result 47530 件
| JaLCDOI | 10.18926/AMO/52899 |
|---|---|
| FullText URL | 68_5_303.pdf |
| Author | Tanaka, Masato| Sugimoto, Yoshihisa| Arataki, Shinya| Takigawa, Tomoyuki| Ozaki, Toshifumi| |
| Abstract | Spinal deformity is an important clinical manifestation of Chiari I malformation (CM-I) and syringomyelia. Here we report the result of an 8-year follow-up of a 13-year-old girl with severe scoliosis associated with Chiari malformation and a large syringomyelia. The patient presented at our hospital at the age of 13 with a 68° scoliosis. Magnetic resonance imaging showed Chiari malformation and a large syringomyelia. Neurosurgical treatment involved foramen magnum decompression and partial C1 laminectomy, but the scoliosis still progressed. We present the first case report of a rare course of scoliosis in a patient with CM-I and a large syringomyelia. |
| Keywords | Chiari I malformation syringomyelia scoliosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 303 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338487 |
| Web of Science KeyUT | 000343269300007 |
| JaLCDOI | 10.18926/AMO/52898 |
|---|---|
| FullText URL | 68_5_291.pdf |
| Author | Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide| |
| Abstract | It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. |
| Keywords | interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 291 |
| End Page | 302 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338486 |
| Web of Science KeyUT | 000343269300006 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53129 |
| JaLCDOI | 10.18926/AMO/52897 |
|---|---|
| FullText URL | 68_5_285.pdf |
| Author | Morisada, Sunao| Ugawa, Toyomu| Nosaka, Nobuyuki| Ujike, Yoshihito| |
| Abstract | Current systems for the evaluation of trauma severity are tedious and difficult to apply in an actual emergency setting. We aimed to develop and assess the accuracy of a more efficient severity evaluation system, termed the Ugawa classification, using brain-type natriuretic peptide (BNP) measurement and the estimated glomerular filtration rate (eGFR). Two-hundred trauma patients were divided into 2 groups using an eGFR cut-off value of 90ml/min/1.73m2 as an indicator of normal renal function and 2 additional groups according to whether the BNP values were greater or less than the age in years. This resulted in 4 subject groups with different combinations of eGFR and BNP. The mean SOFA score, injury severity scores (ISS), trauma and injury severity scores (TRISS), and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores of the groups were compared by Kruskal-Wallis test, and the mortality rate after 90 days was calculated. Significant intergroup differences were found in SOFA scores, ISS scores, and APACHE II-predicted mortality rates. Although no significant differences were found in the mortality rate after 90 days or TRISS-predicted mortality rate among the 4 groups, there was a trend toward increasing trauma severity from group 1 to 4. Thus, the Ugawa classification is as accurate as existing systems, has greater efficiency, and is user-friendly. |
| Keywords | acute injury Acute Physiology and Chronic Health Evaluation II injury severity score sequential organ failure assessment trauma and injury severity score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338485 |
| Web of Science KeyUT | 000343269300005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52958 |
| JaLCDOI | 10.18926/AMO/52896 |
|---|---|
| FullText URL | 68_5_277.pdf |
| Author | Miyasaka, Dai| Ito, Tomoyuki| Imai, Norio| Suda, Ken| Minato, Izumi| Dohmae, Yoichiro| Endo, Naoto| |
| Abstract | The acetabular coverage of the femoral head has been assessed in two-dimensions as the projected covered area or the covered angle on plain radiographs. We present a novel method of the three-dimensional assessment of femoral head coverage obtained by evaluating the covered volume of the femoral head in both normal and dysplastic hips. We also assessed the covered angles on the vertical slices passing through the center of the femoral head. The mean covered volume of the femoral head was 57.4% in normal hips and 26.6% in dysplastic hips. In dysplastic hips, the L-CE, A-CE, and P-CE angles were 7.7°, 21.8°, and 95.8°, respectively, while the acetabular angle was 27.5°. In normal hips, the CE angles were 34.0°, 56.8°, and 109.4°, respectively, while the acetabular angle was 7.2°. Our study suggests the usefulness of a novel 3D assessment for acetabular coverage of the femoral head. This assessment provided the precise 3D information necessary to diagnose hip dysplasia and assess the deficiency of acetabular coverage in these patients. Moreover, we may detect a cut-off between normal and dysplastic hips in the 3D assessment by assessing a large number of dysplastic hips both morphologically and using the new assessment. |
