環境汚染物質(重金属など)の生体膜に対する作用 第4報 カドミウムによるミトコンドリアのK(+)遊出作用及びカドミウムのミトコンドリア膜への結合に対するルテニウムレッドの作用

The effects'of ruthenium red (RR) on the K(+) release induced by Cd(2+) and on the binding of Cd(2+) with mitochondrial membrane were examined and the following results were obtained. 1) The K(+) release of mitochondria induced by Cd(2+) was inhibited by the compounds which had the affinity to the Ca(2+)-binding site, in the order of RR, procaine. 2) Binding of Cd(2+) with mitochondrial membrane was inhibited by RR.