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Title Alternative Drug discovery strategies for drug repositioning based on data science
FullText URL 134_16.pdf
Author Zamami, Yoshito|
Keywords データサイエンス ドラッグリポジショニング 医療情報データベース 生命科学データベース
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 16
End Page 21
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.16
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.16
Title Alternative Viral pathogenesis and the symbiosis between viruses and hosts
FullText URL 134_10.pdf
Author Honda, Tomoyuki|
Keywords ウイルス 宿主 共生 病原性 免疫
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 10
End Page 15
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.10
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.10
Title Alternative The 2020 Incentive Award of the Okayama Medical Association in Cancer Research (2020 Hayashibara Prize and Yamada Prize)
FullText URL 134_7.pdf
Author Matsumoto, Yuji|
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 7
End Page 9
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.7
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.7
Title Alternative The 2020 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2020 Sunada Prize)
FullText URL 134_4.pdf
Author Oda, Naohiro|
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 4
End Page 6
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.4
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.4
Title Alternative The 2020 Incentive Award of the Okayama Medical Association in General Medical Science (2020 Yuuki Prize)
FullText URL 134_1.pdf
Author Asano, Sumie|
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 1
End Page 3
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.1
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.1
Title Alternative Annual report / Institute of Plant Science and Resources, Okayama University
FullText URL IPSR_30.pdf
Author Institute of Plant Science and Resources, Okayama University|
Publication Title Annual Report, Institute of Plant Science and Resources Okayama University
Published Date 2023-03-31
Volume volume30
Start Page 1
End Page 68
ISSN 2186-4918
language Japanese
File Version publisher
Title Alternative Annual report / Institute of Plant Science and Resources, Okayama University
FullText URL IPSR_29.pdf
Author Institute of Plant Science and Resources, Okayama University|
Publication Title Annual Report, Institute of Plant Science and Resources Okayama University
Published Date 2022-03-31
Volume volume29
Start Page 1
End Page 62
ISSN 2186-4918
language Japanese
File Version publisher
FullText URL srfa_112_cover_e.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_colophon.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative The List of Published by Members of the Faculty From January to December 2022
FullText URL srfa_112_023_036.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 23
End Page 36
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Sexual Dimorphism of Arginine Vasotocin Neuron in Birds
FullText URL srfa_112_019_022.pdf
Author Saito, Noboru|
Abstract Arginine vasotocin (AVT) is one of neurohypophysial peptides in birds and is well known both as an antidiuretic and oxytocic hormone. AVT is produced in the hypothalamus and mainly synthesized in magnocellular neurons, supraoptic nucleus (SON) and paraventricular nucleus (PVN). Recent, immunocytochemistry and in situ hybridization results indicate that AVT is also synthesized in parvocellular neurons corresponding to mammalian stria terminalis (nST). The AVT neurons in nST in the male are more numerous than those in the female. Therefore, these data suggest that there is sexual dimorphism in the distribution of AVT neurons. Several experiments involving electrical lesion, testosterone implantation, and the detection of the immediately-early gene expression in birds expressing copulatory behavior suggested that nST and nucleus praeopticus medialis (POM) were related to the reproductive behavior. When male embryo was treated with estradiol, the distribution of AVT neurons assumes the same distribution as found in the female, and reproductive behavior was abolished, suggesting that AVT in the brain has an important role in reproductive behavior.
Keywords arginine vasotocin sexual dimorphism reproductive behavior parvocellular neurons bird
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 19
End Page 22
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Studies on l-Glutamate Oxidase with Strict Substrate Specificity from Streptomyces sp.
FullText URL srfa_112_013_018.pdf
Author Nakayama, Natsume| Inagaki, K.|
Abstract l-glutamate oxidase (LGOX) from Streptomyces sp. is a heterohexameric flavin enzyme that catalyzes the oxidative deamination of l-glutamate to form α-ketoglutarate with ammonia and hydrogen peroxide. LGOX shows strict substrate specificity for l-Glu. In addition, it is highly thermostable and pH stable. Because of these properties, LGOX is currently used as a biosensor for the trace determination of l-Glu in the food industry and clinical laboratories. The full-length cDNA is 2103 bp and is encoded by a single polypeptide chain consisting of 701 residues including subunits α-γ-β. The LGOX gene was heterologously expressed in Escherichia coli JM109. The LGOX precursor expressed in E. coli is a homodimer with weak enzymatic activity and becomes a heterohexamer upon activation by protease treatment. X-ray crystallography and docking studies of purified recombinant LGOX suggest that the Arg305 residue is a key residue for substrate recognition. Mutant analysis showed that Arg305 is essential for substrate recognition, as the activity toward l-Glu was greatly reduced and substrate specificity was changed in some enzymes. The functional analysis of R305E-LGOX, which is an l-Arg oxidase, revealed that R305E-LGOX can be used as a enzyme biosensor for l-Arg.
