-aut-name=TadatomoAtsuo
en-aut-sei=Tadatomo
en-aut-mei=Atsuo
kn-aut-name=只友淳雄
kn-aut-sei=只友
kn-aut-mei=淳雄
aut-affil-num=2
ORCID=

en-aut-name=YoshimotoHiromitsu
en-aut-sei=Yoshimoto
en-aut-mei=Hiromitsu
kn-aut-name=吉本弘満
kn-aut-sei=吉本
kn-aut-mei=弘満
aut-affil-num=3
ORCID=

en-aut-name=MishimaShiro
en-aut-sei=Mishima
en-aut-mei=Shiro
kn-aut-name=三島四郎
kn-aut-sei=三島
kn-aut-mei=四郎
aut-affil-num=4
ORCID=

en-aut-name=SatoKazuto
en-aut-sei=Sato
en-aut-mei=Kazuto
kn-aut-name=佐藤和人
kn-aut-sei=佐藤
kn-aut-mei=和人
aut-affil-num=5
ORCID=

en-aut-name=KimuraSusumu
en-aut-sei=Kimura
en-aut-mei=Susumu
kn-aut-name=木村晋
kn-aut-sei=木村
kn-aut-mei=晋
aut-affil-num=6
ORCID=

en-aut-name=YokoyamaMamoru
en-aut-sei=Yokoyama
en-aut-mei=Mamoru
kn-aut-name=横山衛
kn-aut-sei=横山
kn-aut-mei=衛
aut-affil-num=7
ORCID=

en-aut-name=KobayashiKyozo
en-aut-sei=Kobayashi
en-aut-mei=Kyozo
kn-aut-name=小林喬三
kn-aut-sei=小林
kn-aut-mei=喬三
aut-affil-num=8
ORCID=

en-aut-name=ShindoSadayoshi
en-aut-sei=Shindo
en-aut-mei=Sadayoshi
kn-aut-name=進藤貞義
kn-aut-sei=進藤
kn-aut-mei=貞義
aut-affil-num=9
ORCID=

en-aut-name=HitomiKatashi
en-aut-sei=Hitomi
en-aut-mei=Katashi
kn-aut-name=人見硬
kn-aut-sei=人見
kn-aut-mei=硬
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=263
end-page=268
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on Fatigue Conditions and Fatigue Control Method in a Certain Shipbuilding Company by Means of Filterpaper BPB Staining Method
kn-title=濾紙BPB染色法による某造船工場に於ける疲労調査並びに疲労管理の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of the filterpaper BPB staining (filterpaper spot test), a method devised by Ogata, one of the authors, we studied the conditions of fatigue as well as fatigue control method on 1,039 workers in a certain shipbuilding company, and obtained the following results. 1. The amounts of protein excreted in the urine proved to be in the order of electric technicians, forgers, blacksmiths, coppersmiths and those handling oxygen compressors, demonstrating that the heavier the work the greater is the amount of protein excreted in the urine. 2. After checking the urinary protein contents by this method, we established a method of fatigue control in which we gave a rest for those who showed the urinary protein content of over 0.25%, and obtained fairly satisfactory results. This method serves as a screening test for nephritic patients without apparent objective symptoms. 3. In comparing the amounts of urinary protein before the work with that after the work, generally the urinary protein tended to increase after the work. This seems to be due to the fact that the work in the shipbuilding factory is in general a heavy muscle labor. 4. This method is quite excellent in determining the fatigue due to commutation, and it has been clarified that in the same locality the urinary protein contents are found in the order of those who commute on foot, those by bicycle and those by motorcycle, descending in that order. And in the case of those who commute on foot the longer the distance covered, the greater is the urinary protein content.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

en-aut-name=MatsudaAkira
en-aut-sei=Matsuda
en-aut-mei=Akira
kn-aut-name=松田昭
kn-aut-sei=松田
kn-aut-mei=昭
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=255
end-page=261
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The New Quantitative Method of Hippuric Acid in The Urine of Workers after Exposure to Toluene
kn-title=トルエン作業員の尿中馬尿酸の新定量法について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hippuric acid excretion in the urine of workers after exposure to toluene, was assayed by a modified method of Gaffney's. The results obtained are as follows, 1) The determination of hippuric acid in the urine was carried out by paperchromatography, and 0.1 ml urine was spotted on the filterpaper (40×40cm), developed in the solvent system: buthanol-acetic acid-water, 4:1:1. After drying, the color reaction was brought to completion by spraying with 4 per cent solution of p-dimethylaminobenzaldehyde in acetic anhydride saturated sodium acetate and by heating it in a drying oven for one minute at 135℃. The R(f) value of hippuric acid contained in the urine was 0.8, and it coincided with that of pure hippuric acid, and the absorption spectrum of the methanol eluate of the colored spot of the workers' urine corresponded with that of pure hippuric acid. 2) At the autotricycle factory using the mixture of toluene and benzene (4:1) as a solvent of glue, and also toluene as a component of thinner for spray, an increase of hippuric acid excretion in the urine of workers was recognized after exposure to the solvent gases. 3) In the plastic factory using toluene as a solvent, the group of workers exposed to 50 p.p.m. of toluene in air bad the excretion of the hippuric acid 3.4 times compared with that befor exposure, and the group exposed to 20p.p.m., 1.9 times. These results indicate that the excretion of hippuric acid in the urine is in direct proportion to the concentration of toluene in air.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

