start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=91
end-page=91
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学日本脳炎委員会研究報告第2輯発刊に当りて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=緒方益雄
kn-aut-sei=緒方
kn-aut-mei=益雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=79
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON JAPANESE B ENCEPHALITIS VIRUS (6) OBSERVATIONS ON VARIOUS FORMS OF ANTIGEN EMPLOYED IN HEMAGGLUTINATION OF JAPANESEB ENCEPHALITIS ; ESP. ABOUT TITER OF ANTIGEN DUE TO NAKAYAMA STRAIN
kn-title=日本脳炎の研究 （第6報） 日本脳炎赤血球凝集反応用抗原抽出の種々相に就て 特に中山株に依る抗原抽出に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study have been examined, prozone phenomen as well as titer rising after extracted and centrifuged, employing Okayama 53 C and 53 D Japanese B Encephalitis strain, both I have isolated. The antigen of hemagglutination of Japanese B Encephalitis that has undergone a lowspeed centrifuge, indicates certain lowest value, at immediately after it expanding gradually to the maximum in a week. This is due to inhibiting substances contained in mouse brain, which the antigen is known to digest and reduce at a low temperature, owing to its fermentative action. With the Nakayama strain, it is due to this fact that the antigenal property has often been referred to; if we aim at a low density as well as at a comparatively high temperature in its preparation, this ability would appear without fail. In case the pH at the time of production proves higher than 7.0, antigenical effect appears marked, while weak in inhibition; in case it is low, antigenal virtue proves weak, but strong in inhibiton. These inhibitive substances are the same with those containd in normal component of
mouse brain, which, would not change because of infection to virus. The antigen of hemagglutination  of Japanese B encephalitis prepared from virus infected mouse brain possesses such ferments as to change not only those inhibitive substances of normal compenent of mouse brain, but also those that exist in chickserum.
en-copyright=
kn-copyright=

en-aut-name=FujimotoItsuo
en-aut-sei=Fujimoto
en-aut-mei=Itsuo
kn-aut-name=藤本逸郎
kn-aut-sei=藤本
kn-aut-mei=逸郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=67
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON JAPANESE B ENECPHALITIS VIRUS (5) EFFECTS OF PROTECTING SUBSTANCES ON ANTIGENS IN HEMAGGLUTINATION OF JAPANESE B ENCEPHALITIS VIRUS
kn-title=日本脳炎の研究 （第5報） 日本脳炎赤血球凝集反応用抗原に対する保護物質の影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this experiment the protective ability of the guinea-pig serum as well as sugar and glucose against hemagglutine substance of Japanese B encephalitis virus was reported. In case 0.85% physiological saline water with 5% of inactive guinea-pig serum has been added to antigen, its antigen ability was seen to be made double, and protected from heat under 37°C. That protcctive ability has risen to the top at 5%. When we have prepared some antigens using 0.85% physiololgical scaline water that was added certain inactive guineapig serum to the extent of 2.5%, antigens which has a good titer, and can stand both for the temperature as well as duration of time, besides, preservable, moreover would not lose its specificity may be obtained. Turnip sugar, glucose as well as fruit sugar give certain injurious effect on antigens ; then its action bears close relalion to, not only density, but temperature and lapse of time. Such function of sugars could only be inhibited by antigen protein, a fact that hints at the cue for the future study of antigenal struchlre.
en-copyright=
kn-copyright=

en-aut-name=FujimotoItsuo
en-aut-sei=Fujimoto
en-aut-mei=Itsuo
kn-aut-name=藤本逸郎
kn-aut-sei=藤本
kn-aut-mei=逸郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=53
end-page=65
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON JAPANESE B ENCEPHALITIS VIRUS (4) ON RECEPTOR SUBSTANCES OF JAPANESE B ENCEPHALITIS VIRUS, BY HEMAGGLUTINATION TEST
kn-title=日本脳炎の研究 第4報 日本脳炎の血球擬集反応の擬集元物質に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Having investigated about those receptor substances contained in a chick erythrocytes that were used in hemagglutination reaction by both Okayama 52 A strain as well as Okayama 52 B strain of Japanese B encephalitis virus, obtained the following results. 1) There are contained mach receptor substances in a chick erythrocytes immediately after having been hatched; however, as they grew up, indicated a decrease at 11-14 days, reducing itself to below 10%. 2) likewise, in a chick serum immediately after hatching, various kinds of inhibiting substances may be found out, due to an inhibition test, but they indicate a marked decrease at about 8-11 days, coming down below 10%. From this fact, it, is considered that these two factors have the same or very closely resembled properties. 3) In case we have fixed certain blood preparation specimens by dint of melthanol-formalin 9 : 1 solution and have stained it with Victorian blau, the erythrocytes are apt to be stained deep within one week of hatching, leaving some lipo-protein, non-stainable grobules around those erythrocytes. Thew grobules indicate nothing but lipo-protein contained in plasmas, which bear a close relation to any inhibition-test. 4) Because in case we have inoculated a rabbit with the serum of chick just has been hatched, which contained a great deal of lipo-protein, there would be produced agglutinin that reacts well to chick erythrocytes; this lipo-protein has been taken for a substance quite the same or closely akin to agglutinin receptor substance of chick erythrocytes. 5) If an inhibition test should be carried out by cholesterin and lecithin, the former acts on antigens, which results in depriving the reactions power of erythrocytes toward receptor. From this, it has come to pass that the behavior of cholesterin as inhibition substance as well as receptor substance bears a great significance.
en-copyright=
kn-copyright=

