start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=455
end-page=468
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Effects of Various Anti-Leukemic Agents by Means of SternaI Bone-Marrow Tissue Culture of Various Leukemic Patients Part 3. On the Effects of Various Anti-Leukemic Agents by the Bone-Marrow Tissue Culture in Fluid Medium
kn-title=各種白血病患者胸骨骨髄培養に於ける各種抗白血病剤の影響に関する研究 第�V編 液体培養に於ける各種抗白血病剤の影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In an attempt to clarify the effects of various antileukemic agents on cell division and on the multiplication of leukemic cells, the author performed the bone-marrow tissue culture of various leukemic patients in fluid media. Namely, the author observed the effects of direct addition of urethane, nitromin, myleran, tespamin, colcemid, carzinophilin, actinomycin C, chromomycin, and mitomycin on the changes in the leucocyte count by performing bone marrow tissus culture in fluid media of various leukemic patients, and obtained the following results: 1. In acute myelogenous leukemia nitromin acted inhibitorily a little on the increase of leukocyte count. 2. In chronic myelogenous lcnkemia the inhibitory effect was marked in the descending order of myleran, carzinophilin, nitromin and urethane. 3. In acute lymphocytic leukemia all agents hardly had any inhibitory effect on the increase in the leucocyte count, but nitromin was slightly effective. 4. In chronic lymphocytic leukemia the inhibitory effect was marked in the descending order of nitromin, actinomycin C and tespamin. 5. In monocytic leukemia the inhibitory effect was found to be in the descending order of mitomycin and nitromin. 6. From these experiments, clinically it can be anticipated that nitromin is effective in acute myelogenous leukemia; myleran and carzinophilin in chronic myelogenous leukemia; nitromin and actinomycin C in chronic lymphocytic leukemia; and mitomycin in monocytic leukemia.
en-copyright=
kn-copyright=

en-aut-name=NabeshimaSaburo
en-aut-sei=Nabeshima
en-aut-mei=Saburo
kn-aut-name=鍋島三朗
kn-aut-sei=鍋島
kn-aut-mei=三朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=441
end-page=453
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Effects of Various Anti-Leukemic Agents by Means of Sternal Bone Marrow Tissue Culture of Various Leukemic Patients Part 2. On the Effects of Various Antibiotics and OX Substance by Clinical Tissue Culture of Bone Marrow
kn-title=各種白血病患者胸骨骨髄培養に於ける各種抗白血病剤の影響に関する研究 第�U編 臨床組織培養による抗生物質及びOX物質の影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to elucidate the effects of various antibiotics (carzinophilin, actinomycin C, chromomycin, mitomycin) and OX substance on the function of leukemic cells, the author performed clinical tissue culture of bone marrow of various leukemic patients. First the author performed bone marrow tissue culture of normal persons with addition of various antibiotics and OX substance in graded concentrations and established the maximal concentration of the agents in the medium, which does not impede the bone marrow cell growth. The author observed the effect of direct addition of various antibiotics and OX substance at this maximal concentration on the relative growth of the tissue, the wandering velocity of the cells, and the cell density in the bone-marrow tissue culture of various leukemic patients; and obtained the following results: 1. In acute myelogenous leukemia chromomycin and actinomycin C acted somewhat inhibitorily on the cell growth of the bone marrow. 2. In chronic myelogenous leukemia the inhibitory effect was found, though only slightly, to be in the descending order of carzinophilin, mitomycin, chromomycin and OX substance. 3. In acute lymphocytic leukemia and in chronic lymphocytic leukemia, no agents acted inhibitorily on the cell growth of the bone marrow. 4. In monocytic leukemia mitomycin showed an inhibitory effect to a moderate degree. 5. Judging from the effects of these drugs on leukemic cells, it may be expected that the efficacy of these drugs in the treatment of various leukemias is as follows: In actue myelogenous leukemia chromomycin is mildly effective; in chronic myelogenous leukemia carzinophilin is also mildly effective; and in monocytic leukemia mitomycin mildly effective.
en-copyright=
kn-copyright=

