start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2285
end-page=2289
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Nitrogen Metabolism of the Brain Part 11 Ammonia and Amino Acid Contents of the Rat Brain in Case of the NH(4)Cl Application
kn-title=脳の窒素代謝 第11編 塩化アンモン投与大黒鼠脳髄アンモニア並びにアミノ酸量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In case of the intraperitoneal application of ammonium chloride, ammonia of the rat brain was measured by Conway's microdiffusion method, and amino acid by paperchromatography; the following results were obtained. 1) During the ammonium chloride convulsions (induced by injection of 1ml. of 10% NH(4)Cl), the ammonia and aspartic acid contents of the rat brain increased remarkably, while glutamic acid, glutamine and γ-amino butylic acid contents decreased. 2) Ammonia and amino acids were estimated in 3 hours after NH(4)Cl injeetion (1ml. of 5% NH(4)Cl), and the following data were obtained. a. Ammonia level remarkably rose five minutes after injection, and gradually returned to normal level 3 hours after. b. Glutamic acid decreased. c. The rise of glutamine level found 10 minutes to 1 hour after the application. d. γ-amino butylic acid decreased. e. Aspartic acid level rose on early period. The Conclusion is as follows: 1) In the rat brain, the free ammonia increased after NH(4)Cl injection. 2) Ammonia increased after NH(4)Cl injection was probably reduced, initially by aspartie acid synthetase system and thereafter by glutamine synthetase syestm.
en-copyright=
kn-copyright=

en-aut-name=KawataSaburo
en-aut-sei=Kawata
en-aut-mei=Saburo
kn-aut-name=河田三郎
kn-aut-sei=河田
kn-aut-mei=三郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2277
end-page=2283
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Iron Metabolism in Hookworm Disease Part 3. Iron Tolerance Test in Hookworm Patients
kn-title=鉤虫症の鉄代謝に関する研究 第3編 鉤虫症患者に於ける鉄負荷試験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In performing iron tolerance test in hookworm patients, the following results were obtained: 1. In the intravenous iron tolerance test iron requirement by tissues has been found quite high; and this seems to be due to iron deficiency in the erythropoietic system and a greater up-take of iron (iron depot) on the part of viscera. 2. In the iron absorption tests, on the whole the majority of patients show a poor absorption of iron, but after elimination of hookworms their iron absorption returns to the normal or better.
en-copyright=
kn-copyright=

en-aut-name=NakatsukaGinta
en-aut-sei=Nakatsuka
en-aut-mei=Ginta
kn-aut-name=中塚銀太
kn-aut-sei=中塚
kn-aut-mei=銀太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2267
end-page=2276
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Iron Metabolism in Hookworm Disease Part 2. Non-Hemin Iron Content in the Viscera of the Rabbits given Hookworm Disease Serum Injection or with Various Experimental Anemias
kn-title=鉤虫症の鉄代謝に関する研究 第2編 鉤虫症血清注射時及び各種実験的貧血に於ける臓器非ヘミン鉄量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By studying the effect of hookworm disease serum injection on the iron metabolism in rabbits given such injections and. comparing the same in experimental anemia, the following conclusions have been drawn. 1. In the rabbits given injection of hookworm disease serum, serum iron shows a decrease, while non-hemin iron content in the viscera tends to show an increase in each fraction (4 non-hemin iron fractions of Yoneyama and Konno's method). 2. The results differ from those in phenylhydrazine anemia, collargol anemia and roentgen anemia; and consequently hemolysis, of course, and also a transient disturbance in bone marrow can not be considered as the causative factors of hookworm anemia. 3. From these findings there seems to exist a factor in serum, which inhibits iron mobilization, thus bringing about iron deficiency in the erythropoietic system in bone marrow; and this seems to constitute an important causative factor for the anemia in this disease.
en-copyright=
kn-copyright=

en-aut-name=NakatsukaGinta
en-aut-sei=Nakatsuka
en-aut-mei=Ginta
kn-aut-name=中塚銀太
kn-aut-sei=中塚
kn-aut-mei=銀太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2259
end-page=2266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Iron Metabolism in Hookworm Disease Part 1. Experimental Studies on Non-Hemin Iron Content in the Viscera of Hookworm Disease
kn-title=鉤虫症の鉄代謝に関する研究 第1編 鉤虫症の臓器非ヘミン鉄量に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By estimating serum iron and non-hemin iron of viscera in dogs with experimental hookworm disease, and comparing them with those in normal and blood-depleted anemic dogs used as the control; the following results were obtained: 1. In the highly infected group (macroscopically those showing bloody feces) both serum iron content and non-hemin iron in viscera proved to have decreased, demonstrating a similar tendency as in blood-depleted anemia. 2. In slightly infected group (with intestinal bleeding to the degree of occult bleeding) serum iron content decreases but non-hemin iron content in viscera tends to show the normal or over the normal value. 3. From these data iron deficiency anemia due to disturbance in iron mobilization and bleeding may be pointed out as important factors for hookworm disease.
en-copyright=
kn-copyright=

en-aut-name=NakatsukaGinta
en-aut-sei=Nakatsuka
en-aut-mei=Ginta
kn-aut-name=中塚銀太
kn-aut-sei=中塚
kn-aut-mei=銀太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2245
end-page=2257
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Photosensitizing Dyes on the Bone Marrow Part 3. Effects of Photosensitizing Dyes on Bone-Marrow Tissue Culture in Fluid Medium and on the Respiration of Bone Marrow
kn-title=感光色素の骨髄に及ぼす影響 第3編 骨髄体外液体培養並に骨髄の酸素消費量に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Effects of photosensitizing dyes on the erythropoiesis and the hemoglobin synthesis as well as on the bone marrow respiration as estimated by oxygen consumption of bone marrow with Warburg's apparatus were studied. 1. When dyes such as NK 2, 19, 9, and 243 are added to the culture medium, the erythropoiesis of the bone marrow can be accelerated; and in the case of adding NK 15 and 325 the acceleration of erythropoiesis is slight in degree. The addition of NK 79 or 91 rather decreases the number of red cells. 2. These compounds have been found to have no direct influence on the hemoglobin synthesis. 3. These photosensitizing dyes hardly have any effect on the oxygen consumption of bone marrow. However, it seems that NK 243 and 19 slightly accelerate the oxygen comsumption of bone marrow, whereas NK 79 in contrast has a tendency to inhibit.
en-copyright=
kn-copyright=

