start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=5
article-no=
start-page=231
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120529
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl<sub>4</sub>)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m<sup>3</sup> for 6hrs before or after CCl<sub>4</sub> administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl<sub>4</sub>. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl<sub>4</sub>. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl<sub>4</sub>-induced oxidative damage in the brain, heart, lung, liver, and kidney.
en-copyright=
kn-copyright=

en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TeraokaJunichi
en-aut-sei=Teraoka
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=4
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency

affil-num=5
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency

affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=carbon tetrachloride
kn-keyword=carbon tetrachloride
en-keyword=oxidative damage
kn-keyword=oxidative damage
en-keyword=pre or post radon inhalation
kn-keyword=pre or post radon inhalation
en-keyword=antioxidative function
kn-keyword=antioxidative function
END