en-aut-name=NabeshimaSaburo
en-aut-sei=Nabeshima
en-aut-mei=Saburo
kn-aut-name=鍋島三朗
kn-aut-sei=鍋島
kn-aut-mei=三朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=427
end-page=440
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Effects of Various Anti-Leukemic Agents by Means of Sternal Bone-Marrow Tissue Culture of Various Leukemias Part 1. On the Effects of Urethane and Various Alkylating Agents by Clinical Tissue Culture of Bone Marrow
kn-title=各種白血病患者胸骨骨髄培養に於ける各種抗白血病剤の影響に関する研究 第�T編 臨床組織培養によるウレタン及び細胞毒性物質の影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose clarify the effects of urethane and various alkylating agents(nitromin, myleran, colcemid, tespamin) of the function of leukemic cells, the author performed clinical tissue culture of bone marrow of various leukemic patients First the author performed bone-marrow tissue culture of normal persons with addition of urethane and various alkylating agents in graded concentrations and established the maximal concentration of the agents in the medium, which does not impede bone-marrow cell growth. At this maximal concentration the observation was carried on to see the effect of direct addition of urethane and various alkylating agents on the relative growth of the tissue, the wandering velocity of the cells, and the cell density by performing bone-marrow tissue culture of various Ieukemic patients; and obtained the following results: 1. In acute myelogenous leukemia the inhibitory effect on the bone-marrow cell growth was found to be in the descending order of nitromin, myleran, urethane, colcemid, and tespamin, and it was greatest with nitromin. 2. In chronic myelogenous leukemia the inhibitory effect was found to be in the descending order of nitromin, myleran, urethane, colcemid and tepsamin, and it was marked with nitromin and myleran. 3. In acute lymphocytic leukemia nitromin acted inhibitorily slightly, but other anti-leukemic agents had hardly any inhibitory action. 4. In chronic lymphocytic leukemia the inhibitory effect was found to be in the descending order of tepsamin, urethane, colcemid, nitromin and myleran; among them tespamin and urethane were more effective. 5. In monocytic leukemia moderately inhibitory effect could be recognized in the descending order of nitromin, colcemid, urethane, tespamin and myleran; of them nitromin proved to be more effective. 6. Judging from the effects of these agents on leukemic cells in the treatment of leukemias, one might anticipate the efficacy of these drugs as follows: i. e. in acute myelogenous leukemia nitromin is most effective; in chronic myelogenous leukemia nitromin and myleran are most effective; in chronic lymphocytic leukemia tespamin and urethane are most effective; and in monocytic leukemia nitromin is most effective.
en-copyright=
kn-copyright=

en-aut-name=NabeshimaSaburo
en-aut-sei=Nabeshima
en-aut-mei=Saburo
kn-aut-name=鍋島三朗
kn-aut-sei=鍋島
kn-aut-mei=三朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=417
end-page=425
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Anti-leukemic Chemical Agents -By the Bone-Marrow Tissue Culture- �V. The Effects of Anti-leukemic Chemical Agents on the Bone-Marrow Tissue Culture of Various Leukemic Patients in Fluid Medium
kn-title=抗白血病剤に関する研究―骨髄体外組織培養による― 第�V編 各種白血病患者骨髄液体培養に及ぼす抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed the bone-marrow tissue culture of various leukemic patients in fluid medium with addition of several anti-leukemic chemical agents, and observed changes in the leucocyte count from time to time, and conducted the screening of these agents. The results of the experiment are as follows. In acute myelogenus leukemia the inhibitory effect was found to be in the descending order of Prednisolone, Cortisone and ACTH; in chronic myelogenous leukemia it was in the order of 6MP and Prednisolone; in acute lymphocytic leukemia Prednisolone, ACTH and Cortisone; in chronic lymphocytic leukemia Prednisolone, ACTH, and Cortisone; and in monocytic leukemia 6MP and Prednisolone.
en-copyright=
kn-copyright=

en-aut-name=SatoShiro
en-aut-sei=Sato
en-aut-mei=Shiro
kn-aut-name=佐藤四郎
kn-aut-sei=佐藤
kn-aut-mei=四郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=409
end-page=416
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Anti-leukemic Chemical Agents -By the Bone-Marrow Tissue Culture- �U. The Effects of Anti-leukemic Chemical Agents on the Bone-Marrow Tissue Culture of Various Leukemic Patients
kn-title=抗白血病剤に関する研究―骨髄体外組織培養による― 第�U編 各種白血病患者胸骨骨髄被覆培養に及ぼす抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=At first the author performed the bone-marrow tissue culture of various leukemic patients with addition of several antileukemic agents, and observed the relative growth rate, the cell density, and the wandering velocisy of the cells, and then conducted the screening of these chemical agents for their inhibitory effects on leukemic marrow, and attempted to select the drugs most suitable for each case and obtained the following results. In acute myelogenous leukemia the inhibitory effect was found to be in the descending order of Cortisone, Prednisolone, and 6MP; in chronic myelogenous leukemia it was in the order of 6MP, and Prednisolone; in acute lymphocytic leukemia it was Prednisolone, ACTH and Cortisone; in chronic lymphocytic leukemia Prednisolone, Cortisone and 6MP: and in monocytic leukemia Prednisolone and 6MP.
en-copyright=
kn-copyright=

