start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1821
end-page=1837
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on vector of Umayado Disease in Kagawa-ken part Ⅱ Seasonal Occurrence of Tsutsugamushi
kn-title=香川県下における「馬宿病」の媒介体に関する研究 第二編 「馬宿病」流行地区における恙虫の季節的消長
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract="Umayado Disease" has happened in summer especially at east area of Kagawa-ken. I have studied about what kind of Tsutsugamushi will have increased and made peak at summer. Against this purpose, I have caught rats and collected the Tsutsugamushi living upon the rats twice a month regularly extending full 2 years up, and I have determined that a lot of Trombicula tosa has appeared and made the peak at summer usually. I think Trombicula tosa should be valuable agency to contaminate the Rickettsia orientalis at Kagawa-ken.
en-copyright=
kn-copyright=

en-aut-name=OnoYoshiaki
en-aut-sei=Ono
en-aut-mei=Yoshiaki
kn-aut-name=小野吉昭
kn-aut-sei=小野
kn-aut-mei=吉昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1805
end-page=1820
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON THE TYPES OF TSUTSUGAMUSHI OF AGENT BY CROSS-IMMUNIZATION TEST (Ⅱ)
kn-title=恙虫病病毒の交叉感染試験の研究 第2編 交叉感染試験の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cross-immunization-tests were performed in mice injected with Nitrogen-mustard-N-oxide (NNO) intraperitonealy among many strains of R. tsutsugamushi are strains of Ozeki, Mitani, Tanisawa and ⅩⅩⅡ. Concerning with dosis of drug, NNO was used 0.4 mg per day and used 1-4 times. 1) Ozeki strain, Mitani strain and ⅩⅩⅡ strain are similar in its antigenic structure than Hichito and Tanisawa strains. 2) Hichito and Tanisawa strains are similar in its antigenic strueture than Ozeki, Mitani and ⅩⅩⅡ strains.
en-copyright=
kn-copyright=

en-aut-name=UmetaniYoshihiro
en-aut-sei=Umetani
en-aut-mei=Yoshihiro
kn-aut-name=梅谷美弘
kn-aut-sei=梅谷
kn-aut-mei=美弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1777
end-page=1803
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON THE TYPES OF TSUTSUGAMUSHI OF AGENT BY CROSS-IMMUNIZATION TEST (I)
kn-title=恙虫病病毒の交叉感染試験の研究 第1編 Nitrogen-mustard-N-oxide処理二十日鼠における恙虫病病毒の感染試験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to obstruct their mortality which should be happened by active materials of R. tsutsugamushi Nitrogen-mustard-N-oxide (NNO) was used subcutaneously or intraperitonealv against mice as pre or post management of immunization by active materials. The data is described as follows : 1) Subcutaneous managenent of NNO hnd no effect on decreasing of mortality about mice inoculated by active rickettsial materials. 2) Intraperitoneal injection of NNo had great effect to decrease the mortality about the mice inoculated by active rickettsial materials and to produce the antibodies against reinoculation of homologous rickettsial strain. 3) Concerning with inoculation of rickettsial materials against mice, pre-management had greater effect than post management of NNO to decrease the mortality and to produce the antibodies.
en-copyright=
kn-copyright=

