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FullText URL persica_046_043_052.pdf
Author Nasu, Masako|
Publication Title Persica
Published Date 2019-03-31
Volume volume46
Start Page 43
End Page 52
ISSN 0389-7788
language Japanese
File Version publisher
NAID 120006820631
FullText URL persica_046_031_042.pdf
Author 吉田 安曇|
Publication Title Persica
Published Date 2019-03-31
Volume volume46
Start Page 31
End Page 42
ISSN 0389-7788
language Japanese
File Version publisher
NAID 120006820630
FullText URL persica_046_013_029.pdf
Author Wakimoto, Kyoko|
Publication Title Persica
Published Date 2019-03-31
Volume volume46
Start Page 13
End Page 29
ISSN 0389-7788
language Japanese
File Version publisher
NAID 120006820629
FullText URL persica_046_001_012.pdf
Author 寺西 雅之|
Publication Title Persica
Published Date 2019-03-31
Volume volume46
Start Page 1
End Page 12
ISSN 0389-7788
language Japanese
File Version publisher
NAID 120006820628
FullText URL persica_046_cover.pdf
Publication Title Persica
Published Date 2019-03-31
Volume volume46
ISSN 0389-7788
language Japanese
File Version publisher
FullText URL Nat_Astro_1_0137.pdf
Author Tanaka, Ryoji| Nakamura, Eizo|
Note This is an Accepted Manuscript of an article published by Springer Nature Publishing AG|
Published Date 2017-05-26
Publication Title Nature Astronomy
Volume volume1
Publisher Springer Nature Publishing AG
Start Page 0137
ISSN 23973366
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1038/s41550-017-0137
Related Url isVersionOf https://doi.org/10.1038/s41550-017-0137
FullText URL J_Organ_Chem.pdf
Author Takamura, Hiroyoshi| Kikuchi, Takahiro| Iwamoto, Kohei| Nakao, Eiji| Harada, Naoki| Otsu, Taichi| Endo, Noriyuki| Fukuda, Yuji| Ohno, Osamu| Suenaga, Kiyotake| Guo, Yue-Wei| Kadota, Isao|
Note This is an Accepted Manuscript of an article published by American Chemical Society|
Published Date 2018-08-09
Publication Title The Journal of Organic Chemistry
Volume volume83
Issue issue18
Publisher American Chemical Society
Start Page 11028
End Page 11056
ISSN 0022-3263
NCID AA00704100
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30091605
DOI 10.1021/acs.joc.8b01634
Web of Science KeyUT 000445713000035
Related Url isVersionOf https://doi.org/10.1021/acs.joc.8b01634
FullText URL tetrahed_lett_59_11_955.pdf
Author Takamura, Hiroyoshi|
Keywords Natural product Stereodivergent synthesis Stereodiversification Stereoisomer
Published Date 2018-02-10
Publication Title Tetrahedron Letters
Volume volume59
Issue issue11
Publisher Pergamon Press
Start Page 955
End Page 966
ISSN 00404039
NCID AA00861801
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1016/j.tetlet.2018.02.004
Web of Science KeyUT 000427217400001
Related Url isVersionOf https://doi.org/10.1016/j.tetlet.2018.02.004
FullText URL Front_Microbiol_4_144.pdf
Author Chowdhury, Goutam| Joshi, Sangeeta| Bhattacharya, Sanjay| Sekar, Uma| Birajdar, Balaji| Bhattacharyya, Arpita| Shinoda, Sumio| Ramamurthy, Thandavarayan|
Note This work was supported by the Japan Initiative for Global Research Network for Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology, Japan.|
Published Date 2016-02-11
Publication Title frontiers in Microbiology
Volume volume7
Publisher Frontiers Research Foundation
Start Page 144
ISSN 1664302X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 26904017
DOI 10.3389/fmicb.2016.00144
Web of Science KeyUT 000443434600001
Related Url isVersionOf https://doi.org/10.3389/fmicb.2016.00144
FullText URL Plos_Negl_Trop_Dis_5386.pdf
Author Imamura, Daisuke| Morita, Masatomo| Sekizuka, Tsuyoshi| Mizuno, Tamaki| Takemura, Taichiro| Yamashiro, Tetsu| Chowdhury, Goutam| Pazhani, Gururaja P.| Mukhopadhyay, Asish K.| Ramamurthy, Thandavarayan| Miyoshi, Shin-ichi| Kuroda, Makoto| Shinoda, Sumio| Ohnishi, Makoto|
Note This research is supported by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan, and Japan Agency for Medical Research and Development (AMED).|
Published Date 2017-02-13
Publication Title PLOS Neglected Tropical Diseases
Volume volume11
Issue issue2
Publisher PLOS
Start Page e0005386
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 28192431
DOI 10.1371/journal.pntd.0005386
Web of Science KeyUT 000396406600020
Related Url isVersionOf https://doi.org/10.1371/journal.pntd.0005386
FullText URL Arch_Parasitol_1_2_114.pdf
Author Ganguly, Sandipan| Malhotra, Anil| Chowdhuri, Manish| Ghosal, Ajanta| Sanjib Kumar Sardar| Okamoto, Keinosuke| Dutta, Shanta| Bhattacharya, Sujit K|
Keywords Meningoencephalitis Intractable seizure Coma Amoeba Naegleria fowleri
Published Date 2017-11-30
Publication Title Archives of Parasitology
Volume volume1
Issue issue3
Publisher OMICS International
Start Page 1000114
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
JaLCDOI 10.18926/AMO/56655
FullText URL 73_2_181.pdf
Author Okamura, Tomoka| Washio, Yousuke| Yoshimoto, Junko| Tani, Kazumasa| Tsukahara, Hirokazu| Shimada, Akira|
Abstract Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.