en-aut-name=SatoShiro
en-aut-sei=Sato
en-aut-mei=Shiro
kn-aut-name=佐藤四郎
kn-aut-sei=佐藤
kn-aut-mei=四郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=399
end-page=407
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Anti-leukemic Chemical Agents -By the Bone-Marrow Tissue Culture- �T. The Effects of Anti-leukemic Chemical Agents on the Bone-Marrow Tissse Culture of Normal Rabbit and Normal Person
kn-title=抗白血病剤に関する研究―骨髄体外組織培養による― 第�T編 正常家兎及び健康人胸骨骨髄被覆培養に及ぼす抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to clarify the effects of anti-leukemic clemical agents-antimetabolites (Azan, 6MP, T-431L), hormones (ACTH, Cortisone, Prednisolone)-on the hematopoietic function of bone marrow, especially on the leucocyte series, the author observed the effects of direct addition of these chemical agents on the tissue growth area, the cell density, and the wandering velocity of pseudoeosinophils of the bone marrow by performing the tissue culture of the normal rabbit bone marrow. Likewise, the bone-narrow tissue culture of normal persons has been performed with the addition of several anti-leukemic chemical agents at various concentrations, and established the maximal concentration of the agents in the medium as to not impede the bone-marrow growth; and obtained the following results. 1. Any one of anti-leukemic agents acts inhibitorily on the cell growth and the wandering velocity of the cells of the bone marrow at a higher concentration than at a certain fixed concentration. Of the anitmetabolites used in the present experiments, the inhibitory effect is strong in the descending order of T-431L, Azan and 6MP; and of the hormones it is in the order of Prednisolone, Cortisone and ACTH. 2. The maximal concentration of the media with addition of several anti-leukemic agents, which do not impede the growth of the bone marrow of normal persons is 0.035 mg/ml for Azan; 0.05 mg./ml. for 6MP; 0.01 mg/ml. for T-431L; 0.01 mg/ml. for ACTH; 0.01 mg/ml. for Cortisone ; and 0.01 mg/ml. for Prednisolone.
en-copyright=
kn-copyright=

en-aut-name=SatoShiro
en-aut-sei=Sato
en-aut-mei=Shiro
kn-aut-name=佐藤四郎
kn-aut-sei=佐藤
kn-aut-mei=四郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=387
end-page=398
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Stndies on the Pneumoconiosis of Electric Welders
kn-title=電気熔接工のじん肺について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sadatoshi, one of the authors, had reported previously that he had found 26% of electric welders at a certain heavy industrial plant suffered from pneumoconiosis by roentgenological examination. In this time investigation was done upon 78 electric welders carrying pneumoconiosis without pulmonary tuberculosis and the result was as follows: 1) Chest X-ray findings approved granulated type. No fibrosis, tendency of confluence, emphysema and eggshell calcification. Changes in hilus could not be found at the begining. 2) No visible changes in blood findings. Except, as the type advanced, a tendency of a slight decrease in neutrophil leukocytes and increase in lymphocytes could be seen. 3) No remarkable changes admitted in lung vital capacity and maximum ventulating volume. Expiratory impediment appeared in the third type. 4) Though welding dust contains SiO(2), welder's pneumoconiosis is innocent compared with silicosis. It also seems a little different from siderosis and so is suitable to classify it as "welder's Pneumoconiosis". 5) Occupational career should be cared when taking routine X-rayphotographs.
en-copyright=
kn-copyright=

en-aut-name=SadatoshiKurashi
en-aut-sei=Sadatoshi
en-aut-mei=Kurashi
kn-aut-name=貞利庫司
kn-aut-sei=貞利
kn-aut-mei=庫司
aut-affil-num=1
ORCID=

en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=青山英康
kn-aut-sei=青山
kn-aut-mei=英康
aut-affil-num=2
ORCID=

en-aut-name=ItamiYoshiaki
en-aut-sei=Itami
en-aut-mei=Yoshiaki
kn-aut-name=伊丹仁朗
kn-aut-sei=伊丹
kn-aut-mei=仁朗
aut-affil-num=3
ORCID=

en-aut-name=OnoMinoru
en-aut-sei=Ono
en-aut-mei=Minoru
kn-aut-name=大野稔
kn-aut-sei=大野
kn-aut-mei=稔
aut-affil-num=4
ORCID=

en-aut-name=OhnoKimiyoshi
en-aut-sei=Ohno
en-aut-mei=Kimiyoshi
kn-aut-name=小野公義
kn-aut-sei=小野
kn-aut-mei=公義
aut-affil-num=5
ORCID=

en-aut-name=OharaYasuro
en-aut-sei=Ohara
en-aut-mei=Yasuro
kn-aut-name=尾原安郎
kn-aut-sei=尾原
kn-aut-mei=安郎
aut-affil-num=6
ORCID=

en-aut-name=KatoShozi
en-aut-sei=Kato
en-aut-mei=Shozi
kn-aut-name=加藤尚司
kn-aut-sei=加藤
kn-aut-mei=尚司
aut-affil-num=7
ORCID=

