start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=819
end-page=822
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第24回　岡山リウマチ研究会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山リウマチ研究会
kn-aut-sei=岡山リウマチ研究会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=771
end-page=778
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Flowcytometric studies of effects of heat on DNA synthesis in different thermosensitivities mammalian cell lines
kn-title=温熱感受性の異なる培養細胞の DNA 合成に対する温熱効果―フローサイトメトリーによる研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of heat on DNA synthesis in HeLa S3 cells and L-5 cells was studied using flowcytometry. When D(0) values obtained from survival curves of Ehrlich ascites tumor cells, L-5 cells, HeLa S3 cells and NIH3T3 cells after heating to 43, 44, or 45℃, were compared, HeLa S3 cells were resistant and L-5 cells were sensitive to heating. During heating at 43℃, DNA synthesis (BUdR uptake) of HeLa S3 cells was resistant compared to that of L-5 cells. When the period of DNA synthesis was divided into 3 fractions (early S, mid S and late S), late S phase was the most sensitive fraction to heating at 43℃ for 60 minutes. From these results, relationship between DNA synthesis and thermocytotoxic effects are discussed.
en-copyright=
kn-copyright=

en-aut-name=TanakaSeiryou
en-aut-sei=Tanaka
en-aut-mei=Seiryou
kn-aut-name=田中聖了
kn-aut-sei=田中
kn-aut-mei=聖了
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=Flowcytometry
kn-keyword=Flowcytometry
en-keyword=DNA synthesis
kn-keyword=DNA synthesis
en-keyword=Heating
kn-keyword=Heating
en-keyword=BUdR
kn-keyword=BUdR
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=759
end-page=770
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the pathogenesis of anti-IgE autoantibody in bronchial asthma
kn-title=気管支喘息における血清抗 IgE 自己抗体の基礎的並びに臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the pathogenesis of asthma especially intractable asthma, we measured the serum levels of anti-IgE autoantibody in 46 asthmatics and 39 healthy subjects, using solid-phase enzyme immunoassay. The serum levels of anti-IgE autoantibody in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). The levels of anti-IgE autoantibody in 25 atopic asthmatics were also significantly higher than those in 19 non-atopic asthmatics (p<0.01). Futhermore, significant correlation was observed between the levels of anti-IgE autoantibody and serum IgE (r=0.576, p<0.01). House dust and Candida (p<0.01) specific IgE (RAST) positive asthmatics also tended to have higher serum levels of anti-IgE autoantibody. However, no significant relation was observed between the serum levels of anti-IgE autoantibody and the severity of asthma. Moreover, anti-IgE autoantibody was not significantly related to specific IgG subclass antibody or lymphocyte blastogenesis to mite and Candida, or with the numbers of eosinophils and basophils in peripheral blood. These findings suggest that anti-IgE autoantibody play an important role in the pathogenesis of bronchial asthma, especially atopic asthma associated with IgE-dependent mechanisms.
en-copyright=
kn-copyright=

en-aut-name=YamagataKoichi
en-aut-sei=Yamagata
en-aut-mei=Koichi
kn-aut-name=山縣浩一
kn-aut-sei=山縣
kn-aut-mei=浩一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=抗 IgE 自己抗体
kn-keyword=抗 IgE 自己抗体
en-keyword=アトピー型喘息
kn-keyword=アトピー型喘息
en-keyword=IgE 抗体
kn-keyword=IgE 抗体
en-keyword=IgG アイソタイプ抗体
kn-keyword=IgG アイソタイプ抗体
en-keyword=酵素抗体法
kn-keyword=酵素抗体法
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=751
end-page=758
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diagnostic studies of allergic gastroenteropathy Part 2. Diagnosis for allergic gastroenteropathy using phonoenterography analysis
kn-title=アレルギー性胃腸症の診断に関する研究　第2編　腸音分析法を用いたアレルギー性胃腸症の診断に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Oral challenge with specific allergens is generally used to diagnose allergic gastroenteropathy, but no evaluation criteria have yet been established. Therefore, we examined allergological tests (skin tests, IgE RAST score), oral challenge tests with causative allergens and oral administration tests using sorbitol as a nonspecific stimulator or distilled water as a control. Phonoenterograms were recorded intermittently for up to 5 hours after the tests and analyzed by a pulse density program. The results showed that it is possible to classify allergic gastroenteropathy into six subgroups by the allergological tests, symptoms and intestinal motility analyzed by phonoenterography. Increase of bowel sounds with or without positive allergological test and symptoms indicates a high suspicion of allergic gastroenteropathy. These data suggest that phonoenterography is useful in the diagnosis of this disease. It should also be possible to diagnose latent cases of allergic gastroenteropathy by non IgE-mediated allergic reactions.
en-copyright=
kn-copyright=