en-aut-name=UmetaniYoshihiro
en-aut-sei=Umetani
en-aut-mei=Yoshihiro
kn-aut-name=梅谷美弘
kn-aut-sei=梅谷
kn-aut-mei=美弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1767
end-page=1775
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On an Autopsy Case of Osteogenic Sarcoma
kn-title=Osteogenic Sarcomaの1剖検例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A review of the literature shows that osteogenic sarcoma is not rare, but the pathologic changes of this disease have not clearly reported yet. It is the purpose of this report to describe the pathohistogenetic changes with the clinical aspects in an autopsy case of osteogenic sarcoma. An adult man, 23 years of age, was admitted to the Hiraki Modical Clinic of the Okayama University Hospital, on August 24, 1953, complaining of chest ache and haemoptoe. The x-ray examination of the chest at that time showed base ball-sized, hard, lobulated masses in the both lungs. The pathological diagnosis was osteogenic sarcoma metastasized in both lungs from the right hemural tumor which amputated in a lower third of the right hemur four years ago. The average size of the tumors in lungs was 5-4 cm in diameter. They were usually nonencapsulated, and the cut surface was solid, firm, and grayish-white. Microscopically, there were two types of the histogenetic origins in tumors of the lung. The first histologic form, which is designated here as the "osteogenic cell sarcoma", showed the following characteristics. Microscopically, the component cells were fairly uniform and generally identical with osteolytic cells in various stages of fetal histogenetic cycles of the bone. There were some areas wherein the neoplastic cells showed atypical orientation and the nuclei were large and slightly dark. Mitoses and neoplasmic giant cells were found occasionally. In many neoplasmic cells the various courses of hyalinisation, carcification and osification were recognized. The second histologic form, which is labeled here as the "chondroblastic cell sarcoma", showed the following characteristics. Microscopically, neoplasmic tissues exhibited the chondroblastic cells, which made it possible to translate to osteolytic cells occasionally in some neoplasmic circumstances, and they were consisted of pleomorphic giant cells with the polymorphic cytoplasmas and numerous mitotic figures. As mentioned above, hyalinisation, carcification and osification were also found graduately in the cytoplasmas of such chondroblastic cells as osteolytic cells. In result of histologic examination, this case was malignant osteogenic sarcoma which showed extensive metastases in both lungs within five years.
en-copyright=
kn-copyright=

en-aut-name=KimotoTetsuo
en-aut-sei=Kimoto
en-aut-mei=Tetsuo
kn-aut-name=木本哲夫
kn-aut-sei=木本
kn-aut-mei=哲夫
aut-affil-num=1
ORCID=

en-aut-name=OtaniKyoichiro
en-aut-sei=Otani
en-aut-mei=Kyoichiro
kn-aut-name=大谷恭一郎
kn-aut-sei=大谷
kn-aut-mei=恭一郎
aut-affil-num=2
ORCID=

en-aut-name=YabeTadayoshi
en-aut-sei=Yabe
en-aut-mei=Tadayoshi
kn-aut-name=矢部忠孝
kn-aut-sei=矢部
kn-aut-mei=忠孝
aut-affil-num=3
ORCID=

en-aut-name=TakedaTositeru
en-aut-sei=Takeda
en-aut-mei=Tositeru
kn-aut-name=武田俊輝
kn-aut-sei=武田
kn-aut-mei=俊輝
aut-affil-num=4
ORCID=