en-aut-name=KanaiYoshiaki
en-aut-sei=Kanai
en-aut-mei=Yoshiaki
kn-aut-name=金井義明
kn-aut-sei=金井
kn-aut-mei=義明
aut-affil-num=8
ORCID=

en-aut-name=MitaniYasuo
en-aut-sei=Mitani
en-aut-mei=Yasuo
kn-aut-name=三谷恭夫
kn-aut-sei=三谷
kn-aut-mei=恭夫
aut-affil-num=9
ORCID=

en-aut-name=MotoiMakoto
en-aut-sei=Motoi
en-aut-mei=Makoto
kn-aut-name=元井信
kn-aut-sei=元井
kn-aut-mei=信
aut-affil-num=10
ORCID=

en-aut-name=MoriTakashi
en-aut-sei=Mori
en-aut-mei=Takashi
kn-aut-name=森巍
kn-aut-sei=森
kn-aut-mei=巍
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=玉野三井綜合病院

affil-num=2
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部

affil-num=4
en-affil=
kn-affil=岡山大学医学部

affil-num=5
en-affil=
kn-affil=岡山大学医学部

affil-num=6
en-affil=
kn-affil=岡山大学医学部

affil-num=7
en-affil=
kn-affil=岡山大学医学部

affil-num=8
en-affil=
kn-affil=岡山大学医学部

affil-num=9
en-affil=
kn-affil=岡山大学医学部

affil-num=10
en-affil=
kn-affil=岡山大学医学部

affil-num=11
en-affil=
kn-affil=岡山大学医学部
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=373
end-page=385
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Double and Triple Drug Resistant Tubercle Bacilli 3. A study on the virulency of double and triple drug resistant tubercle bacilli
kn-title=薬剤多重耐性結核菌に関する実験的研究 第3編 多重耐性結核菌の毒力に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to study the degree of virulency of various drug resistant tubercle bacilli, the author injected true double and triple resistant tubercle bacilli obtained from tuberclous patients and also H(37)Rv double and triple resistant strain intraperitoneally into guinea pigs and compared their virulency. 1. On comparing the results of the group inoculated with double resistant bacilli with those in the group injected with susceptible tubercle bacilli, the virulency in the former group was markedly diminished. As for the difference in the virulency of double resistant bacilli according to the combination of drugs, a considerable fall in the virulency can be recognized in the combination of SM-PAS, but the decrease in the virulency is still greater in such combinations as SM-INH and PAS-INH that include INH. In other words, the virulency is controlled and represented by PAS resistance in the case of SM-PAS, whereas it is by INH resistance in the case of SM-INH and PAS-INH. In addition, in the combinations of SM-INH and PAS-INH about the some degree of the decrese in virulency can be recognized on the contrary to expectation, showing hardly any difference between the two. 2. There can be seen about the same degree of the fall in the virulency of the group inoculated with the double resistant bacilli obtained from patients and in that injected with H(37)Rv double resistent strain, showing on significant difference. 3. In the group inoculated with triple resistant bacilli the fall in the virulency is still greater than in the case with double resistant bacilli. Especially so in the triple resistant bacilli that is more resistant to INH. 4. There can be recognized no significant difference in the fall of virulency between the group inoculated with bacilli obtained from patients and the group injected with H(37)Rv triple resistant bacilli. 5. Really, the fall in the virulency of double or triple resistant bacilli is dependent on the drug resistance of the bacilli against INH or PAS, especially on the resistance against INH.
en-copyright=
kn-copyright=

en-aut-name=AitaniKatsuichi
en-aut-sei=Aitani
en-aut-mei=Katsuichi
kn-aut-name=相谷勝一
kn-aut-sei=相谷
kn-aut-mei=勝一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室/大学院医学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=365
end-page=372
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Double and Triple Drug Resistant Tubercle Bacilli 2. The percentage of three drug resistant clone of the so-called triple resistant strains appearing in three different media
kn-title=薬剤多重耐性結核菌に関する実験的研究 第2編 所謂三者耐性株中の三重耐性菌集落混合率に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to find out the actual percentage of the triple resistant clones of the so-called three-drug resistant strains, isolated from 15 patients, the author conducted a series of culture of these bacilli by the combined medium method and also by the cross culture method of a single clone, and obtained the following results. 1. The percentage of the three-drug resistant clone in the three drug medium proved to be 4.2 per cent in the medium composed of 10γ SM-1γ PAS-1γ INH; 7.2 per cent in the medium of 100γ SM-10γ PAS-1γ INH; and 2.0 per cent in the medium of 100γ SM-100γ PAS-10γ INH, demonstrating the percentage lower than in the case of the double resistant strain as described in the previous report. 2. In the case with the cross culture of a single clone, the percentage of the triple resistant bacilli is 10.0 per cent in the medium of 10γ SM-1γ PAS-1γ INH; 6.0 per cent in the medium of 100γ SM-10γ PAS-1γ INH; and 2.5 per cent in the medium of 100γ SM-100γ PAS-10γ INH, showing the values close to those in the combined medium culture. 3. The percentage of each triple resistant strain is a little less than the product of the percentage of three individual clones. 4. It is difficult to carry on the successive transplantation of any one of these triple resistant strains, and this seems to be due to a marked decrease in their proliferating power.
en-copyright=
kn-copyright=