Keywords cytarabine Down syndrome exchange transfusion hydrops fetalis transient abnormal myelopoiesis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 181
End Page 188
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015754
JaLCDOI 10.18926/AMO/56654
FullText URL 73_2_177.pdf
Author Okita, Atsushi| Ohtani, Jun|
Abstract We report a rare case of fistulation to the jejunum after percutaneous endoscopic gastrostomy (PEG). An 85-year-old man with previous cerebral infarction and swallowing disturbance underwent PEG. Nine months later, he developed a high fever and discharge around the gastrostomy button. He was diagnosed with aspiration pneumonia, and administered antibiotic therapy. Examination showed digestive fluid around the gastrostomy button. Gastrointestinal contrast-enhanced CT revealed a gastrojejunocutaneous fistula. The button was removed, and the fistula closed naturally. PEG was performed again. The patient’s postoperative course was uneventful. Gastrojejunocutaneous fistula should be considered in cases involving increased discharge from a gastrostomy fistula.
Keywords percutaneous endoscopic gastrostomy gastrojejunocutaneous fistula
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 177
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015753
JaLCDOI 10.18926/AMO/56653
FullText URL 73_2_173.pdf
Author Tamada, Shoko| Masuyama, Hisashi| Hayata, Kei| Eto, Eriko| Mitsui, Takashi| Eguchi, Takeshi| Maki, Jota| Tani, Kazumasa|
Abstract Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Here we describe the successful management of a pregnancy after abdominal RT (ART). The 34-year-old patient was gravida 1, para 0. When she was 27, she underwent ART for stage Ib1 cervical cancer, and she became pregnant 7 years later. Because her cervical canal was 16.7 mm during early pregnancy, we performed TAC at 12 weeks of pregnancy. Post-surgery, we administered an infusion of ritodrine hydrochloride for tocolysis. A selective caesarean section was performed at 36 weeks, with the delivery of a healthy infant.
Keywords cervical cancer radical trachelectomy pregnancy transabdominal cerclage
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 173
End Page 176
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015752
JaLCDOI 10.18926/AMO/56652
FullText URL 73_2_161.pdf
Author Okamoto, Sachiyo| Matsuoka, Ken-ichi| Sakamoto, Maiko| Usui, Yoshiaki| Fujiwara, Yuki| Kondo, Takumi| Tani, Katsuma| Saeki, Kyosuke| Meguri, Yusuke| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu|
Abstract Second allogeneic stem cell transplantation (allo-SCT) is a potentially curative therapy for patients who relapse after first allo-SCT. Human leukocyte antigen (HLA)-haploidentical related donors provide the broad opportunity to conduct second SCT at the appropriate time, but the efficacy of second SCT from haploidentical donors after relapse has not been established. We retrospectively analyzed the records of 33 patients who underwent second SCT. Twenty patients underwent haplo-SCT with low-dose antithymocyte globulin (ATG), and the other 13 patients underwent conventional- SCTs, including HLA-matched related peripheral blood, unrelated bone marrow or cord blood. Three years after the second SCT, the overall survival (OS) and progression-free survival (PFS) of all patients were 32.5% and 23.9%. Multivariate analyses indicated that non-complete response at second SCT, less than 1-year interval to relapse after first- SCT, and total score ≥ 3 on the hematopoietic cell transplantation-specific comorbidity index were significantly associated with a lower PFS rate. The haplo- and conventional- SCT groups showed equivalent results regarding OS, PFS, cumulative incidences of relapse, non-relapse mortality and graft-versus-host disease. The neutropenic period after transplantation was significantly shorter in haplo- SCT than conventional- SCT (10.5 days vs. 16 days, p=0.001). Our analysis revealed that haplo-SCT could be an alternative therapeutic option for relapsed patients after first SCT.