en-aut-name=ShiomiHumitoshi
en-aut-sei=Shiomi
en-aut-mei=Humitoshi
kn-aut-name=塩見文俊
kn-aut-sei=塩見
kn-aut-mei=文俊
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部病理学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部病理学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1745
end-page=1766
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=1956
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Uterine Movement by Means of a Double-Balloon Technique Part 2. Influences of Sexual Hormones on the Uterine Movement and on the Effect of Oxytocic Agents in Conscious Rabbits
kn-title=2連Balloons留置法による無麻醉兎子宮運動の研究 第2編 無麻醉兎の子宮運動ならびに諸種子宮緊縮薬の作用と性Hormoneとの関係
en-subtitle=
kn-subtitle=
en-abstract=Influences of sexual hormones on the uterine movement and on the effect of oxytocic agents were examined with conscious rabbits in whose uterus double balloons had been installed by the method described in the previous report (this journal 68, 1027, 1956). The height of uterine movement curve gradually decreased in general by ovariectomy but complete ceasure of movement was rare, even one month after the operation. In some cases, decrease of wave height was not so marked, but in such rabbits, there was no cyclic change of the wave height as seen in normal rabbits. Repeated intravenous administration of a definite amount (daily 500 i.u./kg. in 4 divided doses) of estrone in castrated does with diminished uterine movement resulted in an increased height of uterine movement curve. When the number of administration was increased, the contraction wave appeared in the form of grouping at intervals of several minutes to over 10 minutes and this grouped wave was a kind of peristaltic waves. Progesterone (1-2 mg./kg. ) caused a fairly rapid decrease of wave height of uterine movement which had been increased by estrone ; the movement practically stopped after a few hours. Observations on the oxytocic effect of Atonin, Atonin-O, adrenaline, ergot preparations, quinine, Ergoklin, and sparteine in normal rabbits showed that this effect was marked when the wave height of uterine movement is large and slight when the wave height is small. In castrated rabbits, however, the effect of these drugs was slight even in case the wave height was comparatively large. On the coatrary, in　the rabbits under the action of estrone, the　effect of all these drugs was marked dependently neither on the wave height nor on the　rhythmicity. The uterus whose movement had been weakened by progesterone showed decreased sensitivity, not only to Atonin but also to other oxytocic agents. The uterus under the action of pitressin showed tolerance not only against pitocin but also to some other oxytocic agents. This tolerance was also observed during a certain period even after revival of uterine movement which had been stopped by pitressin. From the foregoing findings, it may be said that there is no inevitable relationship between sensitivity of the myometrium to drugs and the state of uterine movement, and that estrone is more closely related to sensitivity of the uterus to drugs rather than to the movement of uterus. In addition, the present series of experiments made it clear that the action of oxytocic
agents does not start in any specific location in the uterus.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AkamatsuOsamu
en-aut-sei=Akamatsu
en-aut-mei=Osamu
kn-aut-name=赤松收
kn-aut-sei=赤松
kn-aut-mei=收
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1737
end-page=1743
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Permeability Studies on Blood Cells by Supravital Stain Ⅴ. Permeability Studies on Leukemic Cells with Special Reference to the Influence of Antileukemic Drugs
kn-title=超生体染色所見から見た血球の細胞膜透過性に関する研究 第5編 骨髄性白血病細胞に於ける色素透過性と，これに及ぼす2，3の白血病治療薬の影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the same method as described in the 1st report permeability of human leakemia cells to dyes was studied using the same dyes as in report Ⅲ comparing to that of matured granulocytes of normal human blood, The myelogenous leukemic cells showed an increased permeability for basic dyes and a depressed permeability for acidic dyes, giving similar data as in the cases of normal bone marrow cells of rabbits (s. Ⅳ Report). ACTH acted as to increase the permeability of both basic and acidic dyes. Nitromin and Azan showed a depressing effect on both series of dyes, especially Azan showed a marked inhibitory effects for the invasion of dyes. Nitrogen musturd B acted as to depress slightly the permeability of acidic dyes, too, but it showed not any effect on the permeability of basic dyes. From these data it was concluded that leukemic cells have similar characteristics for the passive permeability as those of normal young cells in bone marrow. The antileukemic mechanisms of several drugs were discussed from the view point of permeability.
en-copyright=
kn-copyright=

en-aut-name=OguchiMotomitsu
en-aut-sei=Oguchi
en-aut-mei=Motomitsu
kn-aut-name=大口基光
kn-aut-sei=大口
kn-aut-mei=基光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1733
end-page=1736
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Permeability Studies on Blood Cells by Supravital Stain Ⅳ. Permeability Studies on Inflammatory Granulocytes
kn-title=超生体染色所見から見た血球の細胞膜透過性に関する研究 第4編 炎症巣に游出した顆粒球の色素透過性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the previous paper comparative studies of permeability on the matured granulocytes in the circulating blood and on the young cells in the bone marrow has been reported, representing the younger cells are more permeable to basic dyes and lesser permeable to acid dyes than in the matured cells. In this paper the studies on the granulocytes from the inflammatic ascites caused by the intraperitoneal injection of egg white has been reported. Ascites was taken few days after the egg white injection. The method was the same as that described in the previous paper. Dyes were also the same as those in repot Ⅲ. Experiment revealed that those granulocytes from inflammatory fluid showed a marked resistance for the invasion of basie dyes in the media of lower pH level at which the granulocytes in the blood allowed the invasion of the same dyes, while acidic dyes showed an increased stainability of the granulocytes from ascites in those media of the same pH level in which normal granulocytes were stained, i.e. the granulocytes from ascites showed an increased permeability for acidic dyes and a decreased permeability for basic ones. Discussion were made on the permeability of inflammatory cells in the relation of the changed isoelectric point of cytoplasm which may occur in the course of aging.
en-copyright=
kn-copyright=