en-aut-name=AitaniKatsuichi
en-aut-sei=Aitani
en-aut-mei=Katsuichi
kn-aut-name=相谷勝一
kn-aut-sei=相谷
kn-aut-mei=勝一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室/大学院医学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=339
end-page=351
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on the prophylactic Treatment of Cancer with Various Anticancer Agents Part �U. Influence of Anticancer Agents on the Inoculation of Brown-Pearce Carcinoma into Abdominal Wall of Rabbit, and Changes in Peripheral Blood Picture
kn-title=各種制癌剤による手術創の癌再発予防に関する実験的研究 第�U編 各種制癌剤のBrown-Pearce癌の腹壁筋内移植に及ぼす影響とその末梢血液像の変化について（実験的研究）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immediately after inoculation of Brown-Pearce Carcinoma into the abdominal wall of rabbit, various anticancer agents (Nitromin, Carzinophilin, Azan, Tespamin and Mitomycin) were administered locally and their inhibitory effect for growth of tumor in loco with change in peripheral blood picture were observed. Results obtained were as follows: 1. Nitromin; no preventive effect on the inoculated carcinoma, Carzinophilin; most effective in agents tested, and inhibited the tumor growth in five out of ten animals, Azan; inhibited the tumor growth in only one out of ten, Tespamin; no effect like in Nitromin, Mitomycin; inhibited tumor growth in two out of ten. 2. In case of no tumor formation in the abdominal wall, leucemoid reaction, increases in monocytes and neutrophiles were not observed. In case of tumor formation, on the contrary, the reaction and the increases were remarkable.
en-copyright=
kn-copyright=

en-aut-name=SatoYasuo
en-aut-sei=Sato
en-aut-mei=Yasuo
kn-aut-name=佐藤泰雄
kn-aut-sei=佐藤
kn-aut-mei=泰雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=307
end-page=325
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Degenerative Changes in Human Leucocytes in Bone Marrow Tissue Culture �V. A Study on Degenerative Changes in Leucocytes of Various Leukemias and of Several Other Blood Diseases
kn-title=骨髄体外組織培養に於ける人白血球の退行性変化に関する研究 第3編 各種白血病並びに其の他二,三の血液疾患に於ける白血球の退行性変化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the bone marrow tissue culture of various leukemias as well as of several blood diseases conducted with the purpose to see the degenerative changes of the leucocytes appearing in the growth area, the following results were obtained. 1. In the case of acute myelogenous leukemia the degenerative changes of myeloblasts proceed rapidly at an early stage of culture and there appear degeneration granules which can never be observed in normal myeloblasts. Vacuoles and abnormal processes do appear though small in number. 2. In the case of acute lymphocytic leukemia, the appearance of small degeneration granules is marked in the degenerative changes of lymphoblasts. The degenerative changes of lymphocytes proceed slightly slower than in the case of the blasts, and the nonhomogenous condensation or swelling of the nuclei can often be seen. 3. In monocytic leukemia, degenerative changes of monoblasts appear earlier than those of monocytes, and degeneration granules, small vacuoles and various abnormal processes appear most numerously as compared with other kinds of blasts. The changes of promynocytes are relatively rapid and also degeneration granules, small and intermediate vacuoles as well as various abnormal processes can be recognized. In the case of monocytes the changes occur relatively earlier than in the case of those in normal person, and appearance of numerous degeneration granules is typical, large and small vacuoles can also be observed. 4. In the case of chronic myelogenous leukemia, the degenerative changes of myeloblasts take place slower than in the case of acute myelogenous leukemia, but more rapidly than in normal person, In promyelocytes and myelocytes the changes proceed relatively slowly, and in metamyelocytes and neutrophils, the changes proceed somewhat rapidly. Generally, in the case of immature cells degeneration granules, vacuoles and abnormal processes are less in number, but in more mature cells the number of them increases. In the case of mature neutrophils spherical processes appear markedly many and eruption of nucleus is seen rather few. 5. In chronic lymphocytic leukemia degenerative changes of lymphocytes appear somewhat more rapidly than in the case of normal person but they appear slower than those in acute cases, and most of lymphocytes show homogeneous pyknosis. 6. In aplastic anemia the degenerative changes of neutrophils proceed rapidly, having large degeneration granules as well as many vacuoles. Vacolization can also be observed in a high degree. Many abnormal processes appear and the nuclei are also either swollen or erupted. 7. In essential hypochromic anemia the degenerative changes of neutrophils appear rather rapidly and degeneration grenules, small vacuoles, and spherical processes are relatively numerous. 8. The degenerative changes of neutrophils in Banti's disease progress rather rapidly and the disorder in the arrangement of specific granules can be recognized at an early stage. Degeneration granules appear rather rapidly and the nuclei are swollen relatively earlier. 9. idiopathic thrombocytopenic purpura the degenerative changes in neutrophils take place approximately in the same manner as in the case of normal person.
en-copyright=
kn-copyright=

