start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1311
end-page=1321
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on chemotherapy for small cell lung cancer Part 2. Patterns of relapse in patients with small cell lung cancer receiving chemotherapy with or without Radiotherapy
kn-title=肺小細胞癌の化学療法に関する研究　第2編　肺小細胞癌完全寛解例における再発様式の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Between 1976 and 1987, a total of 180 patients with small cell lung cancer who were entered into three protocol studies of an intensive chemotherapy with or without radiotherapy was fully evaluated for tumor response and survival. Of them, 74 patients achieved a complete response (CR) : 47 out of 91 patients with limited disease (LD) and 27 out of 89 patients with extensive disease (ED). The author analysed the pattern of relapse among the 74 patients in an attempt to clarify the role of chest irradiation and/or prophylactic cranial irradiation. Of 47 patients with LD achieving a CR, 20 patients (43%) developed initial relapse in the chest and seven (15%) developed it in the brain. Of the 27 patients with extensive disease, the chest was also the most frequent site of initial relapse (44%) followed by the brain (19%). In patients with LD receiving chemotherapy plus chest irradiation, the rate of initial relapse in the chest and the cumulative actuarial probability for initial chest relapse 2 years later were 29% and 37%, respectively. These figures were siginificantly lower than the rate of 69% and the probability of 69% for patients receiving chemotherapy alone (p<0.05). The patient survival was improved by the addition of chest irradiation substantially, but not significantly. However, long-term disease-free survivors predominated in the group of patients receiving chemotherapy plus chest irradiation. Prophylactic cranial irradiation exerted no significant advantage for prolonging survival. However, it showed a trend for reducing the brain relapse in complete responders. These findings indicate that chest irradiation concomitant with intensive chemotherapy may be effective for prolonging suvival in patients with LD through preventing relapse from the chest.
en-copyright=
kn-copyright=

en-aut-name=YamashitaHidetoshi
en-aut-sei=Yamashita
en-aut-mei=Hidetoshi
kn-aut-name=山下英敏
kn-aut-sei=山下
kn-aut-mei=英敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Pattern of relapse
kn-keyword=Pattern of relapse
en-keyword=Small cell lung cancer
kn-keyword=Small cell lung cancer
en-keyword=chest irradiation
kn-keyword=chest irradiation
en-keyword=prophylactic cranial irradiation
kn-keyword=prophylactic cranial irradiation
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1301
end-page=1310
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on chemotherapy for small cell lung cancer Part 1. Reversal of adriamycin resistance in human small cell lung cancer cells in culture
kn-title=肺小細胞癌の化学療法に関する研究　第1編　Adriamycin 耐性ヒト肺小細胞癌細胞株の耐性解除に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using adriamycin-resistant human small cell lung cancer cells (SBC-3/ADM), which were 30-fold more resistant to adriamycin than the parent cells (SBC-3), the ability of membrane-modifying agents to overcome the drug resistance was analyzed by a soft agar clonogenic assay. SBC-3/ADM was not circumvented by hyperthermia of 42℃ or amphotericin B at a concentration of 50μ M. Verapamil did not enhance the adriamycin cytoxicity in the SBC-3 cells at a concentration of 10μ M, but a 3.2-fold increase in the drug effect occurred in the SBC-3/ADM cells in terms of LD(70). The efflux of intracellular [H(3)] daunomycin from SBC-3/ADM cells was inhibited by verapamil, while the inhibition did not occur in the parent cells. Furthermore, quinidine (50μ M), cepharanthin (10μ M) and chloroquine (50μ M) enhanced the adriamycin cytotoxicity in the SBC-3/ADM cells. These findings suggest that some membrane-modifying agents could partially overcome the acquired resistance to adriamycin in human small cell lung cancer.
en-copyright=
kn-copyright=