en-aut-name=OguchiMotomitsu
en-aut-sei=Oguchi
en-aut-mei=Motomitsu
kn-aut-name=大口基光
kn-aut-sei=大口
kn-aut-mei=基光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1729
end-page=1732
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Permeability Studies on Blood Cells by Supravital Stain Ⅲ. Permeability Studies on Bone Marrow Cells
kn-title=超生体染色所見から見た血球の細胞膜透過性に関する研究 第3編 顆粒球系骨髄細胞の細胞膜透過性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As was demonstrated in the 1st report the granulocytes in the circulating blood of a normal adult rabbit showed the increased permeability for dyes in the range of pH, at which the electrical changes of dyes decreased-alkaline media for basic dyes and acidic media for acidic dyes. In this paper the same experiments performed on the bone marrow cells of normal rabbits have been represented. Observations on myeloblasts, promyelocytes and myelocytes using B.C.B., Nile blue, neutral red and Janus green as basic dyes and eosin, erythrosin as acid dyes revealed that these young cells has an increased permeability for basic dyes and a depressed permeability for acid ones comparing to those of matured granulocytes, e.g. young cells in wet preparation showed an increased stainability for basic dyes at the pH level of 4.8 to 7.0 and a depression of permeability for acidic dyes at the pH level of 2.2 to 5.6. Discussions were made on the difference of permeability between bone marrow cells and matured cells in the relation of maturing of cells accompanied by the elevation of isoelectric point of cytoplasm.
en-copyright=
kn-copyright=

en-aut-name=OguchiMotomitsu
en-aut-sei=Oguchi
en-aut-mei=Motomitsu
kn-aut-name=大口基光
kn-aut-sei=大口
kn-aut-mei=基光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1721
end-page=1727
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Permeability Studies on Blood Cells by Supravital Stain Ⅱ. Influence of Several Drugs on the Permeability of Dyes to Granulocytes
kn-title=超生体染色所見から見た血球の細胞膜透過性に関する研究 第2編 2,3の薬物の顆粒球膜透過性に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using brilliant cresyl blue, Nile blue, neutral red, azur Ⅱ and eosin, the author has observed the influence of saponin, Thyradin (powder of dried thyroid gland), progesterone, cortisone, Kontomin (chlorpromazine) and Megabion (17α-methyl-androstene-3β-17β-diol) on the permeability of dyes to granulocytes. Thyradin and Megabion acted as to accelerate the permeability of both acidic and basic dyes, while cortisone and Kontomin restrained the invasion of these dyes info cells. Saponin promoted the invasion of basic dyes and restrained the invasion of eosin. Progesterone showed a depressing effect on the invasion of basic dyes. From these results the mechanism of the pharmacological action of these drugs was breafly discussed.
en-copyright=
kn-copyright=

en-aut-name=OguchiMotomitsu
en-aut-sei=Oguchi
en-aut-mei=Motomitsu
kn-aut-name=大口基光
kn-aut-sei=大口
kn-aut-mei=基光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1705
end-page=1719
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Permeability Studies on Blood Cells by Supravital Stain Ⅰ. Supravital Stain of Leucocyte and Reticulocyte and the Hydrogen Ion Concentration of Media
kn-title=超生体染色所見から見た血球の細胞膜透過性に関する研究 第1編 各種色素の濾紙電気泳動と,それ等色素の正常家兎白血球,網赤血球への超生体染色所見
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Supravital staining of granulocyte, lymphocyte and reticulocyte was carried out with a series of dyes including both acidie and basic ones. On each dye the affinity to cells was observed in those media which pH were changed serially from 1 to 13 using Mcllvaine's or Sorensen’s buffer solution. On the other hand the increasing or decreasing effect of hydrogen ion concentration of media on the charges of dyes was observed electrophoretically. In general, strongly charged dyes, both positive and negative, failed to invade into cells in the whole range of pH, while the Weakly charged dyes showed a positive stain in a certain region of pH, i. e. the acidic dyes in the acidic media and hasic dyes in the basic media, showing the accelerated permeability of dyes to cells in their fairly discharged states. However, some dyes proved to be inpermeable even in their weakly charged states. This inpermeability was attributed to the large molecnlar weight of the dyes or to the sparing solubility to water, alcohol, ether and ether-alcohol.
en-copyright=
kn-copyright=

