| ID | 68269 |
| フルテキストURL | |
| 著者 |
Kakimoto, Mai
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Fujii, Moe
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Sato, Ikumi
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Honma, Koki
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Nakayama, Hinako
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Kirihara, Sora
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Fukuoka, Taketo
Okayama University, Faculty of Health Sciences, Department of Medical Technology
Ran, Shang
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Hirohata, Satoshi
Okayama University, Academic Field of Health Science
ORCID
Kaken ID
publons
researchmap
Kitamori, Kazuya
Kinjo Gakuin University, College of Human Life and Environment
Yamamoto, Shusei
Okayama University, Graduate School of Health Sciences, Department of Medical Technology
Watanabe, Shogo
Okayama University, Academic Field of Health Science
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| 抄録 | Background: Xanthine oxidase (XO) generates reactive oxygen species during uric acid production. Therefore, XO inhibitors, which suppress oxidative stress, may effectively treat non-alcoholic steatohepatitis (NASH) and atherosclerosis via uric acid reduction. In this study, we examined the antioxidant effect of the XO inhibitor febuxostat on NASH and atherosclerosis in stroke-prone spontaneously hypertensive 5 (SHRSP5/Dmcr) rats.
Methods: SHRSP5/Dmcr rats were divided into three groups: SHRSP5/Dmcr + high-fat and high-cholesterol (HFC) diet [control group, n = 5], SHRSP5/Dmcr + HFC diet + 10% fructose (40 ml/day) [fructose group, n = 5], and SHRSP5/Dmcr + HFC diet + 10% fructose (40 ml/day) + febuxostat (1.0 mg/kg/day) [febuxostat group, n = 5]. Glucose and insulin resistance, blood biochemistry, histopathological staining, endothelial function, and oxidative stress markers were evaluated. Results: Febuxostat reduced the plasma uric acid levels. Oxidative stress-related genes were downregulated, whereas antioxidant factor-related genes were upregulated in the febuxostat group compared with those in the fructose group. Febuxostat also ameliorated inflammation, fibrosis, and lipid accumulation in the liver. Mesenteric lipid deposition decreased in the arteries, and aortic endothelial function improved in the febuxostat group. Conclusions: Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats. |
| キーワード | Anti-inflammatory
Atherosclerosis
Febuxostat
Non-alcoholic steatohepatitis (NASH)
Oxidative stress
Uric acid
|
| 発行日 | 2023-06-27
|
| 出版物タイトル |
Journal of Applied Biomedicine
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| 巻 | 21巻
|
| 号 | 2号
|
| 出版者 | University of South Bohemia in Ceske Budejovice
|
| 開始ページ | 80
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| 終了ページ | 90
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| ISSN | 1214-021X
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| 資料タイプ |
学術雑誌論文
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| 言語 |
英語
|
| OAI-PMH Set |
岡山大学
|
| 著作権者 | © 2023 The Authors.
|
| 論文のバージョン | publisher
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.32725/jab.2023.009
|
| ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/
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| Citation | Kakimoto, M.; Fujii, M.; Sato, I.; Honma, K.; Nakayama, H.; Kirihara, S.; Fukuoka, T.; Ran, S.; Hirohata, S.; Kitamori, K.; Yamamoto, S.; Watanabe, S., Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats. J Appl Biomed 2023, 21 (2), 80-90.
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| 助成機関名 |
Japan Society for the Promotion of Science
Gout Research Foundation of Japan
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| 助成番号 | 15K19178
18K10993
|