en-aut-name=FujimotoItsuo
en-aut-sei=Fujimoto
en-aut-mei=Itsuo
kn-aut-name=藤本逸郎
kn-aut-sei=藤本
kn-aut-mei=逸郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=49
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=著しく遷延せる日本脳炎の一治験例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=長田高寿
kn-aut-sei=長田
kn-aut-mei=高寿
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=木山敦麿
kn-aut-sei=木山
kn-aut-mei=敦麿
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=内田豊
kn-aut-sei=内田
kn-aut-mei=豊
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=方円幸彦
kn-aut-sei=方円
kn-aut-mei=幸彦
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=25
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=AN EPIDEMIOLOGICAL OBSERVATION OF JAPANESE B ENCEPHALITIS PREVAILED OVER OKAYAMA PREFECTURE DURING THE PAST 8 YEAR FROM 1946 TILL 1953
kn-title=昭和21ー28年間，岡山県下に流行せる日本脳炎の疫学的観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From the epidemiological point of view, an observation was made on the features of Japanese B encephalitis, which occurred and prevailed in Okayama Prefecture, where the outbreak of this disease has been reported all these 8 years from 1946 till 1953. Almost every year, the number of patients in this prefecture exceeded the average one of the whole country. In addition, it seemed to indicate serious outbreak with the period of
about 10 years. Every outbreak has taken place between mid-August and early September. Both children and aged people were susceptible to this disease, the mortality being low in children and somewhat high in the aged patients. Male patients were more numerous than female patients. It is interesting to note that, when the local origin of the patients was investigated, it appeared that many children patients were of the southern parts of the prefecture and many aged patients of the northern parts, where the mortality caused by the disease is somewhat higher. Further investigation in this respect will be done in the future. The peak of this disease was usually seen to be reached in the south about two weeks earlier than in the north. Thus it may well be said that the features of the prevalence of this disease have an intimate relation with the climatic condition. The differential diagnosis of this disease was found to be difficult when accompanied with tuberculolus meningitis, ekiri, dysentery and some other disease with encephalitic or meningitic symptom.
en-copyright=
kn-copyright=

en-aut-name=UchidaYutaka
en-aut-sei=Uchida
en-aut-mei=Yutaka
kn-aut-name=内田豊
kn-aut-sei=内田
kn-aut-mei=豊
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=13
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CLINICAL AND EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS. 1. LIPASE ACTIVITIES IN THE LIQUOR CEREBROSPINALIS OF THE PATIENTS
kn-title=日本脳炎に関する臨牀的並びに実験的研究 第一報 日本脳炎患者髄液リパーゼに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lipase activities in 55 materials of liquor cerebrospinalis taken from 27 Japanese B encephalitis patients, admitted to the attached hospital of this school were investigated over a period of 2 years, 1952-1953. 1. The lipase activity of the liquor cerebrospinalis of Japanese B encephalitis patient was ascertained, in most cases, to be low compared with those of the patients of other diseases like those that affect the menix, the brain, or the spinal cord. This is not quite sufficient to differentiate the diagnosis of the Japanese B encephalitis disease from the others cited above. 2. No such appreciable amount of changes in the lipase activity as might he expected in connexion with the length or the gravity of the diseases were fuund, which indicates that the lipase activity cannot help to determine the prognosis.
en-copyright=
kn-copyright=

en-aut-name=KiyamaAtsumaro
en-aut-sei=Kiyama
en-aut-mei=Atsumaro
kn-aut-name=木山敦麿
kn-aut-sei=木山
kn-aut-mei=敦麿
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部内科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10 suppl
article-no=
start-page=1
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS. 1. HAEMOGRAMS OF THE MICE INFECTED WITH JAPANESE B ENCEPHALITIS AND THE EFECTS OF RADIOACTVE P(32) ADMINISTRATION
kn-title=日本脳炎に関する実験的研究 第一報 日本脳炎罹患マウスの血液像，特にそれに及ぼす放射性同位元素P(32)の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Comparative studies on the haemograms of the mice infected with Japanese B encephalitis with or without the administration of radioactive P(32) were made. 1. In the haemogram of the infected mouse a decrease in the number of white blood cells was observed along with the duration, although there occurred no appreciable amount of changes in the numbers of red blood cells and reticulocytes and in the quantity of haemoglobin. This drop in the number of while blood cells was especially remarkable during the infection period. The classification of the white blood cells showed an increase in the percentage of neutrophilic leucocytes and a decrease in the absolute number of lymphocytes. 2. The administration of radio active P(32) to the normal mouse caused some haemogramaberrations, proportional to the amounts of doses: When 30 μc. p(32) was given, the numbers of red blood cells and reticulocytes and ihe quantity of haemogIobin remaining the same as usual, the number of white blood cells showed a considerable decrease, its minimum value appearing 4 or 5 days after the admininistration. 40 μc. dose gave rise to a slight decrease in the numbers of red blood.cells and reticuloocytes and in the quantity of haemoglobin, the decrease in white blood cell number being far more remarkable than that caused by 30 μc. administration. In both of these two cases, the increases in the percentage of neutrophilic leucocytes and the decreases in the absolute number of lymphocytes were also observed. 3. 30 μc. P(32) administration to the infected mouse induced no significant changes in the numbers of red blood cells and reticulocytes and in the quantity of haemo gIobin, but the number of leucocytcs showed a more marked decrease than that of the infected mouse with no P(32) administration, the increase in the percentage of neutrophilic leucocytes having been depressed. In addition, the elongation of the latent period for Encephalitis of the mice were recognized.
en-copyright=
kn-copyright=

en-aut-name=HoenYukihiko
en-aut-sei=Hoen
en-aut-mei=Yukihiko
kn-aut-name=方円幸彦
kn-aut-sei=方円
kn-aut-mei=幸彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END