en-aut-name=OkadaKeisei
en-aut-sei=Okada
en-aut-mei=Keisei
kn-aut-name=岡田啓成
kn-aut-sei=岡田
kn-aut-mei=啓成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2233
end-page=2244
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Photosensitizing Dyes on Bone Marrow Part 2. Effects of Photosensitizing Dyes on the Wandering Velocity and Neutral-Red Vital Staining of Intramedullary Pseudoeosinophils
kn-title=感光色素の骨髄に及ぼす影響 第2編 家兎骨髄体外組織培養に於ける骨髄内偽好酸球の遊走速度及び生体染色に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fffects of 8 photosensitizing dyes added to bone marrow tissue culture in cover slips on the wandering velocity and vital staining of intramedullary pseudoeosinophils were studied in comparison with those in culture without the addition of dyes; and the following results were obtained: 1. When photosensitizing dyes such as NK 15, 2, 19, 9, 325, 91, and 243 are added in the solution of low concentration either at 1×10(-5) mole or at 1×10(-6) mole, the wandering velocity of pseudoeosinophils is accelerated, particularly marked are the effects of NK 2, 19, and 243. On the other hand, NK 79 markedly diminishes the wandering veloity; and when it is added in a form of highly concentrated solution, pseudoeosinophils stop the movement in a short time. 2. When NK. 15, 79, 19, 9 and 325 are added in a highly concentrated form of slution in the determination of neutral-red, cells are found highly stained and again fading in color early. This fact in dicates the lowering of cell activity. When NK. 243, 19, 2, 9 and 15 are added in the form of a low concentration, the stainability to vital staining is lowered, suggesting the greater activity of cell function than that in the culture without addition of dye. 3. The fact that NK. 2 and 243 promote the function of pseudoeosinophils coincides well with the acceleration of the growth of bone marrow tissue by dyes.
en-copyright=
kn-copyright=

en-aut-name=OkadaKeisei
en-aut-sei=Okada
en-aut-mei=Keisei
kn-aut-name=岡田啓成
kn-aut-sei=岡田
kn-aut-mei=啓成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2223
end-page=2232
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Photosensitizing Dyes on Bone Marrow Part 1. Effects of Photosensitizing Dyes on the Growth of Bone Marrow Tissue
kn-title=感光色素の骨髄に及ぼす影響 第1編 家兎骨髄体外組織培養特に組織増生に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By adding 8 different photosensitizing dyes to bone marrow tissue culture (cover slips method). direct effects of these dyes on the growth rate of bone marrow tissue have been studied. 1. Of these photosensitizing dyes NK 243 belonging to the aminovynil series promotes the growth of bone marrow tissue most markedly. 2. Photosensitizing dyes such as NK 19, 2, 9, and 15 help to promote the growth of bone marrow tissue moderately. 3. NK 325 and 91 do not act directly on the bone marrow growth. 4. Trimethincyanine dye, NK 79, inhibits the tissue growth markedly. 5. Correlationship between the chemical structures of dyes and the growth rate of tissue has been studied. As for the type of dye, there are dyes in the aminovynil series and in the cyanine series, that promote the tissue growth. As for the radical nucleus in several dyes belonging to the cyanine series, thiazol and chinolin nucleus, and hepthyl radical in the alkyl group act as to promote the growth of bone marrow. In the halogen series iodine radical promotes the tissue growth more markedly than chlor radical.
en-copyright=
kn-copyright=

en-aut-name=OkadaKeisei
en-aut-sei=Okada
en-aut-mei=Keisei
kn-aut-name=岡田啓成
kn-aut-sei=岡田
kn-aut-mei=啓成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2205
end-page=2221
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hematopoietic Action of Iron, Copper and Cobalt by Rabbit Bone Marrow Tissue Culture in Fluid Medium Part 2 Hematopoietic Actions of Cobalt and Copper
kn-title=家兎骨髄組織液体培養法による鉄, 銅及びコバルトの増血作用に関する研究 第2編 銅及びコバルトの増血作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Hematopoietic actions of cobalt and copper, either singly or in combination with iron have been studied by means of rabbit bone marrow culture in fluid medium. 2. When various cobalt compounds are added singly, with exception of cobalt chloride, every one of them acts markedly to help erythropoiesis, but Hb content on the contrary often decreases by such addition. Consequently, this hypochrome erythropoiesis seems to be due to lack of iron supply. 3. In the case where ferric gluconate is added in combination with cobalt compounds, Hb increses markedly, especially so when the combination is ferric gluconate and cobalt chloride in proportion of 1:50; suggesting that cobalt greatly assists the induction of iron into the heme nucleus. 4. Due to its toxicity, copper addition either singly or in combination with iron does not help erythropoiesis to any great extent, but when in combination with iron as in the case of cobalt copper helps to increase Hb content. 5. The addition of three metals, iron, copper, and cobalt, does not yield the best result, indicating the necessity of giving a consideration to the toxicity arising out of the amount to added.
en-copyright=
kn-copyright=

en-aut-name=KumedaKatsuya
en-aut-sei=Kumeda
en-aut-mei=Katsuya
kn-aut-name=久米田克哉
kn-aut-sei=久米田
kn-aut-mei=克哉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2191
end-page=2204
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hematopoietic Action of Iron, Copper and Cobalt by Rabbit Bone Marrow Tissue Culture in Fluid Medium Part Ⅰ Methodology and Hematopoietic Action of Iron
kn-title=家兎骨髄組織液体培養法による鉄, 銅及びコバルトの増血作用に関する研究 第1編 方法論及び鉄の増血作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author studied various conventional methods of bone marrow tissue culture in fluid medium and its history, and compared these methods with a modified form of own design, and obtained the following results: 1. With this modified method a series of rabbit bone marrow tissue culture in fluid medium has been performed and studied hematopoietic effects of inorganic ferrous and ferric compounds and organic ferric compounds by adding each of these compounds to the medium. As the results it has been found that ferric gluconate proves to be the most effective hematopoietic, moreover, when this compound is added to the medium along with serum, Hb content increases strikingly, thus indicating that serum is an indispensable factor Hem synthesis. 2. Among iron compounds other than ferric gluconate no appreciable difference can be found in their hematolwietic effectiveness, at least from the standpoint of its direct action in bone marrow, it is not the valency of iron itself nor organic or inorganic nature, but rather the form of the compounds, that will have any bearing on the utilization of iron for the production of Hb.
en-copyright=
kn-copyright=

en-aut-name=KumedaKatsuya
en-aut-sei=Kumeda
en-aut-mei=Katsuya
kn-aut-name=久米田克哉
kn-aut-sei=久米田
kn-aut-mei=克哉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2181
end-page=2189
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Ligation of Inferior Vena Cava. Ⅱ. Studies of Peripheral Circulation by Means of Radioisotope P(32)
kn-title=下空静脈結紮術に関する実験的研究 第2編 放射性同位元素による下肢末梢循環について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radioisotope P(32) was injected intramuscularly, subcutaneously, and intracutaneously on the lower leg of rabbit before and after ligation of inferior vena cava. Muscle, subcutaneous, and skin circulations were calculated by local clearance method (Kety) in each case. The following results were obtained. 1) Muscle circulation is markedly impeded immediately after ligation and is restored to normal two or three weeks later with gradual improvement. 2) Subcutaneous and skin circulation are not correlated to muscle circulation following ligation. 3) Skin circualtion is accelerated after ligation. 4) Lumbar sympathetic blockade and injection of Imidalin improved muscle circulation following ligation. 5) Influence of ligation of femoral vein on muscle circulation is less than that in the case of inferior vena cava.
en-copyright=
kn-copyright=

