American Chemical Society Acta Medica Okayama 15237060 21 17 2019 Rhenium-Catalyzed Cyclization via 1,2-Iodine and 1,5-Hydrogen Migration for the Synthesis of 2-Iodo-1H-indenes 6756 6760 EN Masahito Murai Graduate School of Natural Science and Technology, Okayama University Kazuhiko Takai Graduate School of Natural Science and Technology, Okayama University A rhenium complex catalyzed the formation of 2-iodo-1H-indene derivatives through iodine and hydrogen migration of 3-iodopropargyl ethers. The reaction proceeded via generation of 1-iodoalkenylrhenium carbene species by sequential 1,2-iodine and 1,5-hydrogen shifts with readily available precursors under neutral conditions. The reaction mechanism and the reactivity of the generated alkenylcarbene species were also investigated. No potential conflict of interest relevant to this article was reported.