en-aut-name=MiyashitaKatuhiro
en-aut-sei=Miyashita
en-aut-mei=Katuhiro
kn-aut-name=宮下雄博
kn-aut-sei=宮下
kn-aut-mei=雄博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=アレルギー性胃腸症
kn-keyword=アレルギー性胃腸症
en-keyword=腸音分析
kn-keyword=腸音分析
en-keyword=経口誘発試験
kn-keyword=経口誘発試験
en-keyword=ソルビトール
kn-keyword=ソルビトール
en-keyword=pulse density
kn-keyword=pulse density
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=741
end-page=749
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diagnostic studies of allergic gastroenteropathy Part 1. Application of phonoenterography in hypersensitivity of the gastrointestinal tract
kn-title=アレルギー性胃腸症の診断に関する研究　第1編　胃腸管の過敏性における腸音分析法の有用性に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Allergic gastroenteropathy has various gastrointestinal symptoms caused by allergic reactions in the gastrointestinal tract after oral ingestion of specific allergens, but no diagnostic examination has yet been established. To evaluate gastrointestinal motility as a method of diagnosing allergic gastroenteropathy, bowel sounds caused by oral ingestion of distilled water, sorbitol or allergens were recorded intermittently for up to 5 hours after oral administration tests and analyzed by pulse density program. The results showed that bowel sounds in many patients with allergic gastroenteropathy increased much more than that in normal subjects when sorbitol was ingested. The increase in bowel sounds was even more marked after oral ingestion of allergens compared to that after distilled water. These data suggest that phonoenterography after ingestion of sorbitol is useful in screening for allergic gastroenteropathy, and also using this method with ingestion of specific allergens is effective for confirming the diagnosis of this disease.
en-copyright=
kn-copyright=

en-aut-name=MiyashitaKatuhiro
en-aut-sei=Miyashita
en-aut-mei=Katuhiro
kn-aut-name=宮下雄博
kn-aut-sei=宮下
kn-aut-mei=雄博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=アレルギー性胃腸症
kn-keyword=アレルギー性胃腸症
en-keyword=腸音分析
kn-keyword=腸音分析
en-keyword=経口誘発試験
kn-keyword=経口誘発試験
en-keyword=ソルビトール
kn-keyword=ソルビトール
en-keyword=pulse density
kn-keyword=pulse density
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=733
end-page=739
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bacteriological study of chronic otitis media with repeated otorrhea
kn-title=反復する慢性中耳炎耳漏の細菌学的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Microorganisms were investigated in 44 patients with chronic otitis media (COM) and repeated otorrhea. The same species were isolated most frequently from those with repeated otorrhrea (24 of 44 cases). The species were Staph. aureus (10 caces), P.aeruginosa (9 cases), Staph. epidermidis (4 cases), and P.cepacia (1 case). For each species isolated from the same patient, similar sensitivity to antibiotics were observed. Therefore, we considered that reinfection by the bacteria existing in the body caused otorrhea in some cases. After NFLX was administered for MRSA infection in COM, Cephem antibiotics (CEZ, LMOX, etc) showed a recovery of sensitivity to Staph. aureus. We observed a superinfection by Methicillin-Cephem-Resistant Staph. epidermidis (MRSE) after antibiotics therapy for MRSA in COM.
en-copyright=
kn-copyright=

en-aut-name=KosakaMasakazu
en-aut-sei=Kosaka
en-aut-mei=Masakazu
kn-aut-name=小坂正和
kn-aut-sei=小坂
kn-aut-mei=正和
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室
en-keyword=bacteriological study
kn-keyword=bacteriological study
en-keyword=chronic otitis media
kn-keyword=chronic otitis media
en-keyword=sensitivity to antibiotics
kn-keyword=sensitivity to antibiotics
en-keyword=otorrhea
kn-keyword=otorrhea
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=715
end-page=731
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HLA-DNA-DQ typing by PCR-RFLP method in renal transplantation
kn-title=PCR-RFLP 法による HLA-DNA-DQ タイピングと腎移植
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two methods of HLA-DNA typing (PCR-RFLP method and PCR-SSO method) were performed on HLA-DQ in living related, living unrelated and cadaveric renal transplants. These two DNA typing methods allowed more accurate and more detailed typing than the conventional typing method. The effect of DNA histocompatibility of DQA 1 and DQB 1, both typed by the PCR-RFLP method, on clinical outcome and surviving graft rate of renal transplant patients was analyzed. There was no correlation found between the number of mismatches between donor and recipient of DQA 1 typing in cadaveric renal transplants, of DQB 1 typing in cadaveric, living unrelated and living related transplants and the clinical outcome nor the surviving graft rate of renal transplant patients. Both the clinical outcome and the surviving graft rate in the group in which DQ 5 mismatch between donor and recipient was positive were statistically poorer than that in the group in which DQ 5 mismatch was negative. This result suggests the existance of DQ 5 mismatch between donor and recipient greatly influences graft survival after renal transplantation.
en-copyright=
kn-copyright=