en-aut-name=MotoyoshiMasaharu
en-aut-sei=Motoyoshi
en-aut-mei=Masaharu
kn-aut-name=本吉正晴
kn-aut-sei=本吉
kn-aut-mei=正晴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2169
end-page=2180
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on Ligation of Inferior Vena Cava. Ⅰ. Effects of Ligation of Inferior Vena Cava on Circulation and Development of Collateral Circulation
kn-title=下空静脈結紮術に関する実験的研究 第1編 循環系に及ぼす影響並びに副行路形成について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Changes of arterial and venous pressure, and cardiac output were studied following ligation of inferior vena cava below level of renal vein in dogs. Development of collateral circulation after ligation was followed by means of venography using Pyraceton. The following results were obtained. 1) Venous pressure rises six times as high as normal immediately after ligation and thereafter begings to decrease. The decrease of pressure is relatively rapid until one or two hours after ligation, and is retarded thereafter. Venous pressure still remaines one and a half time as high as normal even after 3 months. 2) Arterial pressure decreases about ten mm Hg following ligation of inferior vena cava and cardiac output decreases about 13 per cent, which are not marked in any respect. 3) Collateral circulation develops gradually after ligation and is almost completed three weeks later. Collateral vessels, which run apart from the point of ligation are established three weeks later. Recanalization at the point of ligation are noticeable four weeks later. 4) Vertebral plexus plays a significant role as a collateral circulation through all the course from beginning to the time of recanalization. 5) Moter disturbance of lower extremities and dilatation of veins on the lower abdominal wall are noted as sequelae after ligation. However, these phenomena are temporary and gradually subside.
en-copyright=
kn-copyright=

en-aut-name=MotoyoshiMasaharu
en-aut-sei=Motoyoshi
en-aut-mei=Masaharu
kn-aut-name=本吉正晴
kn-aut-sei=本吉
kn-aut-mei=正晴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2153
end-page=2168
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Liver Metastasis of Gastric Cancer Part Ⅱ Experimental studies on the liver metastasis of gastric cancer
kn-title=胃癌の肝転移に関する研究 第2編 胃癌の肝転移に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the purpose of studying the mechanism of the liver metastasis of gastric cancer, the homogenate of the Brown-Pearce tumor was injected into the portal vein, or transplanted into the well of the stomach, and the following results were obtained. 1. The rate of successful gastric transplantation of the Brown-Pearce tumor was 69.8 per cent. The most favorite site of transplantation was the lesser curvature, and then in the order of pylorus, fundus, the greater curvature, paries ventroeranialis, paries dorsocaudalis. 2. The rate of growth of the transplanted tumor was also higher at the site, where the rate of successful transplantation is higher. The tumor cells were always observed in the vessels of the stomach in those cases with the liver metastasis. 3. Tumor in the lesser curvature most frequently caused the liver metastasis and then ranging from more to less frequency in the following order of that in the pylorus, fundus. the greater curvature, paries ventrocranialis. paries dorsocaudalis. 4. In the same case. the size of the liver metastasis could he classified into some kinds of grade, thus showing that the metastasis was formed with a certain interval and not continuously. 5. The same histopathological patterns were observed in the liver metastasis by portal vein injection as well as by gastric transplantation. 6. The site of the liver metastasis was mostly in the portal vessel system, that is, in the sinusoid and then in the interlobar vein, and rarely in the central vein, or in the arterial system. 7. The histological patterns of the tumor emboli in the liver showed the tendency of growth in all cases, with degenerative process at the time in some cases. This fact shows the tumor cells do not always form even if they reach the liver. 8. The tumor, which had been taken from the stomach, could easily be transplantated into the stomach of other rabbits. This tendency was also observed in case of peritoneal, omental and liver transplantation, thus the organophilic tendency was observed in the tumor transplantation.
en-copyright=
kn-copyright=

en-aut-name=KurozumiK.
en-aut-sei=Kurozumi
en-aut-mei=K.
kn-aut-name=黒住公明
kn-aut-sei=黒住
kn-aut-mei=公明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2139
end-page=2151
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Liver Metastasis of Gastric Cancer Part Ⅰ Clinical study of the liver metastasis of gastric cancer
kn-title=胃癌の肝転移に関する研究 第1編 胃癌の肝転移に関する臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Thirty five cases of the liver metastasis (8.9%) were found among 395 cases of gastric cancer. 2. Ascites was observed in 6 cases (17.1%) and peritonitis carcinomatosa was observed in 8 cases (22.8%) among these 35 patients with the liver metastasis. 3. Benign metastatic type, i.e. the large nodullar localized type and the false type were seen in 71.4% of all, cases and malignant metastatic type, i.e. the small nodular sporadic type was seen in 28.6%. 4. The original tumor of the liver metastatasis was found more at the lesser curvature and cardiac orifice, less at the pylorus, greater curvature and paries ventrocranialis and never at the paries dorsocaudalis. 5. The liver metastasis was found mostly in the first and the second types of Borrmann's classification of gastric cancer and never seen in the third or the fourth type except for one case. 6. Histologically, in these cases of the liver metastasis, adenocarcinoma was 74.4%, carcinoma simplex was 22.8% and scirrhus was 2.8%. 7. Compared with the cases without the liver metastasis, the original tumor of the liver metastasis more Ⅱ and Ⅲ grades of grade of growth, and leses Ⅳ or Ⅴ grade. 8. Compared with the cases without the liver metastasis, in the original tumor of the liver metastasis, typical C type was less, P type showed less progressed tendency and L type was observed in all cases. 9. Thus, the liver metastasis occurs more easily in relatively benign cancer. 10. The liver metastasis is performed by the route of the portal vein thus the site of metastasis is mostly in the sinusoid and the interlobar vein, but not in the central vein. 11. The histological patterns of the tumor emboli in the liver showed the tendency of growth in all cases, with degenerative process at the same time in 37.1%. This fact shows the tumor cells do not always form even if they reach the liver. 12. Even in the macroscopically normal part of the liver with metastasis, emboli of cancer could often be observed. Therefore, the resection of the metastatic part of the liver is less significant, for the radieal operation.
en-copyright=
kn-copyright=

en-aut-name=KurozumiK.
en-aut-sei=Kurozumi
en-aut-mei=K.
kn-aut-name=黒住公明
kn-aut-sei=黒住
kn-aut-mei=公明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2135
end-page=2138
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Free Amino Acids in the Brain (Ⅴ) Free Amino Acids and Related Substances in the Brain of Common Turtle Geoclemys Reevesii in Hibernation
kn-title=脳の遊離アミノ酸について (Ⅴ) 冬眠状態におけるクサガメ脳の遊離アミノ酸およびその関連物質
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From the comparative biochemical standpoint free amino acids and related substances have been isolated and quantatively analyzed from the brain of the common turtle (Geoclemys reevesii) in hibernation, the animal belonging to the reptile family, and the following are the results. 1. In comparison with those in the brain of mammals, aspartic acid, glutamic acid, alanine, serine, and glycine have been found only in extremely small quantities. 2. The quantity of both taurine and threonine has been less than either of them found in the brain of a catfish or a rat. 3. No isoleucine, leucine, lysine, nor histidine can be detected, and unidentified ninhydrin positive substances such as X(4), X(5), and X(6) have been recognized. 4. Despite the small quantity of glutamic acid, the amount of γ-aminobutyric acid has been about the same as found in the brains of mammals. 5. The total quantity of amino-N is less than that in the brain of catfish, frog, or rat.
en-copyright=
kn-copyright=

