胃癌の水解および脱水素酵素の組織化学的研究 第2編 胃癌の臨床像と癌組織の酵素活性との関連性について

Histochemical analysis of enzyme activities of thirteen enzymes in operated stomachs of 100 patients were compared with their clinical findings. Materials and methods of histochemical analysis were the same as the previous report. Enzyme activities in the stomach cancer cells of the patients, who showed serum hypoproteinemia, decrease of blood hemoglobin content, and increase of erthrocyte sedimentation rate, were stronger than those in the patients who had normal level of the above tests. While the relationship between enzyme activities in the stromal elements and the values of clinical tests in those groups showed the reverse tendency. No parallel relationships were observed between the alkaline phosphatase activity in cancer cells and the serum alkaline phosphatase level. Also no correlation between alkaline phosphatase activity in tumor cells and the patients liver dysfunction or liver metastasis. Leucine aminopeptidase was positive in the cancer cells of 35 per cent cases. Generally, the stomach cancers removed from anacidity or hypoacidity patients had a stronger activity of this enzyme than that of normoacidity patients. In general, enzyme activities were decreased in both of the stomach cancer cells and stromal elements obtained from the preoperatively treated with antitumor agents, such as Mitomycin C, Chromomycin A(3), and Cyclohosphamide than those from non-treated oncs. The patients who showed stronger activities in stromal elements showed distinctly a better prognosis than those weaker activities. While the patients who had stronger activities in cancer cells had worse prognosis than those weaker activities.