Oxford University Press (OUP) Acta Medica Okayama 0366-7022 54 6 2025 Vesicle-combined PtBi/C catalyst for base-free conversion of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid upaf104 EN Toshinori Shimanouchi Graduate School of Environmental, Life, Natural Science and Technology, Okayama University Koji Deguchi Graduate School of Environmental, Life, Natural Science and Technology, Okayama University Kazuma Yasuhara Division of Materials Science, Nara Institute of Science and Technology (NAIST) Yukitaka Kimura Graduate School of Environmental, Life, Natural Science and Technology, Okayama University A conversion of 5-hydroxymethylfurfural to 2,5-frandicarboxylic acid (FDCA) was catalyzed by using a catalyst of PtBi-activated carbon (PtBi/C) combined with vesicles made of phospholipid. No alteration of the electron state of the PtBi/C by vesicles was observed. However, FDCA was obtained under mild-temperature and base-free conditions. The yield of FDCA depended on the hydration nature of vesicles. It was therefore suggested that vesicles gave bound water as a novel driving force for the reaction. The present finding would explore an application of vesicles to new catalytic reactions that are different from conventional biochemical reactions. No potential conflict of interest relevant to this article was reported.