en-aut-name=SugiyamaKatsumi
en-aut-sei=Sugiyama
en-aut-mei=Katsumi
kn-aut-name=杉山勝三
kn-aut-sei=杉山
kn-aut-mei=勝三
aut-affil-num=2
ORCID=

en-aut-name=KurodaYasuo
en-aut-sei=Kuroda
en-aut-mei=Yasuo
kn-aut-name=黒田泰生
kn-aut-sei=黒田
kn-aut-mei=泰生
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=247
end-page=253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Investigation of A Dry-Cleaning Shop Using Tetrachloro-ethylene(with a special reference to Fujiwara's substance in the urine of the employees)
kn-title=四塩化エチレン使用ドライクリーニング工場調査成績（特に従業員尿中藤原氏反応陽性物質について）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the working conditions of a dry-cleaning shop where they had previously used trichloro-ethylene but after the renovation of the shop they now use tetrachloro-ethylene instead and obtained the followlng results. 1. The concentration of tetrachloro-ethylene in the air at the time, when washers were open, was found to be 200-250ppm, surpassing the maximum allowable concentration and the average concentration in the air was, however, 25-30ppm, showing a distinct decrease as compared with the concentration of 420ppm near the washers at the time when they had used trichloroethylene. 2. There could be detected Fujiwara's substance in the urine of employees and assuming the substance to be trichloroacetic acid, it was found in the quantity of 14.5mg/l, which, compared with 416mg/l of trichloro-acetic acid, detectable at the time when they had used trichloro-ethylene, was clearly less. It is assumed that one of the factors bringing about such a decrease, is due to the inhalation of lesser amount of ethylene vapor by the the use of less volatile tetrachloro-ethylene in place of trichloro-ethylene. 3. Judging from the Rf value of paper chromatography and absorption spectra of Fujiwara's reaction, it is assumed that Fujiwara's-positive substance in the urine of employees has the chemical structure similar to one of trichloro-acetic acid. 4. In the serum proteins of the employees there could be recognized a diminution of albumin and an increase of β-globulin by paper electrophoresis, in their colloidal reaction an increase of cephalin-cholesterol reaction and the right shift in the cobalt reaction, and an increment of the urinary urobilinogen content. These results seem to indicate a slight disturbance in the liver functions of the employees as the result of their employment for 6years while using trichloro-ethylene and working in the shop for 4years since they began to use tetrachloro-ethylene.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

en-aut-name=SugiyamaKatsumi
en-aut-sei=Sugiyama
en-aut-mei=Katsumi
kn-aut-name=杉山勝三
kn-aut-sei=杉山
kn-aut-mei=勝三
aut-affil-num=2
ORCID=

en-aut-name=KurodaYasuo
en-aut-sei=Kuroda
en-aut-mei=Yasuo
kn-aut-name=黒田泰生
kn-aut-sei=黒田
kn-aut-mei=泰生
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡出大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡出大学医学部公衆衛生学教室

