start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=46
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip
kn-title=先天性股関節脱臼に対するColonna法術後の股関節機能維持期間および股関節症発症時期に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip, especially in terms of duration of the hip function and the onset of coxarthrosis, was investigated. There were 68 hips (63 patients, 54 female and 9 male). The age at the time of the surgery ranged from 11 months to 12 years and 9 months (average 4 years and 3 months). According to the Kaplan-Meier's method, the average survival rate of the hip function was 25 years and 8 months and the survival rate for 25 years was 53%, if the end point was defined as the time hip pain began. Then the average survival rate of hip function was 28 years and the rate was 60.3%, if the end point was defined as the time radiograph showed advanced stage. Clinically, the hip function, especially walking ability, proved to be maintained for long time. The long-term result was worse, when the operation was performed when the patient was older than 6 years old or when patient had previous treatment.
en-copyright=
kn-copyright=

en-aut-name=NagayasuTaisuke
en-aut-sei=Nagayasu
en-aut-mei=Taisuke
kn-aut-name=永易大典
kn-aut-sei=永易
kn-aut-mei=大典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　整形外科学
en-keyword=先天性股関節脱臼
kn-keyword=先天性股関節脱臼
en-keyword=Colonna法
kn-keyword=Colonna法
en-keyword=生存分析
kn-keyword=生存分析
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=医学教育概説―教育評価とその運用―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板谷裕子
kn-aut-sei=板谷
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=全国共同利用施設岐阜大学医学部医学教育開発センター　MEDC （Medical Education Development Center）
en-keyword=Medical education
kn-keyword=Medical education
en-keyword=Concept formation
kn-keyword=Concept formation
en-keyword=Insight leaning
kn-keyword=Insight leaning
en-keyword=Medical interview
kn-keyword=Medical interview
en-keyword=Tutorial
kn-keyword=Tutorial
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Parkinson's disease from a viewpoint of regenerative medicine
kn-title=再生医学から見たパーキンソン病
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.
en-copyright=
kn-copyright=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=伊達勲
kn-aut-sei=伊達
kn-aut-mei=勲
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　神経病態外科学
en-keyword=Parkinson's disease
kn-keyword=Parkinson's disease
en-keyword=neural transplantation
kn-keyword=neural transplantation
en-keyword=regeneration
kn-keyword=regeneration
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=心不全における酸化ストレスの関与：基礎的ならびに臨床的検討 ―岡山大学医学賞（結城賞）を受賞して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=心不全患者において血中の過酸化脂質の上昇などが報告され，活性酸素による酸化ストレスの関与が示唆されている．そこで，心筋が実際に活性酸素を発生するかどうかを，活性酸素を検出する蛍光プローブを用いてラットの培養心筋細胞において検討した．心不全増悪因子であるアンジオテンシンIIおよびtumor necrosis factor(TNF)-alphaを加えると心筋細胞で濃度依存性に活性酸素が発生した．さらにヒトの不全心筋においても実際に酸化ストレスの発生が増強しているかを検討した．過酸化脂質の代謝産物で，有害なアルデヒドである4-Hydroxy-2-nonenal(HNE)によって修飾された蛋白質を免疫染色にて調べたところ，拡張型心筋症患者の心筋において正常心機能者に比べ5倍以上増加していた．さらにβ遮断薬(Carvedilol)により治療を行ったところ心機能の改善とともに，HNE修飾蛋白質が40%低下した．以上の一連の研究により，
活性酸素による酸化ストレスの発生が不全心筋において増強しており，その抑制が心不全治療のターゲットの一つになりうることを明らかにした．
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=中村一文
kn-aut-sei=中村
kn-aut-mei=一文
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=草野研吾
kn-aut-sei=草野
kn-aut-mei=研吾
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=垣下幹夫
kn-aut-sei=垣下
kn-aut-mei=幹夫
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=三浦綾
kn-aut-sei=三浦
kn-aut-mei=綾
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=久松研一
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kn-aut-mei=研一
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西井伸洋
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
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en-aut-name=
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤尾栄起
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=宮地克維
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kn-aut-mei=克維
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=永瀬聡
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kn-aut-mei=聡
aut-affil-num=11
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森田宏
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kn-aut-mei=宏
aut-affil-num=12
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=斎藤博則
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=江森哲郎
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ORCID=

en-aut-name=
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kn-aut-name=浅沼幹人
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en-aut-name=
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kn-aut-name=宮崎正博
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kn-aut-mei=正博
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=中村陽一
kn-aut-sei=中村
kn-aut-mei=陽一
aut-affil-num=17
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松原広己
kn-aut-sei=松原
kn-aut-mei=広己
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=伏見和郎
kn-aut-sei=伏見
kn-aut-mei=和郎
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=豊國伸哉
kn-aut-sei=豊國
kn-aut-mei=伸哉
aut-affil-num=20
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大江透
kn-aut-sei=大江
kn-aut-mei=透
aut-affil-num=21
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=13
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=14
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科

affil-num=15
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　神経情報学

affil-num=16
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　細胞生物学

affil-num=17
en-affil=
kn-affil=松山市民病院循環器内科

affil-num=18
en-affil=
kn-affil=国立病院岡山医療センター循環器科

affil-num=19
en-affil=
kn-affil=北陸先端科学技術大学院大学ナノマテリアルテクノロジーセンター

affil-num=20
en-affil=
kn-affil=京都大学大学院医学研究科病態生物医学

affil-num=21
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　循環器内科
en-keyword=4-Hydroxy-2-nonenal
kn-keyword=4-Hydroxy-2-nonenal
en-keyword=酸化ストレス
kn-keyword=酸化ストレス
en-keyword=心不全
kn-keyword=心不全
en-keyword=β遮断薬
kn-keyword=β遮断薬
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=神経シナプスにおけるエンドサイトーシス機能タンパク質‐膜リン脂質 相互作用機序の人工脂質膜を用いた解析法―岡山大学医学賞（新見賞）を受賞して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=絹田正裕
kn-aut-sei=絹田
kn-aut-mei=正裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　脳神経制御学
en-keyword=endocytosis
kn-keyword=endocytosis
en-keyword=synaptic vesicle
kn-keyword=synaptic vesicle
en-keyword=liposome
kn-keyword=liposome
en-keyword=dynamic light scattering
kn-keyword=dynamic light scattering
en-keyword=phospholipids
kn-keyword=phospholipids
END