en-aut-name=YamashitaHidetoshi
en-aut-sei=Yamashita
en-aut-mei=Hidetoshi
kn-aut-name=山下英敏
kn-aut-sei=山下
kn-aut-mei=英敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human small cell lung cancer cells in culture
kn-keyword=human small cell lung cancer cells in culture
en-keyword=ADM resistant subline
kn-keyword=ADM resistant subline
en-keyword=reversal of resistance
kn-keyword=reversal of resistance
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1287
end-page=1299
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Nutritional effects of branched chain amino acids and lipids in surgical stress after partial hepatectomy in the rat
kn-title=高濃度分岐鎖アミノ酸を窒素源とする成分栄養剤の侵襲下における効果―肝切除ラットを用いて―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The nutritional influence of branched chain amino acids (BCAA) and lipids in surgical stress was examined after 70% hepatectomy in rats. Two types of elemental diet (ED) were given through the gastrostomy tude for 7 days. Group A : ED containing 33% BCAA and 30% lipid (medium chain triglycerides 8.5g＋soy bean oil 1.5g/300 kcal). Group B : ED containing 17% BCAA and 1.5% lipid (soy bean oil 0.49g/300 kcal). Up to the 7th postoperative day, the excretion of nitrogen into urine decreased in group A, but no change occurred in group B. Up to the 5th postoperative day, molar ratio of 3MH to creatinine in urine in group A decreased more rapidly than in group B. Plasma concentration of albumin in group A was higher than in group B on the 7th postoperative day. Fischer ratio was significantly higher in group A than in group B on the 7th postoperative day. Both plasma and muscle levels of Tyr, Met and Gln were higher in group B than in group A, Glu and Ala were lower in group B than in group A. Essential fatty acid deficiency occurred more severely in group B than in group A. While fatty livers were microscopically observed in some livers in group B, there were few fatty deposits in group A.
en-copyright=
kn-copyright=

en-aut-name=MizutaMinoru
en-aut-sei=Mizuta
en-aut-mei=Minoru
kn-aut-name=水田稔
kn-aut-sei=水田
kn-aut-mei=稔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=分岐鎖アミノ酸
kn-keyword=分岐鎖アミノ酸
en-keyword=脂肪乳剤
kn-keyword=脂肪乳剤
en-keyword=経腸栄養
kn-keyword=経腸栄養
en-keyword=脂肪肝
kn-keyword=脂肪肝
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1267
end-page=1286
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=High-power scanning electron microscopy of senile plaques, neurofibrillary tangles, and Pick bodies
kn-title=老人斑，Alzheimer 神経原線維変化，Pick 嗜銀球の超高倍率走査電顕的観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Senile plaques, neurofibrillary tangles, and Pick bodies were examined by modified scanning electron microscopy from a low-power to an ultra high-power range. The amyloid core of the typical plaques was found to be composed of radially arranged rod-shaped components, which were made up of dense aggregation of meandering moniliform amyloid filaments about 15 nm in diameter. Bands with a mesh-like structure were observed outside the crown around the core. The compact plaques were nearly identical to the core alone of the typical plaques. The primitive plaques as a whole were analogous to the mesh-like structure around the typical plaques, and they both contained aggregates of filaments closely resembling amyloid fibers. In neurofibrillary tangles, the flamed shape stretched straight to the peripheries, the globosed shaped formed vortices, and only bundles of parallel filaments were observed. PHFs that constituted these structures were 25-30 nm in diameter, and many appeared constricted to a diameter of about 15 nm by rotating 180° to the left at a cycle of 70-80 nm. In Pick bodies, filaments were interwoven and formed a mesh-like structure, numerous granules were attached the filaments. Some filaments were large, being 20-30 nm in diameter, others were thin, being about 15nm in diameter.
en-copyright=
kn-copyright=