affil-num=3
en-affil=
kn-affil=岡出大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=239
end-page=246
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Allergic Dermatitis in the Occupational Fields (Immunological Specificity, Sensibilization of Iodine and Phenylisocyanate, and Inhibitory Effect of Monovalent Antigen on Immunological and Arthus Reaction)
kn-title=職業性感作性皮膚炎の研究（沃度，phenylisocyanateの特異性，感作原性，並びに1価抗原の阻止作用について）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author studied chemo-immunological specificity of iodated protein and phenylureido protein as well as sensibilization of iodine and phenylisocyanate and obtained the following results. 1) Iodated egg-albumin antibody reacts with iodated human serum albumin antigen and this reaction is inhibited by diiodotyrosine. Phenylureido egg albumin antibody reacts with phenylureido human serum albumin antigen and this reaction is inhibited by phenylureidolysine. 2) According to quantitative preicipitin reaction, in the inhibitory reaction of the monovalent antigen (semihapten) mentioned above, the quantity of precipitin nitrogen decreases in proportion to the increase in mono-valent antigen. 3) Iodated egg-albumin antibody reacts with iodated human-serum albumin antigen by the agar method of Oudin, and phenylureido egg-albumin antibody reacts with phenylureido human-serum albumin antigen. The number of the immunological reaction ring due to chemoimmunological specificity proves to be single. 4) The guinea pigs sensitized by iodated human-serum albumin demonstrate anaphylaxis by intravenous injection of iodated egg-albumin, and guinea pigs sensitized by phenylureido egg-albumin develop Arthus reaction by intracutaneous injection of phenylureido human-serum albumin. 5) When guinea pigs are sensitized subcutaneously with phenylisocyanate, they develop Arthus reaction by phenylisocyanate. Therefore, this is a substance that possesses sensibilization. On the other hand, in the case where Arthus reaction is made to take place by phenylureido human-serum albumin in the guinea pig previously sensitized by phenylureido egg-albumin, when the mixture of phenylureido human-serum albumin and phenylureido-lysine is injected, the reaction is weakened. Namely, there can be observed an inhibitory reaction by monovalent antigen. 6) From these results, it is assumed that allergic skin inflammation and anaphylaxis in the animals sensitized by iodine and phenylisocyanate is due to the antigen-antibody reaction of the determinant groups as diiodotyrosine and phenylureido-lysine respectively.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=231
end-page=238
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Donaggio Reaction in Anderson's Urinary Mucoprotein and Changes in the Excretion of Anderson's Mucoprotein in Fatigue Condition
kn-title=Anderson氏尿ムコ蛋白のDonaggio反応及び疲労時の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed Donaggio reaction and Akamatsu-Shinmei reaction usiug urinary mucoprotein A(1), A(2), A(3), isolated by the benzoic acid adsorption method of Anderson, Tamm's urinary mucoprotein, urinary mucoprotein obtained by talcum powder adsorption method and Winzler's serum mucoprotein. The author also determined the excretion of Anderson's mucoprotein in fatigue condition. The results obtained are as follows. 1) Anderson's mucoprotein proves to be strongly positive to Donaggio reaction and the concentration showing one Donaggio unit is 50-100γ/ml, showing the activity almost similar to that of the Donaggio reaction-positive substance performed by talcum powder adsorption method. 2) The activity of Donaggio reaction of the human serum mucoprotein processed by Winzler's method, whose concentration showing one Donaggio unit being around 31.2γ/ml, seems to be higher than that of the Donaggio reaction-positive substance by talcum powder adsorption method. 3) Anderson's urinary mucoprotein is also positive to Akamatsu-Shinmei reaction. 4) Tamm's urinary mucoprotein is Donaggio reaction negative, but after heating it becomes weakly positive, while to Shinmei reaction, it is weakly positive and heating increases its positivity still further. 5) The concentration of urinary mucoprotein prepared by Anderson's quantitative method, increased in the workers of a department store after the work, and in soccer players after the game. Moreover, the quantity of hourly excretion of urinary mucoprotein also increased after the work in the case of workers in the department store. 6) Donaggio reaction values and the quantities of Anderson's urinary mucoprotein fluctuated in parallel to each other after the work and after the game. 7) The recovery rate of the Donaggio reaction values determined by benzoic acid adsorption method of Anderson proved to be 30-50 per cent showing the values close to those by talcum powder adsorption method of Honda. 8) From these results, it is deduced that the mucoprotein (Donaggio reaction positive substance) prepared by the talcum powder adsorption method resembles very closely to Anderson's mucoprotein and these two are most likely derived from serum α(1)-globulin, and Tamm's mucoprotein that is negative to Donaggio reaction is in all probability a different mucoprotein excreted in the urinary tract.
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=223
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Zinc Fume Fever Part 1. The Fate in Guinea Pigs of Introvenously Injected Zn(65)O and Zn(65)C1(2)
kn-title=亜鉛熱に関する研究 第1編 Zn(65)O，Zn(65)Cl(2)の生体内分布に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=After administering Zn(65)O and Zn(65)Cl(2) to guinea pigs the author investigated the difference in the distribution of these isotopes and also the distribution of Zn(65)Cl(2) in serum fractions and obtained the following results. 1. (a) The in vivo distribution of Zn(65)O was high in the lung, liver, heart, kidney, pancrease and intestine 15 minutes after its administration, in the lung, liver, spleen, pancreas, kidney and int stine two hours later, and two weeks later in the lung, large intestine, heart, liver, spleen, intestine and pancreas, the activity being in the order of the organs mentioned. In addition, the radio-activity detected in the urine is minute as compared with the quantity of Zn(65)O injected. (b) The in vivo distribution of Zn(65)Cl(2) after five hours its administration was found to be in the order of the liver, intestine, pancreas, large intestine, kidney and lung, showing a distinct difference from the the case of Zn(65)O administration. 2. The radio-activity of zinc ions combined with serum protein fractions after the Zn(65)Cl(2) administration was found in β-globulin, γ-globulin, albumin and α-globulin, the activity being descending order mentioned, and the relative specific activity (activity/area under optical density curve) was in the order of γ-globulin (12.5), β-globulin (6.9), albumin (2.3), and α-globulin (1.1).
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=219
end-page=221
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on Fatigue in a Certain Spinning Mill by Means of Filterpaper BPB Staining Method
kn-title=濾紙BPB染色法による某紡績工場作業員疲労調査成績
en-subtitle=
kn-subtitle=
en-abstract=With the filterpaper BPB staining method the author measured the urinary protein contents both before and after the work of those female workers, living in the factory dormitory, and engaged in a certain spinning mill, and obtained the following results. 1. In every shop examined, the urinary protein content is increased after the work. 2. The amounts of urinary protein according to different shops ranged in the order of cotton mixing, spinning (shop Ⅱ), frying, spinning (shop I), weaving, and spooling, showing that the urinary protein content increases in proportion to the intensity of labor. 3. The above results prove that the urinary protein contents are clearly increased after the work because these workers, living in the dormitories, have no commutation fatigue, their meals are fixed and regular, and even in winter their working rooms are kept constantly around 20℃.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=183
end-page=218
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Electroencephalogram and Brain Damage during Circulatory Arrest in Profound Hypothermia by means of Extracorporeal Blood Cooling.
kn-title=血液冷却法による超低体温下循環遮断時の脳波および脳変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Brain damage in profound hypothermia was studied by means of electroencephalogram, brain blood barrier and estimation of activity succinic dehydroganase in dogs. Hypothermia was induced by incorporating a heat-exchange mechanism in pump-oxygenator system and total circulatory arrest was maintained for from 3 to 50 minutes after esophageal temperaure had been reduced to the range of 5℃ to 17℃. Rewarming followed by circulatory arrest was discontinued at about 36℃ of esophageal temperature. Two types of pump-oxygenator, bubble and Kay-Anderson, were used and their advantages were compared. Poor recovery of electroencephalogram and brain damage were found even in many cases where perfusion time for cooling and rewarming is relatively short, ranging from 45 to 55 minutes, in bubble type group. These changes were found more frequently and much more exaggerated in proportion to increase of total perfusion time. Brain damage considered referable to perfusion per se was found only where duration of perfusion extended over 89 minutes in Kay-Anderson group. Perfusion less than 80 minutes is cnosidered safe in this type of oxygenator. Changes of temperature in the jugular vein and brain surface were very closed and the difference between those and esophageal temperature was around 8℃ at the maximum when the latter was aronnd 10℃ and it decreased slightly at the end of cooling.The three closely approximated at around 20℃ on rewarming and the gradient between the former two and the latter became maximum at around 30℃ (esophageal) and it decreased at the end of rewarming. There was found gradient in temperature between brain core and brain surface and the former was closed to esphageal temperature and the latter colosed to temperature in the jugular vein. No marked difference in electric brain activity was noted between the cases with and without additional perfusion during circulatory arrest. It is anticipated that circulatory arrest of 30 minutes duration cause no harmful effect on brain when brain temperature was below 20℃. Esophageal temperature rose regularly compared to temperatue in the jugular vein or brain surface during circulatory arrest. The rapidity of temperature drift was in order of esophagus, brain and jugular vein. At first, decrease in amplitude was noted on cooling, though decrease in frequency was minumum, in electroephalographic changes. Occasionally, reactivation of electroencephalogram was found in spite of general tendency toward flattening, in the coures of cooling. The same phenomenon was observed occasionally after circulatory arrest, though electroencephalogram disappeared compleltely ten minutes after arrest. On rewarming, electroencephalogram reappared at 20℃, which is about 3℃ higher in average temperature when it disappeared on cooling. Changes in electroencephalogram on rewarming was not consistent. Burst at first and then increase in frequency were noted in some cases. and wave of low voltage at first, secondly rapid increase of frequency and then gradual increase of amplitude were noted in another cases. Occasionally, suppression of electroencephalogram recurred after esophageal temperature reached to over 30℃, Decrease in both frequency and amplitude of brain waves were generally noted in most caces at the end of rewarming and return of amplitude to the initial level usually lagged behind that of frequency. Brain damage was found in cases where recovery of brain was poor when examination was performed 20 minutes or more later after completion of the experiment, though it was sometimes unsuccessful to detect brain damage where examination was done earlier than 20 minutes. Brain damage was found mostly in the cortical area of the brain and occasionally in nucleus and brain stem. There were few cases where brain damage was found despite of good recovery in brain acivity. No changes were noted usually in cortical area in those cases and minimum when existed, too. It is remarkable that good recovery of brain activity in electroencephalogram does not always guarantee absense of brain damage. Estimation of the activity of succinic dehydrogenase is considered an excellent method for detection of brain damage, because it makes passible to disclose changes in brain tissue in early period after their occurrence. Bubble type oxygenator is considered disadvantageous to profound hypothermia with rapid blood cooling.
en-copyright=
kn-copyright=