en-aut-name=AoyamaTatsuya
en-aut-sei=Aoyama
en-aut-mei=Tatsuya
kn-aut-name=青山達也
kn-aut-sei=青山
kn-aut-mei=達也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2131
end-page=2134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Free Amino Acids in the Brain (Ⅳ) Free Amino Acids and Related Substances in the Brain of Frog Rana Nigromaculata in Hibernation
kn-title=脳の遊離アミノ酸について(Ⅳ)冬眠状態のカエル脳遊離アミノ酸およびその関連物質
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attempts have been made from comparative biochemical standpoint to isolate and determine free amino acids in the brain of the frog (Rana nigromaculata) in hibernation, the animal belonging to the amphybian family by the ion exchange cbromatography, and the following are the results: 1. Aspartic acid, glutamic acid, alanine, and serine have been found markedly decreased as in the case of the catfish brain as compared with those in the mammalian brains. 2. Taurine has been found more markedly decreased than either in the ease of the catfish brain or of the rat brain. 3. The amounts of unidentified substances X(1), X(2) and acidic amino-group show the values intermediate between those in the catfish brain and those in the rat brain. 4. The amount of γ-aminobutyric acid does not show any marked difference in the brains of all the animals tested. 5. Glycine, isoleucine, leucine, threonine, and lysine yield the values closer to those found in the mammalian brains than those in the catfish brain.
en-copyright=
kn-copyright=

en-aut-name=AoyamaTatsuya
en-aut-sei=Aoyama
en-aut-mei=Tatsuya
kn-aut-name=青山達也
kn-aut-sei=青山
kn-aut-mei=達也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2127
end-page=2129
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Post-mortem Case of Nematol-poisoning
kn-title=ネマトール中毒死の剖検例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Nematol were administrated two young women of twenty-two for the treatment of their anchylostomiasis. It is a particular case, that a pharmacist misgave to the patients fifteen tablets as dosage at the same times. One women of them died of general weakness on the about twelve hours after the internal use. On the post-mortem examination, the most prominent findings are findings of oedema in the lungs and brain, fatty degeneration and cloudy swelling of the liver and the kidney, and bleeding of the submucous tissue of the stomach and the intestines.
en-copyright=
kn-copyright=

en-aut-name=KandaMizuho
en-aut-sei=Kanda
en-aut-mei=Mizuho
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=KusakaHironao
en-aut-sei=Kusaka
en-aut-mei=Hironao
kn-aut-name=草加宏直
kn-aut-sei=草加
kn-aut-mei=宏直
aut-affil-num=2
ORCID=

en-aut-name=FunabikiSadao
en-aut-sei=Funabiki
en-aut-mei=Sadao
kn-aut-name=船曳定雄
kn-aut-sei=船曳
kn-aut-mei=定雄
aut-affil-num=3
ORCID=

en-aut-name=ShiragamiKiyotoshi
en-aut-sei=Shiragami
en-aut-mei=Kiyotoshi
kn-aut-name=白神清敏
kn-aut-sei=白神
kn-aut-mei=清敏
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2119
end-page=2125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Results of Examinations Conducted in the Better Hearing Clinic of Okayama University (1950-51) Part Ⅱ Morphological Classification of the Type of the Eustachian-Tube Orifice and Relationship between Deafness and Adenoid Hypertrophy in school children
kn-title=岡山大学BETTER HEARING CLINICの調査成績（昭和27, 8年度） 第2編 学童耳管咽頭口の型体的分類並に夫と難聴及びアデノイド肥大との関係に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It is understandable that lips of the Eustachian-tube orifice in children show the various shapes, as they are in the course of growing of the tubal cartilage, and their lymphatic tissue are so susceptible to the inflammation due to their physiologically excessive development; and therefore, it is thought abnormal forms of these lips are found more often in children than in adults. In order to explore this point still further, the author examined the lips of the Estachian-tube orifice in 550 sides of the third year in elementary school with the nasopharyngoscope, and classified them into six groups according to the shapes of the lips: group Ⅰ, standard form (basic form); group Ⅱ, swollen form; group Ⅲ, overlapped form; group Ⅳ. intermediate form; group Ⅴ, unobservable form (obstructed from view by adenoid hypertrophy); and group Ⅵ. underdeveloped form. Of these, groups Ⅱ, Ⅲ and Ⅳ are caused by one of the three factors; namely, (A) edema, (B) granule, and (C) node. There is a very little relationship among the so-called adenoid hypertrophy, groups Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ, and the factors A, B, C. The incidence of hard of hearing is more frequent starting with group Ⅲ, followed by groups Ⅳ, Ⅱ, Ⅴ, Ⅵ, and Ⅰ in that order, while it likewise increases in the order of the factors A, B, and C. Looking the degree of hard of hearing from the standpoint of adenoid hypertrophy, deafness due to the changes of the Eustachian-tube orifice in form and factor tends to increase with complication with the adenoid hypertrophy.
en-copyright=
kn-copyright=

en-aut-name=HasegawaEi-ici
en-aut-sei=Hasegawa
en-aut-mei=Ei-ici
kn-aut-name=長谷川栄一
kn-aut-sei=長谷川
kn-aut-mei=栄一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2105
end-page=2118
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Results of Examinations Conducted in the Better Hearing Clinic of Okayama University (1950-51) Part 1 Hearing impairment and its relationship to the diseases of Nose and Throat in school children
kn-title=岡山大学BETTER HEARING CLINICの調査成績（昭和27, 8年度） 第1編 学童の聴力障碍並に夫と鼻咽腔疾患との関係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By conducting hearing tests on 618 pupils of the third year in the elementary school in a sound proof room with the use of an 8-pure tone audiometer along with observations of adenoid hypertrophy by aid of nasopharyngoscope the author carried out detailed examinations of the nose, ear and throat. As for the criterion of deafness, ones that can not hear 2 tones at 20 db or one at 25 db were considered deaf. Deaf ears and doubtful cases for deaf determined by the method just mentioned, were re-examined on two other occasions and the changes in their hearing were investigated. Regarding subjective symptoms as to the hardness of hearing, careful attention were paid on the records previously prepared at individual's home and as the results the following data obtained. 1. The number of those who had been considered to be deaf at the first test gradually decreased significantly at each of of two subsequent tests. 2. The percentage of deaf pupils proved to be 14.8 per cent, while that of deaf ears 11.9 per cent of the total examined. 3. The majority of those who had been considered deaf on the first hearing test but adjudged to be of normal hearing on the following tests, showed the fall in the threshold at 8124 cps.. 4. Therefore, in order to determine the hardness of hearing in young persons it is necessary to pay a special attention to a higher tone and to conduct hearing tests at least three times on different days. 5. Those who were unconsciously deaf amounted to 67.0 per cent of the total deaf pupils, and the same among those whose deafness proved to be slight, namely, witihn average 25 db at speech range in both ears, amounted to 80.8 per cent. 6. Most of unconscious deafness had their origin in the Eustachian tube: and cases with unconscious deafness in both ears having the origin at the tube amounted to 90.2 per cent and the same in one ear amounted to 75.0 per cent. 7. Deafness with its origin at the Eustachian tube occupied the major portion (86.8% ) of those slightly hard of hearing within average 25 db at speeeh range. 8. The lesions of the nasal cavity and the pharynx that had been associated with deafness were simple chronic rhinitis, hypertrophic rhinitis, sinusitis and deviation of the nasal septum. Comparing the incidence of deafness in the ears with these lesions to those without lesions, deafness proved to be more predominant in the ears with the lesions. 9. Deafness in both ears were found quite many among the pupils of poor scholastic standing.
en-copyright=
kn-copyright=

