岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 紡績工場に於ける精紡機受持台数増加と疲労との関係に就いて （附）. 織機の受持台数増加と疲労との関係 1237 1256 EN Michio Nishizaki The author measured the fatigue of female spinners which was caused by the increase of their spinning machines by the fatigue-measuring method of precipitin reaction of urine. As the result of that test, the increase of fatigue was not observed in both of them who handled 5.5 machines(40. S) and 3.5 machines (20. S). The author observed the increase of fatigue in them who laboured for two months with 20 weaving looms (No. 215). No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 抗体及び抗原の実験的研究 第2篇 糖類の大腸菌免疫抗体加熱に依る抗体破壊阻止作用及び大腸菌抗原加熱に依る影響について 1223 1236 EN K. Sasaki It seems to me that when antibody was heated after various saccharides was added to it, saccharides inhibit the change of gathering condition of kolloid particle after the denaturation and heaping up of serum protein and therefore inhibit the destruction of antibody. It seems that in the intensity of the inhibitory action of destruction of antibody of saccharides, 6% glucose water solution is stronger than 9% sugar water solution. It seems that it has stronger inhibitory action to heat antibody after adding sugar to it beforehand than to heat. antibody after dilute it with sugar water solution. In agglutination after heating of antigen, o antigen diminishes its agglutination's titer in overheating than 80°C and recovers its strength in 2 hours heating at 100°C, while hantigen diminishes its agglutination's titer in ascending of heating temperature and together with prolonging the heating hour. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 抗体及び抗原の実験的研究 第1篇 大腸菌O並びにH型菌に依る免疫抗体加熱の影響について 1211 1222 EN K. Sasaki There are thermolable and thermostabile antigen in colibacilli antigen, but the correspondence for heat of antibodies which was obtained from immune rabbit with them was quite contrary when compared with the corre-spondence for heat of antigens. Antibody which was immunized with thermostable antigen lost half its agglutinin and precipitin by heating for 20 minutes at 65°C and these substances were almost destroyed at 75°C and completely at 90°C. While, antibody which was immunized with thermolabile antigen lost a little their strength by heating for 20 minutes at 65°C and these substances were almost destroyed at 75°C, but were noticed being remained a little even at 90°C. Agglutination and precipitation (Ogata Method) of O and H antibody were noticed being diminished in parallel with heat. Therefore, agglutinin and precipitin are considered to be both unitary. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 臓器抗体の抽出に就て 1203 1209 EN Keizo Yamasita Having prepared tissue emulsion employing homogeneizer the following conclusion was obtained by examining freezing thawing method, by extracting antibodies of lung, heart. kidney and liver. 1) Tissue protein content and precipitin amount did not go parallel. 2) Generally speaking, the lesser protein content after extracting tissue emulsion, precipitin content also proved lesser, while the greater the protein proved the precipitin amount showed greater too. Yet no definite ratio seemed exist between the two. 3) It was difficult to estimate or compare the tissue precipitin with these cases where serum precipitin proved below 1:64; to do this at least above 1:128 was needed. 4) Tissue exis of the liver seemed to have less protein than precipitin amount proved by the lung, heart as well as kidney. 5) Such method as freezing thawing indicated here proved to be comparatively good for a extraction method for tissue antibody. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 卵白を抗原とせる過敏症に対する牛血清の影響について（附「ヒスタミンショック」に及ぼす牛血清の影響について）（過敏症実験4） 1195 1201 EN Keizo Yamasita In the experiment of passive and active anaphylaxis by employing crystallin hen's egg white solution conducted about a guinea pig sensitized due to cows serum and normal guinea pigs, as well as in those where histamin shock was investigated between mice injected with cow's serum and normal mice. Such results were obtained. 1) In the passive anaphylaxis experiment by employing antiegg white rabbitserum, effect of cow's serum was scarcely seen. 2) In the active anaphylaxis test by employing hen's egg white, almost no influence of cow's serum was recognized. 