en-aut-name=HirakawaKeiichi
en-aut-sei=Hirakawa
en-aut-mei=Keiichi
kn-aut-name=平川恵一
kn-aut-sei=平川
kn-aut-mei=恵一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=HLA-DNA タイピング
kn-keyword=HLA-DNA タイピング
en-keyword=PCR-RFLP 法
kn-keyword=PCR-RFLP 法
en-keyword=PCR-SSO 法
kn-keyword=PCR-SSO 法
en-keyword=腎移植
kn-keyword=腎移植
en-keyword=DQ 抗原
kn-keyword=DQ 抗原
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=705
end-page=714
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Endothelium-dependent coronary vasodilatory action of adenosine : Examination in open-chest dogs
kn-title=Adenosine の内皮依存性冠血管拡張作用―麻酔開胸犬を用いた検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To evaluate the endothelium-dependent coronary vasodilatory effect of adenosine, especially the role of endothelium-derived nitric oxide (EDNO), the dose-response relationship of exogenous adenosine was examined in open-chest dogs before and after intracoronary administration of N(G)-nitro-L-arginine (NNLA), a potent inhibitor of NO synthesis. NNLA attenuated the vasodilatory effect of acetylcholine to less than 25% of the control, which indicates NO synthesis inhibition. NNLA caused a rightward shift of the adenosine dose-response curve with a significant increase of EC(50), whereas there was no significant change in the slope of the regression line calculated by log-logit transformation. These findings suggest that the coronary vasodilatory effect of adenosine is partially induced through an increase of NO release, and this action may play a role in the regulation of coronary vascular tone.
en-copyright=
kn-copyright=

en-aut-name=ObayashiNaotsugu
en-aut-sei=Obayashi
en-aut-mei=Naotsugu
kn-aut-name=大林直嗣
kn-aut-sei=大林
kn-aut-mei=直嗣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部循環器内科学教室
en-keyword=adenosine
kn-keyword=adenosine
en-keyword=EDNO
kn-keyword=EDNO
en-keyword=coronary endothelium
kn-keyword=coronary endothelium
en-keyword=coronary vasodilation
kn-keyword=coronary vasodilation
en-keyword=open chest dog
kn-keyword=open chest dog
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=695
end-page=703
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Heterogeneity of myocardial oxygen metabolism of the right ventricle
kn-title=右室心筋酸素代謝の不均一性に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine whether the right ventricular (RV) myocardial oxygen metabolism was heterogeneous, oxygen extraction ratios (EO(2)) and regional myocardial blood flow (RMBF) of the basal, middle and apical regions of the RV free wall were studied in open-chest dogs. After control studies, the following interventions were applied; 1) atrial pacing (200 beats/sec), 2) intravenous infusion of isoproterenol (1.0μg/�s/min) and 3) pulmonary artery constriction to raise RV systolic pressure tp 40-50mmHg. The venous blood from three anterior cardiac veins was sampled directly, and RMBF was measured using colored microspheres. EO(2) was significantly lower in all areas of the RV compared to that in the left ventricle (LV). In control, the basal region of the RV extracted more oxygen than the apical region (p<0.01), and RMBF tended to be lower in the basal than the apical. Thus, myocardial oxygen consumption in the control did not differ in each area of the RV. During all interventions, greater increases in EO(2) were observed in the apical and middle regions than in the basal region, and RMBF increased by a similar amount in all three regions. Therefore, we suspected that oxygen metabolism in the RV was dependent on not only RMBF but also EO(2), and varied from region to region. This heterogeneity of oxygen metabolism tended to disappear under RV overload.
en-copyright=
kn-copyright=