en-aut-name=KuyamaKeisuke
en-aut-sei=Kuyama
en-aut-mei=Keisuke
kn-aut-name=久山圭介
kn-aut-sei=久山
kn-aut-mei=圭介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=Senile Plaque
kn-keyword=Senile Plaque
en-keyword=Alzheimer's neurofibrillary changes
kn-keyword=Alzheimer's neurofibrillary changes
en-keyword=Pick body
kn-keyword=Pick body
en-keyword=scanning electron microscopy
kn-keyword=scanning electron microscopy
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1253
end-page=1265
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effect of new elemental diet including enriched branched chain amino acids and MCT on massive resection of small bowel in rat
kn-title=脂肪（MCT）および高濃度分枝鎖アミノ酸を含有した成分栄養剤の侵襲下における効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of a new enteral diet (ED-9) that was mainly composed of BCAA enriched amino acids, MCT and maltose were examined. Rats were subjected to small bowel resection and were administered two different formula for 7 days. The animals were divided into the following four groups : Sham operation and ED-9 (Group A), sham operation and control diet (Elental) (Group B), small bowel resection and ED-9 (Group C), and small bowel resection and control diet (Group D). Body weight loss after operation was similar in both ED-9 and control diet groups. Nitrogen balance and uninary 3 Methy1-histidine excretion demonstrated that ED-9 tended to improve protein preservation. Rats given ED-9 showed elevated ketone bodies and plasma BCAA level but these levels were not extraordinarily high. In conclusion, the formula of enteral nutrition (ED-9) was as effective as Elental on postoperative nutrition in rats.
en-copyright=
kn-copyright=

en-aut-name=SuehiroKazunaga
en-aut-sei=Suehiro
en-aut-mei=Kazunaga
kn-aut-name=末廣和長
kn-aut-sei=末廣
kn-aut-mei=和長
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=成分栄養剤
kn-keyword=成分栄養剤
en-keyword=手術侵襲
kn-keyword=手術侵襲
en-keyword=MCT
kn-keyword=MCT
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1237
end-page=1251
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Brain stem lesions in Pick's disease : Light microscopic and morphometric studies
kn-title=Pick 病の脳幹病変―光顕所見ならびに計測的研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Light microscopic and morphometric studies were performed on brain stem lesions in 8 patients with Pick's disease. Neuronal loss and gliosis were observed in the red nucleus, substantia nigra, and the nucleus of locus ceruleus, but its degree was slight or moderate. Argyrophilic inclusions were observed in 4 patients, strongly argyrophilic in 2 of them and slightly argyrophilic in the other 2. Demyelination was noted in the fronto-pontine tract of the cerebral peduncle in 5 patients, and degeneration was observed in the longitudinal pontine fascicules. Measurements of the specimens showed a smaller brain stem, midbrain, and the pons in the patients with Pick's disease than in the control group ; the difference was the most marked in the midbrain followed by the pons. The medulla oblongata did not differ between the two groups. Both tegmentum and the base were smaller in the midbrain, and the base was smaller in the pons. However, the area/brain weight did not differ between the two groups. The substantia nigra showed a reduction in number of cells and area in the patient group than in the control group. Cells containing melanin were significantly decreased on all the medial, central, and the lateral sides, but the number of cells not containing melanin was similar between the two groups. The decrease in area was more marked. Therefore, the cell density was higher in the patient group. Thus, in the patients with Pick's disease, degeneration was observed at various sites of the brain stem. Some of the changes were secondary to damage to the cerebrum and basal ganglia, but others were primary lesions.
en-copyright=
kn-copyright=