3) In the experiment for histamin shock using mice, in this case also no difference was discovered between cases in which treated with or did not treated with cow's serum. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 海猽の被働性過敏症に於ける抗原再注射場所による影響に就いて （過敏症実験3） 1187 1193 EN Keizo Yamasita On the local influence of antigen reinjection in passive anaphylaxis of guinea pig. 1) There was found no great difference among cases where a guinea pig was sensitized with high value anticrystallines hen's egg white rabbit serum, V. jugunaly, A. caroticaly, as well as, through A. mesentericus. 2) Most part of antigens through the brain and intestines was supposed as the case when injected V. jugunaly, to reach the lung by way of the heart. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 実験的衝撃の生化学的研究 第3篇 インシーリン衝撃施行猫脳髄の焦性ブドウ酸，α-Ketoglutar酸及びアンモニア窒素の消長に就て 1183 1186 EN Jiro Morimoto In Fortsetzung vorhergehender Arbeiten untersuchte der Verfasser an Katzen, welche wiederholend mit Insulinschock behandelt wurden, den Gehalt der Brenztrauben- und α-Ketoglutarsäure sowie des Ammoniakstickstoffes. Das Ergebnis ist folgendes. 1. Die Traubensäure zeigt die Verminderung in gewisser Zeitdauer nach dem Ende der Behandlung. 2. Dagegen die Menge der α-Ketoglutarsäure und des Ammoniakstickstoffes vermehrt sich erheblich. 3. Diese Tatsaehen werden als die Folge der Hirnfunktionssteigerung, welche durch die Insulinsehockbehandlung hervorgerufen wird, betrachtet. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 実験的衝撃の生化学的研究 第2篇 電撃施行猫脳髄の焦性ブドウ酸，α-Ketoglutar酸及びアンモニア窒素の消長に就て 1179 1182 EN Jiro Morimoto Der wiederholend mit Elektroschock behandelte Hirn soll Einfluss auf den Stoffwechsel haben. Bei Katzen wurde die Elektroschockbehandlung wiederholend ausgeführt, wie man in der klinischen Praxis der Psychiatrie anwendet, und dann die Brenztrauben-und α-Ketoglutarsäure sowie den Ammoniakstickstoff bestimmt. Es ergab sich, dass eine leichte Tendenz zur Vermehrung der Brenztraubensäure, deutliche Vermehrung der α-Ketoglutarsäure und des Ammoniakstickstoffes vorhanden sind. Hieraus wird geschlossen, dass die Funktionssteigerung des Hirnes durch die Elektroscbock-behandlung hervorgerufen wird. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 実験的衝撃の生化学的研究 第1篇 正常猫脳髄の焦性ブドウ酸α-Ketoglutar酸及びアンモニア窒素に就て 1173 1177 EN Jiro Morimoto Bei Katzen wurden die Brenztrauben-und α-Ketoglutarsäure nach der Cavallinischen Methode gleichzeitig und der Ammoniakstickstoff im Hirne nach dem Conwayschen Unitverfahren bestimmt. Die Ergebnisse werden wie folgendermassen kurz zusammengefasst. 1. Der Brenztraubensäurewert beträgt ungefähr 400γ pro 100g. Hirn. 2. Die Menge der α-Ketoglutarsäure ist so gering, dass man quantitativ nicht bestimmen kann. 3. Der Ammoniakstickstoffwert beträgt ungefähr 2mg. pro 100g. Hirn. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 癌腫の下垂体前葉-副腎皮質系機能に及ぼす影響について 第4編 副腎皮質予備能について 1161 1171 EN Shigeki Mori The author performed Thorn's tests with ACTH and epinephrine on mice inoculated with cancerous materials, and the following results were obtained: 1. Thorn's tests in mice with transplanted mammary cancer and those injected with cancer tissue extract or urine from cancer patients showed negative results. 2. The products of cancer tissues are regarded to decrease adrenocortical reserve function as a result of the stimulation the pituitary-adrenocortical system. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 癌腫の下垂体前葉-副腎皮質系機能に及ぼす影響について 第3編 循環好酸球数に及ぼす影響 1149 1159 EN Shigeki Mori The author studied the change of circulating eosinophils in mice inoculated with cancerous materials, and the following results were obtained. 1. The number of circulating eosinophils in mice decreased markedly four hours after injection of cancer tissue extract. 2. Urine (0.5cc) obtained from 15 out of 21 patients with gastric cancer decreased the number of circulating eosinophils in mice for over 50 per cent. 3. Same results were obtained from the urine of 2 out of 12 patients with gasttricduodenal ulcer and chronic gastritis. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 癌腫の下垂体前葉-副腎皮質系機能に及ぼす影響について 第2編 下垂体前葉細胞に及ぼす影響 1137 1147 EN Shigeki Mori The author studied the cytological changes of anterior pituitary glands in mice inoculated with cancerous materials, and the following findings were observed: 1. In the pituitary of mice with transplanted mammary cancer, acidophil and basophil cells decreased in number, while the chromophobe ones increased in number. 