en-aut-name=UchidaShinji
en-aut-sei=Uchida
en-aut-mei=Shinji
kn-aut-name=内田眞司
kn-aut-sei=内田
kn-aut-mei=眞司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部循環器内科学教室
en-keyword=myocardial oxygen metabolism
kn-keyword=myocardial oxygen metabolism
en-keyword=right ventricle
kn-keyword=right ventricle
en-keyword=oxygen extraction ratio
kn-keyword=oxygen extraction ratio
en-keyword=regional myocardial blood flow
kn-keyword=regional myocardial blood flow
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=681
end-page=693
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Correlation of vectorcardiographic findings with patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy
kn-title=肥大型心筋症における肥大様式とベクトル心電図の対比検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We compared vectorcardiographic (VCG) findings with the distribution of hypertrophy in patients with hypertrophic cardiomyopathy (HCM). Distribution of left ventricular hypertrophy was determined by both echocardiogram (UCG) and magnetic resonance imaging (MRI). According to the specific hypertrophic site evaluated by UCG and MRI, 43 patients with HCM were classified into 4 types : septal, anterior, posterolateral or apical type. In patients classified as anterior, posterolateral and apical types, the QRS loop was directed toward the hypertrophic site because of increased electromotive force in the hypertrophic site. In contrast, in patients classified as septal types, the QRS loop was directed away from the hypertrophic site. This opposite direction was probably due to altered electromotive force and/or conduction disturbance in the hypertrophic site as the disease progressed. The present study indicates that QRS loop direction suggests the location of hypertrophy. The T loop was most slender in patients with apical hypertrophy and the slenderness was associated with the relative degree of hypertrophy in the apex compared with hypertrophy in other sites.
en-copyright=
kn-copyright=

en-aut-name=ShirakiTeruo
en-aut-sei=Shiraki
en-aut-mei=Teruo
kn-aut-name=白木照夫
kn-aut-sei=白木
kn-aut-mei=照夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=ベクトル心電図
kn-keyword=ベクトル心電図
en-keyword=肥大型心筋症
kn-keyword=肥大型心筋症
en-keyword=心臓超音波
kn-keyword=心臓超音波
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=673
end-page=680
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on nicaraven as a radioprotector : Survival ratio of mice, spleen colony formation, blood picture and lipid peroxidation
kn-title=ニカラベンの放射線防護剤としての有用性の検討―マウス生存率，脾コロニー，末梢血液像，脂質過酸化について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The degree of radiation protection from Nicaraven after whole-body irradiation was investigated in C3H mice. Nicaraven is a free radical scavenging agent, which was shown to improve brain edema and blood flow. Nicaraven was injected intraperitoneally in mice before and/or after whole-body irradiation with 640cGy or 740cGy using Toshiba Lineac LMR-4C (4MV, 6.45×10(-2)C/�s/min). The 30 day survival ratio was improved significantly by Nicaraven (P≦0.02). Endogenous spleen colony formation was investigated after 640cGy. The agent was injected before (pre), after (post) or before and after irradiation (pre-post), and compared with the untreated group (control). Nine days after irradiation, the mean colony formation was 2.00 (pre), 3.09 (post), 4.31 (pre-post) and 1.47 (control). The differences between pre and post (p≦0.01), between pre-post and control (p≦0.01) and between post and control (p≦0.05) were significant. Nicaraven induced recovery of leukocyte and lymphocyte counts after irradiation, but not that of erythrocytes. The effect of the agent on mice liver mitochondrial lipid peroxidation was also investigated. The lag time was not shortened, but reduction of the TBA value was observed. Nicaraven was not only recognized as a radioprotector, but its ability to promote recovery from the damage caused by irradiation was also suggested.
en-copyright=
kn-copyright=

en-aut-name=MoriYasutane
en-aut-sei=Mori
en-aut-mei=Yasutane
kn-aut-name=森泰胤
kn-aut-sei=森
kn-aut-mei=泰胤
aut-affil-num=1
ORCID=

en-aut-name=TakashimaHitoshi
en-aut-sei=Takashima
en-aut-mei=Hitoshi
kn-aut-name=高島均
kn-aut-sei=高島
kn-aut-mei=均
aut-affil-num=2
ORCID=

en-aut-name=SeoHiroyuki
en-aut-sei=Seo
en-aut-mei=Hiroyuki
kn-aut-name=瀬尾裕之
kn-aut-sei=瀬尾
kn-aut-mei=裕之
aut-affil-num=3
ORCID=