en-aut-name=IshiaiShyozo
en-aut-sei=Ishiai
en-aut-mei=Shyozo
kn-aut-name=石合省三
kn-aut-sei=石合
kn-aut-mei=省三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=175
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Supplement of Experimental Study on the properties of the blood remained in the heart of the dead body due to internal bleeding
kn-title=内出血死の死体血液に関する実験的研究補遺
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=On the study of the physical and chemical properties of the blood remained in the heart of the rabbit which died of the internal bleeding by cutting off the mesentery artery, comparing with Irie's reports in which he examined the properties of the blood remained in the heart of the dead body due to external bleeding by cutting off the carotid artery and internal bleeding by liver injury, the following results were obtained: 1) In this experiment: a) the quantity of bleeding was larger relatively, and the time of death was longer than in Irie's experiments; b) the blood sedimentation rate and the blood coagulation time prolonged like the case of liver injury; c) the blood sugar increased like the case of liver injury; d) the quantity of serum calcium and phosphor increased like the case of liver injury. 2) There were no obvious differences between this experiment cud the experiment of liver injury.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=TakahamaKeiichi
en-aut-sei=Takahama
en-aut-mei=Keiichi
kn-aut-name=高浜桂一
kn-aut-sei=高浜
kn-aut-mei=桂一
aut-affil-num=2
ORCID=