en-aut-name=HasegawaEi-ici
en-aut-sei=Hasegawa
en-aut-mei=Ei-ici
kn-aut-name=長谷川栄一
kn-aut-sei=長谷川
kn-aut-mei=栄一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2093
end-page=2103
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Explanted Bone Marrow Tissne by Stained Section Specimens Part 3. Bone Marrow Tissue Culture of Various Experimental Anemias Induced in Rabbits
kn-title=骨髄体外培養組織の切片染色による細胞学的研究 第3編 各種実験的貧血家兎骨髄体外培養組織について（附 全編の総括）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=After perfoming bone marrow tissue culture of various experimental anemias in rabbits, the follwing conclusions were drawn: 1. The accelerated bone marrow function in the anemic rabbit depleted of blood can not be maintained in culture. In the culture the mitotic index falls below that of normal rabbit, and also cell degeneration occurs earlier. 2. Mitosis of bone marrow from normal rabbit is accelerated in the serum of blood-depleted anemic rabbit. 3. The bone marrow function of anemic rabbit induced by collargol administration for a long period of time is highly deteriorated, while in the case given for a short time, disturbances of maturation and multiplication of cells, and inhibition of cells wandering out due to the proliferation of reticulo-endothelial cells in the outer region of the explant can be recognized. 4. In the bone marrow of the rabbit exposed to X-ray the start of mitosis is checked, and also maturation and migration of cells are disturbed. 5. In the bone marrow of the rabbit injected with P(32) mitotic disturbances can be recognized by the rate of acceleration of cell function, and in the case injected with a large doze of P(32) maturation and wandering capacity of cells are disturbed.
en-copyright=
kn-copyright=

en-aut-name=HattoriYoshiyuki
en-aut-sei=Hattori
en-aut-mei=Yoshiyuki
kn-aut-name=服部嘉之
kn-aut-sei=服部
kn-aut-mei=嘉之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2081
end-page=2091
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Explanted Bone Marrow Tissue by Stained Section Specimens Part 2. Bone Marrow Tissue Culture of the Normal, the Myelogenous Leukemic, and the Aplastic Anemic Patients
kn-title=骨髄体外培養組織の切片染色による細胞学的研究 第2編 健康人,骨髄性白血病患者及び再生不良性貧血患者骨髄体外培養組織について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the observation on the tissue culture of bone marrow from normal persons, myelogenous leukemic and aplastic anemic patients the following conclusions were arrived at: 1. Like in the case of bone marrow tissue culture of rabbits, in the bone marrow tissue culture of normal persons wandering cells wander out from the explanted bone marrow, thus forming a growth zone; and at the same time cells without wandering capacity make their appearance in the center of the growth zone. In culture immature cells mature, and having the peak of mitotic index at the 12-hour culture, it rises and falls. In the explant of bone marrow after 4 to 5 days interstitial cells proliferate and the bone marrow tissue loses its peculiarity. Namely, even in the bone marrow tissue culture of the human, the bone marrow cell functions of maturation, multiplication and migration have been recognized again. 2. In the bone marrow tissue culture of myelogenous leukemia the cell maturation in the explanted bone marrow is delayed, and in that of acute form even cultured for a long period of time immature cells can not mature completely and they degenerate in the explanted bone marrow. Although the cell density is high and many immature cells appear in the growth zone, the boundary of growth zone in acute form is clear-cut and in chronic form many matured cells can be observed around the boundary of growth zone. The mitotic index in clture in chronic form maintains a higher value than that in normal person, but in acute form it falls along with the lapse of time. 3. In the tissue culture of aplastic anemia both maturation and mitosis are obstructed, and an increase and enlargement of fat cells, and an increase in mast cells can be recognized.
en-copyright=
kn-copyright=

en-aut-name=HattoriYoshiyuki
en-aut-sei=Hattori
en-aut-mei=Yoshiyuki
kn-aut-name=服部嘉之
kn-aut-sei=服部
kn-aut-mei=嘉之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2069
end-page=2080
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Explanted Bone Marrow Tissue by Stained Section Specimens Part 1. Explanted Bone Marrow Tissue of Normal Rabbit
kn-title=骨髄体外培養組織の切片染色による細胞学的研究 第1編 正常家兎骨髄体外培養組織について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the observations carried on section specimens prepared from the explanted bone marrow tissue of normal rabbits, the following results were obtained: 1. In the regular culture method wandering cells, wandering out of the explanted bone marrow piece, form a growth zone and also cells without wandering capacity appear in the center of the growth zone. In culture immature bone-marrow cells reach maturity, and the mitotic index, having its peak at the 12-hour culture, fluctuates up and down. Namely, in the present study it has been clarified that not only bone marrow cells wander out but also maturation and mitosis take place in bone marrow culture. After 4-5 days' culture interstitial cells grow actively and also fibroblasts are observed to proliferate. 2. Vitamin B(12) helps to promote the mitosis and maturation of bone marrow cells. 3. Folic acid acts on bone marrow in the same manner as vitamin B(12) though to a lesser degree. 4. Nitoromin inhibits the mitosis of bone marrow cells and promotes the degeneration of granular leucocytes. 5. Carzinophilin like nitromin inhibits the mitosis and promotes the cell degeneration. 6. A simple tissue culture method is not simply for supravital observation, but it induces bone marrow cells to wander out, mature, and also induces mitosis although it is inferior to the regular method of tissue culture.
en-copyright=
kn-copyright=