en-aut-name=OguchiMotomitsu
en-aut-sei=Oguchi
en-aut-mei=Motomitsu
kn-aut-name=大口基光
kn-aut-sei=大口
kn-aut-mei=基光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1679
end-page=1704
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Skin Reaction of Rickettsia Tsutsugamushi Ⅱ : Cross-infection and neutralization tests
kn-title=恙虫病毒の皮内反応に関する研究 第二編 交叉感染試験,並びに交叉中和試験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using Ozeki strain, Mitani strain, XXII strain of rat, Tanizawa strain and Shichito strain and their corresponding antisera, the author observed the skin reaction by the intracutaneous inoculation of the alumina gel-treated rickettsia in the rabbits preimmunized by the infection of each strain. By these cross-neutralization test and skin reaction-inhibition test, immunological relationship among these strains was studied. The results are as follows : 1. Ozeki strain, Mitani strain and XXII strain of rat are immunologically allied to one another, namely cross-neutralization is established among them, and the skin reaction is inhibited by one another in the rabbits pre-immunized by the infection of each strain. 2. Cross-neutralization is established between Tanizawa and Shichito strains, and, in the rabbits pre-immunized by the infection of the one strain, the skin reaction is inhibited by the other ; these two strains are also immunologically in near relation to each other.
en-copyright=
kn-copyright=

en-aut-name=FukudaKaname
en-aut-sei=Fukuda
en-aut-mei=Kaname
kn-aut-name=福田要
kn-aut-sei=福田
kn-aut-mei=要
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1651
end-page=1678
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Skin Reaction of Rickettsia Tsutsugamushi Ⅰ : Intracutaneous Reaction by Alumina Gel treated Rickettsia
kn-title=恙虫病毒の皮内反応に関する研究 第一編 Aluminium-Gel処理病毒による皮内反応
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author investigated the occurrence of the skin reaction of rabbit of inoculation of the rickettsial material prepared by the treatment of rickettsia-infected organ emulsion with alumina gel. At the same time, by this skin reaction the infection titer of rickettsia was determined. The results are as follows 1. The alumina geltreated material causes redness in twelve hours after the inoculation, but induration and ulcer formation the most remarkable signs, appear from fourty-eight to seventy-two hours later. After ninety-six hours, both of these redness and induration gradually disappear. 2. The result of the skin reaction by alumina geltreated material should be judged from fourty-eight to seventy-two hours after the inoculation. It is valid to conclude that the criterion of the significant skin reaction is induration and the minimal skin dosis is the one corresponding to the maximal dilution which is much enough to cause this induration on the inoculated part. 3. Regardless of the sorts of strains, the intracutaneous inoculation of living rickettsia causes redness twelve hours after inoculation, of which, however, the duration is short. By the alumina gel treatment, killed material never acquires the ability to cause skin reaction, irrespective of the sorts of strains. 4. The ability of alumina gel treated rickettsial material to cause the significant skin reaction, is concerned with the degree of its dilution and its virulence and not with the sorts of strains.
en-copyright=
kn-copyright=

en-aut-name=FukudaKaname
en-aut-sei=Fukuda
en-aut-mei=Kaname
kn-aut-name=福田要
kn-aut-sei=福田
kn-aut-mei=要
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1645
end-page=1650
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=INFLUENCE OF X-RAY IRRADIATION ON THE ACTION OFGLYCEROPHOSPHATASE AND ARGINASE OF THE UTERINE CANCER TISSUE
kn-title=癌組織GlycerophosphataseおよびArginase作用におよぼすレ線の影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Experimental studies in vitro of the influence of X-ray irradiation on decomposing action of the glycerol extract of alkaline glycerophosphatase and arginase derived from the tissues of cervical cancer of the uterus and the musclature of the healthy uterine fundus have been attempted and the results obtained were reported as follows : 1. It has been shown that the cancerous tissue of cervic uteri contained more phosphoric acid and urea than the musclature of the normal fundus uteri. 2. It was found that the action of alkaline phosphatase and arginase of the uterine cancer tissue demonstrated stronger action than those of the tissue of fundus uteri. 3. Decomposing action of alkaline glycerophosphatase and arginase of the cancerous tissue of cervix uteri and the musclature of fundus could be suppressed when the enzymic extracts were irradiated and its effect was most pronounced with 300 r irradiation dosage. 4. Suppressing action of the alkaline glycerophosphatase when irradiated with X ray on the enzymic extracts of uterine carcinomatous tissue and fundus musclature, the malignant tissue would be more effective than the normal muscle tissue, while, the suppressing effect of the arginase, irradiated effect on enzymic extracts showed variation according to the dosage, but with 300 r, the effect was far more on the enzymic extract of the cancerous tissue.
en-copyright=
kn-copyright=