en-aut-name=OdaTeruyuki
en-aut-sei=Oda
en-aut-mei=Teruyuki
kn-aut-name=小田輝幸
kn-aut-sei=小田
kn-aut-mei=輝幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=Pick病
kn-keyword=Pick病
en-keyword=脳幹病変
kn-keyword=脳幹病変
en-keyword=計測的研究
kn-keyword=計測的研究
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1225
end-page=1235
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects and optimal dose of recombinant human superoxide dismutase during cardiopulmonary bypass
kn-title=体外循環下における心筋の虚血再灌流に関する検討-h-SOD の効果と至適投与量-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The efficacy of recombinant human superoxide dismutase (h-SOD) was examined and its optimal dose when given before reperfusion in an experimental canine cardiopulmonary bypass (CPB) model was determined. Mongrel dogs were placed on total CPB for 130 minutes without aortic cross clamping (Group Ⅰ). Others were placed on CPB for 120 minutes aortic cross clamping with intermittent administration of cardioplegic solution and core cooling (Group Ⅱ). Before reperfusion, saline, and 1 mg, 3 mg, 10 mg and 20 mg h-SOD per kilogram were administered via the aortic root as a bolus injection (Group Ⅲ,Ⅳ,Ⅴ,Ⅵ,Ⅶ). Reperfusion after hypothermic global ischemia with aortic cross clamping deteriorated cardiac function (cardiac index, left ventricular maximum dp/dt), increased myocardial water content and increased cardiac enzyme release (creatinine kinase MB isozyme, α-hydroxybutyric dehydrogenase). Administration of 3 mg/㎏ h-SOD significantly ameliorated this reperfusion injury, protected myocardial function early after CPB and gave a desirable peak serum h-SOD concentration.
en-copyright=
kn-copyright=

en-aut-name=YamadaYukio
en-aut-sei=Yamada
en-aut-mei=Yukio
kn-aut-name=山田幸夫
kn-aut-sei=山田
kn-aut-mei=幸夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=体外循環
kn-keyword=体外循環
en-keyword=心筋保護
kn-keyword=心筋保護
en-keyword=再灌流障害
kn-keyword=再灌流障害
en-keyword=free radicals
kn-keyword=free radicals
en-keyword=superoxide dismutase
kn-keyword=superoxide dismutase
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1215
end-page=1224
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immobilization of denitrifying bacteria using photo-crosslinkable resin prepolymer and some of its properties
kn-title=光硬化性樹脂プレポリマーを用いる脱窒菌の固定化に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The denitrifiers isolated from the activated sludge of night soil treatment plant were immobilized using a photo-crosslinkable resin prepolymer. Denitrifying activity was strongly inhibited during the first period but the activity was increased in the medium containing nitrate and recovered after 1 day. Acetate was an effective hydrogen source and soap was also effective. Methanol could not serve as a hydrogen source. The optimum pH for denitrification by the immobilized bacteria was 7.0 for nitrite and 7.5 for nitrate, and the optimum temperature ranged 30℃ to 40℃. The lowest CH3COONa/NOx-N ratio nessary for getting the highest activity was 4 for nitrite (BOD/NO2-N＝2) and 5 for nitrate (BOD/NO3-N＝2.5). Photo-crosslinkable resin prepolymer gels exhibited stable denitrification activity to the secondarily treated sewage contained 70mg/l of soap.
en-copyright=
kn-copyright=

en-aut-name=ItadaniTsutomu
en-aut-sei=Itadani
en-aut-mei=Tsutomu
kn-aut-name=板谷勉
kn-aut-sei=板谷
kn-aut-mei=勉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
en-keyword=脱窒菌
kn-keyword=脱窒菌
en-keyword=固定化
kn-keyword=固定化
en-keyword=脱窒素
kn-keyword=脱窒素
en-keyword=排水処理
kn-keyword=排水処理
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1207
end-page=1214
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study on nitrification and the BOD removal of the sewage using immobilized activated sludge
kn-title=固定化活性汚泥を用いる排水処理実験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Activated sludge obtained from the night soil treatment plant was immobilized using acrylamide and nitrification and the BOD removal of the sewage were studied by using the immobilized activated sludge which was packed in a single treatment tank. The findings indicated that the ratio of nitrification in the immobilized gel tank was larger than that in the free activated sludge tank in every operation period, and the rate of BOD removal in the immobilized gel tank was roughly equal to that in the free activated sludge tank in this condition. The findings indicated that the application of immobilized activated sludge to the sewage treatment enabled the sewage treatment process to be more efficiency and compact.
en-copyright=
kn-copyright=