en-aut-name=HattoriYoshiyuki
en-aut-sei=Hattori
en-aut-mei=Yoshiyuki
kn-aut-name=服部嘉之
kn-aut-sei=服部
kn-aut-mei=嘉之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2057
end-page=2068
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=1958
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vascular Construction of the Bone Marrow in Human Fetus Part 3. Blood Vessels in the Bone Marrow of Clavicle
kn-title=人胎児骨髄血管構造の研究 第3編 鎖骨骨髄血管に就いて
en-subtitle=
kn-subtitle=
en-abstract=Ossification of the middle part of clavicle derived from the connective-tissue ossification, and in epiphysis the primitive bone marrow origiantes from mesenchymal tissue possessing blood vessels. As for the nutrient foramen, its site, the number, and the angle of penetration into bone wall are not so uniform as in the case of long bone. This seems to be due to the peculiar ossification of the clavicle. Nutrient artery and vein do not necessarily penetrate into the bone wall together and when the two are in company, the nutrient vein usually occupies the position superior to the artery, and often two or three veins are found. Furthermore, one to several auxiliary nutrient foramens ran be observable. The manners of branching and distribution of main nutrient artery and vein are rather regular. On the fourth embryonal month the cartilage canals containing arteries and veins make their appearance on both epiphyses, and by the fifth embryonal month they are connected with the bone marrow of epiphysis.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakazawaTakeshi
en-aut-sei=Nakazawa
en-aut-mei=Takeshi
kn-aut-name=中沢彪
kn-aut-sei=中沢
kn-aut-mei=彪
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2045
end-page=2056
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=1958
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vascular Construction of the Bone Marrow in Human Fetus Part 2. Vascular Construction of the Bone Marrow in the Atlas, Epistropheus, Sacrum and Coccyx
kn-title=人胎児骨髄血管構造の研究 第2編 椎骨骨髄血管(其の2)第一,二頸椎,仙骨及び尾骨に就いて
en-subtitle=
kn-subtitle=
en-abstract=With the use of transparent and stained tissue specimens injected with dye into the bone marrow vessels of the atlas, epistropheus, sacrum, and coccyx in 60 human fetuses over two months old, the author studied development of the bone-marrow blood vessels and obtained the following results: 1. Atals: Nutrient artery and vein are observed radiating from radix arcus vertebrae; and cartilage canals are recognized in forea articularis and tuberculum dorsale. 2. Epistropheus: In the arch and the body, the distribution of blood vessels and growth of cartilage canals resemble those in the thoracic vertebra, but cartilage canals entering from anterior and posterior sides play a role in the formation of primitive bone marrow space in the body unlike that in the case of the thoracic vertebra. By the sixth embryonal month the dens begins to possess its own nutrient artery and vein. From these findings it is assumed that the dens morphologically corresponds to the body of atlas. 3. Sacrum: The manner of blood vessel distribution in the bone marrow of the sacrum is similar to that in a thoracic vertebra but its distribution is not so dense. The growth of cartilage canal in the body of vertebra is quite good and it shows no tendency to deteriorate even in the terminal embryonal stage. On the pars lateralis of the sacrum independent, new nutrient arteries and veins are recognized. 4. Coccyx: The growth of blood vessels is poor in coccyx, and only cartilage canals entering from the anterior and posterior sides can be observed, but no bone marrow formation.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakazawaTakeshi
en-aut-sei=Nakazawa
en-aut-mei=Takeshi
kn-aut-name=中沢彪
kn-aut-sei=中沢
kn-aut-mei=彪
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2033
end-page=2044
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vascular Construction of the Bone Marrow in Human Fetus Part 1. Blood Vessels in the Bone Marrow of Thoracic Vertebra
kn-title=人胎児骨髄血管構造の研究 第1編 椎骨骨髄血管（其の1）胸椎に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By preparing transparent tissue specimens by Spalteholz and stained tissue specimens with dye injection into the bone marrow vessels of thoracic vertebra in 60 human fetuses over two months old, the author studied development of blood vessels in the bone marrow and obtained the following resutls: 1. Ossification in the body of a vertebra commences with entochondrostosis, while that of the arch of a vertebra with exochondrostosis. 2. A pair of large blood vessels entering the cartilage canal from the foramen vertebrae grow into nutrient artery and vein. After entering into the bone marrow the nutrient artery branches off and anastomoses with each other; and in the latter half of the embryonal stage main branches, presenting ring formation, radially send out small branches and at the periphery, anastomosing actively with one another, they form networks. Veins, forming networks of venous sinus and having large vascular space, present a picture like intra-tissue spaces. 3. The nutrient artery and vein at the arch of vertebra enter from incisura vertebrae caudalis or from the underside of the base of spinal process and, immediately branching out, they run in the direction of each process and to the anterior part of the arch of vertebra. 4. The cartilage canal of the body of vertebra plays an important role in growth of the nutrient artery and vein, but those that do not penetrate into the bone marrow, though they branch out and develop, end in blind terminal. These gradually deteriorate after the peak of growth reached around the eighth embryonal month. The cartilage canals at the arch of vertebra are slow in their growth and a few in number. 5. In comparing blood vessels in the bone marrow of thoracic vertebra with those of long bone, it seems that the arch of a vertebra corresponds to the body of bone in the latter, and the body and the process of a vertebra correspond to the epiphysis in the latter.
en-copyright=
kn-copyright=

en-aut-name=NakazawaTakeshi
en-aut-sei=Nakazawa
en-aut-mei=Takeshi
kn-aut-name=中沢彪
kn-aut-sei=中沢
kn-aut-mei=彪
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2027
end-page=2032
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Destructive Action of Ultrasonic Wave on Bacteria
kn-title=超音波による細菌破壊作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From the standpoints of both culture and electronmicroscopy the author studied the destructive action of ultrasonic wave on various bacteria such as B. typbosa, B. coli, B. pyocyaneus, and Staph. aureus, and obtained the following results: 1. B. typhosa, B. pyocyaneus and Staph. aureus all possess about the same degree of resistance against ultrasonic wave, and they can be destroyed all with about the same strength of ultrasonic irradiation. B. coli, however, demonstrated a far greater resistance against ultrasonic irradiation. B. coli, however, demonstrated a far greater resistance against ultrasonic wave than any one of these bacteria. 2. The majority of B. typhosa, B. coli, and B. pyocyaneus, when cxposcd to ultrasonic irradiation, take such steps as firstly swelling of the cell, and then the destruction of the cell membrane either at extremities of longitudinal axis or at the point adjacent to the extremity and discharge of cytoplasm. 3. Most of Staph. aureus, when exposed to ultrasonic irradiation, are destroyed by taking such a course as first the uncoupling of staphylococcic chain, the swelling of those cell bodies thus broken free, and next a part of the swollen and dilatated cell membrane burst open and the outflow of cytoplasm.
en-copyright=
kn-copyright=

en-aut-name=KitanakaHajimu
en-aut-sei=Kitanaka
en-aut-mei=Hajimu
kn-aut-name=北中創
kn-aut-sei=北中
kn-aut-mei=創
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2015
end-page=2025
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Metabolism of Bacteria by Cell-free Extract Report 3. On Bacillus Dysenteriae
kn-title=細菌無細胞液による物質代謝の研究 第3篇 赤痢菌
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Following up the previous experiments, with the use of extracts and acetone powder prepared from several strains of B. dysenteriae such as SM-resistant strain and SM-susceptible strain of Sh. flexneri Ⅱ, this study has been conducted in order to consider some aspects of their metabolism. The results are as follows: 1. It has been possible to obtain cell-free extracts from Sh. flexneri Ⅱ by grinding with emery powder, the extracts containing oxidases of lactate, succinate, and glycine; and also the same three oxidases have been obtained from the acetone-powder prepared from Sh. flexneri Ⅱ. Moreover, the characteristics of those oxidases obtained by the above two methods are exactly the same. 2. No marked difference can be observed in the properties of these three oxidases contained in extract from SM-resistant strain or in those from SM-susceptible strain, of Sh. flexneri Ⅱ, but there is a quantitative difference in oxygen uptake: namely, in SM-resistant strain oxygen uptake on three substrates per hour per mg of N is greater than the same in the case of SM-susceptible strain. 3. It has been confirmed that the properties of three oxidases of this bacillus, namely, oxidases of lactate, succinate, and glycine, are quite similar to the properties of those oxidases found in animals, plants, and bacteria. 4. Glycine oxidase has been extractable only from animal tissues and from and from a few kinds of bacteria, and the one that has been extracted from this bacillus possesses somewhat similar properties as those of animal tissues and other bacteria in that it is not affected by inhibitory agents of the cytochrome system and possesses a relatively narrow pH range of activity. It has been proven that glycine oxidase prepared from Sh. flexneri Ⅱ is a flavoprotein which produces glyoxylic acid and NH(3) by oxidative deamination of glycine. 5. Inhibitory action of malonate can not at all be seen on succinoxidase in resting cells of Sh. flexneri Ⅱ, while this inhibitory action is observable in the case of the acetone powder and cell-free extracts of Sh. flexneri Ⅱ. This phenomena seem to be possibly brought about by permeability of the cell membrane.
en-copyright=
kn-copyright=

