The Japan Institute of Heterocyclic Chemistry Acta Medica Okayama 1881-0942 74 1 2007 An Efficient, One-Pot Synthesis of Fosfomycin Dialkyl Esters from (R)-2-Tosyloxypropanal 983 989 EN Tadashi Hanaya Yuichi Nakamura Hiroshi Yamamoto (R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield. No potential conflict of interest relevant to this article was reported.