en-aut-name=ItadaniTsutomu
en-aut-sei=Itadani
en-aut-mei=Tsutomu
kn-aut-name=板谷勉
kn-aut-sei=板谷
kn-aut-mei=勉
aut-affil-num=1
ORCID=

en-aut-name=HiraiYosikazu
en-aut-sei=Hirai
en-aut-mei=Yosikazu
kn-aut-name=平井義一
kn-aut-sei=平井
kn-aut-mei=義一
aut-affil-num=2
ORCID=

en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=3
ORCID=

en-aut-name=NagamachiEiko
en-aut-sei=Nagamachi
en-aut-mei=Eiko
kn-aut-name=長町栄子
kn-aut-sei=長町
kn-aut-mei=栄子
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=4
en-affil=
kn-affil=順正短期大学保健科
en-keyword=固定化活性汚泥
kn-keyword=固定化活性汚泥
en-keyword=固定化
kn-keyword=固定化
en-keyword=硝化
kn-keyword=硝化
en-keyword=排水処理
kn-keyword=排水処理
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1193
end-page=1205
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical significance of body surface mapping for a diagnosis of left ventricular hypertrophy : Special reference to a differential diagnosis between hypertrophic cardiomyopathy and hypertension-induced left ventricular hypertrophy
kn-title=体表面電位図による心肥大の病態の推定と鑑別診断―特に肥大型心筋症と高血圧性肥大心の鑑別診断を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The present study was conducted to clarify electrophysiological characteristics of left ventricular hypertrophy (LVH) and to discriminate hypertrophic cardiomyopathy (HCM) from hypertension-induced LVH with body surface mapping. QRS area map, QRST area map and VAT map of body surface mapping were recorded on 37 patients with HCM, 37 with essential hypertension (EH) and 21 with aortic regurgitation (AR) using Yamada's method. HCM, EH and AR showed similar patterns of QRS area map. However, the maximum points of QRST area map located at the midsternal line (E5) in HCM, and positioned on the left midclavicular line (G4) in EH and AR. The minimum point of the QRST area map appeared at the left midclavicular line (G3) where the maximum point of the QRS area map was located. These findings indicate that the QRST area map would enable to differentiate HCM from EH and AR. With the VAT map, AR showed closed isochrone lines on the left precordium, which indicated delayed ventricular activation in this region. Statistical analysis revealed that the value of the maximum point of the QRST area (Max. QRST) and the sum of values of the positive QRST area (∑ positive QRST area) differentiates HCM from EH. When the Max. QRST was 0.6μVs or less and the ∑ positive QRST area was 14μVs or less, the diagnostic accuracy of HCM could be made more than 70%. These findings suggested that the diagnostic criteria derived from the QRST area map is of use to distinguish HCM from hypertension-induced LVH.
en-copyright=
kn-copyright=

en-aut-name=MatsubaraKatashi
en-aut-sei=Matsubara
en-aut-mei=Katashi
kn-aut-name=松原堅
kn-aut-sei=松原
kn-aut-mei=堅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部循環器内科学教室
en-keyword=Hypertrophic cardiomyopaty
kn-keyword=Hypertrophic cardiomyopaty
en-keyword=Hypertensive left ventricular hypertrophy
kn-keyword=Hypertensive left ventricular hypertrophy
en-keyword=Body surface mapping
kn-keyword=Body surface mapping
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1183
end-page=1191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Radiographic studies on lumbar spines of steel plant workers in relation to the pathogenesis of low back pain
kn-title=製鉄所従業員における腰椎のX線学的研究―腰痛の発生とX線所見との関連について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, incidence of low back pain (LBP) has been increasing. To clarify the relation between instability of the lumbar spine and LBP in heavy industry workers, radiographic findings were compared with a questionnaire on 2863 workers in a steel plant, as a preliminary study in 1986. In 214 males, 4-direction X-ray examinations of the lumbar vertebrae were obtained and the results were analyzed along with a questionnaire survey. The examined subjects were classified into three groups according to their complaints into : A ; LBP free, B ; LBP moderate, and C ; LBP severe. Degeneration chages of the facet joint, lumbar disc narrowing, angles between vertebrae, and lumbar lordosis were investigated on the X-ray film. In general, the higher the intensity of LBP, the more intervertebral angles at all levels of the lumbar spine and the more severe the degeneration. There was a statistically significant difference between the A and C group in the intervertebral angles at lower levels. Incidence of the lumbar disc narrowing differed between the two groups. The instabilitiy of lumbar spine was found in the C group. Low back pain in the heavy industry workers can be caused by anterior motion factors such as lumbar disc narrowing rather than posterior motion factors such as degeneration of the facet joint.
en-copyright=
kn-copyright=