en-aut-name=KitanakaHajimu
en-aut-sei=Kitanaka
en-aut-mei=Hajimu
kn-aut-name=北中創
kn-aut-sei=北中
kn-aut-mei=創
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=2003
end-page=2014
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Metabolism of Bacteria by Cell-free Extract Report 2. On Bacillus Typhosa
kn-title=細菌無細胞液による物質代謝の研究 第2篇 腸チフス菌の代謝
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using cell-free extracts prepared from such strains of B. typhosa as S-type strain, R-type strain, SM-resistant strain and CM-resistant srain, of S(57), this experiment has been performed to determine enzymological properties of these extracts. The following are the results. 1. Cell-free extracts prepared from these four strains of S(57) by grinding with emery powder: These extracts prove to have respiratory activity on lactate, succinate, and fumarate. 2. Although four strains of S(57) do not show any marked difference in their respiratory activity on such oxidases as lactate, succinate, and fumarate, oxygen uptake per hour per mg of N in cell-free extract of R-type strain is greatest, followed by that of CM-resistant strain, S-type strain, and SM-resistant strain in the order mentioned. 3. Lactic oxidase contained in all these four extracts of S(57) has been verified to be an entirely different oxidase from that found in animal tissues, yeasts, and other bacteria. 4. The action of inhibitory agents, especially that of malonate, on resting bacteria differs markedly from the same on cellfree extracts; and it is indicated that this phenomenon is possibly caused by permeability of cell membrane of bacteria.
en-copyright=
kn-copyright=

en-aut-name=KitanakaHajimu
en-aut-sei=Kitanaka
en-aut-mei=Hajimu
kn-aut-name=北中創
kn-aut-sei=北中
kn-aut-mei=創
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1995
end-page=2002
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Metabolism of Bacteria by Cell-free Extract Report 1. Fundamental Experiment
kn-title=細菌無細胞液による物質代謝の研究 第1篇 基礎実験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study is conducted with the purpose to explore a certain aspects of the metabolism of bacteria by cell-free extracts. First of all a series of experiments have been carried out in order to obtain cell-free extracts of B. typhosa, S(57)S, that have respiratory activity; and the following results have been obtained. 1. Cell-free extracts prepared by ultrasonic and freezing-thawing method have been found to possess low respiratory activity on one or two substrates. 2, No set rules of destruction can be derived from the study of electron-micrographs of B. typhosa, S(57)S, destroyed by ultrasonic radiation and freezing-thawing processes. 3. Cell free extract of B. typhosa prepared by grinding with emery powder has been found to possess strong respiratory activity on lactate, succinate and fumarate.
en-copyright=
kn-copyright=

en-aut-name=KitanakaHajimu
en-aut-sei=Kitanaka
en-aut-mei=Hajimu
kn-aut-name=北中創
kn-aut-sei=北中
kn-aut-mei=創
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1977
end-page=1994
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Carbohydrate Metabolism in Bone-Marrow Tissue Culture of Rabbits Part 3. Carbohydrate Metabolism in the Bone Marrow of Rabbits with Experimental Anemias and Effects of Various Drugs on the Carbohydrate Metabolism in Bone Marrow of Normal Rabbits
kn-title=家兎骨髄体外組織培養に於ける含水炭素代謝の研究 第3編 実験的貧血家兎骨髄の含水炭素代謝並びに正常家兎骨髄含水炭素代謝に及ぼす各種薬物の影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In observations of carbohydrate metabolism in the bone marrow of rabbits with experimental anemias by tissue culture (Carrel's flask method) and in the studies of effects of various drugs on the carbohydrate metabolism in the bone marrow of normal rabbits by tissue culture (the same method) the following findings were obtained: 1) In the bone marrow of rabbits given benzol injection for a short period of time, the carbohydrate metabolism has been inhibited. Moreover, in the bone marrow of rabbits administered with benzol injection for a long time, or injected with phenylhydrazine, korallgol, or exposed to X-rays, the carbohydrate metabolism has been more markedly inhibited. 2) The carbohydrate metabolism has been accelerated in the bone marrow of rabbits depleted of blood. 3) In the bone marrow of rabbits injected with saponin no abnormality can be observed in the carbohydrate metabolism. 4) Vitamin B(12) and bone marrow extracts have been found to act directly upon bone marrow as to promote the carbohydrate metabolism.
en-copyright=
kn-copyright=

en-aut-name=KimuraTakashi
en-aut-sei=Kimura
en-aut-mei=Takashi
kn-aut-name=木村峻士
kn-aut-sei=木村
kn-aut-mei=峻士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1955
end-page=1975
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Carbohydrate Metabolism in Bone-Marrow Tissue Culture of Rabbits Part 2. Effect of Sera of Patients with Various Diseases on Carbohydrate Metabolism of Bone Marrow of Normal Rabbits
kn-title=家兎骨髄体外組織培養に於ける含水炭素代謝の研究 第2編 各種疾患々者血清の家兎骨髄含水炭素代謝に及ぼす影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In investigation of various factors acting on the bone marrow tissue growth in tissue culture (Carrel's flask method) of normal rabbits to which sera of various patients were added, and in observations of effect of such sera on the carbohydrate metabolism of the rabbit bone marrow, the following results were obtained: 1) From these studies it has been found that in sera of hypoplastic anemia, Banti's disease, chronic myelogenous leukemia, monocytic leukemia and lymphocytic leukemia are contained some factors which act directly upon bone marrow as to inhibit the carbohydrate metabolism. As for inhibitory action of these factors, that in hypoplastic anemia proves to be highest, followed by those in monocytic leukemia, Banti's desease, chronic myelogenous leukemia, and in lymphocytic leukomia, in the order mentioned. 2) No factor acting directly upon bone marrow as to inhibit the carbohydrate metabolism has been found in sera of such diseases as idiopathic hypochromic anemia, hookworm anemia, Werlhof's disease, liver cirrhosis, chronic hepatities, chronic nephritis, pulmonary tuberculosis and diabetes mellitus.
en-copyright=
kn-copyright=

en-aut-name=KimuraTakashi
en-aut-sei=Kimura
en-aut-mei=Takashi
kn-aut-name=木村峻士
kn-aut-sei=木村
kn-aut-mei=峻士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1939
end-page=1953
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Carbohydrate Metabolism in Bone-Marrow Tissue Culture of Rabbits Part 1. Carbohydrate Metabolism in Normal Rabbit Bone-Marrow and Effect of Normal Human Serum on the Same Metabolism
kn-title=家兎骨髄体外組織培養に於ける含水炭素代謝の研究 第1編 正常家兎骨髄含水炭素代謝並びに健康人血清の該代謝に及ぼす影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In observation on the carbohydrate metabolism of bone marrow of normal rabbits by bonemarrow tissue culture (Carrel's flask method) and on the effect of normal human serum on carbohydrate metabolism in the same culture, the following results have been obtained: 1) Sugar consumption increases in proportion to the increase in the rate of tissue frowth in culture. 2) Hydrogen ion concentration in substrate tends to turn acidic along with progress of the tissue growth. 3) With an addition of a small quantity of normal human serum the tissue growth is markedly accelerated, and both sugar consumption and the increase in hydrogen-ion concentration are also promoted. 4) With a large amount of normal human serum added to culture medium, on the other hand, the tissue growth is inhibited and gugar consumption and the increase in the hydrogenion concentration are less. 5) When a proper amount of normal human serum is added, no effect is observable on the tissue growth, sugar consumption and on hydrogen-ion concentration.
en-copyright=
kn-copyright=