en-aut-name=KandaM.
en-aut-sei=Kanda
en-aut-mei=M.
kn-aut-name=神田瑞穂
kn-aut-sei=神田
kn-aut-mei=瑞穂
aut-affil-num=1
ORCID=

en-aut-name=NakanishiY.
en-aut-sei=Nakanishi
en-aut-mei=Y.
kn-aut-name=中西喜雄
kn-aut-sei=中西
kn-aut-mei=喜雄
aut-affil-num=2
ORCID=

en-aut-name=MimuraK.
en-aut-sei=Mimura
en-aut-mei=K.
kn-aut-name=三村公正
kn-aut-sei=三村
kn-aut-mei=公正
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=三木久也
kn-aut-sei=三木
kn-aut-mei=久也
aut-affil-num=4
ORCID=

en-aut-name=YamamotoM.
en-aut-sei=Yamamoto
en-aut-mei=M.
kn-aut-name=山本道夫
kn-aut-sei=山本
kn-aut-mei=道夫
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1639
end-page=1644
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An Electroencephalographic Study on Various Diseases by Aird's Method Part Ⅲ. Study on the arachnoiditis cerebralis by Aird's method
kn-title=エアード氏法による各種脳疾患の脳波に関する研究 第3編 エアード氏法による脳蜘網膜炎患者に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(1) In the electroencephalogram of cerebral arachnoiditis, no spike was observed. As abnormal waves, the slow wave of 6-7 cycles was only seen. For the determination of the lesion, the size of the amplitude of α-wave was evalutaed. (2) Arachnoiditis optochiasmatis, stenosis of the Foramen Magendie caused by arachnoid adhesion and arachnoidites of the cisterna magna were not able to be diagnosed by this method. (3) In all cases of arachnoiditis of the cisterna lateralis and arachnoiditis overlying cerebral hemisphere, localization of foci was possible.
en-copyright=
kn-copyright=

en-aut-name=InagakiTakashi
en-aut-sei=Inagaki
en-aut-mei=Takashi
kn-aut-name=稲垣節
kn-aut-sei=稲垣
kn-aut-mei=節
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1597
end-page=1622
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An Electroencephalographic Study on Various Diseases by Aird's Method. Part Ⅰ. Electroencephalography in epilepsy by Aird's method
kn-title=エアード氏法による各種脳疾患の脳波に関する研究 第1編 エアード氏法による癲癇患者の脳波に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fourty and eight cases of epileptjcs were studied electroencephalographjcally by Aird's method before and after the operation and their foci were determined. The foci were compared with those of other methods and they were investigated before and after the operation. The results were as follows : (1) The focus of idiopathic epilepsy in this method was mostly in temporal region, and reached 72% of all cases (total of both sides). (2) The elctroencephalographic focus was on the same side of the focus determined by provocation of the convulsion to 66.6% in idiopathic epilepsy and 88.8% in symptomatic epilepsy. (3) The side of electroencephalographic focus was on the same side of the focus determined by adversive movement to 72.7% in idiopathic epilepsy and 57.1% in symptomatic epilepsy. (4) The side of the electroencephalographic focus was on the same side of the focus determined by pneumoencephalography to 92.6% in idiopathic epilepsy and to 100% in symptomatic epilepsy. (5) The side of the electroenccphalographic focus was on the same side of the determined focus to 87.8% in idiopathic epilepsy to 100% in symptomatic epilepsy and totally 92.9%, (6) The side of the presumed focus by each examination was on the same side of the synthetically determined focus in the order of eleclroencephalography (92.9%), pneumoencephalography (86.5%), initial side of provocated convulsion (72.2%), adversive movement (57.1%). The order was evaluated to be similar in idiopathic as well as symptomatic epilepsy, but generally the grade of their coincidency was higher than symptomatic epilepsy. (7) The epileptics, who showed a displacement, of focus to the frontal lobe after operation, took a good course and the convulsion decreased or dispersed. On the contrary, those, in whom no traveling of the focus or the into the motor area of the same side was seen, usually took an unfavourable course of the convulsive seizure. (8) Most of the symptomatic epilepsy showed no focus in the electroencephalogram after the operation, and accordingly no more convulsion. (9) This method is able to be a good indicator for determination of epileptic focus and judgement of the effect of therapy.
en-copyright=
kn-copyright=

