Wiley Acta Medica Okayama 2050-0904 11 6 2023 ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review e7595 EN Toshihiko Matsuo Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Sumie Hiramatsu]Asano Department of Rheumatology, Kawasaki Medical School Hiroshi Sawachika Department of Rheumatology, Kawasaki Medical School Hirotake Nishimura Department of Pathology, Kawasaki Medical School Key Clinical Message: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, specifically with myeloperoxidase (MPO)-ANCA, would have a risk for developing corneal melt and perforation abruptly in a short period. It is desirable to have a team of collaboration of rheumatologists and other specialties.<br> Abstract: An 80-year old man who had been diagnosed 5.5 years previously as ANCA-associated vasculitis by temporal artery biopsy developed corneal melt and perforation with scleritis in both eyes. He underwent successful cataract surgery and retained ambulatory vision with the aid of intravenous rituximab. Two additional patients with similar manifestations were found in the literature. No potential conflict of interest relevant to this article was reported.