| ID | 16004 |
| Eprint ID | 16004
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| フルテキストURL | |
| タイトル（別表記） | Mononuclear phagocyte abnormality in sarcoidosis I. Studies on superoxide production of blood monocytes in patients with sarcoidosis
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| 著者 |
岸 俊行
岡山大学医学部第二内科学教室
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| 抄録 | The superoxide production of peripheral blood monocytes stimulated by concanavalin A and cytochalasin E was examined in sarcoidosis patients. The superoxide production of monocytes was significantly enhanced in sarcoidosis patients (9.8±6.4 nmol/min/10(6) cells) compared with healthy controls (6.6±3.5) (p<0.02). The levels of superoxide production were 12.4±8.7 in 14 patients with stage 1 sarcoidosis (bilateral hilar lymphadenopathy), 9.4±3.9 in 15 patients with stage 2 sarcoidosis (bilateral hilar lymphadenopathy and parenchymal involvement) and 6.1±2.6 in 4 patients with stage 3 sarcoidosis (parenchymal involvement). These levels were significantly higher in patients with stage 1 and 2 sarcoidosis than in healthy controls. The superoxide production was significantly enhanced in patients with elevated serum lysozyme activity and slightly enhanced in patients with high percentages of T-lymphocytes (over 28%) in bronchoalveolar lavage fluid. These data suggest that peripheral blood monocytes in sarcoidosis patients have been activated by unknown factors.
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| キーワード | superoxide
monocyte
sarcoidosis
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| 発行日 | 1987-10-31
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 99巻
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| 号 | 9-10号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 1131
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| 終了ページ | 1136
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1131/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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