en-aut-name=IwagawaMotoyuki
en-aut-sei=Iwagawa
en-aut-mei=Motoyuki
kn-aut-name=岩河基行
kn-aut-sei=岩河
kn-aut-mei=基行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=Low back pain
kn-keyword=Low back pain
en-keyword=Radiographic study
kn-keyword=Radiographic study
en-keyword=Instability
kn-keyword=Instability
en-keyword=Facet joint
kn-keyword=Facet joint
en-keyword=Lumbar disc narrowing
kn-keyword=Lumbar disc narrowing
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1177
end-page=1181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of renal function by the ultrasonic Doppler technique
kn-title=超音波パルスドップラ法による腎機能評価に関する検討―Dynamic CT 及び Ccr との比較を中心として―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To evaluate the clinical application of the ultrasonic Doppler technique, renal arterial blood flow was measured in 7 normal subjects and 3 patients with renal dysfunction. For the purpose of correction of blood flow measured by the Doppler technique, some basic studies were performed. The ratio of peak diastolic to peak systolic velocity (D/S ratio) correlated well with both the creatinine clearance and the CA ratio calculated from the results of Dynamic CT. There was no correlation between the corrected velocity of the arterial blood flow and the creatinine clearance. The D/S ratio obtained by the ultrasonic Doppler technique is thought to be a useful parameter in the evaluation of the renal function. However, the Dynamic CT is thought to be superior in objectiveness to the ultrasonic Doppler technique.
en-copyright=
kn-copyright=

en-aut-name=SatohShuhei
en-aut-sei=Satoh
en-aut-mei=Shuhei
kn-aut-name=佐藤修平
kn-aut-sei=佐藤
kn-aut-mei=修平
aut-affil-num=1
ORCID=

en-aut-name=KitagawaTakahiro
en-aut-sei=Kitagawa
en-aut-mei=Takahiro
kn-aut-name=北川尚広
kn-aut-sei=北川
kn-aut-mei=尚広
aut-affil-num=2
ORCID=

en-aut-name=SatohNobuo
en-aut-sei=Satoh
en-aut-mei=Nobuo
kn-aut-name=佐藤伸夫
kn-aut-sei=佐藤
kn-aut-mei=伸夫
aut-affil-num=3
ORCID=

en-aut-name=TogamiIzumi
en-aut-sei=Togami
en-aut-mei=Izumi
kn-aut-name=戸上泉
kn-aut-sei=戸上
kn-aut-mei=泉
aut-affil-num=4
ORCID=

en-aut-name=KimotoShin
en-aut-sei=Kimoto
en-aut-mei=Shin
kn-aut-name=木本真
kn-aut-sei=木本
kn-aut-mei=真
aut-affil-num=5
ORCID=

en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
kn-aut-mei=祥夫
aut-affil-num=6
ORCID=

en-aut-name=UnoSatoru
en-aut-sei=Uno
en-aut-mei=Satoru
kn-aut-name=宇埜智
kn-aut-sei=宇埜
kn-aut-mei=智
aut-affil-num=7
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=公文裕巳
kn-aut-sei=公文
kn-aut-mei=裕巳
aut-affil-num=8
ORCID=