en-aut-name=KondoYoshio
en-aut-sei=Kondo
en-aut-mei=Yoshio
kn-aut-name=近藤嘉男
kn-aut-sei=近藤
kn-aut-mei=嘉男
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=熊本大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=熊本大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=161
end-page=174
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on the Postmortem Changes of Enzymic Activities in the Organs and Tissues
kn-title=死後における臓器酵素作用の消長に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The studies on the changes of the activities of cathepsin, amylase and phosphatase in the enzyme solution extracted from the organs and tissues led to the following results. Report I. As the fundamental experiment, the activities of Papayotin and Taka-diastase which hydrolysed the substrates (gelatine and starch) was kept still after 144 hours in an incubator, but the activities of them in their mixed solution was lost more rapidly. Report 2. The activities of cathepsin and phosphatase in the enzyme-solution extracted from the liver and the activity of phosphatase from the femur of the dog was kept still in an incubator after 20 days, but the activity of amylase from the liver was already lost after 3 or 4 days. Report 3. The activities of amylase in the brain, lung, liver, kidney and the thighmuscle of the rabbit was lost 24 to 36 hours after death in summer, 60 to 72 hours in spring and autumn, but was kept still 72 hours in winter.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=TakemuraHideo
en-aut-sei=Takemura
en-aut-mei=Hideo
kn-aut-name=竹丸英夫
kn-aut-sei=竹丸
kn-aut-mei=英夫
aut-affil-num=2
ORCID=

