岡山医学会Acta Medica Okayama0030-155811612004先天性股関節脱臼に対するColonna法術後の股関節機能維持期間および股関節症発症時期に関する研究3946ENTaisukeNagayasuThe long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip, especially in terms of duration of the hip function and the onset of coxarthrosis, was investigated. There were 68 hips (63 patients, 54 female and 9 male). The age at the time of the surgery ranged from 11 months to 12 years and 9 months (average 4 years and 3 months). According to the Kaplan-Meier's method, the average survival rate of the hip function was 25 years and 8 months and the survival rate for 25 years was 53%, if the end point was defined as the time hip pain began. Then the average survival rate of hip function was 28 years and the rate was 60.3%, if the end point was defined as the time radiograph showed advanced stage. Clinically, the hip function, especially walking ability, proved to be maintained for long time. The long-term result was worse, when the operation was performed when the patient was older than 6 years old or when patient had previous treatment.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004医学教育概説―教育評価とその運用―2938ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004再生医学から見たパーキンソン病1727ENIsaoDateIt has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004心不全における酸化ストレスの関与：基礎的ならびに臨床的検討 ―岡山大学医学賞（結城賞）を受賞して―916EN心不全患者において血中の過酸化脂質の上昇などが報告され，活性酸素による酸化ストレスの関与が示唆されている．そこで，心筋が実際に活性酸素を発生するかどうかを，活性酸素を検出する蛍光プローブを用いてラットの培養心筋細胞において検討した．心不全増悪因子であるアンジオテンシンIIおよびtumor necrosis factor(TNF)-alphaを加えると心筋細胞で濃度依存性に活性酸素が発生した．さらにヒトの不全心筋においても実際に酸化ストレスの発生が増強しているかを検討した．過酸化脂質の代謝産物で，有害なアルデヒドである4-Hydroxy-2-nonenal(HNE)によって修飾された蛋白質を免疫染色にて調べたところ，拡張型心筋症患者の心筋において正常心機能者に比べ5倍以上増加していた．さらにβ遮断薬(Carvedilol)により治療を行ったところ心機能の改善とともに，HNE修飾蛋白質が40%低下した．以上の一連の研究により，
活性酸素による酸化ストレスの発生が不全心筋において増強しており，その抑制が心不全治療のターゲットの一つになりうることを明らかにした．No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004神経シナプスにおけるエンドサイトーシス機能タンパク質‐膜リン脂質 相互作用機序の人工脂質膜を用いた解析法―岡山大学医学賞（新見賞）を受賞して―18ENNo potential conflict of interest relevant to this article was reported.