en-aut-name=ShinagawaKoji
en-aut-sei=Shinagawa
en-aut-mei=Koji
kn-aut-name=品川晃二
kn-aut-sei=品川
kn-aut-mei=晃二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=285
end-page=305
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Degenerative Changes in Human Leucocytes in Bone Marrow Tissue Culture �U. Influences of Various Culture Conditions on Degenerative Changes in Neutrophils
kn-title=骨髄体外組織培養に於ける人白血球の退行性変化に関する研究 第2編 各種培養条件の好中球退行性変化に及ぼす影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The normal human bone marrow was cultured in vitro by the clinical tissue culture method devised in our Department in order to see the influences of such factors as the medium temperature, the hydrogen ion concentration, the osmotic pressure in the media, and some single media, on the degenerative changes of neutrophils appearing in the growth area. These results were compared with those in the case of neutrophils cultured in the normal medium. The following are the conclusions. 1. In general the degenerative changes of neutrophils proceed slowly under low temperature but more rapidly at higher temperature. At 15℃ the progress is most slow while on the contrary, at the temperature below 10℃ it is rapid, The number of degeneration granules, vacuoles, and abnormal processes decreases as the bone marrow is cultured at a lower or at a higher temperature centering around 37℃-39℃. More condensed nuclei can be observed at a high temperature, and also at a low temperature. The eruption of the nucleus appears more frequently at low temperature, however, there is almost no nuclear eruption at high temperature. 2. As for the influence of the hydrogen ion concentration, the further away is the pH from that of the normal medium the more rapid is the degenerative changes. In the acid medium the appearance of small degeneration granules is more rapid but the number of vacuoles and sbnormal processes is less, showing no tendency of fusion of nuclear lobes but a strong tendency of non-homogeneous pyknosis. In alkaline medium degeneration granules are less but vacuoles and blisters are numerous, and cytoplasm is swollen, and nucleus tends to swell up or to erupt. 3. As for the influence of the osmotic pressure, in the isotonic solution the degenerative changes appear most slowly, and in the hypotonic solution the swelling of specific granules is marked and degeneration granules are numerous and large with many vacuoles. Cytoplasm and nulcleus are swollen, especially the eruption of the nucleus is striking. In the hypertonic solution the swelling of specific granules is observed, but the number and the size of degeneration granules are small. Vacuoles and abnormal processes are less, while myelin forms can be recognized relatively many. The nucleus and cytoplasm are condensed at the initial stage of the culture but later both of them are swollen. 4. In the single medium such as physiological saline solution, Ringer's solution, serum, or in the isotonic glucose solution, the degenerative changes proceed radidly at an early stage in any of these media, and the changes progress most rapidly in the glucose solution followed by physiological saline solution and Ringer's solution. The progress is slowest in the serum medium but it is more rapid than in the normal medium.
en-copyright=
kn-copyright=

en-aut-name=ShinagawaKoji
en-aut-sei=Shinagawa
en-aut-mei=Koji
kn-aut-name=品川晃二
kn-aut-sei=品川
kn-aut-mei=晃二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=257
end-page=259
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=One Method for the Detection of Vegetative Plankton
kn-title=植物性プランクトン珪藻の検出の1方法について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Authors have had experiment to lessen the trouble on the detection of vegetative plankton under the microscope. Used indian ink. To make 5 and 10% diluted indian ink and to put it into sediment, it is very easily and clearly to contrast with the back ground.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=OkuyamaMasami
en-aut-sei=Okuyama
en-aut-mei=Masami
kn-aut-name=奥山正己
kn-aut-sei=奥山
kn-aut-mei=正己
aut-affil-num=2
ORCID=

en-aut-name=KamimuraOsamu
en-aut-sei=Kamimura
en-aut-mei=Osamu
kn-aut-name=上村修
kn-aut-sei=上村
kn-aut-mei=修
aut-affil-num=3
ORCID=