en-aut-name=TakahamaKeiichi
en-aut-sei=Takahama
en-aut-mei=Keiichi
kn-aut-name=高浜桂一
kn-aut-sei=高浜
kn-aut-mei=桂一
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=熊本大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=153
end-page=160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enzymochemical Studies on the Parenchymatous Poisoning
kn-title=実質毒中毒の酵素化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to investigate the cause of the toxic action of the parenchymatous poisoning which are represented by arsenic and phosphor poisoning, enzymochemical studies on the influences of the parenchymatous poisoning to the activities of cathepsin, phcsphatase and amylase in the organs and serum have been attempad, and the following results were obtained by the experiments of Rep. I, 2 and 3. Rep. I: Uuder the arsenic poisoning, the serum albumin decreased and the activity of cathepsin in the liver was inhibited, but the serum γ-globulin increased and the activity of cathepsin in the serum was strengthened. Rep. 2: The activity of phosphatase in the brain, heart, lung, liver, kidney and serum was inhibited under the acute arsenic poisoning, but the activity of phosphatase in the serum and the organs except the heart were slightly strengthened under the chronic poisoning. Rep. 3: The activity of amylase in the brain, heart, lung, liver, kindey and serum were inhibited slightly under the acute arsenic poisoning, but under the suba_ute and chronic poisoning, the activity of amylase were strengthened obviously, especially in the lung, kidney and heart.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=白石真澄
kn-aut-sei=白石
kn-aut-mei=真澄
aut-affil-num=2
ORCID=

en-aut-name=TakahamaKeiichi
en-aut-sei=Takahama
en-aut-mei=Keiichi
kn-aut-name=高浜桂一
kn-aut-sei=高浜
kn-aut-mei=桂一
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=熊本大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=123
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Study on Capillary Vascularization in the Periodontal Tissue following Gingivectomy and Flap Operation
kn-title=歯槽膿漏症手術創の血管新生に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sixty five normal mature dogs weighing about 5 to 10Kg. fed on under the same condition were used. Gingivectomies were performed in the area of lower anterior teeth, while flap operation in the area of upper anterior teeth in the same dog. Healing process of operated gingivae was followed up during twenty-eight days after operative procedure. Imagawa's gutta percha perfusion methode was adopted for observation immdeiately after, 1day, 3, 7, 14, 21 and 28 days after operation consecutively, and then heads of sacrificed dogs were fixed in 10 percent formalin solution. Transparent specimens were prepared from the operated tissue for stereoscopic observation, while histologic specimens were stained with hematoxylin-eosin by a routine paraffin methode simultaneously. The result obtained were as followed: 1) Vascularization during wound healing of the operated gingiva, alveolar bone and periodontal membrane was fundamentally identical with description by Clark and Akita: new capillary loops which developed from capillary buds connected each other and built a capillary net work on the seventh days and then some capillaries disintegrated. 2) Clusters of capillary loops which developed in the granulation tissue were mainly supplied by the blood vessels of the periodontal membrane especially in the case of gingivectomy. Thus it could be considered that blood vessels of periodontal membrane would play the most important role in the blood supply for the newly formed gingiva in the early stage. 3) Newly formed blood vessles of the gingiva and periodontal membrane as well as branch vessels among of capillary loops were connected each other fourteen days after operation, 4) Reattachment of gingiva to cemeutum was noticed two weeks after operation. At this period capillary loops, which had developed in the wound of flap operations, built capillary net works at the area internal gingival epithelial margin (innere Saumepithel) and were shortened and came closer to cementum at the area where internal gingival epithelial margin attached. It would be considered that this process would stimulate the vitality of cementum and had some relationship in organic union of the connective tissue with cementum. 5) Wound healing was remarkably delayed at gingival papillae, where normal vascularization could not be noticed 28days after operation. Thus it would be better for us to use surgical packs after operation and gingival massage seemed to stimulate normal vascularization.
en-copyright=
kn-copyright=

en-aut-name=SuzukiSatoshi
en-aut-sei=Suzuki
en-aut-mei=Satoshi
kn-aut-name=鈴木達志
kn-aut-sei=鈴木
kn-aut-mei=達志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部歯科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=77
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Etiology of Renal Anemia Part Ⅲ. Studies on Myelopoiesis and Thrombopoiesis by Means of Clinical Bone Marrow Tissue Culture
kn-title=腎性貧血の成因に関する研究 第3編 骨髄の臨床組織培養法による白血球系並びに栓球系造血に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The hematopoietic function of the bone marrow of renal patients and influences of azotemia on the normal bone marrow were studied by means of clinical bone marrow tissue culture. The results obtained are as follows. 1) The marrow myelopoietic function of nephrotic patients was increased, when normal human serum was added to the medium. 2) The myelopoietic function in acute glomerulonephritis showed no significant change in regard to the cell density index but the relative growth rate and cellular migratory velocity were slightly decreased, when the bone marrow was cultured in a medium containing normal human serum. 3) When the bone marrow from patients with chronic glomerulonephritis was cultured in a medium containing normal human serum, the marrow function became activated in a slightly elevated NPN group while it became dep. essed in a highly elevated NPN group. 4) The bone marrow from uremic patients cultured in a medium containing normal human serum showed a growth pattern simulating that of hypoplastic anemia. The relative growth rate was half the control value and the migratory velocity of neutrophilic cells and cell density index were markedly decreased. 5) The bone marrow from patients with chronic renal insufficiency was cultured, to investigate the megakaryocytic function, in a medium containing normal human serum. There was reduction in both megakaryocyte number and percentage of motile forms of megakaryocytes appearing in the growth zone. 6) The normal bone marrow showed a reduced relative growth rate and migratory velocity of neutrophilic cells, when cultured in a medium containing azotemic serum. 7) Similarly, the megakaryocytic function became depressed by an addition of azotemic serum to the medium. From the evifence obtained, it appears that azotemia accompanying chronic renal insufficiency exerts a depressing action on both myelopoietic and megakaryocytic functions. It is conceivable that the bone marrow under such an inhibitory action of a long standing will gradually show a transition to a hypoplastic state.
en-copyright=
kn-copyright=