en-aut-name=InagakiTakashi
en-aut-sei=Inagaki
en-aut-mei=Takashi
kn-aut-name=稲垣節
kn-aut-sei=稲垣
kn-aut-mei=節
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1623
end-page=1637
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An Electroencephalographic Study on Various Diseases by Aird's Method. Part Ⅱ. The electroencephalography in the brain tumor and other few brain disease by Aird's method
kn-title=エアード氏法による各種脳疾患の脳波に関する研究 第2編 エアード氏法による脳腫瘍及びその他2，3の脳疾患の脳波について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thirty cases of brain tumors, encephalomalacia and brain contusion were investigated by Aird's method. (1) The fact that the result of diagnosis localizing the lesion by this method was correct at 100% of all cases except the midline tumors such as hypophyseal tumors, was ascertained by operation. (2) After the operation, the cases, in which the-tumor was completely excised and clinical symptoms recovered, presented normal encephalogram. Therefore we have known, that it excellent value for judgement of the effect of therapy. (3) It is clarified experimentally, that the basic abnormat waves in brain tumors consist slow waves with 3-4-5 cycles, and the slow waves with 6-7 cycles are caused by brain swelling. (4) This method is extremely valuable for the diagnosis and the judgement of the effect of therapy of brain tumors, encephalomalacia and brain contusion etc.
en-copyright=
kn-copyright=

en-aut-name=InagakiTakashi
en-aut-sei=Inagaki
en-aut-mei=Takashi
kn-aut-name=稲垣節
kn-aut-sei=稲垣
kn-aut-mei=節
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1585
end-page=1596
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and Experimental Studies on Iron Metabolism in Hypoplastic Anemia (Panmyelopathia). Part Ⅲ. Effect of the anemia producing substance in serum and organ extracts of hypoplastic anemia on iron metabolism
kn-title=再生不良性貧血（汎骨髓病症）の鉄代謝に関する臨床的並びに実験的研究 第三編 再生不良性貧血患者血清,並びに屍臓器中催貧血性物質の鉄代謝に及ぼす影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author obtained the following results by the injection of serum and organ extracts of hypoplastic anemia to rabbits. 1) By the injection of serum, the red blood cell count decreased 14% to 35%, Hb 6% to 35%, on the other hand reticulocytes increased remarkably. In the examination of the function of R. E. S., the author observed that there was no change after one time's injection, but slightly after repeated injection of 8 time’s. 2) By the injection of organ extracts (2cc per kg) In the case of the injection of bone marrow extracts, the red blood cell count decreased 25%, Hb, 13%, by the injection of the spleen extracts, the red blood cells 20%, Hb 16%, by the injection of the liver extracts, the red cells 14%, Hb 8% respectively. 3) By the injection of serum or organ extracts, the quantity of sernm iron decreased in the biginning (within a few days), then, gradually increased with an advancing anemia. A rise of P(11) and P(111) fraction of depot iron, especially the latter, in the bone marrow indicated the existence of anemia producing substance which disturbed the hematopoietic function in bone marrow, in the serum and organs of patients with hypoplastic anemia as stated in previous parts Ⅰ and Ⅱ.
en-copyright=
kn-copyright=