| Keywords | hip dysplasia three-dimensional imaging femoral head coverage acetabulum patient positioning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 277 |
| End Page | 284 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338484 |
| Web of Science KeyUT | 000343269300004 |
| JaLCDOI | 10.18926/AMO/52895 |
|---|---|
| FullText URL | 68_5_269.pdf |
| Author | Tomoyasu, Yumiko| Higuchi, Hitoshi| Mori, Megumi| Takaya, Kumiko| Honda, Yuka| Yamane, Ayaka| Yabuki, Akiko| Hayashi, Tomoko| Ishii-Maruhama, Minako| Jinzenji, Ayako| Maeda, Shigeru| Kohjitani, Atsushi| Shimada, Masahiko| Miyawaki, Takuya| |
| Abstract | Orofacial pain is often difficult to diagnose and treat. However, there have been few reports on the clinical observation of dental patients with orofacial pain. We retrospectively investigated the characteristics of 221 dental patients who had suffered from persistent orofacial pain. Data were collected from the outpatient medical records in our clinic over the past 12 years. More than half of the patients (53.8%) had suffered with pain for more than 6 months from pain onset until the first visit to our clinic. The main diagnoses were neuropathic pain (30.3%), myofascial pain (23.5%), psychogenic pain (20.4%), odontogenic toothache (17.2%), and others (7.7%) such as temporomandibular disorders and glossitis. The treatments included pharmacotherapy, splint therapy, and others such as nerve block, dental treatment, physiotherapy, and/or psychotherapy. Excluding the patients (52 of 221 initially enrolled patients) with unknown responses to treatment, 65.7% showed remission or a significant improvement in pain in response to treatment. Although only a small group of patients had odontogenic toothache, the rate of improvement was highest for this disorder. In conclusion, early consultation with a dentist is useful to prevent chronicity of odontogenic pain and to make a differential diagnosis in patients with orofacial pain. |
| Keywords | dental patients pain clinic orofacial pain dental anesthesiology clinical observation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 269 |
| End Page | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338483 |
| Web of Science KeyUT | 000343269300003 |
| JaLCDOI | 10.18926/AMO/52894 |
|---|---|
| FullText URL | 68_5_263.pdf |
| Author | Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
| Abstract | Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. |
| Keywords | chronic hepatitis C nursing support interferon therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338482 |
| Web of Science KeyUT | 000343269300002 |
| JaLCDOI | 10.18926/AMO/52893 |
|---|---|
| FullText URL | 68_5_255.pdf |
| Author | Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors. |
| Keywords | motivation reward dopamine operant behavior intracranial self-stimulation |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338481 |
| Web of Science KeyUT | 000343269300001 |
| Author | MINOWA, Hirotsugu| MUNESAWA, Yoshiomi| |
|---|---|
| Published Date | 2014-10-15 |
| Publication Title | 安全工学 |
| Volume | volume53 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | MINOWA, Hirotsugu| MUNESAWA, Yoshiomi| HASHIMOTO, Kohei| |
|---|---|
| Published Date | 2014-10-15 |
| Publication Title | 安全工学 |
| Volume | volume53 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Terayama, Ryuji| Maruhama, Kotaro| Tsuchiya, Hiroki| Mizutani, Masahide| Iida, Seiji| Sugimoto, Tomosada| |
|---|---|
| Published Date | 2014-12 |
| Publication Title | Archives of Oral Biology |
| Volume | volume59 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | 岡山大学文学部| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Others |
| Author | 宮崎 和人| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | 堤 良一| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | 栗林 裕| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | 京 健治| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | Kaneko, Makoto| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | Katagiri, Masumi| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Research Paper |
| Author | 岡山大学文学部| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Others |
| Author | 宮崎 和人| 栗林 裕| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Others |
| Author | 岡山大学文学部| |
|---|---|
| Published Date | 2014-07-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22 |
| Content Type | Others |