en-aut-name=ArimoriShigeru
en-aut-sei=Arimori
en-aut-mei=Shigeru
kn-aut-name=有森茂
kn-aut-sei=有森
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=63
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Etiology of Renal Anemia Part Ⅱ. Studies of Erythropoiesis by Means of Bone Marrow Culture in Fluid Medium
kn-title=腎性貧血の成因に関する研究 第2編 骨髄液体培養法による赤血球系造血に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to study the erythropoietic function of the bone marrow in renal anemia and influences of azotemia on the erythropoietic function, bone marrow culture in fluid medium was performed on patients with renal diseases and healthy individuals. The rate of erythrocyte increase, hemoglobin increase, rate of nucleated cell increase and percentage of erythroblasts were measured. The results are summarized as follows. 1) Enhancement of the erythropoietic function was observed, when normal human serum was added to the medium culturing marrow specimens from patients with acute glomerulonephritis or chronic glomerulonepbritis showing a mild elevation of NPN.2) In patients with chronic glomerulonephritis with azotemia or patients with uremia, an addition of normal human serum to the culture medium had no effect on the already depressed erythropoietic function of the bone marrow. 3) The bone marrow erythropoietic funotion of healthy individuals was markedly decreased, when azotemic serum was added to the fluid medium. It has thus become clear that azotemia in chronic renal insufficiency depresses the marrow erythropoietic function of healthy persons. The cultured bone marrow from patients with a prolonged azotemia resulting from chronic renal insufficiency, therefore, shows depression of the erythropoietic function.
en-copyright=
kn-copyright=

en-aut-name=ArimoriShigeru
en-aut-sei=Arimori
en-aut-mei=Shigeru
kn-aut-name=有森茂
kn-aut-sei=有森
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=43
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of Nucleic Acids on Bone-Marrow Tissue Culture Part 3. Effect of nucleic acids on the erythrocyte series of bone marrow in normal rabbits, normal persons, and patients with aplastic anemia
kn-title=腎性貧血の成因に関する研究 第1編 腎疾患患者血液に関する臨床統計的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The nature of renal anemia has been obscure despite numerous investigations initiated by Bright (1836). The author conducted a statistical analysis, with purpose of elucidating the cause of renal anemia, on peripheral blood pictures and myelograms of a total of 136 patients (80 cases of acute and chronic glomerulonephritis, 35 cases of uremia, 14 cases of nephrosis and 7 cases of polycystic kidneys) being admitted to our department in the past 10 years, and obtained the following results. 1) The hemoglobin and RBC showed a inverse correlation with the NPN and the color index tended to be normochromic or hyperchromic in the presence of elevated NPN. 2) The leukocyte count, as a rule, was within normal limits except for leukopenia observed in severe and prolonged azotemia. 3) The absolute lymphocyte count in the peripheral blood was decreased in azotemia. 4) The platelet count had a inverse correlation with the NPN. 5) Nucleated cells in the bone marrow were decreased in number in severe azotemic cases. 6) Myelograms in azotemia revealed marked maturation arrest and depression of the erythroid series. 7) There was normal to slightly deceased cellularity of the myeloid series in azotemia. 8) The serum iron tended to show a proportional correlation with the NPN and a inverse correlation with the RBC. 9) The serum copper became elevated prior to the increase of the serum iron. 10) In azotemia many sideroblasts appeared in the bone marrow, the sideroblast ratio being over 1.0. 11) Sideroblastograms assumed the normal pattern in nephrosis and the hypoplastic pattern in uremia. In chronic glomerulonephritis there was the intermediate pattern of the two. From the results obtained, it is most likely that renal anemia results from the deleterious effects upon bone marrow hematopoiesis, particularly upon erythropoiesis of the noxious substances present in azotemia. Such a bone marrow dysfunction of severe degree and of prolonged duration would ultimately lead to the development of a clinical picture compatible with hypoplastic anemia.
en-copyright=
kn-copyright=