en-aut-name=MizutaMasaru
en-aut-sei=Mizuta
en-aut-mei=Masaru
kn-aut-name=水田勝
kn-aut-sei=水田
kn-aut-mei=勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1575
end-page=1584
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and Experimental Studies on Iron Metabolism in Hypoplastic Anemia (Panmyelopathia) Part Ⅱ. About the quantity of serum iron and storage iron in hypoplastic anemia
kn-title=再生不良性貧血（汎骨髓病症）の鉄代謝に関する臨床的並びに実験的研究 第二編 再生不良性貧血患者に於ける血清鉄量,並びに貯蔵鉄量に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed the iron tolerance test, iron absorption test and fractional measurement of depot iron(liver, spleen, kidney, duodenum and bune marrow) on patients of hypoplastic anemia, and obtained the result as follows. 1) Iron tolerance test; The amount of serum iron was generally high, that is, 240 γ % on the average. The increased amount of serum iron in 5 minutes after the intravenous administration of 10 mg. gluferricon was 25 γ % to 133 γ % showing the rather wide movement, and was 64 γ % on the average and this is only 33 % of the normal healthy men’s avererage increased amount. The decreasing amount of serum iron in the two hours was 13 γ % to 64 γ % averaging 34 γ % which was one third that of normal subjects (101 γ % ). Namely the decreasing amount in this case was very slight, and in some cases the decreasing amount in two hours was almost equal with that in 5 minutes. 2) Iron absorption test; The increasing quantities of serum iron in two hours after the administration of 1 g reduced iron was 45 γ % on the average. These were slightly lower than those in normal human beings which were 59 γ % on the average. The serum iron in hypoplastic anemia in 4 hours was 265 γ % and in two hours 256 γ % , namely the former only increased by 3.3 % . On the other hand, the decreasing amount of the serum iron of normal human beings was 32 γ % , which decreases by 16.7 % that in two hours. The decreasing amount of serum iron in 6 hours was 33 γ % in normal human being, 11 γ % in hypoplastic anemia. According to these findings, the author confirmed that the absoption of iron in hypoplastic anemia was not only poor, but also retarded. 3) Fractional measurement of depot iron ; Every fractionation of depot iron in liver, spleen, kidney, bone marrow and duodenum was higher than those in other diseases. P(1) fraction in hypoplastic anemia increased 1.2 ×, 1.4 ×, 2.6 ×, 2.8 × and 1.9 × in each organs respectively than those in other diseases. P(11) fraction exhibited an increase of 2.2 ×, 1.3 ×, 0.7 ×, 3.4 × and 2.0 ×. P(111) fraction increased markedly compared with P(1) and P(11), viz., 6.9 ×, 8.4 ×, 7.1 ×, 10.0 ×, 3.8 ×, S(111) fraction, 9.9 ×, 4.8 ×, 10.0 ×, 18.5 ×, 4.8 × in each organ respectively. Namely, P(111) and S(111) fraction increased remarkably in bone marrow. As mentioned above, the quantity of depot iron in hypoplastic anemia was of surplus, and by the investigation of the movement of each fractionation in the course of the metabolism of non-hemin iron, the author confirmed that P(111) and S(111) exhibited a remarkably risein hypoplastic anemia.
en-copyright=
kn-copyright=

en-aut-name=MizutaMasaru
en-aut-sei=Mizuta
en-aut-mei=Masaru
kn-aut-name=水田勝
kn-aut-sei=水田
kn-aut-mei=勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1561
end-page=1574
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and Experimental Studies on Iron Metabolism in Hypoplastic Anemia (Panmyelopathia) Part Ⅰ. About the quantity of serum iron, function of R. E. S., and stored iron in case of many kinds experimental anemia
kn-title=再生不良性貧血（汎骨髓病症）の鉄代謝に関する臨床的並びに実験的研究 第一編 各種実験的貧血に於ける血清鉄量，網内系機能並びに貯蔵鉄量に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author did the measurement of the quantity of serum iron and the fractionation of depot iron (liver, spleen, kidney, duodenum and bone marrow) together with the examination of reticuloendothelial system in various experimental anemic rabbits. Next he investigated the iron metabolism in case of venesection or the administration of phenilhydracine which brings out the accelerating function of the bone marrow, and in case of collargol, benzol, X-ray or saponin which bring out the disturbing function of the bone marrow. And he clarified movements of each fractionation that is P(1), P(11), P(111) or S(111) of non-hemin iron in the intermediate process of iron metabolism. At the time of being disturbed of the hematopoietic function. There is a delicate and important relation between the function of R. E. S. and the iron metabolism. At least, the author can say that P(111) and S(111) iron fraction was metabolized more rapidly and sharply than P(1) and P(11) done, and increased when the hematopoietic function was declined.
en-copyright=
kn-copyright=

en-aut-name=MizutaMasaru
en-aut-sei=Mizuta
en-aut-mei=Masaru
kn-aut-name=水田勝
kn-aut-sei=水田
kn-aut-mei=勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END