en-aut-name=KimuraTakashi
en-aut-sei=Kimura
en-aut-mei=Takashi
kn-aut-name=木村峻士
kn-aut-sei=木村
kn-aut-mei=峻士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1923
end-page=1938
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Drug-Resistance of Tubercle-Bacilli Part 3. Studies on the Virulence of INAH-Resistant Bacilli and Double-Resistant Bacilli, as well as on the Catalase-Activity of INAH-Resistant Bacillus, with a Special Reference to the Relationship Between the Virulence and Catalase Activity
kn-title=結核菌の薬剤耐性に関する研究 第3編 INAH耐性菌, 二重耐性菌の毒力及びINAH耐性菌のCatalase活性特に毒力との関係に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By comparing the virulence of INAH-resistant bacilli obtained in one-step selection and that of the INAH-resistant bacilli stocked in our laboratory, and also by studying the virulence of the INAH-and SM-double-resistant bacilli and the relationship between the catalase activity and the virulence of INAH-resistant bacilli, the author obtained the following results. 1) In the experiment with guinea pigs both the INAH-resistant bacilli obtained by one-step selection and the stock INAH-resistant bacilli proved to not so virulent. 2) The virulence of double resistant bacilli grow weaker when SM-resistant bacilli acquired INAH-resistance, and that of INAH-resistant bacilli remain weakly virulent even when they acquired SM-resistance. 3) On examining catalase activity and the degree of INAH-resistance, on the whole bacilli become catalase-negative as their resistance increases, but some remain catalase positive even when their resistance is high. Therefore, the relationship between INAH-resistance and catalase activity is not absolute. 4) When catalase negative 10 γ-resistant strain is cultured successively in a modified medium, it turns catalase positive. Moreover, it has been proven that catalase negative strain turns to catalase positive due to peculiar conditions of the medium but not due to the decrease in resistance, because even when 10 γ/cc. of INAH is added to the modified medium, bacilli turn to catalase positive just the same. 5) In the study of the relationship between catalase activity and virulence to guinea pigs, it has been found that the virulence of catalase-negative l0 γ-resistant strain is weakened. Even in the case of l0 γ-resistant bacilli which are catalase positive (such as obtained from patient or isolated in a modified medium), their virulence is maintained. In the case of INAH-resistant strain if they are catalase positive, the virulence of the bacilli is maintained in a fair degree. Consequently, it is possible to regain the virulence artificially to a certain extent by changing catalase to positive in a modified medium. Furthermore, in the case of the bacilli isolated in a modified medium and possessing the same degree of catalase positive activity, the virulence proved to be higher when the resistance is decreased. This fact seems to indicate that the virulence of INAH-resistant bacilli is in a way correlated to the resistance irrespective of catalase. 6) The relationship between catalase activity and the virulence to mice can not be detected so clearly as in the case of guinea pigs.
en-copyright=
kn-copyright=

en-aut-name=KageyamaTojiro
en-aut-sei=Kageyama
en-aut-mei=Tojiro
kn-aut-name=景山統二郎
kn-aut-sei=景山
kn-aut-mei=統二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1911
end-page=1921
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Drug-esistance of Tubercle-Bacilli Part 2. A Study on the Double-Resistance of Tubercle-Bacilli
kn-title=結核菌の薬剤耐性に関する研究 第2編 結核菌の二重耐性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed both in vitro and in vivo experiments of double resistant tubercle bacilli with the purpose to determine whether SM or INAH should be used at first to obtain a better result. As the result the following findings were obtained. 1) With the use of H(37)Rv parent strain, SM-resistant H(37)Rv-strain, resistance increment experiments were performed in Kirchner's serum liquid media. In the successive cultures by the tenth successive culture both H(37)Rv parent strain and SM-resistant strain attained the resistance against INAH up to 100 γ/cc., while the parent strain and INAH-resistant strain acquired the resistance against SM up to 10,000 γ/cc. by the tenth successive culture. In other words, in the acquiring of resistance there is a significant difference between SM and INAH. 2) In comparing the resistance increment during ten successive cultures, SM-resistant strain acquired the resistance against INAH later than the parent strain. INAH-resstant strain likewise was slower in acquiring the resistance against SM than the parent strain. Because no difference can be found between the two in vitro experiments, it can not be said that clinically INAH should be better used prior to the use of SM. 3) In the experimental tuberculosis of mice, a fairly high resistance has been acquired by SM injection or INAH injection. 4) In the experiments with mice, the acquiring of resistance against SM in the cases inoculated with INAH-resistant strain is extremely slower than the acquiring of resistanec against INAH in the cases inoculated with SM-resistant strain. Therefore, judging from the experiments with mice, it may be said that clinically INAH would be better used first.
en-copyright=
kn-copyright=

en-aut-name=KageyamaTojiro
en-aut-sei=Kageyama
en-aut-mei=Tojiro
kn-aut-name=景山統二郎
kn-aut-sei=景山
kn-aut-mei=統二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=6
article-no=
start-page=1897
end-page=1909
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Drug-Resistance of Tubercle-Bacilli Part 1. On the Reversibility of Drug Resistance in Tubercle Bacilli
kn-title=結核菌の薬剤耐性に関する研究 第1編 薬剤耐性結核菌の復帰に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With a view to elucidate the mechanism of reversibility of resistant tubercle bacilli, the author has performed in vitro experiments of resistance reversibility by observing changes occurring in successive culture of resistant bacilli together with different antituberculous agents, the filtrate of sensitive strain or dead bacilli, by changing ingredients of successive media; and also by injecting different kinds of antituberculous agents into imice the rever sibility in vivo has been studied. As the result the following interesting data were obtained. 1) In the successive cultures of SM-resistant H(37)Rv-strain and INAH-resistant-H(37)Rv-strain in the medium of Kirchner's albumin or serum liquid medium, each loaded with PAS, Viomycin, Pyrazinamide, INAH or SM, no reversibility of resistance could be recognized. 2) In the successive cultures of SM-resistant H(37)Rv-strain and SM-resistant avian type Takeo strain in the medium loaded with the filtrate of sensitive parent strain or dead bacilli, no reversibility of resistance could be observed. 3) In the cases of successive cultures of SM-resistant-H(37)Rv-strain and INAH-resistant-H(37)Rv-strain in modified media of 1% Ogawa's medium, SM-resistant bacilli revealed no resistance-reversibility in any of these media. INAH-resistant strain successively cultured in the medium containing solely KH(2)PO(4) or only sodium glutamate, they began to show a diminution in resistance about the fifth generation. As for the mechanism of this diminution in resistance it is possible to assume an induced backmutation in modified media. 4) In the experiments with mice, the diminution in resistance has been observed in the cases inoculated with SM-resistant strain and injected with INAH as well as in the cases inoculated with INAH resistant strain and injected with SM. It is assumed that the susceptibility of resistant bacilli to other agents is elevated in vivo.
en-copyright=
kn-copyright=

en-aut-name=KageyamaTojiro
en-aut-sei=Kageyama
en-aut-mei=Tojiro
kn-aut-name=景山統二郎
kn-aut-sei=景山
kn-aut-mei=統二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END