Keywords allogeneic stem cell transplantation haploidentical stem cell transplantation relapse anti-T lymphocyte globulin
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 161
End Page 171
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015751
JaLCDOI 10.18926/AMO/56651
FullText URL 73_2_155.pdf
Author Minami, Daisuke| Kayatani, Hiroe| Sato, Ken| Fujiwara, Keiichi| Shibayama, Takuo| Yonei, Toshiro| Sato, Toshio|
Abstract We investigated the clinical characteristics of refractory asthma associated with the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated data from 10 patients who underwent BT between June 2016 and December 2017 at Okayama Medical Center. The following were measured before and 6 months post-BT: forced expiratory volume in 1.0 s (FEV1), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) level, blood eosinophil counts (Eosi), Asthma Quality of Life Questionnaire (AQLQ) score, and preventive medication use. At baseline, the mean post-bronchodilator FEV1 was 80.9% of the predicted value (range 45.6-115.7%). All patients were being treated with moderate- or high-dose inhaled corticosteroids and long-acting β2 agonists. The AQLQ improved from 4.26±1.67 at baseline to 5.59±0.94 at 6 months post-BT (p<0.05). The %FEV1, FeNO, IgE, and Eosi did not change significantly between baseline and 6 months post-BT. No severe complications were reported. BT was effective for non-allergic and non-eosinophilic in 3 patients, and allergic or eosinophilic in 4 patients. Their AQLQ improved by > 0.5 points post-BT. For both allergic and eosinophilic asthmatics following mepolizumab, BT was not useful. BT was effective for non-allergic and non-eosinophilic or allergic asthmatics, but insufficient for both allergic and eosinophilic following mepolizumab.
Keywords bronchial thermoplasty non-allergic asthma non-eosinophilic asthma airway hyper-responsiveness patient selection
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 155
End Page 160
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015750
JaLCDOI 10.18926/AMO/56650
FullText URL 73_2_147.pdf
Author Hayashi, Masao| Taniguchi, Arata| Kaku, Ryuji| Fujimoto, Shusaku| Isoyama, Satoshi| Manabe, Sei| Yoshida, Tsubasa| Suzuki, Satoshi| Shimizu, Kazuyoshi| Morimatsu, Hiroshi| Momota, Ryusuke|
Abstract Tachycardia is common in intensive care units (ICUs). It is unknown whether tachycardia or prolonged tachycardia affects patient outcomes. We investigated the association between tachycardia and mortality in critically ill patients. This retrospective cohort study’s primary outcome was patient mortality in the ICU and the hospital. We stratified the patients (n=476) by heart rate (HR) as LowHR, MediumHR, and HighHR groups. We also stratified them by their durations of HR >100 (prolonged HR; tachycardia): MildT, ModerateT, and SevereT groups. We determined the six groups’ mortality. The ICU mortality rates of the LowHR, MediumHR, and HighHR groups were 1.0%, 1.5%, and 7.9%, respectively; significantly higher in the HighHR vs. LowHR group. The in-hospital mortality rates of these groups were 1%, 4.5%, and 14.6%, respectively; significantly higher in the HighHR vs. LowHR group. The ICU mortality rates of the MildT, ModerateT, and SevereT groups were 0.9%, 5.6%, and 57.1%, respectively. The mortality of the HRT=0 (i.e., all HR ≤ 100) patients was 0%. The in-hospital mortality rates of the MildT, ModerateT, and SevereT groups were 1.8%, 16.7%, and 85.7%, respectively; that of the HRT=0 patients was 0.5%. Both higher HR and prolonged tachycardia were associated with poor outcomes.
Keywords tachycardia mortality ICU in-hospital
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 147
End Page 153
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015749
JaLCDOI 10.18926/AMO/56649
FullText URL 73_2_135.pdf
Author Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka|
Abstract The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization.
Keywords collagen XVIII basement membrane wound healing re-epithelialization skin
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 135
End Page 146
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015748
JaLCDOI 10.18926/AMO/56648
FullText URL 73_2_127.pdf
Author Iwasaki, Yukari| Miyahara, Kimiko| Miyatake, Nobuyuki| Nakatsuka, Mikiya|
Abstract We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects’ height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects’ intake of energy and nutrients based on meals provided at the subjects’ dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol were measured. Most of the subjects (81.3%) were underweight (body mass index <18.5). The thyroid hormone free T3 value was decreased, but TSH was not increased and was similar to that observed in individuals with anorexia nervosa. In our subjects, thyroid hormone was associated with BMD and nutritional intake. To improve the menstruation abnormality of female athletes and to increase their bone density, the athletes’ weight should be managed by proper nutrient intake and the maintenance of their thyroid function.
Keywords thyroid function nutritious status female high school long-distance runners bone mineral density menstrual condition
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 127
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015747
JaLCDOI 10.18926/AMO/56647
FullText URL 73_2_117.pdf
Author Yamasaki, Yukie| Tamiya, Nanako| Yamamoto, Hideki| Miyaishi, Satoru|
Abstract According to the World Health Organization’s World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Age, sex, manner/cause of death, and various circumstances of the incident were investigated. There were 73 unintentional injury deaths during the study period. Drowning (n=29), suffocation (n=24), and transport accidents (n=13) were the major categories of unintentional injury deaths. Twenty-two cases (30.1%) were autopsied. Differences in the characteristics of the unintentional injury deaths by age were observed. Information which cannot be obtained from Vital Statistics was available from medico-legal documents, and detailed characteristics of unintentional injury deaths among children < 5 years old were elucidated. Investigating medico-legal information is one of the meaningful measures for the prevention of unintentional injury deaths among children in Japan.
Keywords child death unintentional injury prevention medico-legal document
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 125
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015746