2. Analogous findings were obtained on mice injected with extracts from cancer tissues and urine taken from cancer patients. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 癌腫の下垂体前葉-副腎皮質系機能に及ぼす影響について 第1編 副腎皮質に及ぼす影響 1121 1136 EN Shigeki Mori The author made histochemical studies using Dempsey's method on the adrenal cortex of mice inoculated with cancerous materials. The results of this experiment were as follows: 1. Adrenal glands of adult male mice with transplanted mammary cancer were hypertrophic, and acetone-soluble, sudanophilic droplets which were also Schiff-positive, Schultze-positive, autofluorescent and birefringent, decreased markedly in number in zona fasciculata et glomerulosa. 2. Same droplets from zona fasciculata in adult male mice treated with cancer tissue extract or urine from cancer patients showed marked decrease in amount. 3. Cancer tissue extracts increased the weight of adrenal glands, and decreased that of the thymus in mice. 4. The products from cancer tissues are regarded to stimulate pituitary-adrenocortical function. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 遺伝神経病の遺伝子に就ての考察 1117 1120 EN Yakichi Ocho I have mentioned the irregularity of heredity of nervous diseases and tried to account for it. The apparent complexity of human pathogenic gene is caused by considering a number of mutations which have different origins as disease unit. Generally speaking, pathogenic gene may be regarded as normal gene whose functions are degenerated or lost through mutation. So instead of Holmes's formula c=f(G. E), I have found my own, c=f[(P. N. gM)E](P: pathogenic gene, N: normal gene, gM. genotypic milieu). Don't P and M stand rather in the relation of compensation than in that of dominance? Thus in the same disease we find some gene dominant and some ressesive, Expressivity of skipping or hetero and homo may be looked upon as mere difference of quantity. The individual difference of the extent of the site of the pathologic changes is vast, ranging from "formes frustes" to "homo lethal". About these phenomena I have tried to give a systematic and consecutive explanation. As disease examples, I have mentioned, including ones of my own examination, Huntington's chorea, Friedreich's ataxia, athetose double, dystrophia progressiva, etc. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 遺伝神経病の研究 第2篇 特発性両側性アテトーゼに就て 1107 1115 EN Yakichi Ocho From my investigation of one rare family subject to athetose double, I have come to the following conclusions. 1. Athetose double is manifest in all the 3 sublings of a family I have observed. Formes frustes were evident in their father and grandfather on paternal side. The father and mother are cousins. Their half-sister by their step-mother is normal. The brothers' mother is degenerant. Amoung their parents' parents and great uncles and great aunts and great grandfather, there were five degenerants and drunkards. 2. Though athetose double appears to be of ressesive character, it is really not so simple, and this makes me venture a theory of "Dominance Change". No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 66 6 1954 遺伝神経病の研究 第1篇 Huntington舞踏病に就て 1091 1106 EN Yakichi Ocho From my investigations of five families subject to Huntington's Chorea, I have come to the following conclusions. 1. Two of them are considered as double phenotypes of chorea and schizophrenia. Others remind us of double phenotypes of ptosis and the so-called lethal factors. 2. Four families are found to be subject to dementia and psychopathia as much as to choreatic movement; one family is liable only to psychopathia. Two families have a tendency to attempt suicide, commit murder and other crimes. 3. A case of anatomical examination shows a remarkable change in the cerebellar cortex, dentatum and nucleus olivalis, in spite of the slight change in striatum and cerebral cortex. Cases of change in nucleus olivaris may perhaps be rare. 4. Such "Disease Gene" as chorea Huntingtoni or "Lethal Factor", I suppose, is caused by the degradation or loss of functions of "Normal Gene" through mutation. Can it not be reasoned, then, that the very existence of "Disease Gene" brings the functions of "Normal Gene" into relief? No potential conflict of interest relevant to this article was reported.