en-aut-name=HattoriHisashi
en-aut-sei=Hattori
en-aut-mei=Hisashi
kn-aut-name=服部久
kn-aut-sei=服部
kn-aut-mei=久
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐藤浩一
kn-aut-sei=佐藤
kn-aut-mei=浩一
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=251
end-page=256
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two Autopsy Cases That Were Hardly to Determine the Cause of Death for High Degree of Putrefaction
kn-title=腐敗が高度で死因の判定が困難であつた水死体の2鑑定例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Authors have had occasions to perform autopsy on two bodies that were hardly to determine the cause of death for the high degree of putrefaction. One corpse. covered with flanket, was laid on ford and the other was discovered at the river side. In each instance, we could succeed the detection of vegetative plankton in the organs of general circulatory system. and then revealed that the cause of death were attributed to drowning.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=KamimuraOsamu
en-aut-sei=Kamimura
en-aut-mei=Osamu
kn-aut-name=上村修
kn-aut-sei=上村
kn-aut-mei=修
aut-affil-num=2
ORCID=

en-aut-name=OkuyamaMasami
en-aut-sei=Okuyama
en-aut-mei=Masami
kn-aut-name=奥山正己
kn-aut-sei=奥山
kn-aut-mei=正己
aut-affil-num=3
ORCID=

en-aut-name=HattoriHisashi
en-aut-sei=Hattori
en-aut-mei=Hisashi
kn-aut-name=服部久
kn-aut-sei=服部
kn-aut-mei=久
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=247
end-page=250
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Prophylaxis for Infectious Hepatitis 3rd. Report. on the Prophylaxls By Means of Inoculations With Human Serum γ-GIobulin
kn-title=流行性肝炎の予防に関する研究 第三報 人血清γ-Globulinに依る予防について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Prophylactic treatments, including inoculations with γ-globulin derived from human serum and placenta, were taken to the epidemic of infectious hapatitis at kagato-cho, Wake-gum, Okayama Prefecture. After these treatments, observing the emergence of new patients of hepatitis for full one year, following results were obtained. 1) New patients emerged not only in the contrast group but inoculated one. Of the three group, inoculated with human serum γ-globulin, inocnlated with human placental γ-globulin and contrast group, percentage of contraction is higher the inoculated group with human sernm γ-globtlin than others. 2) By the results of the mass examination, two groups were divided, the one included inapparent and latent infections, and the other was healthy cases. Observing the emergence of new patients in the group of healthy cases, percentage of emergence of the inoculated group with human serum and placental r-globulin was apparently lower than the contrast group. 3) From the facts above mentioned, it has been supposed that the inoculations with γ-globulin derived from human serum and placenta proved to have sufficient effect for non infected, but on the contrary little effect for infected before. 4) More than nine months after the inoculations, no prophylactic effect was supposed using inoculations with human serum γ-globulin for infectious hepatitis.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=IwaharaMasao
en-aut-sei=Iwahara
en-aut-mei=Masao
kn-aut-name=岩原正雄
kn-aut-sei=岩原
kn-aut-mei=正雄
aut-affil-num=2
ORCID=

en-aut-name=IwasakiTsujio
en-aut-sei=Iwasaki
en-aut-mei=Tsujio
kn-aut-name=岩崎辻男
kn-aut-sei=岩崎
kn-aut-mei=辻男
aut-affil-num=3
ORCID=

en-aut-name=IshidaTatsuo
en-aut-sei=Ishida
en-aut-mei=Tatsuo
kn-aut-name=石田立夫
kn-aut-sei=石田
kn-aut-mei=立夫
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山県衛生部公衆衛生課

affil-num=4
en-affil=
kn-affil=岡山県衛生部公衆衛生課
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=243
end-page=245
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Prophylaxis for Infectious Hapatitis 2nd. Report. on the Prophylaxis By Means of inoculations with Human Placental γ-Globulin
kn-title=流行性肝炎の予防に関する研究 第二報 人胎盤γ-globulinに依る予防について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) 1,324 villagers of Yoshikawa Village were inoculated with human placental γ-globulin "Neomasin" and sufficient effect was observed during the period of prevailing infectious hepatitis in this district of Jyobo-gun, Okayama prefecture. 2) These inoculations were effective even as late as 7 days before onset of hepatitis. 3) Effect of these inoculations did not depent upon age as well as sex of patient.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=IwaharaMasao
en-aut-sei=Iwahara
en-aut-mei=Masao
kn-aut-name=岩原正雄
kn-aut-sei=岩原
kn-aut-mei=正雄
aut-affil-num=2
ORCID=

en-aut-name=IwasakiTsujio
en-aut-sei=Iwasaki
en-aut-mei=Tsujio
kn-aut-name=岩崎辻男
kn-aut-sei=岩崎
kn-aut-mei=辻男
aut-affil-num=3
ORCID=

en-aut-name=IshidaTatsuo
en-aut-sei=Ishida
en-aut-mei=Tatsuo
kn-aut-name=石田立夫
kn-aut-sei=石田
kn-aut-mei=立夫
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山県衛生部公衆衛生課