Keywords l-glutamate oxidase biosensor substrate recognition X-ray crystallography modification of substrate specificity
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 13
End Page 18
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_007_012.pdf
Author Thao Thu Phan| Fukushima, Keigo| Tanaka, Yoshiyuki| Yasuba, Ken-ichiro| Yoshida, Yuichi| Goto, Tanjuro|
Abstract This study aimed to investigate whether seed cold priming by PEG‒6000, followed by re‒drying would affect the germination, growth, and flowering of Eustoma ‘Exe Lavender’ raised seedling under high temperatures. Seeds of control treatment were not treated with cold‒priming or re‒drying. In experiment 1, seeds were cold‒primed with water and PEG‒6000 at ‒0.75 and ‒1.5 MPa for 5 weeks at 10°C in the dark and then subjected to re‒dried and storage for 30 days at 10°C. The results showed that cold‒primed seeds germinated earlier than those of the control. Compared to water treatment, plants grown from PEG‒6000 treatments and re‒drying showed similar germination rate, bolting rate, days to bolting, bolting node and flowering rate. In experiment 2, cold priming periods by water and ‒1.5 MPa PEG‒6000 were investigated for 4, 5, 6, 7, and 8 weeks. ‘Exe Lavender’ seeds treated with cold water and in the dark for longer than 5 weeks increased their percentage of radicle emergence and decreased germination rate after 30 days of re‒drying and storage. Meanwhile, those treated with cold-PEG did not protrude the radicle even for 8 weeks of priming and maintained the germination rate after re‒drying and storage. Days to bolting and days to flowering tended to decrease when the priming period decreased. The results suggest that the seed cold priming treatment by ‒1.5 MPa PEG‒6000 and subsequent re‒drying improved germination rate and maintained bolting rate and flowering rate in Eustoma compared to cold priming treatment by water raised seedling under high temperature conditions.
Keywords bolting chilling dehydrate PEG-6000 storage
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 7
End Page 12
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_001_006.pdf
Author Yoshida, Yuichi| Hanada, Atsushi| Ooguma, Keita| Yoshida, Kenta| Goto, Tanjuro| Tanaka, Yoshiyuki| Yasuba, Ken-ichiro|
Abstract Long day (LD) treatment is frequently applied for horticultural crops, including strawberry, and sufficient effect similar to 4 to 6hours of day time elongation in the evening can be achieved by 1 to 3hours of night break in the mid night. Incandescent lamps (IC) have long been an important light source, but the general incandescent lamps are out of production and have been replaced with LED or florescent lamps (FL). Thus, we compared light sources and their color temperature (2,800K, warm white similar to IC; 6,500K, daylight) in different lighting programs. The effectiveness of 3 and 4cycles of alternate intermittent lighting, 30min on/30min off, were equal to and larger than 2hours of night break, respectively. Measured intensity of illumination (lux) at the canopy surface by 2,800K LED (6.9W) and FL (12W) was 1.50 and 0.95times as large as IC (54W), but leaf growth under LED and FL was similar to and less vigorous than IC, respectively. On the other hand, intensity values of illumination by 6,500K LED (6.9W) and FL (12W) were both 1.20times as large as 2,800K ones, but 6,500K light sources were much less effective compared to 2,800K ones. Daylight type LED and FL which have higher luminance efficiency but emit less red light compared to warm white ones, are not suitable as alternative light sources for IC.
Keywords daylight Fragaria ×ananassa Duch. intermittent lighting luminance efficiency warm white
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
Start Page 1
End Page 6
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_contents.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL srfa_112_cover.pdf
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2023-02-01
Volume volume112
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL scs_022_colophon.pdf
Publication Title Studies in Cultural Symbiotics
Published Date 2022-12-23
Volume volume22
ISSN 1880-9162
language Japanese
Copyright Holders Copyright © 2022 岡山大学大学院社会文化科学研究科
File Version publisher
JaLCDOI 10.18926/64340
Title Alternative Japanese Translation of “Lunyu Jizhu” (6) (Part 2) ―Xi ZHU’s Interpretation of “Confucian Analects”―
FullText URL scs_022_(001).pdf
Author Sun, Luyi|
Publication Title Studies in Cultural Symbiotics
Published Date 2022-12-23
Volume volume22
Start Page (1)
End Page (25)
ISSN 1880-9162
language Japanese
Copyright Holders Copyright © 2022 岡山大学大学院社会文化科学研究科
File Version publisher
JaLCDOI 10.18926/64339
FullText URL scs_022_107.pdf
Author Yoshinaga, Mitsutoshi|
Publication Title Studies in Cultural Symbiotics
Published Date 2022-12-23
Volume volume22
Start Page 107
End Page 128
ISSN 1880-9162
language Japanese
Copyright Holders Copyright © 2022 岡山大学大学院社会文化科学研究科
File Version publisher
JaLCDOI 10.18926/64338
Title Alternative The Influence of Urumqui-Kuitun Highway Construction on the North Economic Zone of Xinjiang, China
FullText URL scs_022_085.pdf
Author Xue, Yuyang|
Publication Title Studies in Cultural Symbiotics
Published Date 2022-12-23
Volume volume22
Start Page 85
End Page 106
ISSN 1880-9162
language Japanese
Copyright Holders Copyright © 2022 岡山大学大学院社会文化科学研究科
File Version publisher