en-aut-name=OhmoriHiroyuki
en-aut-sei=Ohmori
en-aut-mei=Hiroyuki
kn-aut-name=大森弘之
kn-aut-sei=大森
kn-aut-mei=弘之
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室
en-keyword=超音波パルスドップラ法
kn-keyword=超音波パルスドップラ法
en-keyword=D/S 比
kn-keyword=D/S 比
en-keyword=DCT
kn-keyword=DCT
en-keyword=CA ratio
kn-keyword=CA ratio
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1171
end-page=1176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Tumor lysis syndrome after the effective chemotherapy in a patient with recurrence of colon cancer
kn-title=癌化学療法が奏効し Tumor Lysis Syndrome を呈した結腸癌再発症例の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A case of recurrence of colon cancer with marked tumor reduction after effective chemotherapy is reported. The patient was a 27-years-old female who was admitted to the 1st department of surgery because of a giant abdominal tumor. She had undergone surgery for cecal cancer 16 months before admission. Abdominal and pelvic CT-SCAN revealed a giant tumor (21×18cm) invading the rectum and uterus. Surgical cannulation was performed into bilateral internal iliac arteries, and anti-cancer drugs (5-FU : 5000mg, ADR : 40mg, CDDP : 200mg) were administered intraarterially. The occurrence of hyperkalemia and striking rises in LDH, CEA, CA19-9 after the chemotherapy strongly suggested the tumor lysis syndrome, which to our knowledge, has not been reported as a complication of the treatment of colon carcinoma.
en-copyright=
kn-copyright=

en-aut-name=InoguchiKazuhito
en-aut-sei=Inoguchi
en-aut-mei=Kazuhito
kn-aut-name=井口利仁
kn-aut-sei=井口
kn-aut-mei=利仁
aut-affil-num=1
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=2
ORCID=

en-aut-name=HamanakaSohei
en-aut-sei=Hamanaka
en-aut-mei=Sohei
kn-aut-name=浜中荘平
kn-aut-sei=浜中
kn-aut-mei=荘平
aut-affil-num=3
ORCID=

en-aut-name=MoreiraLuis Fernando
en-aut-sei=Moreira
en-aut-mei=Luis Fernando
kn-aut-name=モレイラルイス・フエルナンド
kn-aut-sei=モレイラ
kn-aut-mei=ルイス・フエルナンド
aut-affil-num=4
ORCID=

en-aut-name=NanbaHiroshi
en-aut-sei=Nanba
en-aut-mei=Hiroshi
kn-aut-name=難波浩
kn-aut-sei=難波
kn-aut-mei=浩
aut-affil-num=5
ORCID=

en-aut-name=OkabayashiTakahiro
en-aut-sei=Okabayashi
en-aut-mei=Takahiro
kn-aut-name=岡林孝弘
kn-aut-sei=岡林
kn-aut-mei=孝弘
aut-affil-num=6
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=7
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=Tumor Lysis Syndrome
kn-keyword=Tumor Lysis Syndrome
en-keyword=結腸癌再発
kn-keyword=結腸癌再発
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1159
end-page=1169
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on hematopoietic progenitor cells in acute leukemia and related disease Part 2. Studies on hematopoietic stem cells in myelodysplastic syndrome
kn-title=急性白血病並びに類縁疾患における造血幹細胞動態に関する研究　第2編　Myelodysplastic Syndrome における造血幹細胞の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Peripheral stem cell assay was done to examine the hematopoietic status of myelodysplastic syndrome (MDS). Four patients with refractory anemia with excess of blasts (RAEB) and 6 with RAEB in transformation (RAEBt) were studied. Efficiencies of colony and cluster formation were not different between RAEB and RAEBt, but colony/cluster ratios in RAEBt tended to be lower than in either RAEB or healthy individuals. Patients were classified into 2 groups, Group A and B, according to the colony/cluster formations. In Group A efficiencies of colony/cluster formation were higher than those in healthy individuals, and in Group B they were lower. Bone marrow nucleated cell counts and peripheral white blood cell counts were not different between Groups A and B. Leukemic conversions were recognized in 4 out of 5 cases in Group B and 2 out of 5 cases in Group A, respectively. On the other hand monocytosis developed in 3 out of 5 cases in Group A, but none in Group B. Some of the colonies and clusters were composed of myeloperoxidase (MPO)-negative neutrophils, although a significant increase of MPO-negative neutrophils was not present in original marrow or peripheral blood. Colonies and clusters in patients with leukemic conversions in Group A were composed of cells with blastlike morphology. These findings indicate that the quantitative and qualitative analyses of colonies and clusters are useful not only for the prediction of leukemic conversion but also for analyses of pathophysiological aspects such as ineffective hemopoiesis and monocytosis in MDS.
en-copyright=
kn-copyright=