affil-num=4
en-affil=
kn-affil=岡山県衛生部公衆衛生課
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=239
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Prophylaxis for Infectious Hepatitis 1st. Report. a Consideration Refer to Prophylaxis in General and Its Effect
kn-title=流行性肝炎の予防に関する研究 第一報 一般予防法とその効果に関する考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Patients, including latent infections, were detected by excuting mass examination for two hamlets of Kumayama-cho, a small town prevailing infectious hepatitis, Akaiwa-gun, Okayama Prefecture. Complete medical treatments of these patients were instructed, and also the cases must be taken care of were adequately leaded. Special efforts were taken to improve sanitary and hygienic practices in the community likewise other intestinal infections. In comparison with other hamlets which did not take adequate treatment, epidemic of infectious hepatitis has been almost protected and remarkable results were obtained after one year. These facts might offer interesting materials to prophylaxis for infectious hepatitis.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=IwaharaMasao
en-aut-sei=Iwahara
en-aut-mei=Masao
kn-aut-name=岩原正雄
kn-aut-sei=岩原
kn-aut-mei=正雄
aut-affil-num=2
ORCID=

en-aut-name=IwasakiTsujio
en-aut-sei=Iwasaki
en-aut-mei=Tsujio
kn-aut-name=岩崎辻男
kn-aut-sei=岩崎
kn-aut-mei=辻男
aut-affil-num=3
ORCID=

en-aut-name=IshidaTatsuo
en-aut-sei=Ishida
en-aut-mei=Tatsuo
kn-aut-name=石田立夫
kn-aut-sei=石田
kn-aut-mei=立夫
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山県衛生部公衆衛生課

affil-num=4
en-affil=
kn-affil=岡山県衛生部公衆衛生課
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=233
end-page=237
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on aldolase and transaminase in rabbits with convulsion Part �V On transaminase activity in serum and cerebral cortex after convulsion
kn-title=痙攣によるAldolase及びTransaminaseの変動に関する実験的研究 第3編 痙攣によるTransaminase活性の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The transaminase activity in serum and cerebral cortex of rabbits were measured by Frankel method. The results were as follows. 1. After convulsion caused by metazol, GOT and GPT activities in the rabbits serum temporarily increased. 2. GOT and GPT activities in cerebral cortex slightly decreased after convulsion.
en-copyright=
kn-copyright=

en-aut-name=OdaKoji
en-aut-sei=Oda
en-aut-mei=Koji
kn-aut-name=小田晧二
kn-aut-sei=小田
kn-aut-mei=晧二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=225
end-page=231
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on aldolase and transaminase activites in rabbits with convulsion Part �U. On serum aldolase activity after convulsion
kn-title=痙攣によるAldolase及びTransaminaseの変動に関する実験的研究 第2編 痙攣によるAldolase活性の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Serum aldalase activity markedly increased after convulsion caused by metrazol injeotion, about twice of the preconvulsive level, and recoverd to the normal level after 1 hour. 2. Same results were observed in the repetitive convulsion caused by hexogen administration. 3. During convulsion, brain aldolase activity did not change, muscle aldolase activities were slightly decreased. 4. In such cases succinyl choline chloride was injected into the rabbits no acceleration was observed in the serum aldolase activity. 5. Therefore, the acceleration of serum aldolase activity in the experimental convulsion was due to the muscle albolase in such a condition.
en-copyright=
kn-copyright=

en-aut-name=OdaKoji
en-aut-sei=Oda
en-aut-mei=Koji
kn-aut-name=小田晧二
kn-aut-sei=小田
kn-aut-mei=晧二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=219
end-page=224
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on aldolase and transaminase activities in rabbits with convulsions Part �T On Aldolase activities in the cerebral cortex of rabbits
kn-title=痙攣によるAldolase及びTransaminaseの変動に関する実験的研究 第1編 正常家兎および脳局所アナフイラキシー家兎大脳皮質のAldolase活性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aldolase activities in the cerebral cortex of normal rabbits and rabbits with latent cerebral local anaphylaxis (LC LA) were measured by using Bruns' method, and influences of glutamic acid, glutamine, aspartic acid, asparagine, and γ-aminobutyric acid on the aldolase activities were evaluated. It has been experimentally probed that LCLA is an epileptic disposition and a state of arrangement of convulsion. The results were as follws. 1) The aldolase activity in the cerebral cortex of rabbits with LCLA is decreased, compared with that of normal rabbits. 2) Glutamic acid accelerates the activity of the cerebral aldolase of normal rabbits. 3) Asparagine accelerates the activity of the cerebral aldolase of LCLA rabbits.
en-copyright=
kn-copyright=

en-aut-name=OdaKoji
en-aut-sei=Oda
en-aut-mei=Koji
kn-aut-name=小田晧二
kn-aut-sei=小田
kn-aut-mei=晧二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
END