培養ＰＣ １２細胞を用いた神経細胞死誘導法の検討

Rat pheochromocytoma (PC12cells) were recently shown to be a useful model for studying the mechanism of cell death and its prevention by different agents. We show here that the diverse reagents of anticancer drugs, protein kinase C inhibitors, H2o2, and βーamyloid peptides also induce cell death in PC12 cells. Cell death was detected by released activity of lactate dehydrogenase (LDH) from intracellular to medium. These results prompted us to investigate whether cell death in PC12 cells might be induced by different pathways.