en-aut-name=NishimuraMasataka
en-aut-sei=Nishimura
en-aut-mei=Masataka
kn-aut-name=西村正隆
kn-aut-sei=西村
kn-aut-mei=正隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=骨髄異形成症候群
kn-keyword=骨髄異形成症候群
en-keyword=造血幹細胞
kn-keyword=造血幹細胞
en-keyword=コロニー形成能
kn-keyword=コロニー形成能
en-keyword=コロニー構成細胞
kn-keyword=コロニー構成細胞
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1147
end-page=1158
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on hematopoietic progenitor cells in acute leukemia and related disease Part 1. Studies on leukemic blast progenitors in acute nonlymphocytic leukemia
kn-title=急性白血病並びに類縁疾患における造血幹細胞動態に関する研究　第1編　急性白血病における Leukemic Blast Progenitors 由来コロニー形成能並びに形成パターンの検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Colonies derived from leukemic blast progenitors were sequentially observed on Days 3, 5, 7, 10 and 14 to evaluate the relation between the kinetics of leukemic blast progenitors and types of acute nonlymphocytic leukemia (ANLL), chemotherapeutic response and leukemic cell kill kinetics. The cells were obtained from 34 patients with typical ANLL and 6 with hypoplastic ANLL. The leukemic colony assay was performed. Colony-counts (CCs) were somewhat higher in M2 and M5 patients than in patients with other FAB subtypes. CCs were significantly lower in patients with hypoplastic ANLL than in those with typical ANLL (22±25 vs 148±205, P<0.02). Time required for 50% reduction in CCs from maximum CCs (Days for 50% reduction) was longer in relapsed than in previously untreated ANLL patients (6.5±2.3 days vs 3.3±1.5 days, P<0.01). In patients with remission both of CCs on Day 7 and maximum CCs were higher than in patients without remission (198±187 vs 69±77, P<0.05 for CCs on Day 7/233±188 vs 107±66, P<0.05 for maximum CCs). Time for 50% reduction was significantly shorter in patients with remission (2.4±0.7 days vs 4.2±1.2 days, P<0.02). The correlation between 「days for 50% reduction」and「acceleration of decrease at PhaseⅡ of leukemic cell kill curve」was noted. These findings indicate that the sequential observation of colonies derived from leukemic progenitors is useful not only for the prediction of the chemotherapeutic response but also for analysis of pathophysiological aspects of ANLL.
en-copyright=
kn-copyright=

en-aut-name=NishimuraMasataka
en-aut-sei=Nishimura
en-aut-mei=Masataka
kn-aut-name=西村正隆
kn-aut-sei=西村
kn-aut-mei=正隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=急性白血病
kn-keyword=急性白血病
en-keyword=白血病由来幹細胞
kn-keyword=白血病由来幹細胞
en-keyword=造血幹細胞
kn-keyword=造血幹細胞
END