岡山医学会Acta Medica Okayama0030-155812312011第173回 岡山外科会7377ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011福山友愛病院6971ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011府中総合病院6768ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011福山市民病院6566ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011ロボット手術の現況と展望6364ENTakashiSaikaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011薬物相互作用（20―経腸栄養剤の薬物相互作用）5962ENKentaroTairaHisashiMatsunagaToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011冠動脈疾患と血行再建術 : インターベンションとバイパス術5758ENMasatoMurakamiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011膝前十字靭帯損傷5355ENNobuhiroAbeNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011希少呼吸器疾患の治療・管理4952ENYasushiTanimotoMitsuneTanimotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011完全内臓逆位症に発症した胃癌の1例4548ENKazuhiroNomaKohjiTanakayaHitoshiTakeuchiEijiKonagaToshiyoshiFujiwaraSitus inversus totalis (SIT) is a relatively rare congenital anomaly with a reported incidence of 1 in 5,000 to 10,000 live births. Although some reports of SIT with malignancy have been published, there have been few reports on SIT with gastric cancer or on the potential complications of surgical intervention in such cases. We here report the case of a patient who underwent surgical treatment for gastric cancer with SIT. The patient was a 54-year-old male, who had been an outpatient with chronic hepatitis and diabetes mellitus. He received an upper endoscopic examination for follow-up of esophageal varices and type 2 ulcerative gastric cancer was found at the posterior wall of the lower stomach. Biopsy was performed and the patient was diagnosed with moderately differentiated gastric cancer. Distal gastrectomy was performed with precise preoperative anatomical analysis in order to confirm that there was no another anomaly, such as cardiovascular or congenital anatomical anomalies except for the inverted position of all of the viscera. Adequate anatomical examination and analysis of the inverted position of related vascular for surgical treatment could lead to safer interventional treatment for malignancies with SIT.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011成人先天性胆道拡張症の6例3943ENHirotoshiTakashimaAkiraSasakiKaoruSasakiWe report six patients with adult congenital biliary dilatation treated by surgery. Of the six cases, five were female and the patients' age at diagnosis ranged from 19 to 51 years old. By Todani's classification for bile duct dilatation, three were categorized as Ta, one as Tb, and two as Wa. All six cases had anomalous arrangement of the pancreatobiliary duct. Resection of the cystic portion and hepaticojejunostomy (Roux-Y) were performed in all. After surgery, one patient classified as Ta and one as Wa had complications of cholangitis and intrahepatic stones. We removed the stones by the percutaneous transhepatic route with dilatation of the stenotic anastomosis, but cholangitis recurred in the Wa patient. Although surgical resection of the cystic portion and reconstruction of biliary tract is considered to be a standard treatment for adult congenital biliary dilatation, this Wa case had complications after surgical treatment. Thus short-term follow-up is necessary to prevent or diagnose stenotic anastomosis following the operation.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011十二指腸潰瘍穿孔に対する治療法の適応についての検討3338ENNobuhiroIshidoRyujiTamuraTakahiroOkamotoYoshihikoKadowakiTakashiMoriBackground: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011Renato Dulbecco ： ダルベッコ培地2731ENMasayoshiNamba現在，医学分野の多くの研究は培養細胞や培養組織を用いてなされている．それらの研究成果が報告されている論文の“材料と方法”の項で，ダルベッコ培地を使用して細胞を培養したといった記載を読んだ研究者は少なくないであろう．また，実際にダルベッコ培地を使用した研究者もいると思う．今回は，この培地を報告したDulbecco（1975年，がんウイルスの研究によってノーベル賞）の波乱万丈の経歴，彼の人脈（多くの人物がノーベル賞を受賞），彼の研究概略などについて紹介したい．そして，筆者のダルベッコ培地に対する見解とその培地を使用した経験について述べる．筆者の結論は，初代細胞培養にはダルベッコ培地が勧められること，また，培養細胞を用いての毒性検定に際しては，使用する培地によって結果が異なることがあるので注意する必要があることである．No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011血管新生negative feedback制御因子Vasohibin-1によるマウス糖尿病性腎症進展制御効果の検討1925ENTatsuyoNasuYoheiMaeshimaMasaruKinomuraKumikoHirokoshi-KawaharaKatsuyukiTanabeHitoshiSugiyamaHikaruSonodaYasufumiSatoHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011生体内におけるEGFR T790M遺伝子変異を持つ肺腺癌細胞に対するバンデタニブの効果1318ENEikiIchiharaKadoakiOhashiNagioTakigawaMasahiroOsawaAtsukoOginoMitsuneTanimotoKatsuyukiKiuraNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812312011アンフィファイジンとN-WASPのダイナミックな相互作用は，アクチン重合を制御する111ENHiroshiYamadaSergiPadilla-ParraSun JooParkToshikiItohMathildeChaineauIlariaMonaldiOttavioCremonaFabioBenfenatiPietro DeCamilliMaïtéCoppey-MoisanMarcTramierThierryGalliKohjiTakeiNo potential conflict of interest relevant to this article was reported.