en-aut-name=OhkawaMotoomi
en-aut-sei=Ohkawa
en-aut-mei=Motoomi
kn-aut-name=大川元臣
kn-aut-sei=大川
kn-aut-mei=元臣
aut-affil-num=4
ORCID=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=5
ORCID=

en-aut-name=YamamotoGoki
en-aut-sei=Yamamoto
en-aut-mei=Goki
kn-aut-name=山本剛禧
kn-aut-sei=山本
kn-aut-mei=剛禧
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=2
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=3
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=4
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=5
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医療技術短期大学部診療放射線技術学科
en-keyword=Radioprotector
kn-keyword=Radioprotector
en-keyword=Nicaraven
kn-keyword=Nicaraven
en-keyword=Radical scavenger
kn-keyword=Radical scavenger
en-keyword=Spleen colony
kn-keyword=Spleen colony
en-keyword=Lipid peroxidation
kn-keyword=Lipid peroxidation
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=665
end-page=671
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis Part 2. Correlation between local lymphocyte response and clinical features in sarcoidosis
kn-title=サルコイドーシス肺リンパ球の Propionibacterium acnes に対する反応性に関する研究 第2編 P. acnes に対する反応性と臨床検査との相関
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Alveolar lymphocyte response by Propionibacterium acnes (P. acnes) in patients with active sarcoidosis was previously reported by our group. The response of alveolar lymphocytes in 34 untreated patients with sarcoidosis was studied in correlation with clinical findings on radiographic, physiologic and bronchoalveolar lavage. There was a significant correlation between lymphocyte blastogenesis and the number of lymphocytes (p<0.05), and CD4(＋) T-cells (p<0.01) obtained by bronchoalveolar lavage. Furthermore, the response was significantly correlated with the activity of Interleukin-2 released by alveolar lymphocytes stimulated by P. acnes (p<0.05). In patients who showed abnormalities on all three clinical examinations, i. e. serum angiotensin converting enzyme activity, number of alveolar lymphocytes and 67Ga scintigraphy of the lung, the response was significantly higher than in the controls (p<0.001) or in patients with none of these abnormalities (p<0.01). These data suggest that the response of alveolar lymphocytes reflects the activity of pulmonary sarcoidosis.
en-copyright=
kn-copyright=

en-aut-name=MaetaTsuyoshi
en-aut-sei=Maeta
en-aut-mei=Tsuyoshi
kn-aut-name=前田剛
kn-aut-sei=前田
kn-aut-mei=剛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Sarcoidosis
kn-keyword=Sarcoidosis
en-keyword=alveolar-lymphocyte
kn-keyword=alveolar-lymphocyte
en-keyword=P. acnes
kn-keyword=P. acnes
en-keyword=Angiotensin-converting enzyme
kn-keyword=Angiotensin-converting enzyme
en-keyword=Gallium-scintigraphy
kn-keyword=Gallium-scintigraphy
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=657
end-page=663
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis Part 1. Specificity of alveolar lymphocyte response to Propionibacterium acnes in sarcoidosis
kn-title=サルコイドーシス肺リンパ球の Propionibacterium acnes に対する反応性に関する研究 第1編 P. acnes に対する反応の特異性に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The fact that alveolar lymphocytes in patients with active sarcoidosis are sensitized by Propionibacterium acnes (P. acnes) was previously reported by our group. Therefore, the responses of alveolar lymphocytes induced by Nocardia rubra and Streptococcus pyogenes were investigated and compared to those of P. acnes. The mean response rate of alveolar lymphocytes to P. acnes was significantly enhanced (1.89±1.45) in 12 untreated sarcoidosis patients compared with the response rates to Nocardia rubra (0.87±0.47) and Streptococcus pyogenes (0.64±0.30). Peripheral lymphocytes did not respond to any cell wall components of these organisms. Our findings indicate that alveolar lymphocytes in sarcoidosis are specifically sensitized by P. acnes, and suggest that P.acnes plays an important role in the induction of alveolar lymphocytes in sarcoidosis.
en-copyright=
kn-copyright=

en-aut-name=MaetaTsuyoshi
en-aut-sei=Maeta
en-aut-mei=Tsuyoshi
kn-aut-name=前田剛
kn-aut-sei=前田
kn-aut-mei=剛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=sarcoidosis
kn-keyword=sarcoidosis
en-keyword=alveolar lymphocyte
kn-keyword=alveolar lymphocyte
en-keyword=blastogenesis
kn-keyword=blastogenesis
en-keyword=P. acnes
kn-keyword=P. acnes
END