en-aut-name=ArimoriShigeru
en-aut-sei=Arimori
en-aut-mei=Shigeru
kn-aut-name=有森茂
kn-aut-sei=有森
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=29
end-page=41
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of Nucleic Acids on Bone-Marrow Tissue Culture Part 3. Effect of nucleic acids on the erythrocyte series of bone marrow in normal rabbits, normal persons, and patients with aplastic anemia
kn-title=核酸の骨髄体外組織培養に及ぼす影響 第3編 健康家兎,健康人並びに再生不良性貧血患者骨髄の赤血球系に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of clinical culture method, the author added RNA and DNA at various directly to the media in which was cultured the bone marrow of normal rabbit, normal person, and aplastic anemia, with the purpose to see the effect of these nucleic acids on the erythropoiesis, and obtained the foliowing results, 1. The addition of RNA and DNA at optimal concentration to the bone marrow tissue culture of normal rabbit clearly accelerated erythropoiesis. 2. The addition of RNA and DNA at optimal concentration revealed a slignt accelerating effect of erythropoiesis of normal human bone marrow in tissue culture. 3. In the case of the bone marrow tissue of aplastic anemia patient, likewise the addition of RNA and DNA at opitimal concentration showed a slignt accelrating effect of erythropoiesis.
en-copyright=
kn-copyright=

en-aut-name=YamasakiRyohei
en-aut-sei=Yamasaki
en-aut-mei=Ryohei
kn-aut-name=山崎良平
kn-aut-sei=山崎
kn-aut-mei=良平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=13
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of Nucleic Acids on Bone-Marrow Tissue Culture Part 2. Effect of nucleic acids on leucocyte and platelet series of normal and aplastic anemia human bone marrow
kn-title=核酸の骨髄体外組織培養に及ぼす影響 第2編 健康人並びに再生不良性貧血患者骨髄の白血球系及び栓球系に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To the bone marrow of aplastic anemia and normal persons, being cultured by means of clinical tissue culture method, RNA and DNA at various concentrations were added directly to the media to see their effects on the leucoyte and platelet series. The following are the results. 1. As for the leucocyte series of normal human bone marrow, the addition of RNA as well as DNA at optimal concentration showed an increase in the growth area and cell density, while in the case of neutrophils their wandering velocity was accelerated. In the case of aplastic anemia human bone marrow the addition of both RNA and DNA at optimal concentration likewise showed a stimulating action on the leucocyte series, and this effect was further enhanced when VB12 was added concomitantly. 2. As regards the platelet series in culture, the addition of RNA and at optimal concentration acceraded the function of megakaryocytes in both bone marrow of normal persons. and aplastic anemia. 3 The stimulating effect of RNA on the platelet series was stronger than of DNA, but the effect of the two nucleic acids on the leucocyte series did not differ significantly.
en-copyright=
kn-copyright=

en-aut-name=YamasakiRyohei
en-aut-sei=Yamasaki
en-aut-mei=Ryohei
kn-aut-name=山崎良平
kn-aut-sei=山崎
kn-aut-mei=良平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1-3
article-no=
start-page=1
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of Nucleic Acids on Bone-Marrow Tissue Culture Part 1. Effect of nucleic acids on the leucocyte series of normal rabbit bone marrow
kn-title=核酸の骨髄体外組織培養に及ぼす影響 第1編 健康家兎骨髄の白血球系に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to determine the effect of nucleic acids on the hematopoietic functions of bone marrow, the author added RNA and DNA at various concentrations directly to normal rabbit bone marrow being cultured by the coverslip method, and obtained the following results. 1. The direct addition of RNA at optimal concentration to the culture medium increased the growth area markedly and also there could be observed an increase in the cell density. In addition, there were recognized a marked acceleration of carbon particle phagocytotic ability in pseudo-eosinophils as well as a slight increment in the wandering velocity of these cells. 2. In the case of the addition of DNA there were recognized a mild increase in the growth area and an increase in the cell density. Moreovr, the carbon particle phagocatotic ability of pseudo-eosinophlis was greatly accelerated but there could be seen no effect on the wandering velocity.
en-copyright=
kn-copyright=

en-aut-name=YamasakiRyohei
en-aut-sei=Yamasaki
en-aut-mei=Ryohei
kn-aut-name=山崎良平
kn-aut-sei=山崎
kn-aut-mei=良平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END