コレラ菌体抽出物質の免疫学的諸反応の研究 1） コレラ菌体抽出物質処置赤血球の溶血反応 2） コレラ菌体抽出物質による沈降反応 3） コレラ菌体抽出物質によるインフルエンザ・ウイルスの赤血球凝集に対する阻止現象

Under various conditions and by various methods, various fractions were extracted from cells of Vibrio comma. The hemolysis and the precipitation were tried with these fractions, and, at the same time, their inhibitory action on the hemagglutination by influenza virus was also studied. The results are summarized as follows: 1) Used as the antigen of hemagglutination, these fractions showed a type specificity, but the appearance and titer of the reaction varied to some extent with the strains of used Vibrio comma. Of all the fractions tested, only the crude nucleoprotein and Boivin's substance showed a significant antigenicity. 2) Used as the precipitinogen, the crude nucleoprotein and polysaccharide showed the most significant result, and Boivin's substance the next. The other fractions were unfit for use. These fractions, the nucleoprotein, the polysaccharide and the Boivin's substance, showed no noticeable variation of strains, but had a clear type specigicity; this fact suggests that these fractions are of practical value in the precipitation. 3) The nucleoprotein or Boivin's substance (endotoxin) rather than Julianelle's substance (polysaccharide) showed a inhibitory action on the hemagglutination by influenza virus. This hemagglutination inhibition was, however, proved to be of no type specificity.